Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6940
Gene name	Zinc finger protein 354A
Gene symbol	ZNF354A
Synonyms (NCBI Gene)	EZNFHEL104HKL1KID-1KID1TCF17
Chromosome	5
Chromosome location	5q35.3

Show/Hide all (41)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048131	hsa-miR-197-3p	CLASH	23622248
MIRT041633	hsa-miR-484	CLASH	23622248
MIRT1523072	hsa-miR-3137	CLIP-seq
MIRT1523073	hsa-miR-3616-3p	CLIP-seq
MIRT1523074	hsa-miR-3682-3p	CLIP-seq
MIRT1523075	hsa-miR-3913-3p	CLIP-seq
MIRT1523076	hsa-miR-4502	CLIP-seq
MIRT1523077	hsa-miR-4721	CLIP-seq
MIRT1523078	hsa-miR-4762-3p	CLIP-seq
MIRT1523079	hsa-miR-489	CLIP-seq
MIRT2377596	hsa-miR-1273d	CLIP-seq
MIRT2377597	hsa-miR-133a	CLIP-seq
MIRT2377598	hsa-miR-133b	CLIP-seq
MIRT1523074	hsa-miR-3682-3p	CLIP-seq
MIRT1523075	hsa-miR-3913-3p	CLIP-seq
MIRT2377599	hsa-miR-4499	CLIP-seq
MIRT1523076	hsa-miR-4502	CLIP-seq
MIRT2377600	hsa-miR-4684-5p	CLIP-seq
MIRT2377601	hsa-miR-4719	CLIP-seq
MIRT1523078	hsa-miR-4762-3p	CLIP-seq
MIRT2377602	hsa-miR-4768-5p	CLIP-seq
MIRT1523079	hsa-miR-489	CLIP-seq
MIRT2377603	hsa-miR-513b	CLIP-seq
MIRT2377604	hsa-miR-548m	CLIP-seq
MIRT2377605	hsa-miR-660	CLIP-seq
MIRT2377596	hsa-miR-1273d	CLIP-seq
MIRT1523072	hsa-miR-3137	CLIP-seq
MIRT2669972	hsa-miR-3148	CLIP-seq
MIRT1523075	hsa-miR-3913-3p	CLIP-seq
MIRT2669973	hsa-miR-4496	CLIP-seq
MIRT2669974	hsa-miR-4668-5p	CLIP-seq
MIRT2377601	hsa-miR-4719	CLIP-seq
MIRT1523079	hsa-miR-489	CLIP-seq
MIRT2377603	hsa-miR-513b	CLIP-seq
MIRT2377605	hsa-miR-660	CLIP-seq
MIRT1523072	hsa-miR-3137	CLIP-seq
MIRT2669972	hsa-miR-3148	CLIP-seq
MIRT1523075	hsa-miR-3913-3p	CLIP-seq
MIRT2669973	hsa-miR-4496	CLIP-seq
MIRT2669974	hsa-miR-4668-5p	CLIP-seq
MIRT1523079	hsa-miR-489	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	23665872
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	9919311
GO:0007605	Process	Sensory perception of sound	TAS	9919311
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
602444	11628	ENSG00000169131

O60765

Protein name

Zinc finger protein 354A (Transcription factor 17) (TCF-17) (Zinc finger protein eZNF)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	13 → 54	KRAB box	Family
PF00096	zf-C2H2	214 → 236	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	242 → 264	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	270 → 292	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	298 → 320	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	354 → 376	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	382 → 404	Zinc finger, C2H2 type	Domain
PF16622	zf-C2H2_11	407 → 432	zinc-finger C2H2-type	Domain
PF00096	zf-C2H2	438 → 460	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	466 → 488	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	494 → 516	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	522 → 544	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	550 → 572	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	578 → 600	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in kidney and inner ear.

Sequence

MAAGQREARPQVSLTFEDVAVLFTRDEWRKLAPSQRNLYRDVMLENYRNLVSLGLPFTKP
KVISLLQQGEDPWEVEKDGSGVSSLGSKSSHKTTKSTQTQDSSFQGLILKRSNRNVPWDL
KLEKPYIYEGRLEKKQDKKGSFQIVSATHKKIPTIERSHKNTELSQNFSPKSVLIRQQIL
PREKTPPKCEIQGNSLKQNSQLLNQPKITADKRYKCSLCEKTFINTSSLRKHEKNHSGEK
LFKCKECSKAFSQSSALIQHQITHTGEKPYICKECGKAFTLSTSLYKHLRTHTVEKSYRC
KECGKSFSRRSGLFIHQKIHAEENPCKYNPGRKASSCSTSLSGCQRIHSRKKSYLCNECG
NTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRCNECGKGFT
SISRLNRHRIIHTGEKFYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSA
LIQHQRMHTGERPYKCNECGKTFRCNSSLSNHQRIHTGEKPYRCEECGISFGQSSALIQH
RRIHTGEKPFKCNTCGKTFRQSSSRIAHQRIHTGEKPYECNTCGKLFNHRSSLTNHYKIH
IEEDP

Sequence length

605

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	35971775	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF354A (zinc finger protein 354A)