Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7020
Gene name	Transcription factor AP-2 alpha
Gene symbol	TFAP2A
Synonyms (NCBI Gene)	AP-2AP-2alphaAP2TFBOFSTFAP2
Chromosome	6
Chromosome location	6p24.3
Summary	The protein encoded by this gene is a transcription factor that binds the consensus sequence 5`-GCCNNNGGC-3`. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of

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SNP ID	Visualize variation	Clinical significance	Consequence
rs267607108	C>T	Pathogenic	Coding sequence variant, missense variant
rs1554110673	T>C	Likely-pathogenic	Stop lost, terminator codon variant
rs1554110735	TT>-	Pathogenic	Coding sequence variant, frameshift variant
rs1554110994	C>G	Likely-pathogenic	Missense variant, coding sequence variant
rs1554112492	->CCGTGCA	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1581257777	->T	Likely-pathogenic	Coding sequence variant, frameshift variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024195	hsa-miR-221-3p	Sequencing	20371350
MIRT027191	hsa-miR-103a-3p	Sequencing	20371350
MIRT027773	hsa-miR-98-5p	Microarray	19088304
MIRT031854	hsa-miR-16-5p	Sequencing	20371350
MIRT044482	hsa-miR-320a	CLASH	23622248
MIRT639294	hsa-miR-3162-3p	HITS-CLIP	19536157
MIRT639293	hsa-miR-4469	HITS-CLIP	19536157
MIRT639291	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT639292	hsa-miR-4287	HITS-CLIP	19536157
MIRT639290	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT639289	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT639288	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT639287	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT639295	hsa-miR-338-5p	HITS-CLIP	23824327
MIRT639294	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT639293	hsa-miR-4469	HITS-CLIP	23824327
MIRT639291	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT639292	hsa-miR-4287	HITS-CLIP	23824327
MIRT639290	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT639289	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT639288	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT639287	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT574414	hsa-miR-222-3p	PAR-CLIP	20371350
MIRT024195	hsa-miR-221-3p	PAR-CLIP	20371350
MIRT574413	hsa-miR-10a-3p	PAR-CLIP	20371350
MIRT574412	hsa-miR-4760-3p	PAR-CLIP	20371350
MIRT315027	hsa-miR-3529-3p	PAR-CLIP	20371350
MIRT574411	hsa-miR-8060	PAR-CLIP	20371350
MIRT574410	hsa-miR-302b-5p	PAR-CLIP	20371350
MIRT574409	hsa-miR-302d-5p	PAR-CLIP	20371350
MIRT574408	hsa-miR-187-5p	PAR-CLIP	20371350
MIRT574407	hsa-miR-548v	PAR-CLIP	20371350
MIRT574406	hsa-miR-664b-5p	PAR-CLIP	20371350
MIRT574404	hsa-miR-3143	PAR-CLIP	20371350
MIRT574405	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT574403	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT574402	hsa-miR-302c-5p	PAR-CLIP	20371350
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT031854	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT466434	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT466433	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT466432	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT466431	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT466429	hsa-miR-646	PAR-CLIP	20371350
MIRT466427	hsa-miR-6165	PAR-CLIP	20371350
MIRT466428	hsa-miR-4476	PAR-CLIP	20371350
MIRT466426	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT466425	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT466424	hsa-miR-214-3p	PAR-CLIP	20371350
MIRT466423	hsa-miR-3619-5p	PAR-CLIP	20371350
MIRT466422	hsa-miR-761	PAR-CLIP	20371350
MIRT466421	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT466420	hsa-miR-8075	PAR-CLIP	20371350
MIRT466419	hsa-miR-3202	PAR-CLIP	20371350
MIRT466418	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT466417	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT466416	hsa-miR-628-5p	PAR-CLIP	20371350
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT031854	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT466434	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT466433	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT466432	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT466431	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT466429	hsa-miR-646	PAR-CLIP	20371350
MIRT466427	hsa-miR-6165	PAR-CLIP	20371350
MIRT466428	hsa-miR-4476	PAR-CLIP	20371350
MIRT466426	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT466425	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT466424	hsa-miR-214-3p	PAR-CLIP	20371350
MIRT466423	hsa-miR-3619-5p	PAR-CLIP	20371350
MIRT466422	hsa-miR-761	PAR-CLIP	20371350
MIRT466421	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT466420	hsa-miR-8075	PAR-CLIP	20371350
MIRT466419	hsa-miR-3202	PAR-CLIP	20371350
MIRT466418	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT466417	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT466416	hsa-miR-628-5p	PAR-CLIP	20371350
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031854	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT466434	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT466433	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT466432	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT466431	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT466429	hsa-miR-646	PAR-CLIP	21572407
MIRT466427	hsa-miR-6165	PAR-CLIP	21572407
MIRT466428	hsa-miR-4476	PAR-CLIP	21572407
MIRT466426	hsa-miR-6876-5p	PAR-CLIP	21572407
MIRT466425	hsa-miR-296-3p	PAR-CLIP	21572407
MIRT466424	hsa-miR-214-3p	PAR-CLIP	21572407
MIRT466423	hsa-miR-3619-5p	PAR-CLIP	21572407
MIRT466422	hsa-miR-761	PAR-CLIP	21572407
MIRT466421	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT466420	hsa-miR-8075	PAR-CLIP	21572407
MIRT466419	hsa-miR-3202	PAR-CLIP	21572407
MIRT466418	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT466417	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT466416	hsa-miR-628-5p	PAR-CLIP	21572407
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031854	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT466434	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT466433	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT466432	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT466431	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT466429	hsa-miR-646	PAR-CLIP	21572407
MIRT466427	hsa-miR-6165	PAR-CLIP	21572407
MIRT466428	hsa-miR-4476	PAR-CLIP	21572407
MIRT466426	hsa-miR-6876-5p	PAR-CLIP	21572407
MIRT466425	hsa-miR-296-3p	PAR-CLIP	21572407
MIRT466424	hsa-miR-214-3p	PAR-CLIP	21572407
MIRT466423	hsa-miR-3619-5p	PAR-CLIP	21572407
MIRT466422	hsa-miR-761	PAR-CLIP	21572407
MIRT466421	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT466420	hsa-miR-8075	PAR-CLIP	21572407
MIRT466419	hsa-miR-3202	PAR-CLIP	21572407
MIRT466418	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT466417	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT466416	hsa-miR-628-5p	PAR-CLIP	21572407
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT031854	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT466434	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT466433	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT466432	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT466431	hsa-miR-503-5p	PAR-CLIP	23446348
MIRT466429	hsa-miR-646	PAR-CLIP	23446348
MIRT466427	hsa-miR-6165	PAR-CLIP	23446348
MIRT466428	hsa-miR-4476	PAR-CLIP	23446348
MIRT466426	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT466425	hsa-miR-296-3p	PAR-CLIP	23446348
MIRT466424	hsa-miR-214-3p	PAR-CLIP	23446348
MIRT466423	hsa-miR-3619-5p	PAR-CLIP	23446348
MIRT466422	hsa-miR-761	PAR-CLIP	23446348
MIRT466421	hsa-miR-873-5p	PAR-CLIP	23446348
MIRT466420	hsa-miR-8075	PAR-CLIP	23446348
MIRT466419	hsa-miR-3202	PAR-CLIP	23446348
MIRT466418	hsa-miR-4524a-5p	PAR-CLIP	23446348
MIRT466417	hsa-miR-4524b-5p	PAR-CLIP	23446348
MIRT466416	hsa-miR-628-5p	PAR-CLIP	23446348
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT031854	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT466434	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT466433	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT466432	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT466431	hsa-miR-503-5p	PAR-CLIP	23592263
MIRT466429	hsa-miR-646	PAR-CLIP	23592263
MIRT466427	hsa-miR-6165	PAR-CLIP	23592263
MIRT466428	hsa-miR-4476	PAR-CLIP	23592263
MIRT466426	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT466425	hsa-miR-296-3p	PAR-CLIP	23592263
MIRT466424	hsa-miR-214-3p	PAR-CLIP	23592263
MIRT466423	hsa-miR-3619-5p	PAR-CLIP	23592263
MIRT466422	hsa-miR-761	PAR-CLIP	23592263
MIRT466421	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT466420	hsa-miR-8075	PAR-CLIP	23592263
MIRT466419	hsa-miR-3202	PAR-CLIP	23592263
MIRT466418	hsa-miR-4524a-5p	PAR-CLIP	23592263
MIRT466417	hsa-miR-4524b-5p	PAR-CLIP	23592263
MIRT466416	hsa-miR-628-5p	PAR-CLIP	23592263
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	26701625
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	26701625
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	26701625
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	26701625
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	26701625
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	26701625
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	26701625
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	26701625
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	26701625
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	26701625
MIRT031854	hsa-miR-16-5p	PAR-CLIP	26701625
MIRT031854	hsa-miR-16-5p	PAR-CLIP	26701625
MIRT031854	hsa-miR-16-5p	PAR-CLIP	26701625
MIRT031854	hsa-miR-16-5p	PAR-CLIP	26701625
MIRT031854	hsa-miR-16-5p	PAR-CLIP	26701625
MIRT466434	hsa-miR-195-5p	PAR-CLIP	26701625
MIRT466434	hsa-miR-195-5p	PAR-CLIP	26701625
MIRT466434	hsa-miR-195-5p	PAR-CLIP	26701625
MIRT466434	hsa-miR-195-5p	PAR-CLIP	26701625
MIRT466434	hsa-miR-195-5p	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT755640	hsa-miR-3960	PAR-CLIP	26701625
MIRT466433	hsa-miR-424-5p	PAR-CLIP	26701625
MIRT466433	hsa-miR-424-5p	PAR-CLIP	26701625
MIRT466433	hsa-miR-424-5p	PAR-CLIP	26701625
MIRT466433	hsa-miR-424-5p	PAR-CLIP	26701625
MIRT466433	hsa-miR-424-5p	PAR-CLIP	26701625
MIRT466432	hsa-miR-497-5p	PAR-CLIP	26701625
MIRT466432	hsa-miR-497-5p	PAR-CLIP	26701625
MIRT466432	hsa-miR-497-5p	PAR-CLIP	26701625
MIRT466432	hsa-miR-497-5p	PAR-CLIP	26701625
MIRT466432	hsa-miR-497-5p	PAR-CLIP	26701625
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	26701625
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	26701625
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	26701625
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	26701625
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	26701625
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	27292025
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	27292025
MIRT031854	hsa-miR-16-5p	PAR-CLIP	27292025
MIRT466434	hsa-miR-195-5p	PAR-CLIP	27292025
MIRT755640	hsa-miR-3960	PAR-CLIP	27292025
MIRT466433	hsa-miR-424-5p	PAR-CLIP	27292025
MIRT466418	hsa-miR-4524a-5p	PAR-CLIP	27292025
MIRT466417	hsa-miR-4524b-5p	PAR-CLIP	27292025
MIRT466432	hsa-miR-497-5p	PAR-CLIP	27292025
MIRT466431	hsa-miR-503-5p	PAR-CLIP	27292025
MIRT466429	hsa-miR-646	PAR-CLIP	27292025
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	27292025
MIRT639294	hsa-miR-3162-3p	HITS-CLIP	19536157
MIRT639293	hsa-miR-4469	HITS-CLIP	19536157
MIRT639291	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT639292	hsa-miR-4287	HITS-CLIP	19536157
MIRT639290	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT639289	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT639288	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT639287	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT639295	hsa-miR-338-5p	HITS-CLIP	23824327
MIRT639294	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT639293	hsa-miR-4469	HITS-CLIP	23824327
MIRT639291	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT639292	hsa-miR-4287	HITS-CLIP	23824327
MIRT639290	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT639289	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT639288	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT639287	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT574414	hsa-miR-222-3p	PAR-CLIP	20371350
MIRT024195	hsa-miR-221-3p	PAR-CLIP	20371350
MIRT574413	hsa-miR-10a-3p	PAR-CLIP	20371350
MIRT574412	hsa-miR-4760-3p	PAR-CLIP	20371350
MIRT315027	hsa-miR-3529-3p	PAR-CLIP	20371350
MIRT574411	hsa-miR-8060	PAR-CLIP	20371350
MIRT574410	hsa-miR-302b-5p	PAR-CLIP	20371350
MIRT574409	hsa-miR-302d-5p	PAR-CLIP	20371350
MIRT574408	hsa-miR-187-5p	PAR-CLIP	20371350
MIRT574407	hsa-miR-548v	PAR-CLIP	20371350
MIRT574406	hsa-miR-664b-5p	PAR-CLIP	20371350
MIRT574404	hsa-miR-3143	PAR-CLIP	20371350
MIRT574405	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT574403	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT574402	hsa-miR-302c-5p	PAR-CLIP	20371350
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT031854	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT466434	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT466433	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT466432	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT466431	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT466429	hsa-miR-646	PAR-CLIP	20371350
MIRT466427	hsa-miR-6165	PAR-CLIP	20371350
MIRT466428	hsa-miR-4476	PAR-CLIP	20371350
MIRT466426	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT466425	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT466424	hsa-miR-214-3p	PAR-CLIP	20371350
MIRT466423	hsa-miR-3619-5p	PAR-CLIP	20371350
MIRT466422	hsa-miR-761	PAR-CLIP	20371350
MIRT466421	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT466420	hsa-miR-8075	PAR-CLIP	20371350
MIRT466419	hsa-miR-3202	PAR-CLIP	20371350
MIRT466418	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT466417	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT466416	hsa-miR-628-5p	PAR-CLIP	20371350
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT031854	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT466434	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT466433	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT466432	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT466431	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT466429	hsa-miR-646	PAR-CLIP	20371350
MIRT466427	hsa-miR-6165	PAR-CLIP	20371350
MIRT466428	hsa-miR-4476	PAR-CLIP	20371350
MIRT466426	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT466425	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT466424	hsa-miR-214-3p	PAR-CLIP	20371350
MIRT466423	hsa-miR-3619-5p	PAR-CLIP	20371350
MIRT466422	hsa-miR-761	PAR-CLIP	20371350
MIRT466421	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT466420	hsa-miR-8075	PAR-CLIP	20371350
MIRT466419	hsa-miR-3202	PAR-CLIP	20371350
MIRT466418	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT466417	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT466416	hsa-miR-628-5p	PAR-CLIP	20371350
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031854	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT466434	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT466433	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT466432	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT466431	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT466429	hsa-miR-646	PAR-CLIP	21572407
MIRT466427	hsa-miR-6165	PAR-CLIP	21572407
MIRT466428	hsa-miR-4476	PAR-CLIP	21572407
MIRT466426	hsa-miR-6876-5p	PAR-CLIP	21572407
MIRT466425	hsa-miR-296-3p	PAR-CLIP	21572407
MIRT466424	hsa-miR-214-3p	PAR-CLIP	21572407
MIRT466423	hsa-miR-3619-5p	PAR-CLIP	21572407
MIRT466422	hsa-miR-761	PAR-CLIP	21572407
MIRT466421	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT466420	hsa-miR-8075	PAR-CLIP	21572407
MIRT466419	hsa-miR-3202	PAR-CLIP	21572407
MIRT466418	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT466417	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT466416	hsa-miR-628-5p	PAR-CLIP	21572407
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031854	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT466434	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT466433	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT466432	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT466431	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT466429	hsa-miR-646	PAR-CLIP	21572407
MIRT466427	hsa-miR-6165	PAR-CLIP	21572407
MIRT466428	hsa-miR-4476	PAR-CLIP	21572407
MIRT466426	hsa-miR-6876-5p	PAR-CLIP	21572407
MIRT466425	hsa-miR-296-3p	PAR-CLIP	21572407
MIRT466424	hsa-miR-214-3p	PAR-CLIP	21572407
MIRT466423	hsa-miR-3619-5p	PAR-CLIP	21572407
MIRT466422	hsa-miR-761	PAR-CLIP	21572407
MIRT466421	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT466420	hsa-miR-8075	PAR-CLIP	21572407
MIRT466419	hsa-miR-3202	PAR-CLIP	21572407
MIRT466418	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT466417	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT466416	hsa-miR-628-5p	PAR-CLIP	21572407
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT031854	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT466434	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT466433	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT466432	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT466431	hsa-miR-503-5p	PAR-CLIP	23446348
MIRT466429	hsa-miR-646	PAR-CLIP	23446348
MIRT466427	hsa-miR-6165	PAR-CLIP	23446348
MIRT466428	hsa-miR-4476	PAR-CLIP	23446348
MIRT466426	hsa-miR-6876-5p	PAR-CLIP	23446348
MIRT466425	hsa-miR-296-3p	PAR-CLIP	23446348
MIRT466424	hsa-miR-214-3p	PAR-CLIP	23446348
MIRT466423	hsa-miR-3619-5p	PAR-CLIP	23446348
MIRT466422	hsa-miR-761	PAR-CLIP	23446348
MIRT466421	hsa-miR-873-5p	PAR-CLIP	23446348
MIRT466420	hsa-miR-8075	PAR-CLIP	23446348
MIRT466419	hsa-miR-3202	PAR-CLIP	23446348
MIRT466418	hsa-miR-4524a-5p	PAR-CLIP	23446348
MIRT466417	hsa-miR-4524b-5p	PAR-CLIP	23446348
MIRT466416	hsa-miR-628-5p	PAR-CLIP	23446348
MIRT466436	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT466435	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT031854	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT466434	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT466433	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT466432	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT466430	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT466431	hsa-miR-503-5p	PAR-CLIP	23592263
MIRT466429	hsa-miR-646	PAR-CLIP	23592263
MIRT466427	hsa-miR-6165	PAR-CLIP	23592263
MIRT466428	hsa-miR-4476	PAR-CLIP	23592263
MIRT466426	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT466425	hsa-miR-296-3p	PAR-CLIP	23592263
MIRT466424	hsa-miR-214-3p	PAR-CLIP	23592263
MIRT466423	hsa-miR-3619-5p	PAR-CLIP	23592263
MIRT466422	hsa-miR-761	PAR-CLIP	23592263
MIRT466421	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT466420	hsa-miR-8075	PAR-CLIP	23592263
MIRT466419	hsa-miR-3202	PAR-CLIP	23592263
MIRT466418	hsa-miR-4524a-5p	PAR-CLIP	23592263
MIRT466417	hsa-miR-4524b-5p	PAR-CLIP	23592263
MIRT466416	hsa-miR-628-5p	PAR-CLIP	23592263
MIRT755640	hsa-miR-3960	Luciferase reporter assayWestern blottingqRT-PCRFlow cytometry	36284637
MIRT1419631	hsa-miR-1202	CLIP-seq
MIRT1419632	hsa-miR-1234	CLIP-seq
MIRT1419633	hsa-miR-1276	CLIP-seq
MIRT1419634	hsa-miR-1283	CLIP-seq
MIRT1419635	hsa-miR-1297	CLIP-seq
MIRT1419636	hsa-miR-1323	CLIP-seq
MIRT1419637	hsa-miR-135a	CLIP-seq
MIRT1419638	hsa-miR-135b	CLIP-seq
MIRT1419639	hsa-miR-138	CLIP-seq
MIRT1419640	hsa-miR-141	CLIP-seq
MIRT1419641	hsa-miR-144	CLIP-seq
MIRT1419642	hsa-miR-15a	CLIP-seq
MIRT1419643	hsa-miR-15b	CLIP-seq
MIRT1419644	hsa-miR-16	CLIP-seq
MIRT1419645	hsa-miR-1908	CLIP-seq
MIRT1419646	hsa-miR-195	CLIP-seq
MIRT1419647	hsa-miR-200a	CLIP-seq
MIRT1419648	hsa-miR-200b	CLIP-seq
MIRT1419649	hsa-miR-200c	CLIP-seq
MIRT1419650	hsa-miR-204	CLIP-seq
MIRT1419651	hsa-miR-211	CLIP-seq
MIRT1419652	hsa-miR-2117	CLIP-seq
MIRT1419653	hsa-miR-214	CLIP-seq
MIRT1419654	hsa-miR-221	CLIP-seq
MIRT1419655	hsa-miR-222	CLIP-seq
MIRT1419656	hsa-miR-2277-5p	CLIP-seq
MIRT1419657	hsa-miR-26a	CLIP-seq
MIRT1419658	hsa-miR-26b	CLIP-seq
MIRT1419659	hsa-miR-30a	CLIP-seq
MIRT1419660	hsa-miR-30b	CLIP-seq
MIRT1419661	hsa-miR-30c	CLIP-seq
MIRT1419662	hsa-miR-30d	CLIP-seq
MIRT1419663	hsa-miR-30e	CLIP-seq
MIRT1419664	hsa-miR-3119	CLIP-seq
MIRT1419665	hsa-miR-3125	CLIP-seq
MIRT1419666	hsa-miR-3148	CLIP-seq
MIRT1419667	hsa-miR-3178	CLIP-seq
MIRT1419668	hsa-miR-3180	CLIP-seq
MIRT1419669	hsa-miR-3180-3p	CLIP-seq
MIRT1419670	hsa-miR-3184	CLIP-seq
MIRT1419671	hsa-miR-3194-5p	CLIP-seq
MIRT1419672	hsa-miR-3196	CLIP-seq
MIRT1419673	hsa-miR-3197	CLIP-seq
MIRT1419674	hsa-miR-323-5p	CLIP-seq
MIRT1419675	hsa-miR-325	CLIP-seq
MIRT1419676	hsa-miR-3545-3p	CLIP-seq
MIRT1419677	hsa-miR-3616-3p	CLIP-seq
MIRT1419678	hsa-miR-3616-5p	CLIP-seq
MIRT1419679	hsa-miR-3617	CLIP-seq
MIRT1419680	hsa-miR-3647-3p	CLIP-seq
MIRT1419681	hsa-miR-3647-5p	CLIP-seq
MIRT1419682	hsa-miR-3676	CLIP-seq
MIRT1419683	hsa-miR-3689a-3p	CLIP-seq
MIRT1419684	hsa-miR-3689c	CLIP-seq
MIRT1419685	hsa-miR-380	CLIP-seq
MIRT1419686	hsa-miR-383	CLIP-seq
MIRT1419687	hsa-miR-3916	CLIP-seq
MIRT1419688	hsa-miR-3919	CLIP-seq
MIRT1419689	hsa-miR-3938	CLIP-seq
MIRT1419690	hsa-miR-3972	CLIP-seq
MIRT1419691	hsa-miR-409-3p	CLIP-seq
MIRT1419692	hsa-miR-410	CLIP-seq
MIRT1419693	hsa-miR-423-5p	CLIP-seq
MIRT1419694	hsa-miR-424	CLIP-seq
MIRT1419695	hsa-miR-4273	CLIP-seq
MIRT1419696	hsa-miR-4274	CLIP-seq
MIRT1419697	hsa-miR-4281	CLIP-seq
MIRT1419698	hsa-miR-429	CLIP-seq
MIRT1419699	hsa-miR-4299	CLIP-seq
MIRT1419700	hsa-miR-4301	CLIP-seq
MIRT1419701	hsa-miR-4311	CLIP-seq
MIRT1419702	hsa-miR-4316	CLIP-seq
MIRT1419703	hsa-miR-4423-5p	CLIP-seq
MIRT1419704	hsa-miR-4465	CLIP-seq
MIRT1419705	hsa-miR-4492	CLIP-seq
MIRT1419706	hsa-miR-4495	CLIP-seq
MIRT1419707	hsa-miR-4498	CLIP-seq
MIRT1419708	hsa-miR-4519	CLIP-seq
MIRT1419709	hsa-miR-4524	CLIP-seq
MIRT1419710	hsa-miR-4539	CLIP-seq
MIRT1419711	hsa-miR-4645-3p	CLIP-seq
MIRT1419712	hsa-miR-4652-3p	CLIP-seq
MIRT1419713	hsa-miR-4666-3p	CLIP-seq
MIRT1419714	hsa-miR-4670-3p	CLIP-seq
MIRT1419715	hsa-miR-4699-5p	CLIP-seq
MIRT1419716	hsa-miR-4710	CLIP-seq
MIRT1419717	hsa-miR-4721	CLIP-seq
MIRT1419718	hsa-miR-4728-5p	CLIP-seq
MIRT1419719	hsa-miR-4753-3p	CLIP-seq
MIRT1419720	hsa-miR-4755-5p	CLIP-seq
MIRT1419721	hsa-miR-4768-5p	CLIP-seq
MIRT1419722	hsa-miR-4792	CLIP-seq
MIRT1419723	hsa-miR-4797-5p	CLIP-seq
MIRT1419724	hsa-miR-4802-3p	CLIP-seq
MIRT1419725	hsa-miR-497	CLIP-seq
MIRT1419726	hsa-miR-503	CLIP-seq
MIRT1419727	hsa-miR-513b	CLIP-seq
MIRT1419728	hsa-miR-541	CLIP-seq
MIRT1419729	hsa-miR-548ae	CLIP-seq
MIRT1419730	hsa-miR-548aj	CLIP-seq
MIRT1419731	hsa-miR-548am	CLIP-seq
MIRT1419732	hsa-miR-548c-3p	CLIP-seq
MIRT1419733	hsa-miR-548o	CLIP-seq
MIRT1419734	hsa-miR-548x	CLIP-seq
MIRT1419735	hsa-miR-555	CLIP-seq
MIRT1419736	hsa-miR-573	CLIP-seq
MIRT1419737	hsa-miR-583	CLIP-seq
MIRT1419738	hsa-miR-599	CLIP-seq
MIRT1419739	hsa-miR-616	CLIP-seq
MIRT1419740	hsa-miR-623	CLIP-seq
MIRT1419741	hsa-miR-628-3p	CLIP-seq
MIRT1419742	hsa-miR-641	CLIP-seq
MIRT1419743	hsa-miR-653	CLIP-seq
MIRT1419744	hsa-miR-654-5p	CLIP-seq
MIRT1419745	hsa-miR-661	CLIP-seq
MIRT1419746	hsa-miR-663	CLIP-seq
MIRT1419747	hsa-miR-744	CLIP-seq
MIRT1419748	hsa-miR-762	CLIP-seq
MIRT1419749	hsa-miR-891b	CLIP-seq
MIRT1419631	hsa-miR-1202	CLIP-seq
MIRT1419635	hsa-miR-1297	CLIP-seq
MIRT1419642	hsa-miR-15a	CLIP-seq
MIRT1419643	hsa-miR-15b	CLIP-seq
MIRT1419644	hsa-miR-16	CLIP-seq
MIRT1419646	hsa-miR-195	CLIP-seq
MIRT1419652	hsa-miR-2117	CLIP-seq
MIRT1419653	hsa-miR-214	CLIP-seq
MIRT1419657	hsa-miR-26a	CLIP-seq
MIRT1419658	hsa-miR-26b	CLIP-seq
MIRT1419671	hsa-miR-3194-5p	CLIP-seq
MIRT1419690	hsa-miR-3972	CLIP-seq
MIRT1419692	hsa-miR-410	CLIP-seq
MIRT1419694	hsa-miR-424	CLIP-seq
MIRT1419695	hsa-miR-4273	CLIP-seq
MIRT1419704	hsa-miR-4465	CLIP-seq
MIRT1419709	hsa-miR-4524	CLIP-seq
MIRT1419712	hsa-miR-4652-3p	CLIP-seq
MIRT1419713	hsa-miR-4666-3p	CLIP-seq
MIRT1419719	hsa-miR-4753-3p	CLIP-seq
MIRT1419725	hsa-miR-497	CLIP-seq
MIRT1419726	hsa-miR-503	CLIP-seq
MIRT1419631	hsa-miR-1202	CLIP-seq
MIRT2348069	hsa-miR-1243	CLIP-seq
MIRT2348070	hsa-miR-1290	CLIP-seq
MIRT1419635	hsa-miR-1297	CLIP-seq
MIRT1419636	hsa-miR-1323	CLIP-seq
MIRT1419640	hsa-miR-141	CLIP-seq
MIRT1419642	hsa-miR-15a	CLIP-seq
MIRT1419643	hsa-miR-15b	CLIP-seq
MIRT1419644	hsa-miR-16	CLIP-seq
MIRT1419646	hsa-miR-195	CLIP-seq
MIRT1419647	hsa-miR-200a	CLIP-seq
MIRT1419648	hsa-miR-200b	CLIP-seq
MIRT1419649	hsa-miR-200c	CLIP-seq
MIRT1419650	hsa-miR-204	CLIP-seq
MIRT1419651	hsa-miR-211	CLIP-seq
MIRT2348071	hsa-miR-2115	CLIP-seq
MIRT1419653	hsa-miR-214	CLIP-seq
MIRT1419654	hsa-miR-221	CLIP-seq
MIRT1419655	hsa-miR-222	CLIP-seq
MIRT1419657	hsa-miR-26a	CLIP-seq
MIRT1419658	hsa-miR-26b	CLIP-seq
MIRT2348072	hsa-miR-3126-5p	CLIP-seq
MIRT2348073	hsa-miR-3129-3p	CLIP-seq
MIRT2348074	hsa-miR-3144-5p	CLIP-seq
MIRT2348075	hsa-miR-3167	CLIP-seq
MIRT2348076	hsa-miR-3185	CLIP-seq
MIRT1419671	hsa-miR-3194-5p	CLIP-seq
MIRT1419674	hsa-miR-323-5p	CLIP-seq
MIRT2348077	hsa-miR-323b-3p	CLIP-seq
MIRT1419677	hsa-miR-3616-3p	CLIP-seq
MIRT2348078	hsa-miR-3622b-5p	CLIP-seq
MIRT1419680	hsa-miR-3647-3p	CLIP-seq
MIRT2348079	hsa-miR-3660	CLIP-seq
MIRT1419682	hsa-miR-3676	CLIP-seq
MIRT2348080	hsa-miR-3688-3p	CLIP-seq
MIRT1419685	hsa-miR-380	CLIP-seq
MIRT1419688	hsa-miR-3919	CLIP-seq
MIRT1419689	hsa-miR-3938	CLIP-seq
MIRT1419690	hsa-miR-3972	CLIP-seq
MIRT1419691	hsa-miR-409-3p	CLIP-seq
MIRT1419692	hsa-miR-410	CLIP-seq
MIRT1419694	hsa-miR-424	CLIP-seq
MIRT2348081	hsa-miR-4252	CLIP-seq
MIRT2348082	hsa-miR-4261	CLIP-seq
MIRT2348083	hsa-miR-4263	CLIP-seq
MIRT1419696	hsa-miR-4274	CLIP-seq
MIRT1419697	hsa-miR-4281	CLIP-seq
MIRT1419698	hsa-miR-429	CLIP-seq
MIRT2348084	hsa-miR-4315	CLIP-seq
MIRT2348085	hsa-miR-4419a	CLIP-seq
MIRT1419703	hsa-miR-4423-5p	CLIP-seq
MIRT2348086	hsa-miR-4435	CLIP-seq
MIRT2348087	hsa-miR-4449	CLIP-seq
MIRT2348088	hsa-miR-4455	CLIP-seq
MIRT1419704	hsa-miR-4465	CLIP-seq
MIRT2348089	hsa-miR-4475	CLIP-seq
MIRT1419706	hsa-miR-4495	CLIP-seq
MIRT2348090	hsa-miR-4506	CLIP-seq
MIRT2348091	hsa-miR-4510	CLIP-seq
MIRT2348092	hsa-miR-4511	CLIP-seq
MIRT1419708	hsa-miR-4519	CLIP-seq
MIRT1419709	hsa-miR-4524	CLIP-seq
MIRT2348093	hsa-miR-4526	CLIP-seq
MIRT1419711	hsa-miR-4645-3p	CLIP-seq
MIRT1419713	hsa-miR-4666-3p	CLIP-seq
MIRT2348094	hsa-miR-4691-3p	CLIP-seq
MIRT2348095	hsa-miR-4698	CLIP-seq
MIRT2348096	hsa-miR-4699-3p	CLIP-seq
MIRT1419715	hsa-miR-4699-5p	CLIP-seq
MIRT1419717	hsa-miR-4721	CLIP-seq
MIRT2348097	hsa-miR-4724-3p	CLIP-seq
MIRT1419720	hsa-miR-4755-5p	CLIP-seq
MIRT2348098	hsa-miR-4787-5p	CLIP-seq
MIRT2348099	hsa-miR-4790-5p	CLIP-seq
MIRT2348100	hsa-miR-4795-3p	CLIP-seq
MIRT1419723	hsa-miR-4797-5p	CLIP-seq
MIRT2348101	hsa-miR-4799-5p	CLIP-seq
MIRT1419725	hsa-miR-497	CLIP-seq
MIRT1419726	hsa-miR-503	CLIP-seq
MIRT1419727	hsa-miR-513b	CLIP-seq
MIRT2348102	hsa-miR-516a-3p	CLIP-seq
MIRT1419732	hsa-miR-548c-3p	CLIP-seq
MIRT1419733	hsa-miR-548o	CLIP-seq
MIRT2348103	hsa-miR-548u	CLIP-seq
MIRT1419735	hsa-miR-555	CLIP-seq
MIRT2348104	hsa-miR-576-5p	CLIP-seq
MIRT1419738	hsa-miR-599	CLIP-seq
MIRT2348105	hsa-miR-606	CLIP-seq
MIRT1419740	hsa-miR-623	CLIP-seq
MIRT1419745	hsa-miR-661	CLIP-seq
MIRT2348106	hsa-miR-876-5p	CLIP-seq
MIRT1419749	hsa-miR-891b	CLIP-seq
MIRT1419642	hsa-miR-15a	CLIP-seq
MIRT1419643	hsa-miR-15b	CLIP-seq
MIRT1419644	hsa-miR-16	CLIP-seq
MIRT1419646	hsa-miR-195	CLIP-seq
MIRT1419653	hsa-miR-214	CLIP-seq
MIRT1419654	hsa-miR-221	CLIP-seq
MIRT1419655	hsa-miR-222	CLIP-seq
MIRT1419694	hsa-miR-424	CLIP-seq
MIRT1419709	hsa-miR-4524	CLIP-seq
MIRT1419725	hsa-miR-497	CLIP-seq
MIRT1419726	hsa-miR-503	CLIP-seq

Show/Hide all (4)

Transcription factor	Regulation	Reference
ETS1	Activation	12843180
KLF12	Repression	10704285;11373277
NR2F2	Activation	20195529
YY1	Activation	18218085

Show/Hide all (62)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	8321221, 9520389, 20066163
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	12586840, 18718911, 31146003
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	7555706, 7559606, 9520389, 21084835
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	7555706, 12586840, 21084835
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	9520389, 11278550, 20066163
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP	31146003
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IBA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	11278550, 20808827
GO:0001501	Process	Skeletal system development	IBA
GO:0001822	Process	Kidney development	IBA
GO:0001822	Process	Kidney development	IMP	21204207
GO:0003404	Process	Optic vesicle morphogenesis	ISS
GO:0003409	Process	Optic cup structural organization	ISS
GO:0003677	Function	DNA binding	IDA	16236267
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	ISS
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	10987820, 11447109, 11694877, 12072434, 12586840, 17318229, 19115315, 24835590, 25416956, 25609649, 25910212, 28514442, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	16236267, 19115315, 20607706
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IMP	12586840
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0007399	Process	Nervous system development	IBA
GO:0007605	Process	Sensory perception of sound	IMP	21204207
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	20607706
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0010842	Process	Retina layer formation	IEP	20607706
GO:0010944	Process	Negative regulation of transcription by competitive promoter binding	IDA	8321221
GO:0010944	Process	Negative regulation of transcription by competitive promoter binding	IMP	11278550
GO:0021559	Process	Trigeminal nerve development	ISS
GO:0021623	Process	Oculomotor nerve formation	ISS
GO:0030501	Process	Positive regulation of bone mineralization	IDA	19578371
GO:0035115	Process	Embryonic forelimb morphogenesis	ISS
GO:0042127	Process	Regulation of cell population proliferation	IBA
GO:0042472	Process	Inner ear morphogenesis	IMP	21204207
GO:0042802	Function	Identical protein binding	IPI	1998122
GO:0043066	Process	Negative regulation of apoptotic process	IBA
GO:0043066	Process	Negative regulation of apoptotic process	IDA	20066163
GO:0043525	Process	Positive regulation of neuron apoptotic process	IDA	20607706
GO:0043565	Function	Sequence-specific DNA binding	IDA	8321221, 12586840
GO:0043565	Function	Sequence-specific DNA binding	IMP	1998122
GO:0045595	Process	Regulation of cell differentiation	IDA	20607706
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	20607706
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	31146003
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	12586840
GO:0045893	Process	Positive regulation of DNA-templated transcription	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	7555706, 7559606, 11278550, 20808827
GO:0048701	Process	Embryonic cranial skeleton morphogenesis	ISS
GO:0060021	Process	Roof of mouth development	IMP	21204207
GO:0060349	Process	Bone morphogenesis	ISS
GO:0061029	Process	Eyelid development in camera-type eye	ISS
GO:0070172	Process	Positive regulation of tooth mineralization	IDA	19578371
GO:0071281	Process	Cellular response to iron ion	IDA	20808827
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:2000378	Process	Negative regulation of reactive oxygen species metabolic process	IDA	20066163

MIM	HGNC	e!Ensembl
107580	11742	ENSG00000137203

P05549

Protein name

Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)

Protein function

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a la

PDB

8J0K , 8J0L , 8J0R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03299	TF_AP-2	211 → 405	Transcription factor AP-2	Family

Sequence

MLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPP
PYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSG
LDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPV
SLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSP
PECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHL
ARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSPLG
NSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNS
HTDNNAKSSDKEEKHRK

Sequence length

437

Interactions

View interactions

	Reactome
			Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation

Show/Hide Causal Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Branchiooculofacial syndrome	Likely pathogenic; Pathogenic	rs1757903817, rs1762047599, rs2114014223, rs2114014460, rs2532377146, rs793888540, rs793888541, rs111460784, rs1761968190, rs2532363988, rs121909574, rs121909575, rs2532363719, rs2532358223, rs267607108 View all (16 more)	RCV001329052 RCV001336553 RCV002226999 RCV002272588 RCV002471854 RCV000172980 RCV000172981 RCV003314315 RCV005871260 RCV003991890 RCV000019530 RCV000019531 RCV000019532 RCV000019534 RCV000019535 RCV000019536 RCV000660306 RCV001270676 RCV000660309 RCV000660308 RCV000660307 RCV000660305 RCV000660304 RCV000660303 RCV000660302 RCV000660301 RCV000660300 RCV000660299 RCV000677704 RCV000995666 RCV001029733 RCV001198037 RCV001262709
Chromatinopathy	Pathogenic	rs121909574	RCV001261299
Melnick-Fraser syndrome	Likely pathogenic	rs2113228864	RCV001375377
TFAP2A-related disorder	Likely pathogenic	rs2114014460	RCV003933735

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Neurodevelopmental abnormality	Uncertain significance	rs1761873980	RCV001264662

Show/Hide Text Mining Associations (101)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	32015686, 32294625, 32533823, 37322027
Adenocarcinoma of Lung	Stimulate	33824285, 39187936
Alzheimer Disease	Associate	24067654
Anophthalmos	Associate	27609212
Arthritis Rheumatoid	Associate	30820026
Astrocytoma	Associate	17471019, 8922411
Autoimmune Diseases	Associate	29561802
Branchial Cleft Anomalies	Associate	23578821
Branchio Oto Renal Syndrome	Associate	18423521, 21781438, 23541344, 23578821, 27609212
Breast Neoplasms	Associate	10497269, 11278455, 14565844, 15467710, 15870067, 15891112, 16260418, 16533807, 16859522, 18218085, 18825690, 19906305, 20025767, 21876733, 23544012 View all (5 more)
Breast Neoplasms	Inhibit	16867219
Carcinogenesis	Associate	10504447, 33213447, 33824285, 35563688, 36707053, 38308202
Carcinoma Hepatocellular	Associate	24659263, 3063603, 35478990
Carcinoma Intraductal Noninfiltrating	Associate	15467710
Carcinoma Non Small Cell Lung	Associate	19147542, 23869238, 36123698
Carcinoma Non Small Cell Lung	Stimulate	37305398
Carcinoma Ovarian Epithelial	Associate	10864206
Carcinoma Pancreatic Ductal	Associate	19817750, 21654541
Carcinoma Renal Cell	Associate	24916699, 31746384, 34870494
Carcinoma Squamous Cell	Associate	10504447, 19742317, 22143938
Cataract	Associate	27609212
Cell Transformation Neoplastic	Associate	7926729
Char syndrome	Associate	33000225
Cholangiocarcinoma	Associate	29084594
Cleft Lip	Associate	19137569, 21781438, 25896037, 34310873
Cleft Palate	Associate	21781438
Colonic Neoplasms	Associate	11429425, 31073530
Colorectal Neoplasms	Associate	11429425, 15331612, 25613817, 30082623, 30700826, 33713277
Coxa Magna	Associate	35118903
Diabetes Mellitus Type 2	Associate	18182154, 25524916, 32041280
Diabetic Nephropathies	Associate	26697505
Digestive System Neoplasms	Associate	32432738
Dyslexia	Associate	19419997
Endometrial Neoplasms	Associate	22194984
Gallbladder Neoplasms	Stimulate	32432738
Genetic Diseases Inborn	Associate	33000225
Glioma	Associate	17471019, 37330579
Glioma	Inhibit	25674231
Gout	Associate	28932319
Heart Defects Congenital	Associate	33000225
Hepatitis B	Inhibit	35478990
Hippocampal Sclerosis	Associate	32189710
HIV Infections	Associate	30177858
Holt Oram syndrome	Associate	33000225
Hypoxia	Inhibit	23275444
Hypoxia	Associate	30926672
Hypoxia Brain	Associate	30926672
Immune System Diseases	Associate	29561802
Infections	Associate	35478990
Inflammation	Associate	10504447
Leukemia	Associate	29561802
Leukemia Lymphocytic Chronic B Cell	Associate	20484983
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	20184741
Leukemia Myeloid	Associate	24067654
Lipoblastoma	Associate	8537497
Lipoma	Associate	8537497
Liposarcoma	Associate	8537497
Lung Neoplasms	Associate	14551210, 1953710, 19654299, 29796116, 32415222, 36831334
Lung Neoplasms	Stimulate	30177858
Lymphatic Metastasis	Associate	19817750, 33824285
Lymphatic Metastasis	Stimulate	37083077
Lymphoma	Associate	29561802
Lymphoma Large B Cell Diffuse	Associate	18288132
Melanoma	Inhibit	10864211, 25625848
Melanoma	Associate	10938273, 12975361, 16946713, 17384650, 17726260, 23275444, 26434590, 26489459
Melanoma Cutaneous Malignant	Associate	10864211, 36631465
Microphthalmos	Associate	27609212
Microsatellite Instability	Associate	19742317
Myopia	Associate	29346494
Neoplasm Metastasis	Associate	16260418, 33824285
Neoplasms	Associate	10487624, 10864206, 10864211, 12733991, 15331612, 15467710, 15870067, 16036108, 16859522, 16901903, 17471019, 18288132, 18825690, 19074833, 19742317 View all (19 more)
Neoplasms	Inhibit	11429425, 14551210, 15891112, 21829699, 21966377, 22194984, 25674231, 30700826, 37305398
Neoplasms	Stimulate	30177858, 37083077
Neoplasms Adipose Tissue	Associate	8537497
Neuroblastoma	Associate	17702766
Neuroectodermal Tumors	Associate	16036108
Nonsyndromic Deafness	Associate	29346494
Norrie disease	Associate	32041280
Obesity	Associate	21840420
Opioid Related Disorders	Associate	35741807
Orofacial Cleft 1	Associate	21039277, 28232668
Osteoarthritis	Associate	31523167
Ovarian Neoplasms	Associate	10864206, 31362717, 33493131
Pancreatic Neoplasms	Associate	21654541
Peters anomaly	Associate	25182519
Prostatic Neoplasms	Associate	21940908
Psoriasis	Associate	10504447
Refractive Errors	Associate	29346494
Retinoblastoma	Associate	20607706
Sarcoma	Associate	25984907
Scalp ear nipple syndrome	Associate	33000225
Squamous Cell Carcinoma of Head and Neck	Associate	17651731, 19089912, 19742317, 27650546, 35524329
Squamous Cell Carcinoma of Head and Neck	Inhibit	32362655
Stomach Neoplasms	Inhibit	21966377
Stomach Neoplasms	Associate	34727954
Teratocarcinoma	Associate	3063603
Thyroid Neoplasms	Associate	12475396
Triple Negative Breast Neoplasms	Associate	31395854
Urinary Bladder Neoplasms	Associate	35563688
Uterine Cervical Neoplasms	Associate	32474464
Uterine Cervical Neoplasms	Stimulate	37083077

TFAP2A (transcription factor AP-2 alpha)