Gene Gene information from NCBI Gene database.
Entrez ID 694
Gene name BTG anti-proliferation factor 1
Gene symbol BTG1
Synonyms (NCBI Gene)
APRO2
Chromosome 12
Chromosome location 12q21.33
Summary This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein int
miRNA miRNA information provided by mirtarbase database.
543
miRTarBase ID miRNA Experiments Reference
MIRT028939 hsa-miR-26b-5p Microarray 19088304
MIRT041705 hsa-miR-484 CLASH 23622248
MIRT041705 hsa-miR-484 CLASH 23622248
MIRT053302 hsa-miR-372-3p Luciferase reporter assayqRT-PCRWestern blot 22020335
MIRT053303 hsa-miR-373-3p Luciferase reporter assayqRT-PCRWestern blot 22020335
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
AR Repression 16281084
HLX Unknown 22897850
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28
GO ID Ontology Definition Evidence Reference
GO:0003712 Function Transcription coregulator activity NAS 11420681
GO:0005515 Function Protein binding IPI 9712883, 9820826, 10617598, 11136725, 16189514, 20211142, 21900206, 27107012, 31515488, 32296183, 35512704
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 9820826, 11420681
GO:0005634 Component Nucleus IMP 11420681
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
109580 1130 ENSG00000133639
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62324
Protein name Protein BTG1 (B-cell translocation gene 1 protein)
Protein function Anti-proliferative protein.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07742 BTG 11 124 BTG family Family
Sequence
Sequence length 171
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  RNA degradation   FOXO-mediated transcription of cell cycle genes
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
EBV-positive nodal T- and NK-cell lymphoma Likely benign rs533912735 RCV004557988
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 24272202, 28922388
Carcinoma Adenosquamous Associate 37650999
Carcinoma Hepatocellular Associate 25173640, 28603285, 31486488
Carcinoma Non Small Cell Lung Inhibit 24264312
Carcinoma Pancreatic Ductal Associate 29076521
Carcinoma Renal Cell Associate 25115181
Carcinoma Squamous Cell Associate 32457282
Dermatitis Atopic Associate 15370698
Endometriosis Associate 31324015
Esophageal Neoplasms Inhibit 24969561