Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7039
Gene name	Transforming growth factor alpha
Gene symbol	TGFA
Synonyms (NCBI Gene)	TFGA
Chromosome	2
Chromosome location	2p13.3
Summary	This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a solu

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miRTarBase ID	miRNA	Experiments	Reference
MIRT035552	hsa-miR-152-3p	Luciferase reporter assay	23460133
MIRT035552	hsa-miR-152-3p	Luciferase reporter assay	23460133
MIRT049451	hsa-miR-92a-3p	CLASH	23622248
MIRT437890	hsa-miR-376c-3p	Luciferase reporter assayWestern blot	23631646
MIRT437890	hsa-miR-376c-3p	Luciferase reporter assayWestern blot	23631646
MIRT712905	hsa-miR-1539	HITS-CLIP	19536157
MIRT712904	hsa-miR-3193	HITS-CLIP	19536157
MIRT712903	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT712902	hsa-miR-1976	HITS-CLIP	19536157
MIRT712901	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT712900	hsa-miR-1913	HITS-CLIP	19536157
MIRT712899	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT712898	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT712897	hsa-miR-4734	HITS-CLIP	19536157
MIRT712896	hsa-miR-4641	HITS-CLIP	19536157
MIRT712895	hsa-miR-4706	HITS-CLIP	19536157
MIRT712894	hsa-miR-4749-5p	HITS-CLIP	19536157
MIRT712893	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712892	hsa-miR-4727-5p	HITS-CLIP	19536157
MIRT712891	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT712890	hsa-miR-6738-3p	HITS-CLIP	19536157
MIRT712905	hsa-miR-1539	HITS-CLIP	19536157
MIRT712904	hsa-miR-3193	HITS-CLIP	19536157
MIRT712903	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT712902	hsa-miR-1976	HITS-CLIP	19536157
MIRT712901	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT712900	hsa-miR-1913	HITS-CLIP	19536157
MIRT712899	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT712898	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT712897	hsa-miR-4734	HITS-CLIP	19536157
MIRT712896	hsa-miR-4641	HITS-CLIP	19536157
MIRT712895	hsa-miR-4706	HITS-CLIP	19536157
MIRT712894	hsa-miR-4749-5p	HITS-CLIP	19536157
MIRT712893	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712892	hsa-miR-4727-5p	HITS-CLIP	19536157
MIRT712891	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT712890	hsa-miR-6738-3p	HITS-CLIP	19536157
MIRT712905	hsa-miR-1539	HITS-CLIP	19536157
MIRT712904	hsa-miR-3193	HITS-CLIP	19536157
MIRT712903	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT712902	hsa-miR-1976	HITS-CLIP	19536157
MIRT712901	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT712900	hsa-miR-1913	HITS-CLIP	19536157
MIRT712899	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT712898	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT712897	hsa-miR-4734	HITS-CLIP	19536157
MIRT712896	hsa-miR-4641	HITS-CLIP	19536157
MIRT712895	hsa-miR-4706	HITS-CLIP	19536157
MIRT712894	hsa-miR-4749-5p	HITS-CLIP	19536157
MIRT712893	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712892	hsa-miR-4727-5p	HITS-CLIP	19536157
MIRT712891	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT712890	hsa-miR-6738-3p	HITS-CLIP	19536157
MIRT652747	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT652746	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT652744	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT652743	hsa-miR-6818-5p	HITS-CLIP	19536157
MIRT652747	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT652746	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT652745	hsa-miR-222-5p	HITS-CLIP	23824327
MIRT652744	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT652743	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT652747	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT652746	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT652745	hsa-miR-222-5p	HITS-CLIP	23824327
MIRT652744	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT652743	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT444605	hsa-miR-6757-5p	PAR-CLIP	22100165
MIRT444604	hsa-miR-4495	PAR-CLIP	22100165
MIRT444603	hsa-miR-6814-5p	PAR-CLIP	22100165
MIRT444602	hsa-miR-3136-3p	PAR-CLIP	22100165
MIRT444601	hsa-miR-7155-3p	PAR-CLIP	22100165
MIRT444599	hsa-miR-30a-5p	PAR-CLIP	22100165
MIRT444600	hsa-miR-30b-5p	PAR-CLIP	22100165
MIRT444598	hsa-miR-30c-5p	PAR-CLIP	22100165
MIRT444597	hsa-miR-30d-5p	PAR-CLIP	22100165
MIRT444596	hsa-miR-30e-5p	PAR-CLIP	22100165
MIRT444595	hsa-miR-7158-3p	PAR-CLIP	22100165
MIRT444594	hsa-miR-203b-3p	PAR-CLIP	22100165
MIRT736318	hsa-miR-340-5p	Luciferase reporter assayqRT-PCR	33661995
MIRT712905	hsa-miR-1539	HITS-CLIP	19536157
MIRT712904	hsa-miR-3193	HITS-CLIP	19536157
MIRT712903	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT712902	hsa-miR-1976	HITS-CLIP	19536157
MIRT712901	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT712900	hsa-miR-1913	HITS-CLIP	19536157
MIRT712899	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT712898	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT712897	hsa-miR-4734	HITS-CLIP	19536157
MIRT712896	hsa-miR-4641	HITS-CLIP	19536157
MIRT712895	hsa-miR-4706	HITS-CLIP	19536157
MIRT712894	hsa-miR-4749-5p	HITS-CLIP	19536157
MIRT712893	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712892	hsa-miR-4727-5p	HITS-CLIP	19536157
MIRT712891	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT712890	hsa-miR-6738-3p	HITS-CLIP	19536157
MIRT712905	hsa-miR-1539	HITS-CLIP	19536157
MIRT712904	hsa-miR-3193	HITS-CLIP	19536157
MIRT712903	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT712902	hsa-miR-1976	HITS-CLIP	19536157
MIRT712901	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT712900	hsa-miR-1913	HITS-CLIP	19536157
MIRT712899	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT712898	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT712897	hsa-miR-4734	HITS-CLIP	19536157
MIRT712896	hsa-miR-4641	HITS-CLIP	19536157
MIRT712895	hsa-miR-4706	HITS-CLIP	19536157
MIRT712894	hsa-miR-4749-5p	HITS-CLIP	19536157
MIRT712893	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712892	hsa-miR-4727-5p	HITS-CLIP	19536157
MIRT712891	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT712890	hsa-miR-6738-3p	HITS-CLIP	19536157
MIRT712905	hsa-miR-1539	HITS-CLIP	19536157
MIRT712904	hsa-miR-3193	HITS-CLIP	19536157
MIRT712903	hsa-miR-3653-5p	HITS-CLIP	19536157
MIRT712902	hsa-miR-1976	HITS-CLIP	19536157
MIRT712901	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT712900	hsa-miR-1913	HITS-CLIP	19536157
MIRT712899	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT712898	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT712897	hsa-miR-4734	HITS-CLIP	19536157
MIRT712896	hsa-miR-4641	HITS-CLIP	19536157
MIRT712895	hsa-miR-4706	HITS-CLIP	19536157
MIRT712894	hsa-miR-4749-5p	HITS-CLIP	19536157
MIRT712893	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712892	hsa-miR-4727-5p	HITS-CLIP	19536157
MIRT712891	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT712890	hsa-miR-6738-3p	HITS-CLIP	19536157
MIRT652747	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT652746	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT652744	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT652743	hsa-miR-6818-5p	HITS-CLIP	19536157
MIRT652747	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT652746	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT652745	hsa-miR-222-5p	HITS-CLIP	23824327
MIRT652744	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT652743	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT652747	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT652746	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT652745	hsa-miR-222-5p	HITS-CLIP	23824327
MIRT652744	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT652743	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT444605	hsa-miR-6757-5p	PAR-CLIP	22100165
MIRT444604	hsa-miR-4495	PAR-CLIP	22100165
MIRT444603	hsa-miR-6814-5p	PAR-CLIP	22100165
MIRT444602	hsa-miR-3136-3p	PAR-CLIP	22100165
MIRT444601	hsa-miR-7155-3p	PAR-CLIP	22100165
MIRT444599	hsa-miR-30a-5p	PAR-CLIP	22100165
MIRT444600	hsa-miR-30b-5p	PAR-CLIP	22100165
MIRT444598	hsa-miR-30c-5p	PAR-CLIP	22100165
MIRT444597	hsa-miR-30d-5p	PAR-CLIP	22100165
MIRT444596	hsa-miR-30e-5p	PAR-CLIP	22100165
MIRT444595	hsa-miR-7158-3p	PAR-CLIP	22100165
MIRT444594	hsa-miR-203b-3p	PAR-CLIP	22100165
MIRT1420997	hsa-miR-101	CLIP-seq
MIRT1420998	hsa-miR-125a-3p	CLIP-seq
MIRT1420999	hsa-miR-1294	CLIP-seq
MIRT1421000	hsa-miR-1298	CLIP-seq
MIRT1421001	hsa-miR-130a	CLIP-seq
MIRT1421002	hsa-miR-130b	CLIP-seq
MIRT1421003	hsa-miR-144	CLIP-seq
MIRT1421004	hsa-miR-148a	CLIP-seq
MIRT1421005	hsa-miR-148b	CLIP-seq
MIRT1421006	hsa-miR-152	CLIP-seq
MIRT1421007	hsa-miR-205	CLIP-seq
MIRT1421008	hsa-miR-2052	CLIP-seq
MIRT1421009	hsa-miR-217	CLIP-seq
MIRT1421010	hsa-miR-2355-5p	CLIP-seq
MIRT1421011	hsa-miR-28-3p	CLIP-seq
MIRT1421012	hsa-miR-301a	CLIP-seq
MIRT1421013	hsa-miR-301b	CLIP-seq
MIRT1421014	hsa-miR-3065-5p	CLIP-seq
MIRT1421015	hsa-miR-3128	CLIP-seq
MIRT1421016	hsa-miR-3140-3p	CLIP-seq
MIRT1421017	hsa-miR-3152-3p	CLIP-seq
MIRT1421018	hsa-miR-3164	CLIP-seq
MIRT1421019	hsa-miR-3173-3p	CLIP-seq
MIRT1421020	hsa-miR-326	CLIP-seq
MIRT1421021	hsa-miR-330-5p	CLIP-seq
MIRT1421022	hsa-miR-34a	CLIP-seq
MIRT1421023	hsa-miR-34c-5p	CLIP-seq
MIRT1421024	hsa-miR-3666	CLIP-seq
MIRT1421025	hsa-miR-3667-3p	CLIP-seq
MIRT1421026	hsa-miR-3681	CLIP-seq
MIRT1421027	hsa-miR-3688-5p	CLIP-seq
MIRT1421028	hsa-miR-3689d	CLIP-seq
MIRT1421029	hsa-miR-3913-3p	CLIP-seq
MIRT1421030	hsa-miR-3934	CLIP-seq
MIRT1421031	hsa-miR-3942-3p	CLIP-seq
MIRT1421032	hsa-miR-4276	CLIP-seq
MIRT1421033	hsa-miR-4286	CLIP-seq
MIRT1421034	hsa-miR-4295	CLIP-seq
MIRT1421035	hsa-miR-4316	CLIP-seq
MIRT1421036	hsa-miR-4422	CLIP-seq
MIRT1421037	hsa-miR-4428	CLIP-seq
MIRT1421038	hsa-miR-4438	CLIP-seq
MIRT1421039	hsa-miR-4477a	CLIP-seq
MIRT1421040	hsa-miR-4477b	CLIP-seq
MIRT1421041	hsa-miR-4493	CLIP-seq
MIRT1421042	hsa-miR-449a	CLIP-seq
MIRT1421043	hsa-miR-449b	CLIP-seq
MIRT1421044	hsa-miR-4501	CLIP-seq
MIRT1421045	hsa-miR-454	CLIP-seq
MIRT1421046	hsa-miR-4645-5p	CLIP-seq
MIRT1421047	hsa-miR-4673	CLIP-seq
MIRT1421048	hsa-miR-4704-3p	CLIP-seq
MIRT1421049	hsa-miR-4720-5p	CLIP-seq
MIRT1421050	hsa-miR-4755-3p	CLIP-seq
MIRT1421051	hsa-miR-4757-5p	CLIP-seq
MIRT1421052	hsa-miR-4760-3p	CLIP-seq
MIRT1421053	hsa-miR-4789-3p	CLIP-seq
MIRT737908	hsa-miR-4793-5p	CLIP-seq
MIRT1421054	hsa-miR-4797-5p	CLIP-seq
MIRT1421055	hsa-miR-4799-3p	CLIP-seq
MIRT1421056	hsa-miR-495	CLIP-seq
MIRT1421057	hsa-miR-499-3p	CLIP-seq
MIRT1421058	hsa-miR-499a-3p	CLIP-seq
MIRT1421059	hsa-miR-5095	CLIP-seq
MIRT1421060	hsa-miR-512-3p	CLIP-seq
MIRT1421061	hsa-miR-526b	CLIP-seq
MIRT1421062	hsa-miR-545	CLIP-seq
MIRT1421063	hsa-miR-548ag	CLIP-seq
MIRT1421064	hsa-miR-548ai	CLIP-seq
MIRT1421065	hsa-miR-552	CLIP-seq
MIRT1421066	hsa-miR-570	CLIP-seq
MIRT1421067	hsa-miR-626	CLIP-seq
MIRT1421068	hsa-miR-664	CLIP-seq
MIRT1421069	hsa-miR-759	CLIP-seq
MIRT1421070	hsa-miR-124	CLIP-seq
MIRT1421071	hsa-miR-1264	CLIP-seq
MIRT1421072	hsa-miR-1285	CLIP-seq
MIRT1421001	hsa-miR-130a	CLIP-seq
MIRT1421002	hsa-miR-130b	CLIP-seq
MIRT1421073	hsa-miR-1321	CLIP-seq
MIRT1421004	hsa-miR-148a	CLIP-seq
MIRT1421005	hsa-miR-148b	CLIP-seq
MIRT1421006	hsa-miR-152	CLIP-seq
MIRT1421074	hsa-miR-216a	CLIP-seq
MIRT1421075	hsa-miR-27a	CLIP-seq
MIRT1421076	hsa-miR-27b	CLIP-seq
MIRT1421012	hsa-miR-301a	CLIP-seq
MIRT1421013	hsa-miR-301b	CLIP-seq
MIRT1421077	hsa-miR-3117-5p	CLIP-seq
MIRT1421078	hsa-miR-3138	CLIP-seq
MIRT1421016	hsa-miR-3140-3p	CLIP-seq
MIRT1421079	hsa-miR-3162-5p	CLIP-seq
MIRT1421018	hsa-miR-3164	CLIP-seq
MIRT1421080	hsa-miR-3169	CLIP-seq
MIRT1421081	hsa-miR-3187-5p	CLIP-seq
MIRT1421082	hsa-miR-3202	CLIP-seq
MIRT1421083	hsa-miR-330-3p	CLIP-seq
MIRT1421024	hsa-miR-3666	CLIP-seq
MIRT1421026	hsa-miR-3681	CLIP-seq
MIRT1421028	hsa-miR-3689d	CLIP-seq
MIRT1421084	hsa-miR-369-3p	CLIP-seq
MIRT1421085	hsa-miR-374a	CLIP-seq
MIRT1421086	hsa-miR-374b	CLIP-seq
MIRT1421029	hsa-miR-3913-3p	CLIP-seq
MIRT1421032	hsa-miR-4276	CLIP-seq
MIRT1421034	hsa-miR-4295	CLIP-seq
MIRT1421087	hsa-miR-4491	CLIP-seq
MIRT1421088	hsa-miR-4513	CLIP-seq
MIRT1421089	hsa-miR-4533	CLIP-seq
MIRT1421045	hsa-miR-454	CLIP-seq
MIRT1421090	hsa-miR-4643	CLIP-seq
MIRT1421091	hsa-miR-4657	CLIP-seq
MIRT1421092	hsa-miR-4711-5p	CLIP-seq
MIRT1421093	hsa-miR-4736	CLIP-seq
MIRT1421094	hsa-miR-4739	CLIP-seq
MIRT1421095	hsa-miR-4740-5p	CLIP-seq
MIRT1421096	hsa-miR-4756-5p	CLIP-seq
MIRT1421097	hsa-miR-4795-3p	CLIP-seq
MIRT1421098	hsa-miR-4800-5p	CLIP-seq
MIRT1421099	hsa-miR-506	CLIP-seq
MIRT1421100	hsa-miR-513a-5p	CLIP-seq
MIRT1421101	hsa-miR-513c	CLIP-seq
MIRT1421102	hsa-miR-514b-5p	CLIP-seq
MIRT1421103	hsa-miR-549	CLIP-seq
MIRT1421104	hsa-miR-612	CLIP-seq
MIRT1421105	hsa-miR-657	CLIP-seq
MIRT1421106	hsa-miR-7	CLIP-seq
MIRT1421069	hsa-miR-759	CLIP-seq
MIRT1421107	hsa-miR-890	CLIP-seq
MIRT737907	hsa-miR-3140-5p	CLIP-seq
MIRT737909	hsa-miR-3148	CLIP-seq
MIRT737906	hsa-miR-3688-3p	CLIP-seq
MIRT737911	hsa-miR-3915	CLIP-seq
MIRT737910	hsa-miR-3928	CLIP-seq
MIRT737912	hsa-miR-4790-3p	CLIP-seq
MIRT737908	hsa-miR-4793-5p	CLIP-seq
MIRT2126336	hsa-miR-1200	CLIP-seq
MIRT2126337	hsa-miR-1207-5p	CLIP-seq
MIRT2126338	hsa-miR-134	CLIP-seq
MIRT2126339	hsa-miR-198	CLIP-seq
MIRT2126340	hsa-miR-3118	CLIP-seq
MIRT1421018	hsa-miR-3164	CLIP-seq
MIRT2126341	hsa-miR-34b	CLIP-seq
MIRT2126342	hsa-miR-3657	CLIP-seq
MIRT1421030	hsa-miR-3934	CLIP-seq
MIRT2126343	hsa-miR-4308	CLIP-seq
MIRT2126344	hsa-miR-4324	CLIP-seq
MIRT2126345	hsa-miR-4669	CLIP-seq
MIRT1421093	hsa-miR-4736	CLIP-seq
MIRT2126346	hsa-miR-4763-3p	CLIP-seq
MIRT2126347	hsa-miR-544b	CLIP-seq
MIRT1421106	hsa-miR-7	CLIP-seq
MIRT1421031	hsa-miR-3942-3p	CLIP-seq
MIRT1420997	hsa-miR-101	CLIP-seq
MIRT2126336	hsa-miR-1200	CLIP-seq
MIRT2348356	hsa-miR-1237	CLIP-seq
MIRT2348357	hsa-miR-1248	CLIP-seq
MIRT1421003	hsa-miR-144	CLIP-seq
MIRT2348358	hsa-miR-1914	CLIP-seq
MIRT2348359	hsa-miR-302f	CLIP-seq
MIRT2348360	hsa-miR-3147	CLIP-seq
MIRT2348361	hsa-miR-323-3p	CLIP-seq
MIRT1421025	hsa-miR-3667-3p	CLIP-seq
MIRT2126344	hsa-miR-4324	CLIP-seq
MIRT2348362	hsa-miR-4425	CLIP-seq
MIRT2348363	hsa-miR-4778-5p	CLIP-seq
MIRT737908	hsa-miR-4793-5p	CLIP-seq
MIRT2126347	hsa-miR-544b	CLIP-seq
MIRT1421063	hsa-miR-548ag	CLIP-seq
MIRT1421064	hsa-miR-548ai	CLIP-seq
MIRT1421029	hsa-miR-3913-3p	CLIP-seq
MIRT1421083	hsa-miR-330-3p	CLIP-seq
MIRT1421106	hsa-miR-7	CLIP-seq
MIRT1421083	hsa-miR-330-3p	CLIP-seq
MIRT1421106	hsa-miR-7	CLIP-seq
MIRT2692958	hsa-miR-2682	CLIP-seq
MIRT1421083	hsa-miR-330-3p	CLIP-seq
MIRT2692959	hsa-miR-3686	CLIP-seq
MIRT2692960	hsa-miR-4290	CLIP-seq
MIRT2692961	hsa-miR-4299	CLIP-seq
MIRT2692962	hsa-miR-4328	CLIP-seq
MIRT2692963	hsa-miR-449c	CLIP-seq
MIRT2692964	hsa-miR-4514	CLIP-seq
MIRT2692965	hsa-miR-455-5p	CLIP-seq
MIRT2692966	hsa-miR-4635	CLIP-seq
MIRT2692967	hsa-miR-4652-3p	CLIP-seq
MIRT2692968	hsa-miR-4692	CLIP-seq
MIRT2692969	hsa-miR-4699-5p	CLIP-seq
MIRT2692970	hsa-miR-4709-3p	CLIP-seq
MIRT2692971	hsa-miR-582-3p	CLIP-seq
MIRT1421106	hsa-miR-7	CLIP-seq

Show/Hide all (5)

Transcription factor	Regulation	Reference
AR	Activation	11556855
ESR1	Activation	11517191
ESR1	Unknown	10828826
ESR2	Activation	11517191
SP1	Unknown	10828826

Show/Hide all (44)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005154	Function	Epidermal growth factor receptor binding	IBA
GO:0005154	Function	Epidermal growth factor receptor binding	IDA	6315706, 11278323
GO:0005515	Function	Protein binding	IPI	12297049, 15064403, 15652357, 18757723, 24658140, 25416956, 28988771, 31980649, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	8702723
GO:0005615	Component	Extracellular space	IDA	12743035
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	10918572
GO:0007166	Process	Cell surface receptor signaling pathway	IDA	11278323
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IBA
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IDA	6315706
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IEA
GO:0008083	Function	Growth factor activity	IBA
GO:0008083	Function	Growth factor activity	IDA	11278323
GO:0008083	Function	Growth factor activity	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IBA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0009986	Component	Cell surface	IDA	12743035
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IDA	17553928
GO:0030297	Function	Transmembrane receptor protein tyrosine kinase activator activity	IEA
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0031410	Component	Cytoplasmic vesicle	IDA	15064403
GO:0033116	Component	Endoplasmic reticulum-Golgi intermediate compartment membrane	TAS
GO:0035556	Process	Intracellular signal transduction	TAS	10861448
GO:0038134	Process	ERBB2-EGFR signaling pathway	IDA	8702723
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	11278323
GO:0045840	Process	Positive regulation of mitotic nuclear division	IBA
GO:0048018	Function	Receptor ligand activity	IDA	8702723
GO:0048018	Function	Receptor ligand activity	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	15064403
GO:0050679	Process	Positive regulation of epithelial cell proliferation	IDA	11278323
GO:0051781	Process	Positive regulation of cell division	IEA
GO:0060749	Process	Mammary gland alveolus development	IEA
GO:0072574	Process	Hepatocyte proliferation	IEA

MIM	HGNC	e!Ensembl
190170	11765	ENSG00000163235

P01135

Protein name

Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1)]

Protein function

TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

PDB

1GK5 , 1MOX , 1YUF , 1YUG , 2TGF , 3E50 , 3TGF , 4TGF , 5KN5 , 7SZ5 , 7SZ7

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. {ECO:0000269|PubMed:10523832}.

Sequence

MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTC
RFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVL
IHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV

Sequence length

160

Interactions

View interactions

	KEGG		Reactome
	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Estrogen signaling pathway Pathways in cancer Colorectal cancer Renal cell carcinoma Pancreatic cancer Glioma Prostate cancer Non-small cell lung cancer Hepatocellular carcinoma		PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign	rs11466221	RCV005904570
Uterine corpus endometrial carcinoma	Benign	rs11466221	RCV005904571

Show/Hide Text Mining Associations (143)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acanthosis Nigricans	Associate	3279155
Adenocarcinoma	Associate	17647268, 36928883
Adenocarcinoma	Stimulate	8097369
Adenocarcinoma of Lung	Associate	27207663
Adenoma	Stimulate	1519669
Aneuploidy	Associate	10861689
Anodontia	Associate	18790474, 29893310
Arthritis Psoriatic	Associate	1512472, 8064230
Arthritis Psoriatic	Stimulate	2476168
Asthma	Stimulate	38253462
Bacteremia	Associate	39966757
Bacterial Infections	Associate	17220369
Barrett Esophagus	Associate	1351861
Bipolar Disorder	Associate	38484669
Bone Resorption	Stimulate	11005785
Bone Resorption	Associate	19143022
Brain Neoplasms	Associate	2705509
Breast Diseases	Associate	1320636
Breast Neoplasms	Associate	10903426, 11323501, 1711294, 17218988, 19749156, 23729230, 2521857, 25344915, 29581982, 30279141, 30916164, 8390290, 9667651
Carcinogenesis	Associate	19124482, 22700631, 24133589, 28239819, 29581982, 7819044
Carcinoma	Associate	1519669
Carcinoma Basal Cell	Associate	3279155
Carcinoma Hepatocellular	Associate	15040026, 19321179, 22700631, 28456666, 35007301
Carcinoma Hepatocellular	Stimulate	16581947, 27046040
Carcinoma Non Small Cell Lung	Associate	1337797, 15015570, 17647268, 22863020, 24133589, 28239819, 36583451
Carcinoma Non Small Cell Lung	Stimulate	32599262
Carcinoma Renal Cell	Associate	11171960, 12944410, 15956968, 19052740, 34399807, 8886918
Carcinoma Squamous Cell	Associate	10428482, 1337797, 1503897, 1663788, 9828815
Carcinoma Squamous Cell	Stimulate	2002254
Cartilage Diseases	Associate	27701424
Celiac Disease	Associate	22136669
Chordoma	Associate	34550531
Cleft Lip	Associate	1352354, 1361101, 19444471, 7977355, 8105683, 8644715
Cleft Palate	Associate	1346481, 1352355, 19444471, 23940636, 24007308, 2570526, 7485164, 7977355, 8105683, 8554055
Cleft Palate	Stimulate	9610799
Clinical Deterioration	Stimulate	25997515
Cognitive Dysfunction	Associate	37686198
Colonic Neoplasms	Associate	1696954, 1698444, 2365825
Colorectal Neoplasms	Associate	11857296, 12657625, 15304500, 1558785, 19124482, 2365825, 24023735, 24114668, 24166893, 24916700, 31133691, 31253868
COVID 19	Associate	35967328
Cysts	Associate	9208810
Diabetic Foot	Associate	37380899
Diabetic Retinopathy	Associate	35506311
Disease	Associate	1512472
Drug Related Side Effects and Adverse Reactions	Stimulate	1512230
Duodenal Ulcer	Stimulate	9176072
Dysplastic Nevus Syndrome	Stimulate	7963661
Endometrial Neoplasms	Associate	16826583, 8641991
Endophthalmitis	Stimulate	30296277
Epilepsy Post Traumatic	Inhibit	38557165
Epstein Barr Virus Infections	Stimulate	10950106
Fibrosis	Associate	16610058, 19535569, 22700631, 37874141
Gastroesophageal Reflux	Associate	10732760
Gastrointestinal Neoplasms	Associate	24520077
Glioblastoma	Associate	21649900, 2705509
Glioma	Associate	15701286
Glomerulonephritis IGA	Stimulate	40322064
Granulosa Cell Tumor	Associate	23155381
Hamartoma	Associate	20389100
Hay Wells syndrome	Associate	9610799
Head and Neck Neoplasms	Associate	20443891
Helicobacter Infections	Stimulate	9176072
Hemangioblastoma	Associate	7639324
Hepatitis C	Associate	16610058
Hereditary Breast and Ovarian Cancer Syndrome	Associate	35290621
Hip Injuries	Associate	11005785
Hydatidiform Mole	Associate	11737472
Hypereosinophilic Syndrome	Associate	1696954
Hyperkeratosis Epidermolytic	Stimulate	2002254
Hyperplasia	Stimulate	21505178
Hypoxia	Stimulate	11171960, 22863020
Hypoxia	Associate	19328625, 29482638
Infections	Stimulate	10950106, 37874141
Inflammation	Associate	10732760, 26064952, 37834363
Inflammation	Stimulate	25997515
Kidney Diseases	Associate	19535569
Kidney Neoplasms	Associate	19052740
Kidney Neoplasms	Stimulate	34399807
Leukemia Lymphocytic Chronic B Cell	Associate	26984929
Leukemia Myeloid Acute	Associate	26984929
Leukemia Promyelocytic Acute	Inhibit	26984929
Lip Diseases	Associate	2570526
Liver Cirrhosis	Associate	22700631
Liver Failure	Associate	15040026
Lung Neoplasms	Associate	1299622, 1337797
Lymphatic Metastasis	Associate	10732760, 24133589
Melanoma	Associate	15580309, 2736210, 33916908, 7963661
Mesothelioma	Associate	14692808, 7947089
Mesothelioma Malignant	Associate	14692808, 15756029
Molar Hypomineralization	Associate	33406080
Myasthenia Gravis	Associate	28045063
Neoplasm Metastasis	Stimulate	11857296, 29581982
Neoplasm Metastasis	Associate	21594709, 32020849
Neoplasms	Associate	10081495, 10732760, 15010475, 15015570, 1519669, 15304500, 16033092, 16581947, 16622555, 1663788, 1711294, 17922051, 17962208, 18316548, 1850725 View all (24 more)
Neoplasms	Stimulate	11092985, 8097369
Neoplasms Mesothelial	Associate	14692808
Neural Tube Defects	Stimulate	26984929
Neurobehavioral Manifestations	Associate	37834363
Neuroblastoma	Associate	12709435, 18927293
Neuroendocrine Tumors	Associate	8826857
Nevus Pigmented	Associate	7963661
Nonsyndromic Deafness	Associate	27356075
Nonsyndromic sensorineural hearing loss	Associate	27356075
Odontogenic Cysts	Associate	9208810
Orofacial Cleft 1	Associate	1352354, 19444471, 19937600, 23940636, 9610799
Osteoarthritis	Associate	27701424, 33055079
Osteosarcoma	Associate	27458156, 32020849
Ovarian Neoplasms	Associate	10081495, 10098742, 10811499, 29482638, 8695362
Pachyonychia Congenita	Stimulate	36116508
Pancreatic Neoplasms	Associate	23426533, 23608755, 23764046, 33661995, 8260363
Pancreatic Neoplasms	Stimulate	9665487
Pancreatitis Chronic	Associate	23608755
Parkinson Disease	Associate	37834363
Pigmentation Disorders	Associate	7963661
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Stimulate	26984929
Prostatic Neoplasms	Associate	10360641, 19143022, 22469032, 36623397
Prosthesis Failure	Associate	11005785
Psoriasis	Stimulate	11173656, 2002254
Psoriasis	Associate	1512472, 27185339, 8064230
Psychotic Disorders	Associate	25970596
Pulmonary Disease Chronic Obstructive	Associate	21861887, 22701684
Pyruvate Carboxylase Deficiency Disease	Associate	8381655
Retinal Dysplasia	Associate	1351861
Rhabdoid Tumor	Associate	11267936
Rhabdomyosarcoma	Associate	7577472
Schizophrenia	Associate	24743863
Sebaceous Tumors Somatic	Associate	1519669
Sertoli Cell Only Syndrome	Associate	8804155
Skin Diseases	Associate	17267001, 3279155
Skin Diseases	Stimulate	2002254
Small Cell Lung Carcinoma	Associate	1337797
Squamous Cell Carcinoma of Head and Neck	Associate	1696954, 20927317, 2478181, 28723928
Stomach Neoplasms	Associate	17922051, 2108945, 2168868, 31151932
Thyroid Cancer Papillary	Associate	20877637
Thyroid Neoplasms	Associate	12733712
Thyroiditis	Associate	12733712
Trigeminal Neuralgia	Inhibit	34067581
Triple Negative Breast Neoplasms	Associate	23729230
Ulcer	Associate	9176072
Urinary Bladder Neoplasms	Associate	17267001
von Hippel Lindau Disease	Inhibit	11171960
Vulvar Neoplasms	Associate	9067409
Wilms Tumor	Associate	21594709

TGFA (transforming growth factor alpha)