Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7030
Gene name	Transcription factor binding to IGHM enhancer 3
Gene symbol	TFE3
Synonyms (NCBI Gene)	MRXSPFRCCP2RCCX1TFEAbHLHe33
Chromosome	X
Chromosome location	Xp11.23
Summary	This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta)

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017158	hsa-miR-335-5p	Microarray	18185580
MIRT037852	hsa-miR-455-3p	CLASH	23622248
MIRT1420433	hsa-let-7a	CLIP-seq
MIRT1420434	hsa-let-7b	CLIP-seq
MIRT1420435	hsa-let-7c	CLIP-seq
MIRT1420436	hsa-let-7d	CLIP-seq
MIRT1420437	hsa-let-7e	CLIP-seq
MIRT1420438	hsa-let-7f	CLIP-seq
MIRT1420439	hsa-let-7g	CLIP-seq
MIRT1420440	hsa-let-7i	CLIP-seq
MIRT1420441	hsa-miR-1207-5p	CLIP-seq
MIRT1420442	hsa-miR-124	CLIP-seq
MIRT1420443	hsa-miR-1262	CLIP-seq
MIRT1420444	hsa-miR-186	CLIP-seq
MIRT1420445	hsa-miR-1909	CLIP-seq
MIRT1420446	hsa-miR-1915	CLIP-seq
MIRT1420447	hsa-miR-200b	CLIP-seq
MIRT1420448	hsa-miR-200c	CLIP-seq
MIRT1420449	hsa-miR-202	CLIP-seq
MIRT1420450	hsa-miR-2861	CLIP-seq
MIRT1420451	hsa-miR-3189-3p	CLIP-seq
MIRT1420452	hsa-miR-320a	CLIP-seq
MIRT1420453	hsa-miR-320b	CLIP-seq
MIRT1420454	hsa-miR-320c	CLIP-seq
MIRT1420455	hsa-miR-320d	CLIP-seq
MIRT1420456	hsa-miR-331-5p	CLIP-seq
MIRT1420457	hsa-miR-3714	CLIP-seq
MIRT1420458	hsa-miR-3910	CLIP-seq
MIRT1420459	hsa-miR-429	CLIP-seq
MIRT1420460	hsa-miR-4300	CLIP-seq
MIRT1420461	hsa-miR-4429	CLIP-seq
MIRT1420462	hsa-miR-4455	CLIP-seq
MIRT1420463	hsa-miR-4458	CLIP-seq
MIRT1420464	hsa-miR-4500	CLIP-seq
MIRT1420465	hsa-miR-4678	CLIP-seq
MIRT1420466	hsa-miR-4701-3p	CLIP-seq
MIRT1420467	hsa-miR-4726-3p	CLIP-seq
MIRT1420468	hsa-miR-4763-3p	CLIP-seq
MIRT1420469	hsa-miR-4795-3p	CLIP-seq
MIRT1420470	hsa-miR-506	CLIP-seq
MIRT1420471	hsa-miR-549	CLIP-seq
MIRT1420472	hsa-miR-609	CLIP-seq
MIRT1420473	hsa-miR-920	CLIP-seq
MIRT1420474	hsa-miR-939	CLIP-seq
MIRT1420475	hsa-miR-940	CLIP-seq
MIRT1420476	hsa-miR-98	CLIP-seq
MIRT1554549	hsa-miR-4793-5p	CLIP-seq
MIRT2126253	hsa-miR-1	CLIP-seq
MIRT2126254	hsa-miR-1227	CLIP-seq
MIRT2126255	hsa-miR-1293	CLIP-seq
MIRT2126256	hsa-miR-1587	CLIP-seq
MIRT1420446	hsa-miR-1915	CLIP-seq
MIRT2126257	hsa-miR-193a-5p	CLIP-seq
MIRT2126258	hsa-miR-206	CLIP-seq
MIRT2126259	hsa-miR-3074-5p	CLIP-seq
MIRT2126260	hsa-miR-3126-5p	CLIP-seq
MIRT2126261	hsa-miR-3179	CLIP-seq
MIRT2126262	hsa-miR-3182	CLIP-seq
MIRT2126263	hsa-miR-3190	CLIP-seq
MIRT2126264	hsa-miR-3202	CLIP-seq
MIRT2126265	hsa-miR-361-3p	CLIP-seq
MIRT2126266	hsa-miR-3673	CLIP-seq
MIRT2126267	hsa-miR-378g	CLIP-seq
MIRT2126268	hsa-miR-3911	CLIP-seq
MIRT2126269	hsa-miR-4271	CLIP-seq
MIRT2126270	hsa-miR-4279	CLIP-seq
MIRT2126271	hsa-miR-4302	CLIP-seq
MIRT2126272	hsa-miR-4312	CLIP-seq
MIRT2126273	hsa-miR-4316	CLIP-seq
MIRT2126274	hsa-miR-4419a	CLIP-seq
MIRT2126275	hsa-miR-4447	CLIP-seq
MIRT2126276	hsa-miR-4472	CLIP-seq
MIRT2126277	hsa-miR-4483	CLIP-seq
MIRT2126278	hsa-miR-4492	CLIP-seq
MIRT2126279	hsa-miR-4498	CLIP-seq
MIRT2126280	hsa-miR-4505	CLIP-seq
MIRT2126281	hsa-miR-4510	CLIP-seq
MIRT2126282	hsa-miR-4656	CLIP-seq
MIRT2126283	hsa-miR-4663	CLIP-seq
MIRT2126284	hsa-miR-4667-3p	CLIP-seq
MIRT2126285	hsa-miR-4668-5p	CLIP-seq
MIRT2126286	hsa-miR-4675	CLIP-seq
MIRT2126287	hsa-miR-4691-5p	CLIP-seq
MIRT2126288	hsa-miR-4710	CLIP-seq
MIRT2126289	hsa-miR-4720-3p	CLIP-seq
MIRT2126290	hsa-miR-4725-3p	CLIP-seq
MIRT1420467	hsa-miR-4726-3p	CLIP-seq
MIRT2126291	hsa-miR-4727-5p	CLIP-seq
MIRT2126292	hsa-miR-4728-5p	CLIP-seq
MIRT2126293	hsa-miR-4731-5p	CLIP-seq
MIRT2126294	hsa-miR-4741	CLIP-seq
MIRT2126295	hsa-miR-4747-5p	CLIP-seq
MIRT2126296	hsa-miR-4755-3p	CLIP-seq
MIRT1554549	hsa-miR-4793-5p	CLIP-seq
MIRT2126297	hsa-miR-483-3p	CLIP-seq
MIRT2126298	hsa-miR-502-5p	CLIP-seq
MIRT2126299	hsa-miR-613	CLIP-seq
MIRT2126300	hsa-miR-628-5p	CLIP-seq
MIRT2126301	hsa-miR-762	CLIP-seq
MIRT1420441	hsa-miR-1207-5p	CLIP-seq
MIRT2348285	hsa-miR-1285	CLIP-seq
MIRT1420446	hsa-miR-1915	CLIP-seq
MIRT2348286	hsa-miR-3187-5p	CLIP-seq
MIRT2348287	hsa-miR-4436b-3p	CLIP-seq
MIRT2348288	hsa-miR-4695-3p	CLIP-seq
MIRT1420467	hsa-miR-4726-3p	CLIP-seq
MIRT2126292	hsa-miR-4728-5p	CLIP-seq
MIRT1420468	hsa-miR-4763-3p	CLIP-seq
MIRT2348289	hsa-miR-612	CLIP-seq
MIRT2640892	hsa-miR-1197	CLIP-seq
MIRT2640893	hsa-miR-122	CLIP-seq
MIRT1420443	hsa-miR-1262	CLIP-seq
MIRT2348285	hsa-miR-1285	CLIP-seq
MIRT2640894	hsa-miR-1286	CLIP-seq
MIRT2640895	hsa-miR-1913	CLIP-seq
MIRT1420446	hsa-miR-1915	CLIP-seq
MIRT2640896	hsa-miR-203	CLIP-seq
MIRT2640897	hsa-miR-204	CLIP-seq
MIRT2640898	hsa-miR-211	CLIP-seq
MIRT2640899	hsa-miR-2114	CLIP-seq
MIRT2640900	hsa-miR-3161	CLIP-seq
MIRT2640901	hsa-miR-3184	CLIP-seq
MIRT2640902	hsa-miR-3185	CLIP-seq
MIRT2348286	hsa-miR-3187-5p	CLIP-seq
MIRT1420451	hsa-miR-3189-3p	CLIP-seq
MIRT2640903	hsa-miR-324-3p	CLIP-seq
MIRT1420456	hsa-miR-331-5p	CLIP-seq
MIRT2640904	hsa-miR-342-5p	CLIP-seq
MIRT2640905	hsa-miR-3622a-3p	CLIP-seq
MIRT2640906	hsa-miR-3622b-3p	CLIP-seq
MIRT2640907	hsa-miR-3646	CLIP-seq
MIRT2640908	hsa-miR-3661	CLIP-seq
MIRT2640909	hsa-miR-3667-3p	CLIP-seq
MIRT1420457	hsa-miR-3714	CLIP-seq
MIRT2640910	hsa-miR-3913-3p	CLIP-seq
MIRT2640911	hsa-miR-423-5p	CLIP-seq
MIRT2640912	hsa-miR-4287	CLIP-seq
MIRT2640913	hsa-miR-4421	CLIP-seq
MIRT2126275	hsa-miR-4447	CLIP-seq
MIRT1420462	hsa-miR-4455	CLIP-seq
MIRT2640914	hsa-miR-4469	CLIP-seq
MIRT2126276	hsa-miR-4472	CLIP-seq
MIRT2640915	hsa-miR-4488	CLIP-seq
MIRT2640916	hsa-miR-4511	CLIP-seq
MIRT2640917	hsa-miR-4522	CLIP-seq
MIRT2640918	hsa-miR-4651	CLIP-seq
MIRT2640919	hsa-miR-4664-5p	CLIP-seq
MIRT1420465	hsa-miR-4678	CLIP-seq
MIRT2640920	hsa-miR-4685-3p	CLIP-seq
MIRT2126287	hsa-miR-4691-5p	CLIP-seq
MIRT2640921	hsa-miR-4697-5p	CLIP-seq
MIRT1420466	hsa-miR-4701-3p	CLIP-seq
MIRT2640922	hsa-miR-4714-5p	CLIP-seq
MIRT2640923	hsa-miR-4723-5p	CLIP-seq
MIRT1420467	hsa-miR-4726-3p	CLIP-seq
MIRT2640924	hsa-miR-4749-3p	CLIP-seq
MIRT2640925	hsa-miR-4757-5p	CLIP-seq
MIRT2640926	hsa-miR-4766-5p	CLIP-seq
MIRT2640927	hsa-miR-4768-3p	CLIP-seq
MIRT1554549	hsa-miR-4793-5p	CLIP-seq
MIRT2640928	hsa-miR-4794	CLIP-seq
MIRT2640929	hsa-miR-4802-5p	CLIP-seq
MIRT2126297	hsa-miR-483-3p	CLIP-seq
MIRT2640930	hsa-miR-489	CLIP-seq
MIRT2640931	hsa-miR-508-5p	CLIP-seq
MIRT1420471	hsa-miR-549	CLIP-seq
MIRT2640932	hsa-miR-593	CLIP-seq
MIRT2640933	hsa-miR-608	CLIP-seq
MIRT1420472	hsa-miR-609	CLIP-seq
MIRT2348289	hsa-miR-612	CLIP-seq
MIRT2640934	hsa-miR-618	CLIP-seq
MIRT2640935	hsa-miR-631	CLIP-seq
MIRT2640936	hsa-miR-642a	CLIP-seq
MIRT2640937	hsa-miR-665	CLIP-seq
MIRT2640938	hsa-miR-769-5p	CLIP-seq
MIRT1420475	hsa-miR-940	CLIP-seq
MIRT2640892	hsa-miR-1197	CLIP-seq
MIRT2640893	hsa-miR-122	CLIP-seq
MIRT1420443	hsa-miR-1262	CLIP-seq
MIRT2640894	hsa-miR-1286	CLIP-seq
MIRT2692928	hsa-miR-1299	CLIP-seq
MIRT2640895	hsa-miR-1913	CLIP-seq
MIRT1420446	hsa-miR-1915	CLIP-seq
MIRT2640896	hsa-miR-203	CLIP-seq
MIRT2640897	hsa-miR-204	CLIP-seq
MIRT2640898	hsa-miR-211	CLIP-seq
MIRT2640899	hsa-miR-2114	CLIP-seq
MIRT2692929	hsa-miR-3148	CLIP-seq
MIRT2640900	hsa-miR-3161	CLIP-seq
MIRT2640901	hsa-miR-3184	CLIP-seq
MIRT2640902	hsa-miR-3185	CLIP-seq
MIRT1420451	hsa-miR-3189-3p	CLIP-seq
MIRT2640903	hsa-miR-324-3p	CLIP-seq
MIRT1420456	hsa-miR-331-5p	CLIP-seq
MIRT2640904	hsa-miR-342-5p	CLIP-seq
MIRT2640907	hsa-miR-3646	CLIP-seq
MIRT2692930	hsa-miR-3647-3p	CLIP-seq
MIRT2640908	hsa-miR-3661	CLIP-seq
MIRT2640909	hsa-miR-3667-3p	CLIP-seq
MIRT1420457	hsa-miR-3714	CLIP-seq
MIRT2640910	hsa-miR-3913-3p	CLIP-seq
MIRT2640911	hsa-miR-423-5p	CLIP-seq
MIRT2640912	hsa-miR-4287	CLIP-seq
MIRT2640913	hsa-miR-4421	CLIP-seq
MIRT2126275	hsa-miR-4447	CLIP-seq
MIRT1420462	hsa-miR-4455	CLIP-seq
MIRT2640914	hsa-miR-4469	CLIP-seq
MIRT2126276	hsa-miR-4472	CLIP-seq
MIRT2640915	hsa-miR-4488	CLIP-seq
MIRT2640916	hsa-miR-4511	CLIP-seq
MIRT2640917	hsa-miR-4522	CLIP-seq
MIRT2640918	hsa-miR-4651	CLIP-seq
MIRT2640919	hsa-miR-4664-5p	CLIP-seq
MIRT1420465	hsa-miR-4678	CLIP-seq
MIRT2640920	hsa-miR-4685-3p	CLIP-seq
MIRT2126287	hsa-miR-4691-5p	CLIP-seq
MIRT2640921	hsa-miR-4697-5p	CLIP-seq
MIRT1420466	hsa-miR-4701-3p	CLIP-seq
MIRT2640922	hsa-miR-4714-5p	CLIP-seq
MIRT2640923	hsa-miR-4723-5p	CLIP-seq
MIRT1420467	hsa-miR-4726-3p	CLIP-seq
MIRT2640924	hsa-miR-4749-3p	CLIP-seq
MIRT2640925	hsa-miR-4757-5p	CLIP-seq
MIRT2640926	hsa-miR-4766-5p	CLIP-seq
MIRT2640927	hsa-miR-4768-3p	CLIP-seq
MIRT1554549	hsa-miR-4793-5p	CLIP-seq
MIRT2640928	hsa-miR-4794	CLIP-seq
MIRT2640929	hsa-miR-4802-5p	CLIP-seq
MIRT2126297	hsa-miR-483-3p	CLIP-seq
MIRT2640930	hsa-miR-489	CLIP-seq
MIRT2640931	hsa-miR-508-5p	CLIP-seq
MIRT2692931	hsa-miR-513a-3p	CLIP-seq
MIRT1420471	hsa-miR-549	CLIP-seq
MIRT2640932	hsa-miR-593	CLIP-seq
MIRT2640933	hsa-miR-608	CLIP-seq
MIRT1420472	hsa-miR-609	CLIP-seq
MIRT2640934	hsa-miR-618	CLIP-seq
MIRT2640935	hsa-miR-631	CLIP-seq
MIRT2692932	hsa-miR-660	CLIP-seq
MIRT2640937	hsa-miR-665	CLIP-seq
MIRT2640938	hsa-miR-769-5p	CLIP-seq
MIRT2692933	hsa-miR-875-3p	CLIP-seq
MIRT1420475	hsa-miR-940	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
E2F3	Unknown	12748276

Show/Hide all (47)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	ISS
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	24448649
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	24448649
GO:0003700	Function	DNA-binding transcription factor activity	ISS
GO:0003700	Function	DNA-binding transcription factor activity	NAS	1685140
GO:0005515	Function	Protein binding	IPI	15507434, 26168401, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	24448649, 36608670
GO:0005634	Component	Nucleus	IDA	22692423
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IMP	21209915
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	22692423
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	24448649, 36608670
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005829	Component	Cytosol	IDA	24448649, 36608670
GO:0005829	Component	Cytosol	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006959	Process	Humoral immune response	IEA
GO:0006959	Process	Humoral immune response	ISS
GO:0007040	Process	Lysosome organization	IDA	24448649
GO:0016020	Component	Membrane	IEA
GO:0045670	Process	Regulation of osteoclast differentiation	IEA
GO:0045785	Process	Positive regulation of cell adhesion	IMP	21209915
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IMP	29146937
GO:0045893	Process	Positive regulation of DNA-templated transcription	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	21209915
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS
GO:0046983	Function	Protein dimerization activity	IEA
GO:0090336	Process	Positive regulation of brown fat cell differentiation	ISS
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	23885019
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
314310	11752	ENSG00000068323

P19532

Protein name

Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33)

Protein function

Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:24448649, PubMed:29146937, PubMed:30733432, PubMed:31672913, PubMed:37079666). Specifically recognizes and binds E-box seque

PDB

7F09

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15951	MITF_TFEB_C_3_N	113 → 266	MITF/TFEB/TFEC/TFE3 N-terminus	Family
PF00010	HLH	347 → 400	Helix-loop-helix DNA-binding domain	Domain
PF11851	DUF3371	432 → 574	Domain of unknown function (DUF3371)	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous in fetal and adult tissues. {ECO:0000269|PubMed:8986805}.

Sequence

MSHAAEPARDGVEASAEGPRAVFVLLEERRPADSAQLLSLNSLLPESGIVADIELENVLD
PDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAGGSRTPAMSSSSSSRVLLRQQL
MRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQ
THLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPT
GSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSG
NLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRF
NINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQAN
RSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVG
GGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGA
LSPLRAASDPLLSSVSPAVSKASSRRSSFSMEEES

Sequence length

575

Interactions

View interactions

	KEGG
	Mitophagy - animal Transcriptional misregulation in cancer Renal cell carcinoma

Show/Hide Causal Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Intellectual developmental disorder, X-linked, syndromic, with pigmentary mosaicism and coarse facies	Pathogenic; Likely pathogenic	rs2147777346, rs2147777343, rs2147776381, rs2064742925, rs2147776168, rs2147776463, rs2147776445, rs2520162033, rs2520164693, rs2520162018	RCV001732146 RCV001733804 RCV001733805 RCV001733806 RCV001733807 RCV001775203 RCV001775204 RCV002291368 RCV002468809 RCV003153063 RCV003234809 RCV001732102 RCV001732109
Intellectual disability	Likely pathogenic	rs2064742830	RCV001255376
Neurodevelopmental abnormality	Likely pathogenic; Pathogenic	rs2064742925	RCV001732101
Neurodevelopmental disorder	Pathogenic	rs2147777346	RCV001374939
Renal cell carcinoma	Likely pathogenic; Pathogenic	rs2064742925	RCV004798904
Thyroid cancer, nonmedullary, 1	Pathogenic	rs2147776168	RCV005920690

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Renal cell carcinoma, Xp11-associated	Uncertain significance; Conflicting classifications of pathogenicity	rs782782345, rs782285732	RCV001803670 RCV005399396
See cases	Uncertain significance	rs868924892	RCV002252906
TFE3-Associated Neurodevelopmental disorder	Uncertain significance	rs2147780092	RCV001420672
TFE3-related disorder	Uncertain significance	rs1218432951, rs1047731769, rs1277025733, rs1286561719, rs1557075315	RCV004756316 RCV003402871 RCV003400483 RCV003894503 RCV003949328

Show/Hide Text Mining Associations (58)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenoma Pleomorphic	Associate	31467228
Angiomyolipoma	Associate	25550868, 36740682
Burkitt Lymphoma	Associate	12719541
Calcinosis	Associate	29713041
Calcinosis Cutis	Associate	20154303, 20665500, 22037260
Capillary Malformation Arteriovenous Malformation	Associate	39486419
Carcinogenesis	Associate	27673450, 35396773
Carcinoma Adenoid Cystic	Associate	25485635
Carcinoma Medullary	Associate	26415891
Carcinoma Pancreatic Ductal	Stimulate	30030118
Carcinoma Pancreatic Ductal	Associate	31381571
Carcinoma Renal Cell	Associate	11438465, 12719541, 18278810, 19396149, 20154303, 20421778, 20665500, 20679884, 21504709, 21602817, 22037260, 22100019, 22446944, 23628822, 23817689 View all (62 more)
Chromosome Xp11.3 Deletion Syndrome	Associate	22100019, 23628822, 23828314, 24427344, 26191243, 26636097, 26880493, 27893792, 28587544, 29333109, 29890986, 33019842, 34784933, 35452181
Chronic Pain	Associate	35699228
Deafness X Linked 1	Associate	21602817
Death	Stimulate	37448552
Familial renal cell carcinoma	Associate	34148064
Fasciitis	Associate	31043173
Fatty Liver	Associate	26999124
Fibromatosis Aggressive	Associate	31043173
Focal cortical dysplasia of Taylor	Associate	39486419
Gastrointestinal Stromal Tumors	Associate	31043173, 37528481
Glioblastoma	Associate	35269968, 35757013
Gliosarcoma	Associate	35757013, 38358216
Hemangioendothelioma	Associate	30459475, 34381186
Hemangioendothelioma Epithelioid	Associate	23737213, 24986479, 26840265, 31467228, 31537895, 34148063
Hutchinson's Melanotic Freckle	Associate	26975036
Hypoxia Brain	Associate	30849994
Inflammation	Associate	25550868
Kidney Diseases	Associate	36740682
Kidney Failure Chronic	Associate	18278810
Kidney Neoplasms	Associate	11438465, 12719541, 15992428, 23038766, 24228124, 24735727, 26415891, 26975036, 28713889, 38599381, 40442772
Lesch Nyhan Syndrome	Stimulate	33899786
Lymphatic Metastasis	Stimulate	34660181
Malignant mesenchymal tumor	Associate	32889887
Melanoma	Associate	30705290, 32881934
Metabolic Diseases	Associate	26999124
Mitochondrial Diseases	Associate	33019842, 37269887
Neoplasm Metastasis	Associate	34660181, 35438716, 35462576, 35801771, 36740682
Neoplasms	Associate	11438465, 12719541, 18983462, 20421778, 21602817, 22100019, 23628822, 24339735, 25337301, 26191243, 26840265, 26975036, 27733182, 28731045, 29713041 View all (27 more)
Neoplasms	Inhibit	38599381
Neoplasms Cystic Mucinous and Serous	Associate	29713041
Neuroendocrine Tumors	Stimulate	30030118
Ovarian Neoplasms	Associate	31973910, 37528481
Pancreatic Neoplasms	Stimulate	30030118
Perivascular Epithelioid Cell Neoplasms	Associate	25337301, 25517951, 26722497, 26975036, 31467228, 32146802, 32889887, 33180365, 35699228, 35848761, 36367123, 36647157, 37041531, 37448552, 38219952 View all (4 more)
Sarcoma	Associate	22949933, 29104083, 30459475
Sarcoma Alveolar Soft Part	Associate	11438465, 12719541, 20421778, 21602817, 23828314, 24427344, 24493828, 26369552, 26415891, 27673450, 28766250, 29216400, 30458744, 31467228, 31782115 View all (6 more)
Small Cell Lung Carcinoma	Associate	33899786
Soft Tissue Neoplasms	Associate	33147323
Solitary Fibrous Tumors	Associate	32566457
Squamous Cell Carcinoma of Head and Neck	Associate	35462576
Thyroid Cancer Papillary	Associate	29713041, 34660181
Translocation Genetic	Associate	21602817, 35848761
Tuberous Sclerosis	Associate	39486419
Urogenital Diseases	Associate	21504709
Uterine Cervical Neoplasms	Associate	36705569
Wilms Tumor	Associate	30458744

TFE3 (transcription factor binding to IGHM enhancer 3)