TEF (TEF transcription factor, PAR bZIP family member)

Gene

• Entrez ID: 7008
• Gene name: TEF transcription factor, PAR bZIP family member
• Gene symbol: TEF
• Synonyms (NCBI Gene): -
• Chromosome: 22
• Chromosome location: 22q13.2
• Summary: This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021130	hsa-miR-186-5p	Sequencing	20371350
MIRT046057	hsa-miR-125b-5p	CLASH	23622248
MIRT053156	hsa-miR-125a-5p	qRT-PCR	24675842
MIRT698678	hsa-miR-499a-3p	HITS-CLIP	23313552
MIRT698677	hsa-miR-499b-3p	HITS-CLIP	23313552
MIRT698676	hsa-miR-181a-5p	HITS-CLIP	23313552
MIRT698675	hsa-miR-181b-5p	HITS-CLIP	23313552
MIRT698674	hsa-miR-181c-5p	HITS-CLIP	23313552
MIRT698673	hsa-miR-181d-5p	HITS-CLIP	23313552
MIRT698672	hsa-miR-4262	HITS-CLIP	23313552
MIRT698671	hsa-miR-1224-3p	HITS-CLIP	23313552
MIRT698670	hsa-miR-1470	HITS-CLIP	23313552
MIRT698669	hsa-miR-4667-3p	HITS-CLIP	23313552
MIRT698668	hsa-miR-532-3p	HITS-CLIP	23313552
MIRT698667	hsa-miR-4766-5p	HITS-CLIP	23313552
MIRT698666	hsa-miR-1260a	HITS-CLIP	23313552
MIRT698665	hsa-miR-1260b	HITS-CLIP	23313552
MIRT698664	hsa-miR-642a-5p	HITS-CLIP	23313552
MIRT301709	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT301712	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT301711	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT301710	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT301707	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT301706	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT565424	hsa-miR-137	PAR-CLIP	20371350
MIRT301715	hsa-miR-4282	PAR-CLIP	20371350
MIRT301716	hsa-miR-6508-5p	PAR-CLIP	20371350
MIRT301718	hsa-miR-8067	PAR-CLIP	20371350
MIRT565423	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT565422	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT565421	hsa-miR-518d-5p	PAR-CLIP	20371350
MIRT565420	hsa-miR-518e-5p	PAR-CLIP	20371350
MIRT565419	hsa-miR-518f-5p	PAR-CLIP	20371350
MIRT565418	hsa-miR-519a-5p	PAR-CLIP	20371350
MIRT565417	hsa-miR-519b-5p	PAR-CLIP	20371350
MIRT565416	hsa-miR-519c-5p	PAR-CLIP	20371350
MIRT565415	hsa-miR-520c-5p	PAR-CLIP	20371350
MIRT565414	hsa-miR-522-5p	PAR-CLIP	20371350
MIRT565413	hsa-miR-523-5p	PAR-CLIP	20371350
MIRT565412	hsa-miR-526a	PAR-CLIP	20371350
MIRT565411	hsa-miR-4777-5p	PAR-CLIP	20371350
MIRT301717	hsa-miR-7703	PAR-CLIP	20371350
MIRT301714	hsa-miR-4325	PAR-CLIP	20371350
MIRT565410	hsa-miR-374b-3p	PAR-CLIP	20371350
MIRT698678	hsa-miR-499a-3p	HITS-CLIP	23313552
MIRT698677	hsa-miR-499b-3p	HITS-CLIP	23313552
MIRT698676	hsa-miR-181a-5p	HITS-CLIP	23313552
MIRT698675	hsa-miR-181b-5p	HITS-CLIP	23313552
MIRT698674	hsa-miR-181c-5p	HITS-CLIP	23313552
MIRT698673	hsa-miR-181d-5p	HITS-CLIP	23313552
MIRT698672	hsa-miR-4262	HITS-CLIP	23313552
MIRT698671	hsa-miR-1224-3p	HITS-CLIP	23313552
MIRT698670	hsa-miR-1470	HITS-CLIP	23313552
MIRT698669	hsa-miR-4667-3p	HITS-CLIP	23313552
MIRT698668	hsa-miR-532-3p	HITS-CLIP	23313552
MIRT698667	hsa-miR-4766-5p	HITS-CLIP	23313552
MIRT698666	hsa-miR-1260a	HITS-CLIP	23313552
MIRT698665	hsa-miR-1260b	HITS-CLIP	23313552
MIRT698664	hsa-miR-642a-5p	HITS-CLIP	23313552
MIRT301709	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT301712	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT301711	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT301710	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT301707	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT301706	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT565424	hsa-miR-137	PAR-CLIP	20371350
MIRT301715	hsa-miR-4282	PAR-CLIP	20371350
MIRT301716	hsa-miR-6508-5p	PAR-CLIP	20371350
MIRT301718	hsa-miR-8067	PAR-CLIP	20371350
MIRT565423	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT565422	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT565421	hsa-miR-518d-5p	PAR-CLIP	20371350
MIRT565420	hsa-miR-518e-5p	PAR-CLIP	20371350
MIRT565419	hsa-miR-518f-5p	PAR-CLIP	20371350
MIRT565418	hsa-miR-519a-5p	PAR-CLIP	20371350
MIRT565417	hsa-miR-519b-5p	PAR-CLIP	20371350
MIRT565416	hsa-miR-519c-5p	PAR-CLIP	20371350
MIRT565415	hsa-miR-520c-5p	PAR-CLIP	20371350
MIRT565414	hsa-miR-522-5p	PAR-CLIP	20371350
MIRT565413	hsa-miR-523-5p	PAR-CLIP	20371350
MIRT565412	hsa-miR-526a	PAR-CLIP	20371350
MIRT565411	hsa-miR-4777-5p	PAR-CLIP	20371350
MIRT301717	hsa-miR-7703	PAR-CLIP	20371350
MIRT301714	hsa-miR-4325	PAR-CLIP	20371350
MIRT565410	hsa-miR-374b-3p	PAR-CLIP	20371350
MIRT1417844	hsa-miR-3124-3p	CLIP-seq
MIRT1417845	hsa-miR-3135b	CLIP-seq
MIRT1417846	hsa-miR-338-3p	CLIP-seq
MIRT1417847	hsa-miR-3652	CLIP-seq
MIRT1417848	hsa-miR-3665	CLIP-seq
MIRT1417849	hsa-miR-3691-3p	CLIP-seq
MIRT1417850	hsa-miR-3944-5p	CLIP-seq
MIRT1417851	hsa-miR-4430	CLIP-seq
MIRT1417852	hsa-miR-4455	CLIP-seq
MIRT1417853	hsa-miR-4499	CLIP-seq
MIRT1417854	hsa-miR-4530	CLIP-seq
MIRT1417855	hsa-miR-4690-3p	CLIP-seq
MIRT1417856	hsa-miR-4691-3p	CLIP-seq
MIRT1417857	hsa-miR-609	CLIP-seq
MIRT1417858	hsa-miR-657	CLIP-seq
MIRT1417859	hsa-miR-1226	CLIP-seq
MIRT1417860	hsa-miR-1234	CLIP-seq
MIRT1417861	hsa-miR-1237	CLIP-seq
MIRT1417862	hsa-miR-1252	CLIP-seq
MIRT1417863	hsa-miR-1254	CLIP-seq
MIRT1417864	hsa-miR-125b	CLIP-seq
MIRT1417865	hsa-miR-1262	CLIP-seq
MIRT1417866	hsa-miR-1273g	CLIP-seq
MIRT1417867	hsa-miR-1276	CLIP-seq
MIRT1417868	hsa-miR-1293	CLIP-seq
MIRT1417869	hsa-miR-1321	CLIP-seq
MIRT1417870	hsa-miR-147	CLIP-seq
MIRT1417871	hsa-miR-149	CLIP-seq
MIRT1417872	hsa-miR-185	CLIP-seq
MIRT1417873	hsa-miR-1913	CLIP-seq
MIRT1417874	hsa-miR-2278	CLIP-seq
MIRT1417875	hsa-miR-2467-3p	CLIP-seq
MIRT1417876	hsa-miR-3064-5p	CLIP-seq
MIRT1417877	hsa-miR-3116	CLIP-seq
MIRT1417878	hsa-miR-3125	CLIP-seq
MIRT1417879	hsa-miR-3126-5p	CLIP-seq
MIRT1417880	hsa-miR-3127-3p	CLIP-seq
MIRT1417845	hsa-miR-3135b	CLIP-seq
MIRT1417881	hsa-miR-3145-5p	CLIP-seq
MIRT1417882	hsa-miR-3166	CLIP-seq
MIRT1417883	hsa-miR-3177-5p	CLIP-seq
MIRT1417884	hsa-miR-3183	CLIP-seq
MIRT1417885	hsa-miR-3185	CLIP-seq
MIRT1417886	hsa-miR-324-3p	CLIP-seq
MIRT1417887	hsa-miR-326	CLIP-seq
MIRT1417888	hsa-miR-330-5p	CLIP-seq
MIRT1417889	hsa-miR-338-5p	CLIP-seq
MIRT1417890	hsa-miR-339-3p	CLIP-seq
MIRT1417891	hsa-miR-3616-3p	CLIP-seq
MIRT1417892	hsa-miR-3646	CLIP-seq
MIRT1417893	hsa-miR-3650	CLIP-seq
MIRT1417847	hsa-miR-3652	CLIP-seq
MIRT1417894	hsa-miR-3655	CLIP-seq
MIRT1417895	hsa-miR-3911	CLIP-seq
MIRT1417896	hsa-miR-3916	CLIP-seq
MIRT1417897	hsa-miR-3925-3p	CLIP-seq
MIRT1417898	hsa-miR-3978	CLIP-seq
MIRT1417899	hsa-miR-409-5p	CLIP-seq
MIRT1417900	hsa-miR-4254	CLIP-seq
MIRT1417901	hsa-miR-4257	CLIP-seq
MIRT1417902	hsa-miR-4286	CLIP-seq
MIRT1417903	hsa-miR-4290	CLIP-seq
MIRT1417904	hsa-miR-4306	CLIP-seq
MIRT1417905	hsa-miR-4319	CLIP-seq
MIRT1417906	hsa-miR-4419a	CLIP-seq
MIRT1417851	hsa-miR-4430	CLIP-seq
MIRT1417907	hsa-miR-4483	CLIP-seq
MIRT1417853	hsa-miR-4499	CLIP-seq
MIRT1417908	hsa-miR-4505	CLIP-seq
MIRT1417909	hsa-miR-4510	CLIP-seq
MIRT1417910	hsa-miR-4514	CLIP-seq
MIRT1417911	hsa-miR-4519	CLIP-seq
MIRT1417912	hsa-miR-4527	CLIP-seq
MIRT1417854	hsa-miR-4530	CLIP-seq
MIRT1417913	hsa-miR-4644	CLIP-seq
MIRT1417914	hsa-miR-4646-3p	CLIP-seq
MIRT1417915	hsa-miR-4646-5p	CLIP-seq
MIRT1417916	hsa-miR-4659a-5p	CLIP-seq
MIRT1417917	hsa-miR-4659b-5p	CLIP-seq
MIRT1417918	hsa-miR-4685-5p	CLIP-seq
MIRT1417919	hsa-miR-4690-5p	CLIP-seq
MIRT1417920	hsa-miR-4691-5p	CLIP-seq
MIRT1417921	hsa-miR-4692	CLIP-seq
MIRT1417922	hsa-miR-4701-3p	CLIP-seq
MIRT1417923	hsa-miR-4709-3p	CLIP-seq
MIRT1417924	hsa-miR-4723-3p	CLIP-seq
MIRT1417925	hsa-miR-4725-5p	CLIP-seq
MIRT1417926	hsa-miR-4727-5p	CLIP-seq
MIRT1417927	hsa-miR-4728-5p	CLIP-seq
MIRT1417928	hsa-miR-4732-5p	CLIP-seq
MIRT1417929	hsa-miR-4738-5p	CLIP-seq
MIRT1417930	hsa-miR-4739	CLIP-seq
MIRT1417931	hsa-miR-4747-5p	CLIP-seq
MIRT1417932	hsa-miR-4753-5p	CLIP-seq
MIRT1417933	hsa-miR-4756-5p	CLIP-seq
MIRT1417934	hsa-miR-4768-3p	CLIP-seq
MIRT1417935	hsa-miR-4768-5p	CLIP-seq
MIRT1417936	hsa-miR-4771	CLIP-seq
MIRT1417937	hsa-miR-4776-3p	CLIP-seq
MIRT1417938	hsa-miR-4794	CLIP-seq
MIRT1417939	hsa-miR-504	CLIP-seq
MIRT1417940	hsa-miR-508-5p	CLIP-seq
MIRT1417941	hsa-miR-520a-5p	CLIP-seq
MIRT1417942	hsa-miR-525-5p	CLIP-seq
MIRT1417943	hsa-miR-548aa	CLIP-seq
MIRT1417944	hsa-miR-570	CLIP-seq
MIRT1417945	hsa-miR-596	CLIP-seq
MIRT1417946	hsa-miR-603	CLIP-seq
MIRT1417947	hsa-miR-634	CLIP-seq
MIRT1417948	hsa-miR-642b	CLIP-seq
MIRT1417949	hsa-miR-644	CLIP-seq
MIRT1417950	hsa-miR-660	CLIP-seq
MIRT1417951	hsa-miR-665	CLIP-seq
MIRT1417952	hsa-miR-766	CLIP-seq
MIRT2125409	hsa-miR-1197	CLIP-seq
MIRT2125410	hsa-miR-4279	CLIP-seq
MIRT1417920	hsa-miR-4691-5p	CLIP-seq
MIRT2125411	hsa-miR-4717-3p	CLIP-seq
MIRT2125412	hsa-miR-4733-3p	CLIP-seq
MIRT1417937	hsa-miR-4776-3p	CLIP-seq
MIRT2125413	hsa-miR-640	CLIP-seq
MIRT2125409	hsa-miR-1197	CLIP-seq
MIRT2347738	hsa-miR-1225-3p	CLIP-seq
MIRT1417884	hsa-miR-3183	CLIP-seq
MIRT2347739	hsa-miR-342-5p	CLIP-seq
MIRT2347740	hsa-miR-3663-3p	CLIP-seq
MIRT2347741	hsa-miR-3936	CLIP-seq
MIRT2347742	hsa-miR-4323	CLIP-seq
MIRT2347743	hsa-miR-4466	CLIP-seq
MIRT2347744	hsa-miR-4533	CLIP-seq
MIRT2347745	hsa-miR-4537	CLIP-seq
MIRT2347746	hsa-miR-4664-5p	CLIP-seq
MIRT1417924	hsa-miR-4723-3p	CLIP-seq
MIRT2347747	hsa-miR-4758-3p	CLIP-seq
MIRT1417946	hsa-miR-603	CLIP-seq
MIRT1417948	hsa-miR-642b	CLIP-seq
MIRT2347748	hsa-miR-675	CLIP-seq
MIRT2125409	hsa-miR-1197	CLIP-seq
MIRT2347738	hsa-miR-1225-3p	CLIP-seq
MIRT2347749	hsa-miR-140-3p	CLIP-seq
MIRT1417875	hsa-miR-2467-3p	CLIP-seq
MIRT1417901	hsa-miR-4257	CLIP-seq
MIRT1417854	hsa-miR-4530	CLIP-seq
MIRT1417937	hsa-miR-4776-3p	CLIP-seq
MIRT2640585	hsa-miR-1205	CLIP-seq
MIRT2347738	hsa-miR-1225-3p	CLIP-seq
MIRT1417862	hsa-miR-1252	CLIP-seq
MIRT1417871	hsa-miR-149	CLIP-seq
MIRT1417873	hsa-miR-1913	CLIP-seq
MIRT2640586	hsa-miR-2964a-3p	CLIP-seq
MIRT1417876	hsa-miR-3064-5p	CLIP-seq
MIRT2640587	hsa-miR-3128	CLIP-seq
MIRT2640588	hsa-miR-3140-5p	CLIP-seq
MIRT2640589	hsa-miR-3152-5p	CLIP-seq
MIRT1417884	hsa-miR-3183	CLIP-seq
MIRT1417885	hsa-miR-3185	CLIP-seq
MIRT1417886	hsa-miR-324-3p	CLIP-seq
MIRT1417887	hsa-miR-326	CLIP-seq
MIRT1417888	hsa-miR-330-5p	CLIP-seq
MIRT1417847	hsa-miR-3652	CLIP-seq
MIRT1417897	hsa-miR-3925-3p	CLIP-seq
MIRT1417903	hsa-miR-4290	CLIP-seq
MIRT2347742	hsa-miR-4323	CLIP-seq
MIRT1417851	hsa-miR-4430	CLIP-seq
MIRT1417908	hsa-miR-4505	CLIP-seq
MIRT2640590	hsa-miR-451b	CLIP-seq
MIRT1417912	hsa-miR-4527	CLIP-seq
MIRT1417915	hsa-miR-4646-5p	CLIP-seq
MIRT2640591	hsa-miR-4694-5p	CLIP-seq
MIRT2125411	hsa-miR-4717-3p	CLIP-seq
MIRT2640592	hsa-miR-4720-5p	CLIP-seq
MIRT1417924	hsa-miR-4723-3p	CLIP-seq
MIRT1417926	hsa-miR-4727-5p	CLIP-seq
MIRT1417929	hsa-miR-4738-5p	CLIP-seq
MIRT1417931	hsa-miR-4747-5p	CLIP-seq
MIRT1417932	hsa-miR-4753-5p	CLIP-seq
MIRT2347747	hsa-miR-4758-3p	CLIP-seq
MIRT1417935	hsa-miR-4768-5p	CLIP-seq
MIRT1417938	hsa-miR-4794	CLIP-seq
MIRT2640593	hsa-miR-4799-3p	CLIP-seq
MIRT2640594	hsa-miR-499-3p	CLIP-seq
MIRT1417943	hsa-miR-548aa	CLIP-seq
MIRT1417946	hsa-miR-603	CLIP-seq
MIRT1417948	hsa-miR-642b	CLIP-seq
MIRT1417952	hsa-miR-766	CLIP-seq
MIRT2640585	hsa-miR-1205	CLIP-seq
MIRT1417862	hsa-miR-1252	CLIP-seq
MIRT1417871	hsa-miR-149	CLIP-seq
MIRT1417873	hsa-miR-1913	CLIP-seq
MIRT1417876	hsa-miR-3064-5p	CLIP-seq
MIRT1417884	hsa-miR-3183	CLIP-seq
MIRT1417885	hsa-miR-3185	CLIP-seq
MIRT1417886	hsa-miR-324-3p	CLIP-seq
MIRT1417887	hsa-miR-326	CLIP-seq
MIRT1417888	hsa-miR-330-5p	CLIP-seq
MIRT1417847	hsa-miR-3652	CLIP-seq
MIRT1417903	hsa-miR-4290	CLIP-seq
MIRT2347742	hsa-miR-4323	CLIP-seq
MIRT1417851	hsa-miR-4430	CLIP-seq
MIRT1417908	hsa-miR-4505	CLIP-seq
MIRT1417912	hsa-miR-4527	CLIP-seq
MIRT1417915	hsa-miR-4646-5p	CLIP-seq
MIRT1417924	hsa-miR-4723-3p	CLIP-seq
MIRT1417926	hsa-miR-4727-5p	CLIP-seq
MIRT1417931	hsa-miR-4747-5p	CLIP-seq
MIRT1417932	hsa-miR-4753-5p	CLIP-seq
MIRT1417935	hsa-miR-4768-5p	CLIP-seq
MIRT1417938	hsa-miR-4794	CLIP-seq
MIRT1417946	hsa-miR-603	CLIP-seq
MIRT1417948	hsa-miR-642b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003690	Function	Double-stranded DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32814053, 32911434
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	7835883
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048511	Process	Rhythmic process	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 188595
• HGNC: 11722
• e!Ensembl: ENSG00000167074

Protein

• UniProt ID: Q10587
• Protein name: Thyrotroph embryonic factor
• Protein function: Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.
• PDB: 4U5T
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07716	bZIP_2	232 → 285	Basic region leucine zipper	Coiled-coil

• Sequence:

  MSDAGGGKKPPVDPQAGPGPGPGRAAGERGLSGSFPLVLKKLMENPPREARLDKEKGKEK
  LEEDEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHN
  LLLPVAELEGKESASSSTASPPSSSTAIFQPSETVSSTESSLEKERETPSPIDPNCVEVD
  VNFNPDPADLVLSSVPGGELFNPRKHKFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRR
  KKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKY
  GPL

• Sequence length: 303