Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7019
Gene name Gene Name - the full gene name approved by the HGNC.	Transcription factor A, mitochondrial
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TFAM
Synonyms (NCBI Gene) Gene synonyms aliases	MTDPS15, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3
Disease Acronyms (UniProt) Disease acronyms from UniProt database	MTDPS15
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q21.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer`s and P

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SNP ID	Visualize variation	Clinical significance	Consequence
rs757075712	C>T	Likely-pathogenic, pathogenic	Non coding transcript variant, coding sequence variant, downstream transcript variant, missense variant, intron variant, genic downstream transcript variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT050062	hsa-miR-26a-5p	CLASH	23622248
MIRT049528	hsa-miR-92a-3p	CLASH	23622248
MIRT049528	hsa-miR-92a-3p	CLASH	23622248
MIRT047391	hsa-miR-34a-5p	CLASH	23622248
MIRT041703	hsa-miR-484	CLASH	23622248
MIRT038986	hsa-miR-15a-3p	CLASH	23622248
MIRT053166	hsa-miR-200a-3p	Luciferase reporter assay, Western blot	24684598
MIRT054314	hsa-miR-494-3p	Luciferase reporter assay, Microarray, qRT-PCR	23047984
MIRT466459	hsa-miR-3609	HITS-CLIP	21572407
MIRT466460	hsa-miR-548ah-5p	HITS-CLIP	21572407
MIRT466458	hsa-miR-106a-5p	HITS-CLIP	21572407
MIRT466457	hsa-miR-106b-5p	HITS-CLIP	21572407
MIRT466456	hsa-miR-17-5p	HITS-CLIP	21572407
MIRT466455	hsa-miR-20a-5p	HITS-CLIP	21572407
MIRT466454	hsa-miR-20b-5p	HITS-CLIP	21572407
MIRT466453	hsa-miR-519d-3p	HITS-CLIP	21572407
MIRT466452	hsa-miR-526b-3p	HITS-CLIP	21572407
MIRT466451	hsa-miR-93-5p	HITS-CLIP	21572407
MIRT466450	hsa-miR-4796-3p	HITS-CLIP	21572407
MIRT466449	hsa-miR-3912-3p	HITS-CLIP	21572407
MIRT466448	hsa-miR-519a-3p	HITS-CLIP	21572407
MIRT466447	hsa-miR-519b-3p	HITS-CLIP	21572407
MIRT466446	hsa-miR-519c-3p	HITS-CLIP	21572407
MIRT466445	hsa-miR-101-5p	HITS-CLIP	21572407
MIRT466444	hsa-miR-142-5p	HITS-CLIP	21572407
MIRT466443	hsa-miR-5590-3p	HITS-CLIP	21572407
MIRT466442	hsa-miR-4677-3p	HITS-CLIP	21572407
MIRT466441	hsa-miR-4679	HITS-CLIP	21572407
MIRT466440	hsa-miR-4424	HITS-CLIP	21572407
MIRT466439	hsa-miR-337-3p	HITS-CLIP	21572407
MIRT466437	hsa-miR-448	HITS-CLIP	21572407
MIRT630549	hsa-miR-8485	HITS-CLIP	23824327
MIRT652751	hsa-miR-6767-3p	HITS-CLIP	23824327
MIRT652750	hsa-miR-8064	HITS-CLIP	23824327
MIRT621851	hsa-miR-4432	HITS-CLIP	23824327
MIRT621850	hsa-miR-8087	HITS-CLIP	23824327
MIRT630549	hsa-miR-8485	HITS-CLIP	23824327
MIRT621849	hsa-miR-4719	HITS-CLIP	23824327
MIRT652751	hsa-miR-6767-3p	HITS-CLIP	23824327
MIRT652750	hsa-miR-8064	HITS-CLIP	23824327
MIRT621848	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT621849	hsa-miR-4719	HITS-CLIP	23824327
MIRT652751	hsa-miR-6767-3p	HITS-CLIP	23824327
MIRT652750	hsa-miR-8064	HITS-CLIP	23824327
MIRT621851	hsa-miR-4432	HITS-CLIP	23824327
MIRT621850	hsa-miR-8087	HITS-CLIP	23824327
MIRT630549	hsa-miR-8485	HITS-CLIP	23824327
MIRT621849	hsa-miR-4719	HITS-CLIP	23824327
MIRT621848	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT630548	hsa-miR-6083	HITS-CLIP	23824327
MIRT621851	hsa-miR-4432	HITS-CLIP	23824327
MIRT621850	hsa-miR-8087	HITS-CLIP	23824327
MIRT621849	hsa-miR-4719	HITS-CLIP	23824327
MIRT621848	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT466459	hsa-miR-3609	PAR-CLIP	20371350
MIRT466460	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT466458	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT466457	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT466456	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT466455	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT466454	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT466453	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT466452	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT466451	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT466450	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT466449	hsa-miR-3912-3p	PAR-CLIP	20371350
MIRT466448	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT466447	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT466446	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT466445	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT466444	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT466443	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT466442	hsa-miR-4677-3p	PAR-CLIP	20371350
MIRT466441	hsa-miR-4679	PAR-CLIP	20371350
MIRT466440	hsa-miR-4424	PAR-CLIP	20371350
MIRT466439	hsa-miR-337-3p	PAR-CLIP	20371350
MIRT466437	hsa-miR-448	PAR-CLIP	20371350
MIRT526413	hsa-miR-6871-5p	PAR-CLIP	22012620
MIRT526412	hsa-miR-3690	PAR-CLIP	22012620
MIRT526411	hsa-miR-4254	PAR-CLIP	22012620
MIRT526410	hsa-miR-6128	PAR-CLIP	22012620
MIRT526409	hsa-miR-1-3p	PAR-CLIP	22012620
MIRT526408	hsa-miR-206	PAR-CLIP	22012620
MIRT526407	hsa-miR-613	PAR-CLIP	22012620
MIRT526406	hsa-miR-6878-5p	PAR-CLIP	22012620
MIRT526405	hsa-miR-6731-5p	PAR-CLIP	22012620
MIRT526404	hsa-miR-8085	PAR-CLIP	22012620
MIRT526403	hsa-miR-1343-3p	PAR-CLIP	22012620
MIRT526402	hsa-miR-6783-3p	PAR-CLIP	22012620
MIRT526401	hsa-miR-30c-1-3p	PAR-CLIP	22012620
MIRT526400	hsa-miR-30c-2-3p	PAR-CLIP	22012620
MIRT526399	hsa-miR-6788-5p	PAR-CLIP	22012620
MIRT526398	hsa-miR-2054	PAR-CLIP	22012620
MIRT466459	hsa-miR-3609	PAR-CLIP	23446348
MIRT466460	hsa-miR-548ah-5p	PAR-CLIP	23446348
MIRT466458	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT466457	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT466456	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT466455	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT466454	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT466453	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT466452	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT466451	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT466450	hsa-miR-4796-3p	PAR-CLIP	23446348
MIRT466449	hsa-miR-3912-3p	PAR-CLIP	23446348
MIRT466448	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT466447	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT466446	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT466445	hsa-miR-101-5p	PAR-CLIP	23446348
MIRT466444	hsa-miR-142-5p	PAR-CLIP	23446348
MIRT466443	hsa-miR-5590-3p	PAR-CLIP	23446348
MIRT466441	hsa-miR-4679	PAR-CLIP	23446348
MIRT466440	hsa-miR-4424	PAR-CLIP	23446348
MIRT466439	hsa-miR-337-3p	PAR-CLIP	23446348
MIRT466437	hsa-miR-448	PAR-CLIP	23446348
MIRT466459	hsa-miR-3609	PAR-CLIP	23592263
MIRT466460	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT466458	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT466457	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT466456	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT466455	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT466454	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT466453	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT466452	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT466451	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT466450	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT466449	hsa-miR-3912-3p	PAR-CLIP	23592263
MIRT466448	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT466447	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT466446	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT466445	hsa-miR-101-5p	PAR-CLIP	23592263
MIRT466444	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT466443	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT466442	hsa-miR-4677-3p	PAR-CLIP	23592263
MIRT466441	hsa-miR-4679	PAR-CLIP	23592263
MIRT466440	hsa-miR-4424	PAR-CLIP	23592263
MIRT466439	hsa-miR-337-3p	PAR-CLIP	23592263
MIRT466438	hsa-miR-203b-3p	PAR-CLIP	23592263
MIRT466437	hsa-miR-448	PAR-CLIP	23592263
MIRT731449	hsa-miR-199a-3p	Luciferase reporter assay, Western blot	28126676
MIRT731449	hsa-miR-199a-3p	Luciferase reporter assay, Western blot	28126676
MIRT732746	hsa-miR-376a-3p	qRT-PCR	31930701
MIRT733131	hsa-miR-181a-5p	RNA-seq, qRT-PCR	33670365
MIRT733132	hsa-miR-181b-5p	RNA-seq, qRT-PCR	33670365
MIRT466459	hsa-miR-3609	HITS-CLIP	21572407
MIRT466460	hsa-miR-548ah-5p	HITS-CLIP	21572407
MIRT466458	hsa-miR-106a-5p	HITS-CLIP	21572407
MIRT466457	hsa-miR-106b-5p	HITS-CLIP	21572407
MIRT466456	hsa-miR-17-5p	HITS-CLIP	21572407
MIRT466455	hsa-miR-20a-5p	HITS-CLIP	21572407
MIRT466454	hsa-miR-20b-5p	HITS-CLIP	21572407
MIRT466453	hsa-miR-519d-3p	HITS-CLIP	21572407
MIRT466452	hsa-miR-526b-3p	HITS-CLIP	21572407
MIRT466451	hsa-miR-93-5p	HITS-CLIP	21572407
MIRT466450	hsa-miR-4796-3p	HITS-CLIP	21572407
MIRT466449	hsa-miR-3912-3p	HITS-CLIP	21572407
MIRT466448	hsa-miR-519a-3p	HITS-CLIP	21572407
MIRT466447	hsa-miR-519b-3p	HITS-CLIP	21572407
MIRT466446	hsa-miR-519c-3p	HITS-CLIP	21572407
MIRT466445	hsa-miR-101-5p	HITS-CLIP	21572407
MIRT466444	hsa-miR-142-5p	HITS-CLIP	21572407
MIRT466443	hsa-miR-5590-3p	HITS-CLIP	21572407
MIRT466442	hsa-miR-4677-3p	HITS-CLIP	21572407
MIRT466441	hsa-miR-4679	HITS-CLIP	21572407
MIRT466440	hsa-miR-4424	HITS-CLIP	21572407
MIRT466439	hsa-miR-337-3p	HITS-CLIP	21572407
MIRT466437	hsa-miR-448	HITS-CLIP	21572407
MIRT630549	hsa-miR-8485	HITS-CLIP	23824327
MIRT652751	hsa-miR-6767-3p	HITS-CLIP	23824327
MIRT652750	hsa-miR-8064	HITS-CLIP	23824327
MIRT621851	hsa-miR-4432	HITS-CLIP	23824327
MIRT621850	hsa-miR-8087	HITS-CLIP	23824327
MIRT630549	hsa-miR-8485	HITS-CLIP	23824327
MIRT621849	hsa-miR-4719	HITS-CLIP	23824327
MIRT652751	hsa-miR-6767-3p	HITS-CLIP	23824327
MIRT652750	hsa-miR-8064	HITS-CLIP	23824327
MIRT621848	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT621849	hsa-miR-4719	HITS-CLIP	23824327
MIRT652751	hsa-miR-6767-3p	HITS-CLIP	23824327
MIRT652750	hsa-miR-8064	HITS-CLIP	23824327
MIRT621851	hsa-miR-4432	HITS-CLIP	23824327
MIRT621850	hsa-miR-8087	HITS-CLIP	23824327
MIRT630549	hsa-miR-8485	HITS-CLIP	23824327
MIRT621849	hsa-miR-4719	HITS-CLIP	23824327
MIRT621848	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT630548	hsa-miR-6083	HITS-CLIP	23824327
MIRT621851	hsa-miR-4432	HITS-CLIP	23824327
MIRT621850	hsa-miR-8087	HITS-CLIP	23824327
MIRT621849	hsa-miR-4719	HITS-CLIP	23824327
MIRT621848	hsa-miR-499a-5p	HITS-CLIP	23824327
MIRT466459	hsa-miR-3609	PAR-CLIP	20371350
MIRT466460	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT466458	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT466457	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT466456	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT466455	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT466454	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT466453	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT466452	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT466451	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT466450	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT466449	hsa-miR-3912-3p	PAR-CLIP	20371350
MIRT466448	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT466447	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT466446	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT466445	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT466444	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT466443	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT466442	hsa-miR-4677-3p	PAR-CLIP	20371350
MIRT466441	hsa-miR-4679	PAR-CLIP	20371350
MIRT466440	hsa-miR-4424	PAR-CLIP	20371350
MIRT466439	hsa-miR-337-3p	PAR-CLIP	20371350
MIRT466437	hsa-miR-448	PAR-CLIP	20371350
MIRT526413	hsa-miR-6871-5p	PAR-CLIP	22012620
MIRT526412	hsa-miR-3690	PAR-CLIP	22012620
MIRT526411	hsa-miR-4254	PAR-CLIP	22012620
MIRT526410	hsa-miR-6128	PAR-CLIP	22012620
MIRT526409	hsa-miR-1-3p	PAR-CLIP	22012620
MIRT526408	hsa-miR-206	PAR-CLIP	22012620
MIRT526407	hsa-miR-613	PAR-CLIP	22012620
MIRT526406	hsa-miR-6878-5p	PAR-CLIP	22012620
MIRT526405	hsa-miR-6731-5p	PAR-CLIP	22012620
MIRT526404	hsa-miR-8085	PAR-CLIP	22012620
MIRT526403	hsa-miR-1343-3p	PAR-CLIP	22012620
MIRT526402	hsa-miR-6783-3p	PAR-CLIP	22012620
MIRT526401	hsa-miR-30c-1-3p	PAR-CLIP	22012620
MIRT526400	hsa-miR-30c-2-3p	PAR-CLIP	22012620
MIRT526399	hsa-miR-6788-5p	PAR-CLIP	22012620
MIRT526398	hsa-miR-2054	PAR-CLIP	22012620
MIRT466459	hsa-miR-3609	PAR-CLIP	23446348
MIRT466460	hsa-miR-548ah-5p	PAR-CLIP	23446348
MIRT466458	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT466457	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT466456	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT466455	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT466454	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT466453	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT466452	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT466451	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT466450	hsa-miR-4796-3p	PAR-CLIP	23446348
MIRT466449	hsa-miR-3912-3p	PAR-CLIP	23446348
MIRT466448	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT466447	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT466446	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT466445	hsa-miR-101-5p	PAR-CLIP	23446348
MIRT466444	hsa-miR-142-5p	PAR-CLIP	23446348
MIRT466443	hsa-miR-5590-3p	PAR-CLIP	23446348
MIRT466441	hsa-miR-4679	PAR-CLIP	23446348
MIRT466440	hsa-miR-4424	PAR-CLIP	23446348
MIRT466439	hsa-miR-337-3p	PAR-CLIP	23446348
MIRT466437	hsa-miR-448	PAR-CLIP	23446348
MIRT466459	hsa-miR-3609	PAR-CLIP	23592263
MIRT466460	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT466458	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT466457	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT466456	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT466455	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT466454	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT466453	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT466452	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT466451	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT466450	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT466449	hsa-miR-3912-3p	PAR-CLIP	23592263
MIRT466448	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT466447	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT466446	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT466445	hsa-miR-101-5p	PAR-CLIP	23592263
MIRT466444	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT466443	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT466442	hsa-miR-4677-3p	PAR-CLIP	23592263
MIRT466441	hsa-miR-4679	PAR-CLIP	23592263
MIRT466440	hsa-miR-4424	PAR-CLIP	23592263
MIRT466439	hsa-miR-337-3p	PAR-CLIP	23592263
MIRT466438	hsa-miR-203b-3p	PAR-CLIP	23592263
MIRT466437	hsa-miR-448	PAR-CLIP	23592263
MIRT1419574	hsa-miR-1244	CLIP-seq
MIRT1419575	hsa-miR-1257	CLIP-seq
MIRT1419576	hsa-miR-1270	CLIP-seq
MIRT1419577	hsa-miR-1273e	CLIP-seq
MIRT1419578	hsa-miR-1914	CLIP-seq
MIRT1419579	hsa-miR-1972	CLIP-seq
MIRT1419580	hsa-miR-199b-3p	CLIP-seq
MIRT1419581	hsa-miR-23a	CLIP-seq
MIRT1419582	hsa-miR-23b	CLIP-seq
MIRT1419583	hsa-miR-23c	CLIP-seq
MIRT1419584	hsa-miR-298	CLIP-seq
MIRT1419585	hsa-miR-3074-5p	CLIP-seq
MIRT1419586	hsa-miR-3119	CLIP-seq
MIRT1419587	hsa-miR-3129-5p	CLIP-seq
MIRT1419588	hsa-miR-3144-3p	CLIP-seq
MIRT1419589	hsa-miR-3160-3p	CLIP-seq
MIRT1419590	hsa-miR-330-3p	CLIP-seq
MIRT1419591	hsa-miR-34b	CLIP-seq
MIRT1419592	hsa-miR-3611	CLIP-seq
MIRT1419593	hsa-miR-3662	CLIP-seq
MIRT1419594	hsa-miR-3664-5p	CLIP-seq
MIRT1419595	hsa-miR-3914	CLIP-seq
MIRT1419596	hsa-miR-3920	CLIP-seq
MIRT1419597	hsa-miR-4259	CLIP-seq
MIRT1419598	hsa-miR-4289	CLIP-seq
MIRT1419599	hsa-miR-4427	CLIP-seq
MIRT1419600	hsa-miR-4438	CLIP-seq
MIRT1419601	hsa-miR-4487	CLIP-seq
MIRT1419602	hsa-miR-4531	CLIP-seq
MIRT1419603	hsa-miR-4666-3p	CLIP-seq
MIRT1419604	hsa-miR-4680-3p	CLIP-seq
MIRT1419605	hsa-miR-4687-3p	CLIP-seq
MIRT1419606	hsa-miR-4705	CLIP-seq
MIRT1419607	hsa-miR-4714-5p	CLIP-seq
MIRT1419608	hsa-miR-4715-5p	CLIP-seq
MIRT1419609	hsa-miR-4724-3p	CLIP-seq
MIRT1419610	hsa-miR-4728-3p	CLIP-seq
MIRT1419611	hsa-miR-4797-3p	CLIP-seq
MIRT1419612	hsa-miR-491-3p	CLIP-seq
MIRT1419613	hsa-miR-518a-5p	CLIP-seq
MIRT1419614	hsa-miR-520g	CLIP-seq
MIRT1419615	hsa-miR-520h	CLIP-seq
MIRT1419616	hsa-miR-527	CLIP-seq
MIRT1419617	hsa-miR-548ag	CLIP-seq
MIRT1419618	hsa-miR-548ai	CLIP-seq
MIRT1419619	hsa-miR-548m	CLIP-seq
MIRT1419620	hsa-miR-550a	CLIP-seq
MIRT1419621	hsa-miR-556-5p	CLIP-seq
MIRT1419622	hsa-miR-558	CLIP-seq
MIRT1419623	hsa-miR-582-3p	CLIP-seq
MIRT1419624	hsa-miR-593	CLIP-seq
MIRT1419625	hsa-miR-607	CLIP-seq
MIRT1419626	hsa-miR-620	CLIP-seq
MIRT1419627	hsa-miR-626	CLIP-seq
MIRT1419628	hsa-miR-647	CLIP-seq
MIRT1419629	hsa-miR-875-5p	CLIP-seq
MIRT1419630	hsa-miR-936	CLIP-seq
MIRT1419575	hsa-miR-1257	CLIP-seq
MIRT2126079	hsa-miR-1283	CLIP-seq
MIRT2126080	hsa-miR-194	CLIP-seq
MIRT1419579	hsa-miR-1972	CLIP-seq
MIRT2126081	hsa-miR-3074-3p	CLIP-seq
MIRT2126082	hsa-miR-3126-3p	CLIP-seq
MIRT1419588	hsa-miR-3144-3p	CLIP-seq
MIRT2126083	hsa-miR-3163	CLIP-seq
MIRT1419595	hsa-miR-3914	CLIP-seq
MIRT1419599	hsa-miR-4427	CLIP-seq
MIRT2126084	hsa-miR-4461	CLIP-seq
MIRT1419603	hsa-miR-4666-3p	CLIP-seq
MIRT2126085	hsa-miR-4678	CLIP-seq
MIRT1419604	hsa-miR-4680-3p	CLIP-seq
MIRT1419607	hsa-miR-4714-5p	CLIP-seq
MIRT2126086	hsa-miR-4793-5p	CLIP-seq
MIRT2126087	hsa-miR-486-5p	CLIP-seq
MIRT2126088	hsa-miR-548ae	CLIP-seq
MIRT2126089	hsa-miR-548aj	CLIP-seq
MIRT2126090	hsa-miR-548am	CLIP-seq
MIRT2126091	hsa-miR-548x	CLIP-seq
MIRT2126092	hsa-miR-568	CLIP-seq
MIRT2126093	hsa-miR-587	CLIP-seq
MIRT2126094	hsa-miR-629	CLIP-seq
MIRT2126095	hsa-miR-640	CLIP-seq
MIRT1419629	hsa-miR-875-5p	CLIP-seq
MIRT1419574	hsa-miR-1244	CLIP-seq
MIRT1419575	hsa-miR-1257	CLIP-seq
MIRT1419577	hsa-miR-1273e	CLIP-seq
MIRT2126079	hsa-miR-1283	CLIP-seq
MIRT2126080	hsa-miR-194	CLIP-seq
MIRT2348060	hsa-miR-1976	CLIP-seq
MIRT1419580	hsa-miR-199b-3p	CLIP-seq
MIRT1419581	hsa-miR-23a	CLIP-seq
MIRT1419582	hsa-miR-23b	CLIP-seq
MIRT1419583	hsa-miR-23c	CLIP-seq
MIRT2126081	hsa-miR-3074-3p	CLIP-seq
MIRT1419586	hsa-miR-3119	CLIP-seq
MIRT2126082	hsa-miR-3126-3p	CLIP-seq
MIRT1419587	hsa-miR-3129-5p	CLIP-seq
MIRT1419588	hsa-miR-3144-3p	CLIP-seq
MIRT1419590	hsa-miR-330-3p	CLIP-seq
MIRT1419591	hsa-miR-34b	CLIP-seq
MIRT1419593	hsa-miR-3662	CLIP-seq
MIRT1419594	hsa-miR-3664-5p	CLIP-seq
MIRT2348061	hsa-miR-3671	CLIP-seq
MIRT2348062	hsa-miR-3672	CLIP-seq
MIRT1419598	hsa-miR-4289	CLIP-seq
MIRT1419599	hsa-miR-4427	CLIP-seq
MIRT1419600	hsa-miR-4438	CLIP-seq
MIRT2126084	hsa-miR-4461	CLIP-seq
MIRT1419603	hsa-miR-4666-3p	CLIP-seq
MIRT2126085	hsa-miR-4678	CLIP-seq
MIRT1419604	hsa-miR-4680-3p	CLIP-seq
MIRT1419606	hsa-miR-4705	CLIP-seq
MIRT1419607	hsa-miR-4714-5p	CLIP-seq
MIRT2348063	hsa-miR-4722-3p	CLIP-seq
MIRT1419610	hsa-miR-4728-3p	CLIP-seq
MIRT2348064	hsa-miR-4775	CLIP-seq
MIRT2126086	hsa-miR-4793-5p	CLIP-seq
MIRT1419611	hsa-miR-4797-3p	CLIP-seq
MIRT2126087	hsa-miR-486-5p	CLIP-seq
MIRT1419612	hsa-miR-491-3p	CLIP-seq
MIRT1419613	hsa-miR-518a-5p	CLIP-seq
MIRT1419614	hsa-miR-520g	CLIP-seq
MIRT1419615	hsa-miR-520h	CLIP-seq
MIRT1419616	hsa-miR-527	CLIP-seq
MIRT2348065	hsa-miR-548ad	CLIP-seq
MIRT2126092	hsa-miR-568	CLIP-seq
MIRT2348066	hsa-miR-570	CLIP-seq
MIRT2126093	hsa-miR-587	CLIP-seq
MIRT2348067	hsa-miR-590-3p	CLIP-seq
MIRT1419624	hsa-miR-593	CLIP-seq
MIRT2348068	hsa-miR-603	CLIP-seq
MIRT1419625	hsa-miR-607	CLIP-seq
MIRT1419627	hsa-miR-626	CLIP-seq
MIRT2126094	hsa-miR-629	CLIP-seq
MIRT1419629	hsa-miR-875-5p	CLIP-seq
MIRT1419630	hsa-miR-936	CLIP-seq
MIRT2126081	hsa-miR-3074-3p	CLIP-seq
MIRT2433805	hsa-miR-4727-5p	CLIP-seq
MIRT2433806	hsa-miR-4763-5p	CLIP-seq
MIRT2348068	hsa-miR-603	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
MYC	Unknown	15988031

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000976	Function	Transcription regulatory region sequence-specific DNA binding	IBA	21873635
GO:0001018	Function	Mitochondrial promoter sequence-specific DNA binding	IDA	19304746
GO:0001223	Function	Transcription coactivator binding	IEA
GO:0003682	Function	Chromatin binding	IDA	18063578
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	12897151, 25416956, 29445193, 29568061, 32296183
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005739	Component	Mitochondrion	IDA
GO:0005759	Component	Mitochondrial matrix	IDA	29445193
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006390	Process	Mitochondrial transcription	IMP	22037171
GO:0006391	Process	Transcription initiation from mitochondrial promoter	IBA	21873635
GO:0006391	Process	Transcription initiation from mitochondrial promoter	IDA	20410300
GO:0006391	Process	Transcription initiation from mitochondrial promoter	TAS
GO:0007005	Process	Mitochondrion organization	TAS
GO:0008301	Function	DNA binding, bending	IBA	21873635
GO:0031072	Function	Heat shock protein binding	IEA
GO:0032991	Component	Protein-containing complex	IDA	29445193
GO:0033108	Process	Mitochondrial respiratory chain complex assembly	IEA
GO:0034246	Function	Mitochondrial transcription factor activity	IMP	22037171
GO:0042645	Component	Mitochondrial nucleoid	IDA	18063578, 24703694
GO:0043565	Function	Sequence-specific DNA binding	IDA	29445193
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	20410300

MIM	HGNC	e!Ensembl
600438	11741	ENSG00000108064

Protein

UniProt ID

Q00059

Protein name

Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2)

Protein function

Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193, PubMed:32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and PO

PDB

3FGH , 3TMM , 3TQ6 , 4NNU , 4NOD , 6ERP , 6ERQ , 6HB4 , 6HC3 , 7LBW , 7LBX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00505	HMG_box	50 → 118	HMG (high mobility group) box	Domain
PF09011	HMG_box_2	152 → 219	HMG-box domain	Domain

Sequence

MAFLRSMWGVLSALGRSGAELCTGCGSRLRSPFSFVYLPRWFSSVLASCPKKPVSSYLRF
SKEQLPIFKAQNPDAKTTELIRRIAQRWRELPDSKKKIYQDAYRAEWQVYKEEISRFKEQ
LTPSQIMSLEKEIMDKHLKRKAMTKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQE
KLKTVKENWKNLSDSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRTIKKQRK
YGAEEC

Sequence length

246

Interactions

View interactions

	KEGG		Reactome
	Apelin signaling pathway Huntington disease		Mitochondrial transcription initiation Transcriptional activation of mitochondrial biogenesis

Show/Hide Causal Diseases (6)

Disease term	Disease name	dbSNP ID	References
Causal
Alzheimer disease	Familial Alzheimer Disease (FAD), Alzheimer Disease, Late Onset, Alzheimer Disease, Early Onset, Alzheimer`s Disease, Alzheimer`s Disease, Focal Onset	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039 View all (65 more)	17192785
Cardiomyopathic mitochondrial dna depletion syndrome	MITOCHONDRIAL DNA DEPLETION SYNDROME 15 (HEPATOCEREBRAL TYPE)	rs121909723, rs121912683, rs267607261, rs267607267, rs398122942, rs398124303, rs863224209, rs757075712, rs869312995, rs886041081, rs886041082, rs886041080, rs770816416, rs375401970, rs140992482, rs1560841701 View all (1 more)	27448789
Cholestasis	Cholestasis	rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039
Liver failure	Liver Failure	rs118203990, rs118203991, rs118203992, rs387907022, rs201861847, rs796065037, rs759315662, rs368196005, rs796052121, rs369437593, rs367683258, rs766314948, rs368085185, rs770446752, rs753039116 View all (10 more)
Neuronal ceroid lipofuscinosis	Ceroid lipofuscinosis, neuronal 1, infantile	rs118203975, rs118203976, rs118203977, rs267607235, rs140948465, rs1740291234, rs386833969, rs104894385, rs104894386, rs121908292, rs267606738, rs1555274312, rs119455953, rs119455954, rs119455955 View all (397 more)	21224254
Parkinson disease	Parkinson Disease, Secondary Vascular, Secondary Parkinson Disease	rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432 View all (84 more)	28595911

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Source
Unknown
Cirrhosis	Cirrhosis	ClinVar
Cardiomyopathic Mitochondrial DNA Depletion Syndrome	mitochondrial DNA depletion syndrome 15 (hepatocerebral type)	GenCC
Gout	Gout	GWAS

Show/Hide Text Mining Associations (77)

Disease Name	Relationship Type	References
Associations from Text Mining
AA amyloidosis	Associate	19496804
Acute Kidney Injury	Associate	33494815
Adenocarcinoma of Lung	Associate	23645454
Alzheimer Disease	Associate	18830724, 31081111
Alzheimer Disease	Inhibit	22077634, 26881032
Arthritis Rheumatoid	Associate	40035723
Birt Hogg Dube Syndrome	Associate	21162720
Bowen's Disease	Stimulate	21514422
Brain Diseases	Associate	37098490
Breast Neoplasms	Associate	23172368, 27746856
Carcinogenesis	Associate	29856906, 30242167, 35163779, 36719981
Carcinoma Endometrioid	Associate	20232213
Carcinoma Hepatocellular	Associate	36601865
Carcinoma Ovarian Epithelial	Associate	25243473, 36229065
Carcinoma Renal Cell	Associate	25243473, 27231905, 35308143
Chromosome Breakage	Associate	36613786
Cognitive Dysfunction	Inhibit	26881032
Colonic Neoplasms	Associate	27732955
Colorectal Neoplasms	Associate	21205083, 27732955, 30157478, 39210159
Colorectal Neoplasms	Stimulate	27878255
Depressive Disorder	Associate	25844556
Diabetes Gestational	Inhibit	25437179
Diabetes Mellitus	Inhibit	28864016
Diabetes Mellitus Type 2	Associate	37679776
Down Syndrome	Associate	12803480, 23291000
Endometrial Neoplasms	Associate	20232213
Endotoxemia	Associate	33273525
Erythrocytosis Familial 2	Associate	35760869
Esophageal Squamous Cell Carcinoma	Associate	23109849, 29447301, 36038893
Glioblastoma	Associate	29747444
Hashimoto Disease	Associate	12428064
Head and Neck Neoplasms	Associate	36833361
Hyperglycemia	Inhibit	28433632
Hyperplasia	Associate	30745857
Hypoxia Ischemia Brain	Associate	34098747
Immunologic Deficiency Syndromes	Associate	26605748, 26893822
Keratoconus	Associate	27783701
Kidney Neoplasms	Associate	21162720
Leigh Disease	Associate	22390282
Lung Neoplasms	Associate	24367550
Lymphatic Metastasis	Stimulate	20232213
Malnutrition	Stimulate	26646563
Mammary Analogue Secretory Carcinoma	Associate	34609437
Melanoma	Associate	30242167, 33670365
Mitochondrial Diseases	Associate	12428064, 12803480, 18332166, 22077634, 23152058, 25844556, 29747444, 31081111, 31930701, 33273525, 33731350, 35091324, 35163779
Mitochondrial Myopathy with a Defect in Mitochondrial Protein Transport	Associate	31689514
Myasthenia Gravis	Associate	33308266
Mycoplasma Infections	Associate	36601865
Neoplasm Metastasis	Associate	36601865
Neoplasms	Associate	18028422, 20739229, 22098591, 23104437, 27231905, 29259235, 29747444, 29856906, 30862036, 33628590, 35760869
Neoplasms Cystic Mucinous and Serous	Associate	36229065
Neoplasms Squamous Cell	Inhibit	24367550
Neuroinflammatory Diseases	Associate	36674978
Obesity	Associate	35748248
Optic Atrophy Hereditary Leber	Associate	22390282
Osteosarcoma	Associate	30816440
Ovarian Neoplasms	Associate	22098591, 36012230
Parkinson Disease	Associate	19374590, 21205083, 22361577, 23939409, 24768991, 31930701, 33539026, 36674978
Parkinson Disease	Inhibit	31689514
Paroxysmal ventricular fibrillation	Associate	38079076
Peritonitis	Inhibit	24204994
Polycystic Ovary Syndrome	Associate	30745857
Pre Eclampsia	Associate	27573305
Prostatic Neoplasms	Associate	36719981
Prostatitis	Associate	36719981
Pulmonary Disease Chronic Obstructive	Associate	17459894, 26893822, 31198067, 34831227
Pulmonary Disease Chronic Obstructive	Inhibit	24367550
Sepsis	Associate	33273525, 33494815
Sexual Dysfunction Physiological	Associate	21205083
Skin Neoplasms	Associate	21514422
Sleep Deprivation	Associate	36613786
Smoke Inhalation Injury	Associate	31198067
Squamous Cell Carcinoma of Head and Neck	Associate	28438434
Stomach Neoplasms	Associate	29259235, 35163779
Visceral myopathy familial external ophthalmoplegia	Associate	30310528, 36311265, 38040710
von Hippel Lindau Disease	Associate	35760869
Weight Gain	Associate	29554135

TFAM (transcription factor A, mitochondrial)