Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6908
Gene name Gene Name - the full gene name approved by the HGNC.
TATA-box binding protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TBP
Synonyms (NCBI Gene) Gene synonyms aliases
GTF2D, GTF2D1, HDL4, SCA17, TBP1, TFIID
Disease Acronyms (UniProt) Disease acronyms from UniProt database
SCA17
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q27
Summary Summary of gene provided in NCBI Entrez Gene.
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly,
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT051286 hsa-miR-16-5p CLASH 23622248
MIRT040014 hsa-miR-615-3p CLASH 23622248
MIRT734136 hsa-miR-613 Western blotting, Immunofluorescence, qRT-PCR 32943930
MIRT1414826 hsa-miR-1206 CLIP-seq
MIRT1414827 hsa-miR-1273g CLIP-seq
Transcription factors
Transcription factor Regulation Reference
AR Unknown 9238003
BTAF1 Repression 20627952
BTAF1 Unknown 14988402;15509807;16858867
CDX1 Unknown 17158164
CREM Unknown 10409662
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IDA 24289924
GO:0000791 Component Euchromatin IDA 19861239
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding IDA 7933101, 9027316, 16540471
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
GO:0000979 Function RNA polymerase II core promoter sequence-specific DNA binding IDA 29111974
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600075 11588 ENSG00000112592
Protein
UniProt ID P20226
Protein name TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)
Protein function The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TAT
PDB 1C9B , 1CDW , 1JFI , 1NVP , 1TGH , 4ROC , 4ROD , 4ROE , 5FUR , 5IY6 , 5IY7 , 5IY8 , 5IY9 , 5IYA , 5IYB , 5IYC , 5IYD , 5N9G , 6MZD , 6MZL , 6MZM , 6O9L , 7EDX , 7EG7 , 7EG8 , 7EG9 , 7EGA , 7EGB , 7EGC , 7EGD , 7EGE , 7EGF , 7EGI , 7EGJ , 7ENA , 7ENC , 7LBM , 7NVR , 7NVS , 7NVT , 7NVU , 7NVY , 7NVZ , 7NW0 , 7ZWC , 7ZWD , 7ZX7 , 7ZX8 , 7ZXE , 8BVW , 8BYQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00352 TBP 162 244 Transcription factor TFIID (or TATA-binding protein, TBP) Domain
PF00352 TBP 252 335 Transcription factor TFIID (or TATA-binding protein, TBP) Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed, with levels highest in the testis and ovary. {ECO:0000269|PubMed:17570761}.
Sequence
MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQ
QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVAAAAVQQSTSQQATQGTSGQAPQ
LFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDL
KTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARV
VQKL
GFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRI
VLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGF
RKTT
Sequence length 339
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Basal transcription factors
Huntington disease
Spinocerebellar ataxia
Human papillomavirus infection
Human T-cell leukemia virus 1 infection
Viral carcinogenesis
  B-WICH complex positively regulates rRNA expression
RNA Polymerase II Pre-transcription Events
Regulation of TP53 Activity through Phosphorylation
RNA polymerase II transcribes snRNA genes
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Estrogen-dependent gene expression
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Apraxia Apraxias rs121908377, rs121908378, rs1135401820, rs1178491246, rs1584969672
Nystagmus Nystagmus, End-Position rs137852207, rs137852208, rs1928435502, rs137852209, rs137852210, rs1929191668, rs137852211, rs137852212, rs2124209414, rs387906720, rs387906721, rs1602791884, rs786205896
Parkinson disease Parkinsonian Disorders, PARKINSON DISEASE, LATE-ONSET rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432
View all (84 more)
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
19566714, 16054804
Unknown
Disease term Disease name Evidence References Source
Mental depression Depressive disorder ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 37694353
Adenocarcinoma of Lung Associate 36261009
Adenoma Stimulate 28415573
Aging Premature Associate 35069971
Amyotrophic Lateral Sclerosis Associate 23424617
Anodontia Associate 37894839
Arthritis Rheumatoid Associate 37894839
Asthma Chronic Obstructive Pulmonary Disease Overlap Syndrome Associate 15147363
Astrocytoma Associate 20511187
Ataxia Associate 15989694