TFPI (tissue factor pathway inhibitor)
|
Gene
Gene information from NCBI Gene database.
|
|
| Entrez ID | 7035 |
| Gene name | Tissue factor pathway inhibitor |
| Gene symbol | TFPI |
| Synonyms (NCBI Gene) |
EPILACITFITFPI1
|
| Chromosome | 2 |
| Chromosome location | 2q32.1 |
| Summary | This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates addit |
|
miRNA
miRNA information provided by mirtarbase database.
616
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
|
|||||||
|
|||||||
|
Protein
Protein information from UniProt database.
|
|||||||||||||||||||||
|
UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
|
P10646 | ||||||||||||||||||||
| Protein name | Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) | ||||||||||||||||||||
| Protein function | Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoprot | ||||||||||||||||||||
| PDB | 1ADZ , 1IRH , 1TFX , 4BQD , 4DTG , 5NMV , 6BX8 , 7V1N | ||||||||||||||||||||
| Family and domains |
Pfam
|
||||||||||||||||||||
| Tissue specificity | TISSUE SPECIFICITY: Mostly in endothelial cells. | ||||||||||||||||||||
| Sequence |
|
||||||||||||||||||||
| Sequence length | 304 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
|
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
|
|||||||||
|
|||||||||