Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7052
Gene name Gene Name - the full gene name approved by the HGNC.
Transglutaminase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TGM2
Synonyms (NCBI Gene) Gene synonyms aliases
G(h), TG(C), TGC, hTG2, tTG
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q11.23
Summary Summary of gene provided in NCBI Entrez Gene.
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006814 hsa-miR-1285-3p Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 22294552
MIRT006814 hsa-miR-1285-3p Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 22294552
MIRT019710 hsa-miR-375 Microarray 20215506
MIRT020574 hsa-miR-155-5p Proteomics 18668040
MIRT025339 hsa-miR-34a-5p Proteomics 21566225
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000785 Component Chromatin IDA 9575137
GO:0000786 Component Nucleosome IDA 30867594, 32273471
GO:0003810 Function Protein-glutamine gamma-glutamyltransferase activity IBA
GO:0003810 Function Protein-glutamine gamma-glutamyltransferase activity IDA 7649299, 9252372, 12506096, 23941696
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
190196 11778 ENSG00000198959
Protein
UniProt ID P21980
Protein name Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine d
Protein function Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-link
PDB 1KV3 , 2Q3Z , 3LY6 , 3S3J , 3S3P , 3S3S , 4PYG , 6A8P , 6KZB , 8TR9 , 9BC2 , 9BC3 , 9BC4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00868 Transglut_N 4 122 Transglutaminase family Domain
PF01841 Transglut_core 255 359 Transglutaminase-like superfamily Family
PF00927 Transglut_C 473 573 Transglutaminase family, C-terminal ig like domain Domain
PF00927 Transglut_C 587 686 Transglutaminase family, C-terminal ig like domain Domain
Sequence
Sequence length 687
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Huntington disease  
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Mellitus type 2 diabetes mellitus N/A N/A GenCC
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
AA amyloidosis Associate 10722712, 21790128
Adenocarcinoma Associate 24828664
Adenocarcinoma of Lung Associate 28002389
Adenoma Associate 18235007
Adenoma Islet Cell Associate 29052687
Alzheimer Disease Associate 10521460, 11013236, 22009441
Alzheimer Disease Stimulate 40401986
Ameloblastoma Associate 39675431
Arthritis Reactive Associate 9575137
Arthritis Rheumatoid Associate 20527084