Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7024
Gene name Gene Name - the full gene name approved by the HGNC.
Transcription factor CP2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TFCP2
Synonyms (NCBI Gene) Gene synonyms aliases
LBP1C, LSF, LSF1D, SEF, TFCP2C
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q13.12-q13.13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoter
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020695 hsa-miR-155-5p Proteomics 18668040
MIRT043398 hsa-miR-331-3p CLASH 23622248
MIRT542401 hsa-miR-329-3p HITS-CLIP 23313552
MIRT542400 hsa-miR-362-3p HITS-CLIP 23313552
MIRT542399 hsa-miR-603 HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0000987 Function Cis-regulatory region sequence-specific DNA binding IDA 16263792
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
189889 11748 ENSG00000135457
Protein
UniProt ID Q12800
Protein name Alpha-globin transcription factor CP2 (SAA3 enhancer factor) (Transcription factor LSF)
Protein function Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04516 CP2 44 260 CP2 transcription factor Family
PF18016 SAM_3 319 382 SAM domain (Sterile alpha motif) Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level). {ECO:0000269|PubMed:10455131, ECO:0000269|PubMed:7828600, ECO:0000269|PubMed:8157699}.
Sequence
MAWALKLPLADEVIESGLVQDFDASLSGIGQELGAGAYSMSDVLALPIFKQEESSLPPDN
ENKILPFQYVLCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKLGELPEINGKLVKSIF
RVVFHDRRLQYTEHQQLEGWRWNRPGDRILDIDIPMSVGIIDPRANPTQLNTVEFLWDPA
KRTSVFIQVHCISTEFTMRKHGGEKGVPFRVQIDTFKENENGEYTEHLHSASCQIKVFKP
KGADRKQKTDREKMEKRTPH
EKEKYQPSYETTILTECSPWPEITYVNNSPSPGFNSSHSS
FSLGEGNGSPNHQPEPPPPVTDNLLPTTTPQEAQQWLHRNRFSTFTRLFTNFSGADLLKL
TRDDVIQICGPADGIRLFNALK
GRMVRPRLTIYVCQESLQLREQQQQQQQQQQKHEDGDS
NGTFFVYHAIYLEELTAVELTEKIAQLFSISPCQISQIYKQGPTGIHVLISDEMIQNFQE
EACFILDTMKAETNDSYHIILK
Sequence length 502
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 16710089 ClinVar
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 10888618
Alzheimer Disease Associate 11283204, 16272261, 28286146
Calcinosis Cutis Stimulate 25609232
Carcinoma Associate 38168093
Carcinoma Basal Cell Associate 32631335
Carcinoma Hepatocellular Associate 25609232, 32539694
Colorectal Neoplasms Stimulate 25337247
Colorectal Neoplasms Associate 32539694, 33892791, 35710032, 36741376
Diabetes Gestational Associate 34116986
Endometriosis Associate 35072229