CRIPTO3 (cripto, EGF-CFC family member 3)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 6998
Gene name Cripto, EGF-CFC family member 3
Gene symbol CRIPTO3
Synonyms (NCBI Gene)
CR-3CRIPTOCRIPTO-3TDGF1P3TDGF2TDGF3
Chromosome X
Chromosome location Xq23
miRNA miRNA information provided by mirtarbase database.
64
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (64)
miRTarBase ID miRNA Experiments Reference
MIRT531035 hsa-miR-4436b-3p PAR-CLIP 22012620
MIRT531034 hsa-miR-4632-5p PAR-CLIP 22012620
MIRT531033 hsa-miR-6735-5p PAR-CLIP 22012620
MIRT531032 hsa-miR-6879-5p PAR-CLIP 22012620
MIRT531031 hsa-miR-7843-5p PAR-CLIP 22012620
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (16)
GO ID Ontology Definition Evidence Reference
GO:0001568 Process Blood vessel development IBA
GO:0005576 Component Extracellular region IBA
GO:0005886 Component Plasma membrane IDA 18835250
GO:0005886 Component Plasma membrane IEA
GO:0007165 Process Signal transduction IDA 18835250
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P51864
Protein name Protein CRIPTO3 (Cripto, EGF-CFC family member 3) (Cripto-3 growth factor) (Epidermal growth factor-like cripto protein CR3) (Teratocarcinoma-derived growth factor 1 pseudogene 3) (Teratocarcinoma-derived growth factor 3)
Protein function Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Activates the Nodal-dependent signaling pathway.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09443 CFC 115 → 149 Cripto_Frl-1_Cryptic (CFC) Domain
Tissue specificity TISSUE SPECIFICITY: Expressed weakly in lung, colon and breast. Expressed also strongly in primary cancer tissues; lung and colon cancers. {ECO:0000269|PubMed:18835250}.
Sequence 
MDCRKMVRFSYSVIWIMAISKAFELGLVAGLGHQEFARPSRGDLAFRDDSIWPQEEPAIR
PRSSQRVLPMGIQHSKELNRTCCLNGGTCMLESFCACPPSFYGRNCEHDVRKENCGSVPH
DTWLPKKCSLCKCWHGQLRCFPQAFLPGCDGLVMDEHLVASRTPELPPSARTTTFMLAGI
CLSIQSYY
Sequence length 188
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (4)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CORONARY ARTERY DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEMORRHOID — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations