Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7050
Gene name	TGFB induced factor homeobox 1
Gene symbol	TGIF1
Synonyms (NCBI Gene)	HPE4TGIF
Chromosome	18
Chromosome location	18p11.31
Summary	The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously charact

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SNP ID	Visualize variation	Clinical significance	Consequence
rs28939693	A>G,T	Pathogenic, likely-benign	Coding sequence variant, missense variant
rs121909066	C>G	Pathogenic	Missense variant, coding sequence variant
rs121909067	C>G	Pathogenic	Missense variant, coding sequence variant
rs121909068	A>C,G	Pathogenic	Missense variant, coding sequence variant
rs121909069	C>T	Pathogenic	Missense variant, coding sequence variant
rs121909070	C>G	Pathogenic	Intron variant, genic upstream transcript variant, 5 prime UTR variant, upstream transcript variant
rs202123354	G>A	Conflicting-interpretations-of-pathogenicity	Upstream transcript variant, intron variant, genic upstream transcript variant, 5 prime UTR variant
rs886041249	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1057517835	G>A	Pathogenic	Missense variant, coding sequence variant
rs1555650923	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1555651112	->T	Likely-pathogenic	Frameshift variant, coding sequence variant

314

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004287	hsa-miR-21-5p	Western blot	19906824
MIRT641082	hsa-miR-186-5p	HITS-CLIP	23824327
MIRT641081	hsa-miR-6507-5p	HITS-CLIP	23824327
MIRT641080	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT483883	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT641079	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT641078	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT641077	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT641076	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT641075	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT483875	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT117352	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT117353	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT117361	hsa-miR-5692a	PAR-CLIP	21572407
MIRT117356	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT533834	hsa-miR-5700	PAR-CLIP	21572407
MIRT117357	hsa-miR-3163	PAR-CLIP	21572407
MIRT553661	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT117359	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT117352	hsa-miR-19a-3p	PAR-CLIP	22012620
MIRT117353	hsa-miR-19b-3p	PAR-CLIP	22012620
MIRT117356	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT533834	hsa-miR-5700	PAR-CLIP	22012620
MIRT533833	hsa-miR-3942-5p	PAR-CLIP	22012620
MIRT533832	hsa-miR-4703-5p	PAR-CLIP	22012620
MIRT533831	hsa-miR-3908	PAR-CLIP	22012620
MIRT533830	hsa-miR-374b-3p	PAR-CLIP	22012620
MIRT080071	hsa-miR-4717-3p	PAR-CLIP	22012620
MIRT533829	hsa-miR-520f-5p	PAR-CLIP	22012620
MIRT117362	hsa-miR-1253	PAR-CLIP	22012620
MIRT533828	hsa-miR-6770-5p	PAR-CLIP	22012620
MIRT080073	hsa-miR-6716-5p	PAR-CLIP	22012620
MIRT080057	hsa-miR-597-3p	PAR-CLIP	22012620
MIRT080059	hsa-miR-2117	PAR-CLIP	22012620
MIRT533827	hsa-miR-4684-5p	PAR-CLIP	22012620
MIRT080069	hsa-miR-3692-3p	PAR-CLIP	22012620
MIRT483889	hsa-miR-548c-3p	PAR-CLIP	23592263
MIRT483888	hsa-miR-495-3p	PAR-CLIP	23592263
MIRT483887	hsa-miR-5688	PAR-CLIP	23592263
MIRT483886	hsa-miR-7-1-3p	PAR-CLIP	23592263
MIRT483885	hsa-miR-7-2-3p	PAR-CLIP	23592263
MIRT483884	hsa-miR-9500	PAR-CLIP	23592263
MIRT483883	hsa-miR-3613-3p	PAR-CLIP	23592263
MIRT080071	hsa-miR-4717-3p	PAR-CLIP	23592263
MIRT483882	hsa-miR-3179	PAR-CLIP	23592263
MIRT117365	hsa-miR-3148	PAR-CLIP	23592263
MIRT483881	hsa-miR-3202	PAR-CLIP	23592263
MIRT483880	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT483878	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483879	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483877	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT483876	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT483875	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT641082	hsa-miR-186-5p	HITS-CLIP	23824327
MIRT641081	hsa-miR-6507-5p	HITS-CLIP	23824327
MIRT641080	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT483883	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT641079	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT641078	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT641077	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT641076	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT641075	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT483875	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT117352	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT117353	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT117361	hsa-miR-5692a	PAR-CLIP	21572407
MIRT117356	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT533834	hsa-miR-5700	PAR-CLIP	21572407
MIRT117357	hsa-miR-3163	PAR-CLIP	21572407
MIRT553661	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT117359	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT117352	hsa-miR-19a-3p	PAR-CLIP	22012620
MIRT117353	hsa-miR-19b-3p	PAR-CLIP	22012620
MIRT117356	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT533834	hsa-miR-5700	PAR-CLIP	22012620
MIRT533833	hsa-miR-3942-5p	PAR-CLIP	22012620
MIRT533832	hsa-miR-4703-5p	PAR-CLIP	22012620
MIRT533831	hsa-miR-3908	PAR-CLIP	22012620
MIRT533830	hsa-miR-374b-3p	PAR-CLIP	22012620
MIRT080071	hsa-miR-4717-3p	PAR-CLIP	22012620
MIRT533829	hsa-miR-520f-5p	PAR-CLIP	22012620
MIRT117362	hsa-miR-1253	PAR-CLIP	22012620
MIRT533828	hsa-miR-6770-5p	PAR-CLIP	22012620
MIRT080073	hsa-miR-6716-5p	PAR-CLIP	22012620
MIRT080057	hsa-miR-597-3p	PAR-CLIP	22012620
MIRT080059	hsa-miR-2117	PAR-CLIP	22012620
MIRT533827	hsa-miR-4684-5p	PAR-CLIP	22012620
MIRT080069	hsa-miR-3692-3p	PAR-CLIP	22012620
MIRT483889	hsa-miR-548c-3p	PAR-CLIP	23592263
MIRT483888	hsa-miR-495-3p	PAR-CLIP	23592263
MIRT483887	hsa-miR-5688	PAR-CLIP	23592263
MIRT483886	hsa-miR-7-1-3p	PAR-CLIP	23592263
MIRT483885	hsa-miR-7-2-3p	PAR-CLIP	23592263
MIRT483884	hsa-miR-9500	PAR-CLIP	23592263
MIRT483883	hsa-miR-3613-3p	PAR-CLIP	23592263
MIRT080071	hsa-miR-4717-3p	PAR-CLIP	23592263
MIRT483882	hsa-miR-3179	PAR-CLIP	23592263
MIRT117365	hsa-miR-3148	PAR-CLIP	23592263
MIRT483881	hsa-miR-3202	PAR-CLIP	23592263
MIRT483880	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT483878	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT483879	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT483877	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT483876	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT483875	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT755939	hsa-miR-299-3p	Luciferase reporter assayWestern blottingqRT-PCRImmunoprecipitaion (IP)Immunohistochemistry (IHC)Flow cytometryRNA pull down assay	38067260
MIRT1421559	hsa-miR-1	CLIP-seq
MIRT1421560	hsa-miR-101	CLIP-seq
MIRT1421561	hsa-miR-1292	CLIP-seq
MIRT1421562	hsa-miR-139-5p	CLIP-seq
MIRT1421563	hsa-miR-144	CLIP-seq
MIRT1421564	hsa-miR-146a	CLIP-seq
MIRT1421565	hsa-miR-146b-5p	CLIP-seq
MIRT1421566	hsa-miR-194	CLIP-seq
MIRT1421567	hsa-miR-19a	CLIP-seq
MIRT1421568	hsa-miR-19b	CLIP-seq
MIRT1421569	hsa-miR-2052	CLIP-seq
MIRT1421570	hsa-miR-206	CLIP-seq
MIRT1421571	hsa-miR-23a	CLIP-seq
MIRT1421572	hsa-miR-23b	CLIP-seq
MIRT1421573	hsa-miR-23c	CLIP-seq
MIRT1421574	hsa-miR-25	CLIP-seq
MIRT755939	hsa-miR-299-3p	CLIP-seq
MIRT1421575	hsa-miR-3145-3p	CLIP-seq
MIRT1421576	hsa-miR-3168	CLIP-seq
MIRT1421577	hsa-miR-32	CLIP-seq
MIRT1421578	hsa-miR-342-3p	CLIP-seq
MIRT1421579	hsa-miR-3617	CLIP-seq
MIRT1421580	hsa-miR-363	CLIP-seq
MIRT1421581	hsa-miR-3647-3p	CLIP-seq
MIRT1421582	hsa-miR-367	CLIP-seq
MIRT1421583	hsa-miR-3673	CLIP-seq
MIRT1421584	hsa-miR-3692	CLIP-seq
MIRT1421585	hsa-miR-3945	CLIP-seq
MIRT1421586	hsa-miR-412	CLIP-seq
MIRT1421587	hsa-miR-4251	CLIP-seq
MIRT1421588	hsa-miR-4253	CLIP-seq
MIRT1421589	hsa-miR-4264	CLIP-seq
MIRT1421590	hsa-miR-4265	CLIP-seq
MIRT1421591	hsa-miR-4296	CLIP-seq
MIRT1421592	hsa-miR-4297	CLIP-seq
MIRT1421593	hsa-miR-4303	CLIP-seq
MIRT1421594	hsa-miR-432	CLIP-seq
MIRT1421595	hsa-miR-4322	CLIP-seq
MIRT1421596	hsa-miR-4329	CLIP-seq
MIRT1421597	hsa-miR-4417	CLIP-seq
MIRT1421598	hsa-miR-4471	CLIP-seq
MIRT1421599	hsa-miR-4477a	CLIP-seq
MIRT1421600	hsa-miR-4491	CLIP-seq
MIRT1421601	hsa-miR-452	CLIP-seq
MIRT1421602	hsa-miR-4645-3p	CLIP-seq
MIRT1421603	hsa-miR-4657	CLIP-seq
MIRT1421604	hsa-miR-4676-3p	CLIP-seq
MIRT1421605	hsa-miR-4707-5p	CLIP-seq
MIRT1421606	hsa-miR-4709-3p	CLIP-seq
MIRT1421607	hsa-miR-4742-3p	CLIP-seq
MIRT1421608	hsa-miR-4760-3p	CLIP-seq
MIRT1421609	hsa-miR-4762-3p	CLIP-seq
MIRT1421610	hsa-miR-4766-3p	CLIP-seq
MIRT1421611	hsa-miR-4766-5p	CLIP-seq
MIRT1421612	hsa-miR-4793-5p	CLIP-seq
MIRT1421613	hsa-miR-4797-3p	CLIP-seq
MIRT1421614	hsa-miR-589	CLIP-seq
MIRT1421615	hsa-miR-613	CLIP-seq
MIRT1421616	hsa-miR-622	CLIP-seq
MIRT1421617	hsa-miR-630	CLIP-seq
MIRT1421618	hsa-miR-641	CLIP-seq
MIRT1421619	hsa-miR-802	CLIP-seq
MIRT1421620	hsa-miR-92a	CLIP-seq
MIRT1421621	hsa-miR-92b	CLIP-seq
MIRT1421622	hsa-miR-943	CLIP-seq
MIRT1421559	hsa-miR-1	CLIP-seq
MIRT1421561	hsa-miR-1292	CLIP-seq
MIRT1421563	hsa-miR-144	CLIP-seq
MIRT1421564	hsa-miR-146a	CLIP-seq
MIRT1421565	hsa-miR-146b-5p	CLIP-seq
MIRT1421566	hsa-miR-194	CLIP-seq
MIRT1421569	hsa-miR-2052	CLIP-seq
MIRT1421570	hsa-miR-206	CLIP-seq
MIRT1421574	hsa-miR-25	CLIP-seq
MIRT755939	hsa-miR-299-3p	CLIP-seq
MIRT1421575	hsa-miR-3145-3p	CLIP-seq
MIRT1421577	hsa-miR-32	CLIP-seq
MIRT1421579	hsa-miR-3617	CLIP-seq
MIRT1421580	hsa-miR-363	CLIP-seq
MIRT1421582	hsa-miR-367	CLIP-seq
MIRT1421583	hsa-miR-3673	CLIP-seq
MIRT1421584	hsa-miR-3692	CLIP-seq
MIRT1421585	hsa-miR-3945	CLIP-seq
MIRT1421586	hsa-miR-412	CLIP-seq
MIRT1421587	hsa-miR-4251	CLIP-seq
MIRT1421588	hsa-miR-4253	CLIP-seq
MIRT1421589	hsa-miR-4264	CLIP-seq
MIRT1421590	hsa-miR-4265	CLIP-seq
MIRT1421591	hsa-miR-4296	CLIP-seq
MIRT1421592	hsa-miR-4297	CLIP-seq
MIRT1421593	hsa-miR-4303	CLIP-seq
MIRT1421595	hsa-miR-4322	CLIP-seq
MIRT1421596	hsa-miR-4329	CLIP-seq
MIRT1421597	hsa-miR-4417	CLIP-seq
MIRT1421598	hsa-miR-4471	CLIP-seq
MIRT1421599	hsa-miR-4477a	CLIP-seq
MIRT1421600	hsa-miR-4491	CLIP-seq
MIRT1421601	hsa-miR-452	CLIP-seq
MIRT1421602	hsa-miR-4645-3p	CLIP-seq
MIRT1421603	hsa-miR-4657	CLIP-seq
MIRT1421604	hsa-miR-4676-3p	CLIP-seq
MIRT1421605	hsa-miR-4707-5p	CLIP-seq
MIRT1421606	hsa-miR-4709-3p	CLIP-seq
MIRT1421607	hsa-miR-4742-3p	CLIP-seq
MIRT1421608	hsa-miR-4760-3p	CLIP-seq
MIRT1421609	hsa-miR-4762-3p	CLIP-seq
MIRT1421610	hsa-miR-4766-3p	CLIP-seq
MIRT1421611	hsa-miR-4766-5p	CLIP-seq
MIRT1421612	hsa-miR-4793-5p	CLIP-seq
MIRT1421613	hsa-miR-4797-3p	CLIP-seq
MIRT1421623	hsa-miR-495	CLIP-seq
MIRT1421614	hsa-miR-589	CLIP-seq
MIRT1421615	hsa-miR-613	CLIP-seq
MIRT1421616	hsa-miR-622	CLIP-seq
MIRT1421617	hsa-miR-630	CLIP-seq
MIRT1421618	hsa-miR-641	CLIP-seq
MIRT1421619	hsa-miR-802	CLIP-seq
MIRT1421620	hsa-miR-92a	CLIP-seq
MIRT1421621	hsa-miR-92b	CLIP-seq
MIRT1421622	hsa-miR-943	CLIP-seq
MIRT1421559	hsa-miR-1	CLIP-seq
MIRT1421563	hsa-miR-144	CLIP-seq
MIRT1421564	hsa-miR-146a	CLIP-seq
MIRT1421565	hsa-miR-146b-5p	CLIP-seq
MIRT1421566	hsa-miR-194	CLIP-seq
MIRT1421567	hsa-miR-19a	CLIP-seq
MIRT1421568	hsa-miR-19b	CLIP-seq
MIRT1421569	hsa-miR-2052	CLIP-seq
MIRT1421570	hsa-miR-206	CLIP-seq
MIRT1421576	hsa-miR-3168	CLIP-seq
MIRT1421579	hsa-miR-3617	CLIP-seq
MIRT1421581	hsa-miR-3647-3p	CLIP-seq
MIRT1421583	hsa-miR-3673	CLIP-seq
MIRT1421584	hsa-miR-3692	CLIP-seq
MIRT1421585	hsa-miR-3945	CLIP-seq
MIRT1421587	hsa-miR-4251	CLIP-seq
MIRT1421588	hsa-miR-4253	CLIP-seq
MIRT1421589	hsa-miR-4264	CLIP-seq
MIRT1421593	hsa-miR-4303	CLIP-seq
MIRT1421594	hsa-miR-432	CLIP-seq
MIRT1421596	hsa-miR-4329	CLIP-seq
MIRT1421601	hsa-miR-452	CLIP-seq
MIRT1421604	hsa-miR-4676-3p	CLIP-seq
MIRT1421606	hsa-miR-4709-3p	CLIP-seq
MIRT1421607	hsa-miR-4742-3p	CLIP-seq
MIRT1421609	hsa-miR-4762-3p	CLIP-seq
MIRT1421610	hsa-miR-4766-3p	CLIP-seq
MIRT1421612	hsa-miR-4793-5p	CLIP-seq
MIRT1421613	hsa-miR-4797-3p	CLIP-seq
MIRT1421614	hsa-miR-589	CLIP-seq
MIRT1421615	hsa-miR-613	CLIP-seq
MIRT1421617	hsa-miR-630	CLIP-seq
MIRT1421618	hsa-miR-641	CLIP-seq
MIRT1421619	hsa-miR-802	CLIP-seq
MIRT1421622	hsa-miR-943	CLIP-seq
MIRT1421559	hsa-miR-1	CLIP-seq
MIRT1421561	hsa-miR-1292	CLIP-seq
MIRT1421563	hsa-miR-144	CLIP-seq
MIRT1421566	hsa-miR-194	CLIP-seq
MIRT1421570	hsa-miR-206	CLIP-seq
MIRT1421571	hsa-miR-23a	CLIP-seq
MIRT1421572	hsa-miR-23b	CLIP-seq
MIRT1421573	hsa-miR-23c	CLIP-seq
MIRT1421574	hsa-miR-25	CLIP-seq
MIRT2348463	hsa-miR-28-3p	CLIP-seq
MIRT755939	hsa-miR-299-3p	CLIP-seq
MIRT1421575	hsa-miR-3145-3p	CLIP-seq
MIRT1421577	hsa-miR-32	CLIP-seq
MIRT1421578	hsa-miR-342-3p	CLIP-seq
MIRT1421579	hsa-miR-3617	CLIP-seq
MIRT1421580	hsa-miR-363	CLIP-seq
MIRT1421582	hsa-miR-367	CLIP-seq
MIRT1421583	hsa-miR-3673	CLIP-seq
MIRT1421584	hsa-miR-3692	CLIP-seq
MIRT2348464	hsa-miR-3910	CLIP-seq
MIRT1421585	hsa-miR-3945	CLIP-seq
MIRT1421586	hsa-miR-412	CLIP-seq
MIRT1421588	hsa-miR-4253	CLIP-seq
MIRT1421589	hsa-miR-4264	CLIP-seq
MIRT1421590	hsa-miR-4265	CLIP-seq
MIRT1421591	hsa-miR-4296	CLIP-seq
MIRT1421592	hsa-miR-4297	CLIP-seq
MIRT1421594	hsa-miR-432	CLIP-seq
MIRT1421595	hsa-miR-4322	CLIP-seq
MIRT1421597	hsa-miR-4417	CLIP-seq
MIRT1421598	hsa-miR-4471	CLIP-seq
MIRT1421600	hsa-miR-4491	CLIP-seq
MIRT1421602	hsa-miR-4645-3p	CLIP-seq
MIRT1421603	hsa-miR-4657	CLIP-seq
MIRT1421605	hsa-miR-4707-5p	CLIP-seq
MIRT1421606	hsa-miR-4709-3p	CLIP-seq
MIRT1421607	hsa-miR-4742-3p	CLIP-seq
MIRT1421611	hsa-miR-4766-5p	CLIP-seq
MIRT1421612	hsa-miR-4793-5p	CLIP-seq
MIRT1421613	hsa-miR-4797-3p	CLIP-seq
MIRT2348465	hsa-miR-548an	CLIP-seq
MIRT1421615	hsa-miR-613	CLIP-seq
MIRT1421616	hsa-miR-622	CLIP-seq
MIRT1421617	hsa-miR-630	CLIP-seq
MIRT1421618	hsa-miR-641	CLIP-seq
MIRT1421619	hsa-miR-802	CLIP-seq
MIRT1421620	hsa-miR-92a	CLIP-seq
MIRT1421621	hsa-miR-92b	CLIP-seq
MIRT1421622	hsa-miR-943	CLIP-seq
MIRT1421566	hsa-miR-194	CLIP-seq
MIRT1421610	hsa-miR-4766-3p	CLIP-seq
MIRT1421613	hsa-miR-4797-3p	CLIP-seq
MIRT1421619	hsa-miR-802	CLIP-seq

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Transcription factor	Regulation	Reference
HDAC4	Activation	17610967

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	10764806
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	10764806
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	10764806
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	10764806
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP	10764806
GO:0001843	Process	Neural tube closure	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	TAS	8537382
GO:0005515	Function	Protein binding	IPI	16189514, 18511908, 21516116, 25416956, 25873176, 25910212, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0007368	Process	Determination of left/right symmetry	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0009953	Process	Dorsal/ventral pattern formation	IEA
GO:0010470	Process	Regulation of gastrulation	IEA
GO:0010629	Process	Negative regulation of gene expression	IEA
GO:0030182	Process	Neuron differentiation	IEA
GO:0035881	Process	Amacrine cell differentiation	IEA
GO:0038092	Process	Nodal signaling pathway	IEA
GO:0048144	Process	Fibroblast proliferation	IEA
GO:0048146	Process	Positive regulation of fibroblast proliferation	IEA
GO:0048387	Process	Negative regulation of retinoic acid receptor signaling pathway	IEA
GO:0060041	Process	Retina development in camera-type eye	IEA
GO:0070410	Function	Co-SMAD binding	IEA
GO:0071363	Process	Cellular response to growth factor stimulus	IEA
GO:1902871	Process	Positive regulation of amacrine cell differentiation	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
602630	11776	ENSG00000177426

Q15583

Protein name

Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1)

Protein function

Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. A

PDB

2LK2 , 6FQP , 6FQQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05920	Homeobox_KN	182 → 221	Homeobox KN domain	Family

Sequence

MVLAQSRVSAGVGSPHCSGSGGGGSDSFPWPASHPGNPQCSFSTAFLASPRLSRGTLAYL
PPAPWSSLATPSALLGSSCAPPPPPARCPQPRALSPELGTKAGPRRPHRWELPRSPSQGA
QGPAPRRRLLETMKGIVAASGSETEDEDSMDIPLDLSSSAGSGKRRRRGNLPKESVQILR
DWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTIS
RRGAKISETSSVESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPS
VICHTTVTALKDVPFSLCQSVGVGQNTDIQQIAAKNFTDTSLMYPEDTCKSGPSTNTQSG
LFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA

Sequence length

401

Interactions

View interactions

	KEGG		Reactome
	TGF-beta signaling pathway		Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

128

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Holoprosencephaly 4	Pathogenic; Likely pathogenic	rs121909067, rs121909070, rs2510043843, rs2510045920, rs2510032473, rs1555650923	RCV000007395 RCV000007398 RCV003333665 RCV003455849 RCV003881687 RCV000640538

Show/Hide Unknown Diseases (13)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs238533	RCV005904150
Clear cell carcinoma of kidney	Benign	rs2229334	RCV005894743
Disorder of sexual differentiation	Conflicting classifications of pathogenicity	rs11571509	RCV001568337
Gastric cancer	Benign	rs238533	RCV005904153
Hepatocellular carcinoma	Benign	rs2229334, rs238533	RCV005894742 RCV005904151
Holoprosencephaly sequence	Benign; Conflicting classifications of pathogenicity; Likely benign; Uncertain significance	rs238132, rs138292737, rs2229337, rs4468717, rs2229333, rs2229335, rs2229336, rs115682894, rs34622075, rs886053783, rs886053785, rs397858239	RCV000259321 RCV000318965 RCV000375922 RCV000293052 RCV000331659 RCV000344600 RCV000406285 RCV000399057 RCV000303438 RCV000397446 RCV000360564 RCV000297785
Lung cancer	Benign	rs238533, rs145725785	RCV005904155 RCV005907020
Melanoma	Benign	rs145725785	RCV005907019
Nonpapillary renal cell carcinoma	Benign	rs238533	RCV005904152
Ovarian serous cystadenocarcinoma	Likely benign	rs115682894	RCV005894745
TGIF1-related disorder	Conflicting classifications of pathogenicity; Likely benign; Benign; Uncertain significance	rs202189171, rs373881756, rs747833883, rs1393606991, rs557543525, rs1232226883, rs780454778, rs539858187, rs1387503723, rs2229334, rs921452393, rs145725785, rs148390122	RCV003938955 RCV003984194 RCV003964505 RCV003902049 RCV003973909 RCV003899273 RCV003943971 RCV003949489 RCV003969594 RCV003983018 RCV003979932 RCV003948095 RCV003908495
Uterine carcinosarcoma	Benign	rs238533	RCV005904154
Uterine corpus endometrial carcinoma	Benign	rs74669006, rs2229334	RCV005917234 RCV005894744

Show/Hide Text Mining Associations (39)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Juvenile	Associate	24709693
Arthritis Rheumatoid	Inhibit	36614150
Bone Diseases	Associate	34391399
Breast Neoplasms	Associate	34391399
Bronchiolitis Obliterans Syndrome	Inhibit	25979625
Carcinoma Hepatocellular	Associate	12593671
Central Nervous System Vascular Malformations	Associate	21940735, 22310223
Chromosome 18p deletion syndrome	Associate	30122583
Colorectal Neoplasms	Associate	29986714
Combined Pituitary Hormone Deficiency	Associate	34440302
Diabetes Insipidus	Associate	34440302
Diabetes Mellitus	Associate	36978091
Diabetic Nephropathies	Stimulate	36978091
Encephalitis Tick Borne	Associate	36753372
Esophageal Squamous Cell Carcinoma	Associate	34878149
Fibrosis	Associate	35588782
Genetic Diseases Inborn	Associate	30122583
Glioma	Stimulate	32857719, 35569122
Glycosuria Renal	Associate	36978091
Hereditary renal agenesis	Associate	34440302
Hodgkin Disease	Stimulate	33539429
Holoprosencephaly	Associate	16199538, 19431187, 20531442, 21940735, 21995818, 22310223, 23276570, 26278930, 34440302, 34884456, 7485158
Hyperlipidemia Familial Combined	Associate	23877856
Hypopituitarism	Associate	34440302
Leiomyoma	Stimulate	19524896
Leukemia Myeloid Acute	Associate	36753372
Lung Diseases	Associate	29703138
Lung Neoplasms	Associate	20849603
Mouth Neoplasms	Associate	21237437
Neoplasm Metastasis	Associate	34878149
Neoplasms	Inhibit	20534969, 34391399
Neoplasms	Associate	20849603, 20966545, 34878149, 34884456
Neoplasms Squamous Cell	Associate	34878149
Neural Tube Defects	Associate	21940735
Pregnancy Ectopic	Associate	34440302
Spinal Dysraphism	Associate	21940735
Squamous Cell Carcinoma of Head and Neck	Associate	21237437, 24119525
Stomach Neoplasms	Associate	26464633, 32196592
Urinary Bladder Neoplasms	Associate	24577895

TGIF1 (TGFB induced factor homeobox 1)