Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6944
Gene name Gene Name - the full gene name approved by the HGNC.
Vacuolar protein sorting 72 homolog
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
VPS72
Synonyms (NCBI Gene) Gene synonyms aliases
CFL1, Swc2, TCFL1, YL-1, YL1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT039650 hsa-miR-615-3p CLASH 23622248
MIRT479323 hsa-miR-4438 PAR-CLIP 23592263
MIRT479321 hsa-miR-4751 PAR-CLIP 23592263
MIRT479322 hsa-miR-6716-5p PAR-CLIP 23592263
MIRT479320 hsa-miR-4271 PAR-CLIP 23592263
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II TAS 7702631
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 15647280, 16189514, 16230350, 25416956, 28514442, 32296183
GO:0005634 Component Nucleus IBA 21873635
GO:0005654 Component Nucleoplasm TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600607 11644 ENSG00000163159
Protein
UniProt ID Q15906
Protein name Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1)
Protein function Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/
PDB 5FUG , 8QR1 , 8X15 , 8X19 , 8X1C , 8XVG , 8XVT , 9C57 , 9C62
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05764 YL1 7 216 YL1 nuclear protein Family
PF08265 YL1_C 291 319 YL1 nuclear protein C-terminal domain Domain
Sequence
Sequence length 364
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  ATP-dependent chromatin remodeling  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Associations from Text Mining
Disease Name Relationship Type References
Amyotrophic Lateral Sclerosis Associate 33892821
Carcinoma Hepatocellular Associate 35383533, 37249275
Neoplasms Associate 9507883
Personality Disorders Associate 9507883
Prostatic Neoplasms Associate 9507883