Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
6908
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
TATA-box binding protein |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
TBP |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
GTF2D, GTF2D1, HDL4, SCA17, TBP1, TFIID |
Disease Acronyms (UniProt)
Disease acronyms from UniProt database
|
SCA17 |
Chromosome
Chromosome number
|
6 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
6q27 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, |
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000785 |
Component |
Chromatin |
IDA |
24289924 |
GO:0000791 |
Component |
Euchromatin |
IDA |
19861239 |
GO:0000976 |
Function |
Transcription regulatory region sequence-specific DNA binding |
IDA |
7933101, 9027316, 16540471 |
GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IEA |
|
GO:0000979 |
Function |
RNA polymerase II core promoter sequence-specific DNA binding |
IDA |
29111974 |
GO:0000995 |
Function |
RNA polymerase III general transcription initiation factor activity |
IMP |
26638071 |
GO:0001046 |
Function |
Core promoter sequence-specific DNA binding |
IDA |
9841876 |
GO:0001091 |
Function |
RNA polymerase II general transcription initiation factor binding |
IPI |
8670811, 29111974 |
GO:0001093 |
Function |
TFIIB-class transcription factor binding |
IPI |
9841876 |
GO:0001103 |
Function |
RNA polymerase II repressing transcription factor binding |
IEA |
|
GO:0001939 |
Component |
Female pronucleus |
IEA |
|
GO:0001940 |
Component |
Male pronucleus |
IEA |
|
GO:0005515 |
Function |
Protein binding |
IPI |
1465435, 7667268, 7680771, 7724559, 7729427, 7799929, 8006019, 8504927, 8626665, 9045704, 9603525, 9674425, 9748258, 10391676, 10567391, 10619841, 11029584, 11438666, 12040021, 12217962, 12552007, 15207618, 16641295, 17158164, 17268553, 17318177, 17884155, 18391197, 24418534, 2649661 |
GO:0005634 |
Component |
Nucleus |
IDA |
9841876, 27007846 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005669 |
Component |
Transcription factor TFIID complex |
IDA |
7729427, 14580349, 27007846, 27193682, 29111974 |
GO:0005672 |
Component |
Transcription factor TFIIA complex |
IDA |
7724559 |
GO:0005737 |
Component |
Cytoplasm |
IEA |
|
GO:0006352 |
Process |
DNA-templated transcription, initiation |
IBA |
21873635 |
GO:0006361 |
Process |
Transcription initiation from RNA polymerase I promoter |
TAS |
|
GO:0006362 |
Process |
Transcription elongation from RNA polymerase I promoter |
TAS |
|
GO:0006363 |
Process |
Termination of RNA polymerase I transcription |
TAS |
|
GO:0006366 |
Process |
Transcription by RNA polymerase II |
IC |
7729427 |
GO:0006366 |
Process |
Transcription by RNA polymerase II |
IDA |
7724559 |
GO:0006366 |
Process |
Transcription by RNA polymerase II |
IMP |
27193682 |
GO:0006366 |
Process |
Transcription by RNA polymerase II |
TAS |
|
GO:0006367 |
Process |
Transcription initiation from RNA polymerase II promoter |
IC |
7729427 |
GO:0006367 |
Process |
Transcription initiation from RNA polymerase II promoter |
TAS |
|
GO:0006383 |
Process |
Transcription by RNA polymerase III |
IDA |
9027316 |
GO:0006383 |
Process |
Transcription by RNA polymerase III |
IMP |
26638071 |
GO:0007283 |
Process |
Spermatogenesis |
IEA |
|
GO:0008134 |
Function |
Transcription factor binding |
IPI |
7724559, 8626665, 9722567, 11005381, 12676957 |
GO:0016032 |
Process |
Viral process |
IEA |
|
GO:0016251 |
Function |
RNA polymerase II general transcription initiation factor activity |
IBA |
21873635 |
GO:0016251 |
Function |
RNA polymerase II general transcription initiation factor activity |
IDA |
9841876, 27193682 |
GO:0017162 |
Function |
Aryl hydrocarbon receptor binding |
IPI |
15641800 |
GO:0019899 |
Function |
Enzyme binding |
IPI |
25336585 |
GO:0032991 |
Component |
Protein-containing complex |
IMP |
15641800 |
GO:0042795 |
Process |
SnRNA transcription by RNA polymerase II |
TAS |
|
GO:0045815 |
Process |
Positive regulation of gene expression, epigenetic |
TAS |
|
GO:0045893 |
Process |
Positive regulation of transcription, DNA-templated |
IEA |
|
GO:0051123 |
Process |
RNA polymerase II preinitiation complex assembly |
IDA |
9841876 |
GO:0070491 |
Function |
Repressing transcription factor binding |
IPI |
18838386 |
GO:0097550 |
Component |
Transcription preinitiation complex |
IDA |
9841876 |
GO:0140223 |
Function |
General transcription initiation factor activity |
IBA |
21873635 |
GO:1901796 |
Process |
Regulation of signal transduction by p53 class mediator |
TAS |
|
|
UniProt ID |
P20226
|
Protein name |
TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit) |
Protein function |
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TAT |
PDB |
1C9B
,
1CDW
,
1JFI
,
1NVP
,
1TGH
,
4ROC
,
4ROD
,
4ROE
,
5FUR
,
5IY6
,
5IY7
,
5IY8
,
5IY9
,
5IYA
,
5IYB
,
5IYC
,
5IYD
,
5N9G
,
6MZD
,
6MZL
,
6MZM
,
6O9L
,
7EDX
,
7EG7
,
7EG8
,
7EG9
,
7EGA
,
7EGB
,
7EGC
,
7EGD
,
7EGE
,
7EGF
,
7EGI
,
7EGJ
,
7ENA
,
7ENC
,
7LBM
,
7NVR
,
7NVS
,
7NVT
,
7NVU
,
7NVY
,
7NVZ
,
7NW0
,
7ZWC
,
7ZWD
,
7ZX7
,
7ZX8
,
7ZXE
,
8BVW
,
8BYQ
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00352
|
TBP |
162 → 244 |
Transcription factor TFIID (or TATA-binding protein, TBP) |
Domain |
PF00352
|
TBP |
252 → 335 |
Transcription factor TFIID (or TATA-binding protein, TBP) |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Widely expressed, with levels highest in the testis and ovary. {ECO:0000269|PubMed:17570761}. |
Sequence |
|
Sequence length |
339 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Apraxia |
Apraxias |
rs121908377, rs121908378, rs1135401820, rs1178491246, rs1584969672 |
|
Nystagmus |
Nystagmus, End-Position |
rs137852207, rs137852208, rs1928435502, rs137852209, rs137852210, rs1929191668, rs137852211, rs137852212, rs2124209414, rs387906720, rs387906721, rs1602791884, rs786205896 |
|
Parkinson disease |
Parkinsonian Disorders, PARKINSON DISEASE, LATE-ONSET |
rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121918104, rs1589451049, rs104893877, rs104893878, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106 View all (84 more) |
|
Schizophrenia |
Schizophrenia |
rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 View all (12 more) |
19566714, 16054804 |
Spinocerebellar ataxia |
SPINOCEREBELLAR ATAXIA 17, Spinocerebellar ataxia type 17 |
rs80356538, rs80356539, rs56144125, rs28937887, rs80356544, rs80356540, rs80356542, rs1941485201, rs121918306, rs151344520, rs151344519, rs151344521, rs151344523, rs151344512, rs193922926, rs104894393, rs587776685, rs121908216, rs121908215, rs121908217, rs121909326, rs121918511, rs121918512, rs121918513, rs121918514, rs121918515, rs121918516, rs121918517, rs121918518, rs1555808841, rs104894699, rs104894700, rs121912425, rs121913123, rs267606939, rs201486601, rs387906679, rs151344514, rs151344515, rs151344517, rs387907033, rs387907089, rs794726680, rs761213683, rs794726681, rs1555779353, rs151344513, rs151344518, rs151344522, rs397514535, rs397514536, rs318240735, rs386134171, rs386134158, rs386134159, rs386134160, rs386134161, rs386134162, rs386134163, rs386134164, rs386134165, rs386134166, rs386134168, rs386134170, rs386134169, rs146859515, rs373728971, rs397515475, rs397515476, rs587777052, rs121908247, rs121908200, rs398122959, rs587777127, rs587777128, rs587777235, rs587777340, rs587777341, rs587777342, rs587777344, rs587777345, rs587777346, rs587777347, rs587780326, rs587777670, rs587777671, rs606231451, rs606231452, rs540331226, rs144272231, rs690016544, rs727502823, rs372250159, rs793888526, rs876657385, rs869320748, rs876657386, rs786205229, rs876657387, rs774694340, rs786205867, rs794727411, rs797044955, rs797044872, rs797045634, rs797045240, rs765592794, rs797045900, rs748445058, rs863223919, rs765987297, rs863224882, rs753611141, rs869025292, rs869025293, rs755221106, rs869312685, rs751181600, rs886037832, rs875989881, rs372245668, rs879255601, rs876657414, rs752281590, rs879253883, rs1114167316, rs879255651, rs879255653, rs879255654, rs886039392, rs540839115, rs886039762, rs201128942, rs886041279, rs531656357, rs1057519453, rs1057519454, rs573267388, rs1057519561, rs200277996, rs1064795856, rs749320057, rs750331613, rs1131692265, rs761564262, rs1555768154, rs1210764379, rs758937084, rs1555475283, rs1555475375, rs760424025, rs1555806333, rs1554308513, rs1554274719, rs1554317158, rs201920319, rs1553724533, rs1554985851, rs768831597, rs1554986345, rs1555755878, rs1554902760, rs368143665, rs1555370787, rs1322796318, rs1553756062, rs772345347, rs149905705, rs1555475794, rs760752847, rs1555781806, rs1555738369, rs1554986337, rs1184563885, rs1553758021, rs1559718601, rs1206950481, rs1568523843, rs748984540, rs1557539450, rs1557541619, rs771145682, rs1564808324, rs1567283195, rs752352896, rs1557794465, rs547792505, rs193922929, rs1571636501, rs1571636508, rs1571939827, rs1571939905, rs1559603328, rs1562374476, rs1599651549, rs1590020571, rs1598832526, rs1575415900, rs779142717, rs781016340, rs1366090807, rs1579319300, rs1311909367, rs1589625941, rs749656742, rs1317590341, rs1599943097, rs1590955348, rs749679347, rs1590911156, rs1395191127, rs1405576707, rs541484241, rs1598820860, rs1598832568, rs1589611043, rs758809498, rs754446573 View all (203 more) |
|
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Mental depression |
Depressive disorder |
|
|
ClinVar |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Adenocarcinoma |
Associate
|
37694353 |
Adenocarcinoma of Lung |
Associate
|
36261009 |
Adenoma |
Stimulate
|
28415573 |
Aging Premature |
Associate
|
35069971 |
Amyotrophic Lateral Sclerosis |
Associate
|
23424617 |
Anodontia |
Associate
|
37894839 |
Arthritis Rheumatoid |
Associate
|
37894839 |
Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome |
Associate
|
15147363 |
Astrocytoma |
Associate
|
20511187 |
Ataxia |
Associate
|
15989694 |
Atherosclerosis |
Associate
|
32033288, 37240358 |
Autoimmune Diseases |
Associate
|
32033288 |
beta Thalassemia |
Associate
|
40197981 |
Breast Neoplasms |
Associate
|
18211679, 39408874, 39838295 |
Breast Neoplasms Male |
Associate
|
26694100 |
Carcinogenesis |
Associate
|
18567809, 28415573 |
Carcinoma Hepatocellular |
Associate
|
19200351, 23811755, 37020316 |
Carcinoma Non Small Cell Lung |
Associate
|
28262749, 37694353 |
Carcinoma Renal Cell |
Associate
|
17559644 |
Carcinoma Squamous Cell |
Associate
|
24457517 |
Cardiovascular Diseases |
Associate
|
28105927 |
Cerebellar Ataxia |
Associate
|
26267067, 36476347 |
Chordoma |
Associate
|
38282590 |
Cognition Disorders |
Associate
|
22889412, 31522753, 36422518 |
Colonic Neoplasms |
Associate
|
28415573 |
Colorectal Neoplasms |
Associate
|
28415573, 32424999, 37558778 |
Death |
Associate
|
36422518 |
Delta Beta Thalassemia |
Associate
|
23424617 |
Depressive Disorder |
Associate
|
28585930 |
Dystonia |
Associate
|
32033288 |
Frontotemporal Dementia |
Associate
|
37146135 |
Genetic Diseases Inborn |
Associate
|
28105927, 30933216, 34906452 |
Glaucoma Open Angle |
Associate
|
39684516 |
Glioblastoma |
Associate
|
19257903, 34705606 |
Heart Diseases |
Associate
|
22530004 |
Hemophilia B |
Associate
|
23424617 |
Huntington Disease |
Associate
|
18418687 |
Huntington Disease Like Syndrome |
Associate
|
36476347 |
Hypopharyngeal Neoplasms |
Associate
|
31173291 |
Hypoxia |
Associate
|
28415573 |
Inflammation |
Associate
|
26694100 |
Inflammatory Bowel Diseases |
Associate
|
32424999 |
Laryngeal Neoplasms |
Associate
|
31173291 |
Leukemia Myeloid Acute |
Associate
|
29316424 |
Liposarcoma |
Associate
|
11278855 |
Liver Neoplasms |
Associate
|
34752497 |
Lung Neoplasms |
Associate
|
23424617 |
Lupus Erythematosus Systemic |
Associate
|
15147363 |
Lymphoma Large B Cell Diffuse |
Associate
|
35069971 |
Machado Joseph Disease |
Associate
|
29057148 |
Macrophage Activation Syndrome |
Associate
|
32033288 |
Multiple System Atrophy |
Associate
|
33502644 |
Myocardial Infarction |
Associate
|
23424617 |
Neoplasm Metastasis |
Associate
|
36261009 |
Neoplasms |
Associate
|
18211679, 19650912, 26516624, 28415573, 33092533 |
Neoplasms |
Inhibit
|
21108695 |
Neuroacanthocytosis |
Associate
|
39292690 |
Nevus Sebaceous of Jadassohn |
Associate
|
38247858 |
Obesity |
Associate
|
26694100, 28105927 |
Osteoarthritis |
Associate
|
24080205, 38247858 |
Ovarian Neoplasms |
Associate
|
36978087 |
Parkinson Disease |
Associate
|
39914017 |
Periodontitis |
Associate
|
29116140 |
Personality Disorders |
Associate
|
28105927 |
Prostatic Neoplasms |
Associate
|
27700103, 8662737 |
Schizophrenia |
Associate
|
19566714 |
Scleroderma Systemic |
Stimulate
|
15147363 |
Spherocytosis Hereditary |
Associate
|
16037067, 21071415 |
Spinocerebellar Ataxia 17 |
Associate
|
15989694, 18418687, 19075547, 19566714, 22530004, 22889412, 25549101, 32377295, 34171784, 34906452, 36422518, 36476347 |
Spinocerebellar Ataxias |
Associate
|
24972706, 33502644, 34171784, 34565721, 39456985 |
Spinocerebellar Degenerations |
Associate
|
26374734 |
Squamous Cell Carcinoma of Head and Neck |
Associate
|
19650912 |
Thrombophlebitis |
Associate
|
23424617 |
Triple Negative Breast Neoplasms |
Associate
|
18211679 |
Urinary Bladder Neoplasms |
Associate
|
33057113, 37542643 |
|