Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	6944
Gene name	Vacuolar protein sorting 72 homolog
Gene symbol	VPS72
Synonyms (NCBI Gene)	CFL1Swc2TCFL1YL-1YL1
Chromosome	1
Chromosome location	1q21.3
Summary	The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones

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miRTarBase ID	miRNA	Experiments	Reference
MIRT039650	hsa-miR-615-3p	CLASH	23622248
MIRT479323	hsa-miR-4438	PAR-CLIP	23592263
MIRT479321	hsa-miR-4751	PAR-CLIP	23592263
MIRT479322	hsa-miR-6716-5p	PAR-CLIP	23592263
MIRT479320	hsa-miR-4271	PAR-CLIP	23592263
MIRT479319	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT479318	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT479317	hsa-miR-4450	PAR-CLIP	23592263
MIRT479316	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT479315	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT479314	hsa-miR-5095	PAR-CLIP	23592263
MIRT479313	hsa-miR-7151-3p	PAR-CLIP	23592263
MIRT479312	hsa-miR-2110	PAR-CLIP	23592263
MIRT479311	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT479310	hsa-miR-2053	PAR-CLIP	23592263
MIRT479323	hsa-miR-4438	PAR-CLIP	23592263
MIRT479321	hsa-miR-4751	PAR-CLIP	23592263
MIRT479322	hsa-miR-6716-5p	PAR-CLIP	23592263
MIRT479320	hsa-miR-4271	PAR-CLIP	23592263
MIRT479319	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT479318	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT479317	hsa-miR-4450	PAR-CLIP	23592263
MIRT479316	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT479315	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT479314	hsa-miR-5095	PAR-CLIP	23592263
MIRT479313	hsa-miR-7151-3p	PAR-CLIP	23592263
MIRT479312	hsa-miR-2110	PAR-CLIP	23592263
MIRT479311	hsa-miR-6857-5p	PAR-CLIP	23592263
MIRT479310	hsa-miR-2053	PAR-CLIP	23592263
MIRT1487383	hsa-miR-1224-5p	CLIP-seq
MIRT1487384	hsa-miR-1225-3p	CLIP-seq
MIRT1487385	hsa-miR-1253	CLIP-seq
MIRT1487386	hsa-miR-143	CLIP-seq
MIRT1487387	hsa-miR-191	CLIP-seq
MIRT1487388	hsa-miR-3120-3p	CLIP-seq
MIRT1487389	hsa-miR-3127-5p	CLIP-seq
MIRT1487390	hsa-miR-3148	CLIP-seq
MIRT1487391	hsa-miR-3175	CLIP-seq
MIRT1487392	hsa-miR-335	CLIP-seq
MIRT1487393	hsa-miR-383	CLIP-seq
MIRT1487394	hsa-miR-3918	CLIP-seq
MIRT1487395	hsa-miR-3919	CLIP-seq
MIRT1487396	hsa-miR-4270	CLIP-seq
MIRT1487397	hsa-miR-4303	CLIP-seq
MIRT1487398	hsa-miR-4305	CLIP-seq
MIRT1487399	hsa-miR-4323	CLIP-seq
MIRT1487400	hsa-miR-4423-3p	CLIP-seq
MIRT1487401	hsa-miR-4434	CLIP-seq
MIRT1487402	hsa-miR-4436b-3p	CLIP-seq
MIRT1487403	hsa-miR-4441	CLIP-seq
MIRT1487404	hsa-miR-4511	CLIP-seq
MIRT1487405	hsa-miR-4516	CLIP-seq
MIRT1487406	hsa-miR-451b	CLIP-seq
MIRT1487407	hsa-miR-4649-3p	CLIP-seq
MIRT1487408	hsa-miR-4668-5p	CLIP-seq
MIRT1487409	hsa-miR-4756-3p	CLIP-seq
MIRT1487410	hsa-miR-4759	CLIP-seq
MIRT1487411	hsa-miR-4762-3p	CLIP-seq
MIRT1487412	hsa-miR-4770	CLIP-seq
MIRT1487413	hsa-miR-548b-3p	CLIP-seq
MIRT1487414	hsa-miR-649	CLIP-seq
MIRT1487389	hsa-miR-3127-5p	CLIP-seq
MIRT1487394	hsa-miR-3918	CLIP-seq
MIRT1487402	hsa-miR-4436b-3p	CLIP-seq
MIRT1487386	hsa-miR-143	CLIP-seq
MIRT1487391	hsa-miR-3175	CLIP-seq
MIRT1487393	hsa-miR-383	CLIP-seq
MIRT1487395	hsa-miR-3919	CLIP-seq
MIRT1487409	hsa-miR-4756-3p	CLIP-seq
MIRT1487412	hsa-miR-4770	CLIP-seq
MIRT1487384	hsa-miR-1225-3p	CLIP-seq
MIRT1487385	hsa-miR-1253	CLIP-seq
MIRT1487387	hsa-miR-191	CLIP-seq
MIRT1487388	hsa-miR-3120-3p	CLIP-seq
MIRT1487391	hsa-miR-3175	CLIP-seq
MIRT1487392	hsa-miR-335	CLIP-seq
MIRT1487396	hsa-miR-4270	CLIP-seq
MIRT1487399	hsa-miR-4323	CLIP-seq
MIRT1487401	hsa-miR-4434	CLIP-seq
MIRT1487403	hsa-miR-4441	CLIP-seq
MIRT1487405	hsa-miR-4516	CLIP-seq
MIRT1487406	hsa-miR-451b	CLIP-seq
MIRT1487384	hsa-miR-1225-3p	CLIP-seq
MIRT1487385	hsa-miR-1253	CLIP-seq
MIRT1487387	hsa-miR-191	CLIP-seq
MIRT1487388	hsa-miR-3120-3p	CLIP-seq
MIRT1487391	hsa-miR-3175	CLIP-seq
MIRT1487392	hsa-miR-335	CLIP-seq
MIRT1487396	hsa-miR-4270	CLIP-seq
MIRT1487399	hsa-miR-4323	CLIP-seq
MIRT1487401	hsa-miR-4434	CLIP-seq
MIRT1487403	hsa-miR-4441	CLIP-seq
MIRT1487405	hsa-miR-4516	CLIP-seq
MIRT1487406	hsa-miR-451b	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	TAS	7702631
GO:0000786	Component	Nucleosome	IDA	27153538
GO:0000786	Component	Nucleosome	NAS	16634648
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	15647280, 16189514, 16230350, 25416956, 28514442, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	7702631
GO:0005654	Component	Nucleoplasm	TAS
GO:0006325	Process	Chromatin organization	IEA
GO:0006338	Process	Chromatin remodeling	NAS	16634648
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	16634648
GO:0016607	Component	Nuclear speck	IDA
GO:0032991	Component	Protein-containing complex	IDA	14966270
GO:0035019	Process	Somatic stem cell population maintenance	IEA
GO:0035267	Component	NuA4 histone acetyltransferase complex	IDA	27153538
GO:0042393	Function	Histone binding	IEA
GO:0042393	Function	Histone binding	IPI	26974126
GO:0042981	Process	Regulation of apoptotic process	NAS	14966270
GO:0045815	Process	Transcription initiation-coupled chromatin remodeling	IMP	26974126
GO:0045893	Process	Positive regulation of DNA-templated transcription	NAS	27153538
GO:0051726	Process	Regulation of cell cycle	IMP	27153538
GO:0140713	Function	Histone chaperone activity	IMP	26974126
GO:1905168	Process	Positive regulation of double-strand break repair via homologous recombination	IDA	27153538
GO:2000779	Process	Regulation of double-strand break repair	NAS	14966270

MIM	HGNC	e!Ensembl
600607	11644	ENSG00000163159

Q15906

Protein name

Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1)

Protein function

Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/

PDB

5FUG , 8QR1 , 8X15 , 8X19 , 8X1C , 8XVG , 8XVT , 9C57 , 9C62

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05764	YL1	7 → 216	YL1 nuclear protein	Family
PF08265	YL1_C	291 → 319	YL1 nuclear protein C-terminal domain	Domain

Sequence

MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSD
FDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRKVNTPAGSSQKAREEKALLPL
ELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITE
ELNLRSLETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPA
PSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPAL
YRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQK
IVIK

Sequence length

364

Interactions

View interactions

	KEGG
	ATP-dependent chromatin remodeling

VPS72 (vacuolar protein sorting 72 homolog)