Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6945
Gene name Gene Name - the full gene name approved by the HGNC.	MAX dimerization protein MLX
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MLX
Synonyms (NCBI Gene) Gene synonyms aliases	MAD7, MXD7, TCFL4, TF4, bHLHd13
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q21.2
Summary Summary of gene provided in NCBI Entrez Gene.	The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene prod

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miRTarBase ID	miRNA	Experiments	Reference
MIRT028193	hsa-miR-33a-5p	Sequencing	20371350
MIRT049076	hsa-miR-92a-3p	CLASH	23622248
MIRT046985	hsa-miR-218-5p	CLASH	23622248
MIRT045597	hsa-miR-149-5p	CLASH	23622248
MIRT044847	hsa-miR-320a	CLASH	23622248
MIRT043912	hsa-miR-378a-3p	CLASH	23622248
MIRT041914	hsa-miR-484	CLASH	23622248
MIRT036245	hsa-miR-320b	CLASH	23622248
MIRT738750	hsa-miR-3132	PAR-CLIP	26701625
MIRT738750	hsa-miR-3132	PAR-CLIP	26701625
MIRT1152522	hsa-miR-1273e	CLIP-seq
MIRT1152523	hsa-miR-339-5p	CLIP-seq
MIRT1152524	hsa-miR-3614-5p	CLIP-seq
MIRT1152525	hsa-miR-4287	CLIP-seq
MIRT1152526	hsa-miR-4421	CLIP-seq
MIRT1152527	hsa-miR-4469	CLIP-seq
MIRT1152528	hsa-miR-4685-3p	CLIP-seq
MIRT1152529	hsa-miR-1238	CLIP-seq
MIRT1152522	hsa-miR-1273e	CLIP-seq
MIRT1152530	hsa-miR-2467-5p	CLIP-seq
MIRT1152531	hsa-miR-3188	CLIP-seq
MIRT1152532	hsa-miR-3200-5p	CLIP-seq
MIRT1152533	hsa-miR-3668	CLIP-seq
MIRT1152534	hsa-miR-3935	CLIP-seq
MIRT1152535	hsa-miR-3975	CLIP-seq
MIRT738749	hsa-miR-4451	CLIP-seq
MIRT1152536	hsa-miR-4649-3p	CLIP-seq
MIRT1152537	hsa-miR-4722-3p	CLIP-seq
MIRT1152538	hsa-miR-4762-5p	CLIP-seq
MIRT1152539	hsa-miR-4775	CLIP-seq
MIRT1152540	hsa-miR-4782-5p	CLIP-seq
MIRT1152541	hsa-miR-485-5p	CLIP-seq
MIRT1152542	hsa-miR-548c-3p	CLIP-seq
MIRT1152543	hsa-miR-1304	CLIP-seq
MIRT1152544	hsa-miR-24	CLIP-seq
MIRT1152530	hsa-miR-2467-5p	CLIP-seq
MIRT1152545	hsa-miR-3184	CLIP-seq
MIRT1152531	hsa-miR-3188	CLIP-seq
MIRT1152546	hsa-miR-3613-5p	CLIP-seq
MIRT1152547	hsa-miR-3675-5p	CLIP-seq
MIRT1152548	hsa-miR-3677-5p	CLIP-seq
MIRT1152549	hsa-miR-3914	CLIP-seq
MIRT1152550	hsa-miR-3928	CLIP-seq
MIRT1152535	hsa-miR-3975	CLIP-seq
MIRT1152551	hsa-miR-423-5p	CLIP-seq
MIRT1152552	hsa-miR-4276	CLIP-seq
MIRT738749	hsa-miR-4451	CLIP-seq
MIRT1152553	hsa-miR-4530	CLIP-seq
MIRT1152554	hsa-miR-4532	CLIP-seq
MIRT1152555	hsa-miR-4701-5p	CLIP-seq
MIRT1152556	hsa-miR-4710	CLIP-seq
MIRT1152541	hsa-miR-485-5p	CLIP-seq
MIRT1152557	hsa-miR-588	CLIP-seq
MIRT1152558	hsa-miR-889	CLIP-seq
MIRT1152559	hsa-miR-935	CLIP-seq
MIRT1152529	hsa-miR-1238	CLIP-seq
MIRT738749	hsa-miR-4451	CLIP-seq
MIRT1152539	hsa-miR-4775	CLIP-seq
MIRT1152540	hsa-miR-4782-5p	CLIP-seq
MIRT738749	hsa-miR-4451	CLIP-seq
MIRT1152529	hsa-miR-1238	CLIP-seq
MIRT2043535	hsa-miR-1343	CLIP-seq
MIRT2043536	hsa-miR-3177-5p	CLIP-seq
MIRT2043537	hsa-miR-3192	CLIP-seq
MIRT1152533	hsa-miR-3668	CLIP-seq
MIRT2043538	hsa-miR-3691-3p	CLIP-seq
MIRT2043539	hsa-miR-370	CLIP-seq
MIRT2043540	hsa-miR-378g	CLIP-seq
MIRT2043541	hsa-miR-4436a	CLIP-seq
MIRT2043542	hsa-miR-4731-5p	CLIP-seq
MIRT1152539	hsa-miR-4775	CLIP-seq
MIRT1152540	hsa-miR-4782-5p	CLIP-seq
MIRT2043543	hsa-miR-492	CLIP-seq
MIRT2043544	hsa-miR-5096	CLIP-seq
MIRT2043545	hsa-miR-539	CLIP-seq
MIRT2043546	hsa-miR-581	CLIP-seq
MIRT2043539	hsa-miR-370	CLIP-seq
MIRT738749	hsa-miR-4451	CLIP-seq
MIRT1152553	hsa-miR-4530	CLIP-seq
MIRT738749	hsa-miR-4451	CLIP-seq
MIRT2454209	hsa-miR-1255a	CLIP-seq
MIRT2454210	hsa-miR-1255b	CLIP-seq
MIRT1152522	hsa-miR-1273e	CLIP-seq
MIRT1152543	hsa-miR-1304	CLIP-seq
MIRT1152544	hsa-miR-24	CLIP-seq
MIRT1152530	hsa-miR-2467-5p	CLIP-seq
MIRT1152531	hsa-miR-3188	CLIP-seq
MIRT2454211	hsa-miR-3605-5p	CLIP-seq
MIRT1152535	hsa-miR-3975	CLIP-seq
MIRT2454212	hsa-miR-4274	CLIP-seq
MIRT2454213	hsa-miR-4433	CLIP-seq
MIRT738749	hsa-miR-4451	CLIP-seq
MIRT2454214	hsa-miR-4459	CLIP-seq
MIRT2454215	hsa-miR-4503	CLIP-seq
MIRT2454216	hsa-miR-4768-3p	CLIP-seq
MIRT1152541	hsa-miR-485-5p	CLIP-seq
MIRT2043544	hsa-miR-5096	CLIP-seq
MIRT1152529	hsa-miR-1238	CLIP-seq
MIRT2454209	hsa-miR-1255a	CLIP-seq
MIRT2454210	hsa-miR-1255b	CLIP-seq
MIRT1152522	hsa-miR-1273e	CLIP-seq
MIRT2571694	hsa-miR-1277	CLIP-seq
MIRT1152543	hsa-miR-1304	CLIP-seq
MIRT2571695	hsa-miR-1323	CLIP-seq
MIRT2571696	hsa-miR-138	CLIP-seq
MIRT2571697	hsa-miR-142-3p	CLIP-seq
MIRT2571698	hsa-miR-150	CLIP-seq
MIRT2571699	hsa-miR-18a	CLIP-seq
MIRT2571700	hsa-miR-18b	CLIP-seq
MIRT2571701	hsa-miR-205	CLIP-seq
MIRT2571702	hsa-miR-217	CLIP-seq
MIRT1152544	hsa-miR-24	CLIP-seq
MIRT1152530	hsa-miR-2467-5p	CLIP-seq
MIRT1152531	hsa-miR-3188	CLIP-seq
MIRT2571703	hsa-miR-323b-3p	CLIP-seq
MIRT2571704	hsa-miR-33a	CLIP-seq
MIRT2571705	hsa-miR-33b	CLIP-seq
MIRT2454211	hsa-miR-3605-5p	CLIP-seq
MIRT2571706	hsa-miR-3616-3p	CLIP-seq
MIRT2571707	hsa-miR-3620	CLIP-seq
MIRT2571708	hsa-miR-3622a-5p	CLIP-seq
MIRT2571709	hsa-miR-365	CLIP-seq
MIRT2571710	hsa-miR-3652	CLIP-seq
MIRT1152533	hsa-miR-3668	CLIP-seq
MIRT1152548	hsa-miR-3677-5p	CLIP-seq
MIRT2571711	hsa-miR-3926	CLIP-seq
MIRT1152535	hsa-miR-3975	CLIP-seq
MIRT2571712	hsa-miR-409-3p	CLIP-seq
MIRT1152552	hsa-miR-4276	CLIP-seq
MIRT2571713	hsa-miR-4282	CLIP-seq
MIRT2571714	hsa-miR-4423-3p	CLIP-seq
MIRT2571715	hsa-miR-4423-5p	CLIP-seq
MIRT2571716	hsa-miR-4430	CLIP-seq
MIRT2571717	hsa-miR-4446-3p	CLIP-seq
MIRT738749	hsa-miR-4451	CLIP-seq
MIRT2571718	hsa-miR-4456	CLIP-seq
MIRT2571719	hsa-miR-4457	CLIP-seq
MIRT2571720	hsa-miR-4473	CLIP-seq
MIRT2571721	hsa-miR-4492	CLIP-seq
MIRT2571722	hsa-miR-4498	CLIP-seq
MIRT2571723	hsa-miR-451	CLIP-seq
MIRT2571724	hsa-miR-4514	CLIP-seq
MIRT1152553	hsa-miR-4530	CLIP-seq
MIRT2571725	hsa-miR-4640-5p	CLIP-seq
MIRT2571726	hsa-miR-4645-5p	CLIP-seq
MIRT2571727	hsa-miR-4648	CLIP-seq
MIRT2571728	hsa-miR-4654	CLIP-seq
MIRT2571729	hsa-miR-4673	CLIP-seq
MIRT2571730	hsa-miR-4687-3p	CLIP-seq
MIRT2571731	hsa-miR-4692	CLIP-seq
MIRT2571732	hsa-miR-4698	CLIP-seq
MIRT1152555	hsa-miR-4701-5p	CLIP-seq
MIRT2571733	hsa-miR-4713-5p	CLIP-seq
MIRT2571734	hsa-miR-4721	CLIP-seq
MIRT2571735	hsa-miR-4726-5p	CLIP-seq
MIRT2043542	hsa-miR-4731-5p	CLIP-seq
MIRT2571736	hsa-miR-4735-3p	CLIP-seq
MIRT2571737	hsa-miR-4761-5p	CLIP-seq
MIRT2571738	hsa-miR-4769-5p	CLIP-seq
MIRT1152541	hsa-miR-485-5p	CLIP-seq
MIRT2043544	hsa-miR-5096	CLIP-seq
MIRT2571739	hsa-miR-512-3p	CLIP-seq
MIRT2571740	hsa-miR-513a-3p	CLIP-seq
MIRT2571741	hsa-miR-520f	CLIP-seq
MIRT2571742	hsa-miR-532-3p	CLIP-seq
MIRT2571743	hsa-miR-548a-3p	CLIP-seq
MIRT2571744	hsa-miR-548e	CLIP-seq
MIRT2571745	hsa-miR-548f	CLIP-seq
MIRT2571746	hsa-miR-548o	CLIP-seq
MIRT2571747	hsa-miR-548p	CLIP-seq
MIRT2571748	hsa-miR-550b	CLIP-seq
MIRT1152557	hsa-miR-588	CLIP-seq
MIRT2571749	hsa-miR-607	CLIP-seq
MIRT2571750	hsa-miR-624	CLIP-seq
MIRT2571751	hsa-miR-635	CLIP-seq
MIRT2571752	hsa-miR-637	CLIP-seq
MIRT2571753	hsa-miR-645	CLIP-seq
MIRT2571754	hsa-miR-762	CLIP-seq
MIRT1152558	hsa-miR-889	CLIP-seq
MIRT1152559	hsa-miR-935	CLIP-seq
MIRT2571755	hsa-miR-938	CLIP-seq
MIRT1152529	hsa-miR-1238	CLIP-seq
MIRT1152522	hsa-miR-1273e	CLIP-seq
MIRT2571694	hsa-miR-1277	CLIP-seq
MIRT1152543	hsa-miR-1304	CLIP-seq
MIRT2571695	hsa-miR-1323	CLIP-seq
MIRT2571697	hsa-miR-142-3p	CLIP-seq
MIRT2571698	hsa-miR-150	CLIP-seq
MIRT2571699	hsa-miR-18a	CLIP-seq
MIRT2571700	hsa-miR-18b	CLIP-seq
MIRT2571701	hsa-miR-205	CLIP-seq
MIRT2571702	hsa-miR-217	CLIP-seq
MIRT1152544	hsa-miR-24	CLIP-seq
MIRT1152530	hsa-miR-2467-5p	CLIP-seq
MIRT1152531	hsa-miR-3188	CLIP-seq
MIRT2571703	hsa-miR-323b-3p	CLIP-seq
MIRT2571704	hsa-miR-33a	CLIP-seq
MIRT2571705	hsa-miR-33b	CLIP-seq
MIRT2571707	hsa-miR-3620	CLIP-seq
MIRT2571708	hsa-miR-3622a-5p	CLIP-seq
MIRT2571709	hsa-miR-365	CLIP-seq
MIRT1152533	hsa-miR-3668	CLIP-seq
MIRT1152548	hsa-miR-3677-5p	CLIP-seq
MIRT2571711	hsa-miR-3926	CLIP-seq
MIRT1152535	hsa-miR-3975	CLIP-seq
MIRT2571712	hsa-miR-409-3p	CLIP-seq
MIRT1152552	hsa-miR-4276	CLIP-seq
MIRT2571713	hsa-miR-4282	CLIP-seq
MIRT2571714	hsa-miR-4423-3p	CLIP-seq
MIRT2571715	hsa-miR-4423-5p	CLIP-seq
MIRT2571719	hsa-miR-4457	CLIP-seq
MIRT2571720	hsa-miR-4473	CLIP-seq
MIRT2571723	hsa-miR-451	CLIP-seq
MIRT2571724	hsa-miR-4514	CLIP-seq
MIRT1152553	hsa-miR-4530	CLIP-seq
MIRT2571725	hsa-miR-4640-5p	CLIP-seq
MIRT2571726	hsa-miR-4645-5p	CLIP-seq
MIRT2571727	hsa-miR-4648	CLIP-seq
MIRT2571728	hsa-miR-4654	CLIP-seq
MIRT2571729	hsa-miR-4673	CLIP-seq
MIRT2571730	hsa-miR-4687-3p	CLIP-seq
MIRT2571731	hsa-miR-4692	CLIP-seq
MIRT2571732	hsa-miR-4698	CLIP-seq
MIRT1152555	hsa-miR-4701-5p	CLIP-seq
MIRT2571733	hsa-miR-4713-5p	CLIP-seq
MIRT2571735	hsa-miR-4726-5p	CLIP-seq
MIRT2571736	hsa-miR-4735-3p	CLIP-seq
MIRT2571737	hsa-miR-4761-5p	CLIP-seq
MIRT2571738	hsa-miR-4769-5p	CLIP-seq
MIRT1152541	hsa-miR-485-5p	CLIP-seq
MIRT2043544	hsa-miR-5096	CLIP-seq
MIRT2571739	hsa-miR-512-3p	CLIP-seq
MIRT2571740	hsa-miR-513a-3p	CLIP-seq
MIRT2571741	hsa-miR-520f	CLIP-seq
MIRT2571742	hsa-miR-532-3p	CLIP-seq
MIRT2571743	hsa-miR-548a-3p	CLIP-seq
MIRT2571744	hsa-miR-548e	CLIP-seq
MIRT2571745	hsa-miR-548f	CLIP-seq
MIRT2571746	hsa-miR-548o	CLIP-seq
MIRT2571747	hsa-miR-548p	CLIP-seq
MIRT2571748	hsa-miR-550b	CLIP-seq
MIRT1152557	hsa-miR-588	CLIP-seq
MIRT2571749	hsa-miR-607	CLIP-seq
MIRT2571750	hsa-miR-624	CLIP-seq
MIRT2571751	hsa-miR-635	CLIP-seq
MIRT2571753	hsa-miR-645	CLIP-seq
MIRT1152558	hsa-miR-889	CLIP-seq
MIRT1152559	hsa-miR-935	CLIP-seq
MIRT2571755	hsa-miR-938	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	10918583
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	10918583
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	10918583
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP	10918583
GO:0003677	Function	DNA binding	IDA	11230181
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	NAS	10918583
GO:0005515	Function	Protein binding	IPI	16189514, 22458338, 25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	10918583
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	10918583
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	10593926, 10918583
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0031965	Component	Nuclear membrane	IDA
GO:0042803	Function	Protein homodimerization activity	IPI	11230181
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	11230181
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	11073985
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046982	Function	Protein heterodimerization activity	IPI	11230181
GO:0046983	Function	Protein dimerization activity	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	11230181
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
602976	11645	ENSG00000108788

Protein

UniProt ID

Q9UH92

Protein name

Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4)

Protein function

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repre

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00010	HLH	130 → 188	Helix-loop-helix DNA-binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in all tissues tested, including spleen, thymus, prostate, ovary, intestine, colon, peripheral blood leukocyte, heart, liver, skeletal muscle and kidney. Lower levels of expression in testis, brain, placenta and lung. {ECO:00

Sequence

MTEPGASPEDPWVKASPVGAHAGEGRAGRARARRGAGRRGASLLSPKSPTLSVPRGCRED
SSHPACAKVEYAYSDNSLDPGLFVESTRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQE
AYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKT
IDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFN
VFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY

Sequence length

298

Interactions

View interactions

	KEGG		Reactome
	Insulin resistance Non-alcoholic fatty liver disease		ChREBP activates metabolic gene expression

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes mellitus or coronary artery disease (pleiotropy), Type 2 diabetes (time to event), Type 2 diabetes	N/A	N/A	GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	33083483
Aortic Dissection	Associate	33083483
Aortic Valve Insufficiency	Associate	30354298
Autoimmune Diseases	Associate	23830516
Bone Diseases Metabolic	Associate	21092186
Coronary Disease	Associate	23840567
Diabetes Mellitus Type 2	Associate	30956117
Hypoxia	Inhibit	21192937
Inflammatory Bowel Diseases	Associate	23830516
Takayasu Arteritis	Associate	23830516, 26996483, 27769046, 30354298

MLX (MAX dimerization protein MLX)