| GO ID |
Ontology |
Definition |
Evidence |
Reference |
|
GO:0000166 |
Function |
Nucleotide binding |
IEA |
|
|
GO:0001501 |
Process |
Skeletal system development |
IEA |
|
|
GO:0001501 |
Process |
Skeletal system development |
ISS |
|
|
GO:0001525 |
Process |
Angiogenesis |
IEA |
|
|
GO:0001701 |
Process |
In utero embryonic development |
IEA |
|
|
GO:0001701 |
Process |
In utero embryonic development |
ISS |
|
|
GO:0001822 |
Process |
Kidney development |
IEA |
|
|
GO:0001822 |
Process |
Kidney development |
ISS |
|
|
GO:0001824 |
Process |
Blastocyst development |
IEA |
|
|
GO:0001837 |
Process |
Epithelial to mesenchymal transition |
IDA |
15761148 |
|
GO:0001935 |
Process |
Endothelial cell proliferation |
IEA |
|
|
GO:0001937 |
Process |
Negative regulation of endothelial cell proliferation |
IEA |
|
|
GO:0001938 |
Process |
Positive regulation of endothelial cell proliferation |
ISS |
|
|
GO:0002088 |
Process |
Lens development in camera-type eye |
IEA |
|
|
GO:0003222 |
Process |
Ventricular trabecula myocardium morphogenesis |
IEA |
|
|
GO:0003222 |
Process |
Ventricular trabecula myocardium morphogenesis |
ISS |
|
|
GO:0003223 |
Process |
Ventricular compact myocardium morphogenesis |
IEA |
|
|
GO:0003223 |
Process |
Ventricular compact myocardium morphogenesis |
ISS |
|
|
GO:0003342 |
Process |
Proepicardium development |
ISS |
|
|
GO:0004672 |
Function |
Protein kinase activity |
IDA |
19736306 |
|
GO:0004672 |
Function |
Protein kinase activity |
IEA |
|
|
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IDA |
12065756, 18625725 |
|
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IEA |
|
|
GO:0004675 |
Function |
Transmembrane receptor protein serine/threonine kinase activity |
IDA |
12015308, 19736306 |
|
GO:0004675 |
Function |
Transmembrane receptor protein serine/threonine kinase activity |
IEA |
|
|
GO:0005024 |
Function |
Transforming growth factor beta receptor activity |
IC |
1326540 |
|
GO:0005024 |
Function |
Transforming growth factor beta receptor activity |
IDA |
12015308, 12065756, 14633705 |
|
GO:0005024 |
Function |
Transforming growth factor beta receptor activity |
IEA |
|
|
GO:0005024 |
Function |
Transforming growth factor beta receptor activity |
IMP |
1333888 |
|
GO:0005024 |
Function |
Transforming growth factor beta receptor activity |
IMP |
18625725 |
|
GO:0005025 |
Function |
Transforming growth factor beta receptor activity, type I |
IBA |
|
|
GO:0005025 |
Function |
Transforming growth factor beta receptor activity, type I |
IDA |
8752209 |
|
GO:0005025 |
Function |
Transforming growth factor beta receptor activity, type I |
ISS |
|
|
GO:0005102 |
Function |
Signaling receptor binding |
IEA |
|
|
GO:0005114 |
Function |
Type II transforming growth factor beta receptor binding |
IDA |
11157754 |
|
GO:0005114 |
Function |
Type II transforming growth factor beta receptor binding |
IPI |
1333888 |
|
GO:0005515 |
Function |
Protein binding |
IPI |
8622651, 10025408, 11278302, 11279102, 11583628, 12015308, 14517293, 14580334, 15702480, 15761148, 17099224, 18243111, 18625725, 18758450, 18974388, 19732720, 20856203, 21791611, 22344298, 23723426, 23868260, 24263861, 24658140, 25893292, 26583432 |
|
GO:0005524 |
Function |
ATP binding |
IDA |
12065756 |
|
GO:0005524 |
Function |
ATP binding |
IEA |
|
|
GO:0005634 |
Component |
Nucleus |
IDA |
26583432 |
|
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
|
GO:0005768 |
Component |
Endosome |
IDA |
26583432 |
|
GO:0005768 |
Component |
Endosome |
IEA |
|
|
GO:0005886 |
Component |
Plasma membrane |
IBA |
|
|
GO:0005886 |
Component |
Plasma membrane |
IDA |
17878231, 21791611, 25893292 |
|
GO:0005886 |
Component |
Plasma membrane |
IEA |
|
|
GO:0005886 |
Component |
Plasma membrane |
NAS |
18243111, 20207738 |
|
GO:0005886 |
Component |
Plasma membrane |
TAS |
|
|
GO:0005923 |
Component |
Bicellular tight junction |
IDA |
15761148 |
|
GO:0005923 |
Component |
Bicellular tight junction |
IEA |
|
|
GO:0005929 |
Component |
Cilium |
IDA |
|
|
GO:0006355 |
Process |
Regulation of DNA-templated transcription |
IDA |
14517293 |
|
GO:0006355 |
Process |
Regulation of DNA-templated transcription |
IMP |
15702480 |
|
GO:0006915 |
Process |
Apoptotic process |
IEA |
|
|
GO:0006915 |
Process |
Apoptotic process |
IEA |
|
|
GO:0007165 |
Process |
Signal transduction |
IDA |
14633705 |
|
GO:0007178 |
Process |
Cell surface receptor protein serine/threonine kinase signaling pathway |
IEA |
|
|
GO:0007179 |
Process |
Transforming growth factor beta receptor signaling pathway |
IBA |
|
|
GO:0007179 |
Process |
Transforming growth factor beta receptor signaling pathway |
IC |
1326540 |
|
GO:0007179 |
Process |
Transforming growth factor beta receptor signaling pathway |
IDA |
18548003 |
|
GO:0007179 |
Process |
Transforming growth factor beta receptor signaling pathway |
IDA |
1333888, 9311995, 9389648, 11157754, 12065756 |
|
GO:0007179 |
Process |
Transforming growth factor beta receptor signaling pathway |
IEA |
|
|
GO:0007179 |
Process |
Transforming growth factor beta receptor signaling pathway |
IEA |
|
|
GO:0007179 |
Process |
Transforming growth factor beta receptor signaling pathway |
IGI |
22714950 |
|
GO:0007179 |
Process |
Transforming growth factor beta receptor signaling pathway |
IMP |
1333888, 24978044, 27693460, 28251559 |
|
GO:0007179 |
Process |
Transforming growth factor beta receptor signaling pathway |
ISS |
|
|
GO:0007399 |
Process |
Nervous system development |
IBA |
|
|
GO:0007507 |
Process |
Heart development |
IBA |
|
|
GO:0007507 |
Process |
Heart development |
IEA |
|
|
GO:0007507 |
Process |
Heart development |
ISS |
|
|
GO:0008284 |
Process |
Positive regulation of cell population proliferation |
IMP |
14633705 |
|
GO:0008354 |
Process |
Germ cell migration |
IEA |
|
|
GO:0008354 |
Process |
Germ cell migration |
ISS |
|
|
GO:0008584 |
Process |
Male gonad development |
IEA |
|
|
GO:0009791 |
Process |
Post-embryonic development |
IEA |
|
|
GO:0009952 |
Process |
Anterior/posterior pattern specification |
IEA |
|
|
GO:0009952 |
Process |
Anterior/posterior pattern specification |
ISS |
|
|
GO:0009986 |
Component |
Cell surface |
IDA |
25893292 |
|
GO:0009986 |
Component |
Cell surface |
IEA |
|
|
GO:0010468 |
Process |
Regulation of gene expression |
IEA |
|
|
GO:0010468 |
Process |
Regulation of gene expression |
ISS |
|
|
GO:0010628 |
Process |
Positive regulation of gene expression |
IMP |
27162619 |
|
GO:0010628 |
Process |
Positive regulation of gene expression |
ISS |
|
|
GO:0010717 |
Process |
Regulation of epithelial to mesenchymal transition |
ISS |
|
|
GO:0010718 |
Process |
Positive regulation of epithelial to mesenchymal transition |
IEA |
|
|
GO:0010718 |
Process |
Positive regulation of epithelial to mesenchymal transition |
ISS |
|
|
GO:0016020 |
Component |
Membrane |
IEA |
|
|
GO:0016020 |
Component |
Membrane |
ISS |
|
|
GO:0016301 |
Function |
Kinase activity |
IEA |
|
|
GO:0016361 |
Function |
Activin receptor activity, type I |
IBA |
|
|
GO:0016740 |
Function |
Transferase activity |
IEA |
|
|
GO:0018105 |
Process |
Peptidyl-serine phosphorylation |
IDA |
15761148 |
|
GO:0019838 |
Function |
Growth factor binding |
IPI |
14517293 |
|
GO:0030154 |
Process |
Cell differentiation |
IEA |
|
|
GO:0030199 |
Process |
Collagen fibril organization |
IEA |
|
|
GO:0030199 |
Process |
Collagen fibril organization |
ISS |
|
|
GO:0030307 |
Process |
Positive regulation of cell growth |
IDA |
18625725 |
|
GO:0030334 |
Process |
Regulation of cell migration |
IEA |
|
|
GO:0030335 |
Process |
Positive regulation of cell migration |
IDA |
19736306 |
|
GO:0030336 |
Process |
Negative regulation of cell migration |
IMP |
23424236 |
|
GO:0031396 |
Process |
Regulation of protein ubiquitination |
IDA |
18758450 |
|
GO:0031625 |
Function |
Ubiquitin protein ligase binding |
IPI |
12151385 |
|
GO:0032331 |
Process |
Negative regulation of chondrocyte differentiation |
IEA |
|
|
GO:0032331 |
Process |
Negative regulation of chondrocyte differentiation |
ISS |
|
|
GO:0032924 |
Process |
Activin receptor signaling pathway |
IBA |
|
|
GO:0032924 |
Process |
Activin receptor signaling pathway |
ISS |
|
|
GO:0035556 |
Process |
Intracellular signal transduction |
ISS |
|
|
GO:0036446 |
Process |
Myofibroblast differentiation |
IMP |
28251559 |
|
GO:0042060 |
Process |
Wound healing |
TAS |
9759503 |
|
GO:0042118 |
Process |
Endothelial cell activation |
ISS |
|
|
GO:0043062 |
Process |
Extracellular structure organization |
TAS |
9759503 |
|
GO:0043065 |
Process |
Positive regulation of apoptotic process |
IEA |
|
|
GO:0043066 |
Process |
Negative regulation of apoptotic process |
IEA |
|
|
GO:0043235 |
Component |
Receptor complex |
IDA |
8774881, 14517293 |
|
GO:0043542 |
Process |
Endothelial cell migration |
IEA |
|
|
GO:0045121 |
Component |
Membrane raft |
IDA |
25893292 |
|
GO:0045121 |
Component |
Membrane raft |
IEA |
|
|
GO:0045893 |
Process |
Positive regulation of DNA-templated transcription |
IDA |
9311995, 9389648 |
|
GO:0045893 |
Process |
Positive regulation of DNA-templated transcription |
ISS |
|
|
GO:0046332 |
Function |
SMAD binding |
IBA |
|
|
GO:0046332 |
Function |
SMAD binding |
IDA |
12065756, 18625725 |
|
GO:0046332 |
Function |
SMAD binding |
IEA |
|
|
GO:0046332 |
Function |
SMAD binding |
IPI |
8980228, 9311995 |
|
GO:0046847 |
Process |
Filopodium assembly |
IEA |
|
|
GO:0046872 |
Function |
Metal ion binding |
IEA |
|
|
GO:0048179 |
Component |
Activin receptor complex |
IBA |
|
|
GO:0048185 |
Function |
Activin binding |
IBA |
|
|
GO:0048538 |
Process |
Thymus development |
IEA |
|
|
GO:0048538 |
Process |
Thymus development |
ISS |
|
|
GO:0048663 |
Process |
Neuron fate commitment |
IEA |
|
|
GO:0048663 |
Process |
Neuron fate commitment |
ISS |
|
|
GO:0048701 |
Process |
Embryonic cranial skeleton morphogenesis |
IEA |
|
|
GO:0048701 |
Process |
Embryonic cranial skeleton morphogenesis |
ISS |
|
|
GO:0048705 |
Process |
Skeletal system morphogenesis |
IEA |
|
|
GO:0048705 |
Process |
Skeletal system morphogenesis |
ISS |
|
|
GO:0048762 |
Process |
Mesenchymal cell differentiation |
ISS |
|
|
GO:0048762 |
Process |
Mesenchymal cell differentiation |
TAS |
9759503 |
|
GO:0048844 |
Process |
Artery morphogenesis |
IEA |
|
|
GO:0048844 |
Process |
Artery morphogenesis |
ISS |
|
|
GO:0048870 |
Process |
Cell motility |
IMP |
18625725 |
|
GO:0050431 |
Function |
Transforming growth factor beta binding |
IDA |
11157754 |
|
GO:0050431 |
Function |
Transforming growth factor beta binding |
IDA |
14633705 |
|
GO:0050431 |
Function |
Transforming growth factor beta binding |
IEA |
|
|
GO:0050431 |
Function |
Transforming growth factor beta binding |
IMP |
1333888 |
|
GO:0050431 |
Function |
Transforming growth factor beta binding |
IPI |
1326540 |
|
GO:0050431 |
Function |
Transforming growth factor beta binding |
ISS |
|
|
GO:0051491 |
Process |
Positive regulation of filopodium assembly |
IEA |
|
|
GO:0051496 |
Process |
Positive regulation of stress fiber assembly |
IEA |
|
|
GO:0051496 |
Process |
Positive regulation of stress fiber assembly |
ISS |
|
|
GO:0051726 |
Process |
Regulation of cell cycle |
TAS |
9759503 |
|
GO:0051897 |
Process |
Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
IDA |
18625725 |
|
GO:0060017 |
Process |
Parathyroid gland development |
IEA |
|
|
GO:0060017 |
Process |
Parathyroid gland development |
ISS |
|
|
GO:0060021 |
Process |
Roof of mouth development |
IEA |
|
|
GO:0060021 |
Process |
Roof of mouth development |
ISS |
|
|
GO:0060037 |
Process |
Pharyngeal system development |
IEA |
|
|
GO:0060037 |
Process |
Pharyngeal system development |
ISS |
|
|
GO:0060043 |
Process |
Regulation of cardiac muscle cell proliferation |
IEA |
|
|
GO:0060043 |
Process |
Regulation of cardiac muscle cell proliferation |
ISS |
|
|
GO:0060317 |
Process |
Cardiac epithelial to mesenchymal transition |
ISS |
|
|
GO:0060391 |
Process |
Positive regulation of SMAD protein signal transduction |
IDA |
9311995, 9389648, 11157754, 12015308, 18625725, 19736306 |
|
GO:0060391 |
Process |
Positive regulation of SMAD protein signal transduction |
IGI |
22714950 |
|
GO:0060391 |
Process |
Positive regulation of SMAD protein signal transduction |
IMP |
27693460 |
|
GO:0060412 |
Process |
Ventricular septum morphogenesis |
IEA |
|
|
GO:0060412 |
Process |
Ventricular septum morphogenesis |
ISS |
|
|
GO:0060978 |
Process |
Angiogenesis involved in coronary vascular morphogenesis |
IEA |
|
|
GO:0060978 |
Process |
Angiogenesis involved in coronary vascular morphogenesis |
ISS |
|
|
GO:0060982 |
Process |
Coronary artery morphogenesis |
IEA |
|
|
GO:0060982 |
Process |
Coronary artery morphogenesis |
ISS |
|
|
GO:0061450 |
Process |
Trophoblast cell migration |
IDA |
34432647 |
|
GO:0061450 |
Process |
Trophoblast cell migration |
IDA |
34432647 |
|
GO:0070021 |
Component |
Transforming growth factor beta ligand-receptor complex |
IPI |
18243111, 20207738 |
|
GO:0070021 |
Component |
Transforming growth factor beta ligand-receptor complex |
ISS |
|
|
GO:0070161 |
Component |
Anchoring junction |
IEA |
|
|
GO:0070411 |
Function |
I-SMAD binding |
IPI |
11278251 |
|
GO:0070723 |
Process |
Response to cholesterol |
IDA |
17878231 |
|
GO:0070723 |
Process |
Response to cholesterol |
IEA |
|
|
GO:0071363 |
Process |
Cellular response to growth factor stimulus |
IBA |
|
|
GO:0071560 |
Process |
Cellular response to transforming growth factor beta stimulus |
IDA |
19494318 |
|
GO:0071560 |
Process |
Cellular response to transforming growth factor beta stimulus |
IEA |
|
|
GO:0097305 |
Process |
Response to alcohol |
IEA |
|
|
GO:0101023 |
Process |
Vascular endothelial cell proliferation |
IBA |
|
|
GO:1901203 |
Process |
Positive regulation of extracellular matrix assembly |
IMP |
28251559 |
|
GO:1902462 |
Process |
Positive regulation of mesenchymal stem cell proliferation |
IGI |
22714950 |
|
GO:1902554 |
Component |
Serine/threonine protein kinase complex |
IEA |
|
|
GO:1904018 |
Process |
Positive regulation of vasculature development |
IMP |
27693460 |
|
GO:1905007 |
Process |
Positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation |
IEA |
|
|
GO:1905007 |
Process |
Positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation |
ISS |
|
|
GO:1905075 |
Process |
Positive regulation of tight junction disassembly |
IEA |
|
|
GO:1905075 |
Process |
Positive regulation of tight junction disassembly |
ISS |
|
|
GO:1905223 |
Process |
Epicardium morphogenesis |
IEA |
|
|
GO:1905223 |
Process |
Epicardium morphogenesis |
ISS |
|
|
GO:2000026 |
Process |
Regulation of multicellular organismal development |
IEA |
|
|
GO:2001235 |
Process |
Positive regulation of apoptotic signaling pathway |
IDA |
18758450 |
|
GO:2001237 |
Process |
Negative regulation of extrinsic apoptotic signaling pathway |
IMP |
18625725 |