TBCA (tubulin folding cofactor A)

Gene

• Entrez ID: 6902
• Gene name: Tubulin folding cofactor A
• Gene symbol: TBCA
• Synonyms (NCBI Gene): -
• Chromosome: 5
• Chromosome location: 5q14.1
• Summary: The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubuli

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001495	hsa-miR-155-5p	pSILAC	18668040
MIRT001495	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT001495	hsa-miR-155-5p	Proteomics	18668040
MIRT664211	hsa-miR-3156-5p	HITS-CLIP	23824327
MIRT664210	hsa-miR-4733-5p	HITS-CLIP	23824327
MIRT664209	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT664208	hsa-miR-494-3p	HITS-CLIP	23824327
MIRT664207	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT664206	hsa-miR-1264	HITS-CLIP	23824327
MIRT664205	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT664204	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT664203	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT664202	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT664201	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT664200	hsa-miR-5696	HITS-CLIP	23824327
MIRT664199	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT664198	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT664197	hsa-miR-3685	HITS-CLIP	23824327
MIRT664196	hsa-miR-384	HITS-CLIP	23824327
MIRT664195	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT664194	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT648181	hsa-miR-186-5p	HITS-CLIP	23824327
MIRT648180	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT664211	hsa-miR-3156-5p	HITS-CLIP	23824327
MIRT664210	hsa-miR-4733-5p	HITS-CLIP	23824327
MIRT664209	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT664208	hsa-miR-494-3p	HITS-CLIP	23824327
MIRT664207	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT664206	hsa-miR-1264	HITS-CLIP	23824327
MIRT664205	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT664204	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT664203	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT664202	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT664201	hsa-miR-103a-2-5p	HITS-CLIP	23824327
MIRT664200	hsa-miR-5696	HITS-CLIP	23824327
MIRT664199	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT664198	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT664197	hsa-miR-3685	HITS-CLIP	23824327
MIRT664196	hsa-miR-384	HITS-CLIP	23824327
MIRT664195	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT664194	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT648181	hsa-miR-186-5p	HITS-CLIP	23824327
MIRT648180	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT1413941	hsa-miR-23a	CLIP-seq
MIRT1413942	hsa-miR-23b	CLIP-seq
MIRT1413943	hsa-miR-23c	CLIP-seq
MIRT1413944	hsa-miR-380	CLIP-seq
MIRT1413945	hsa-miR-4495	CLIP-seq
MIRT1413946	hsa-miR-4705	CLIP-seq
MIRT1413947	hsa-miR-548ac	CLIP-seq
MIRT1413948	hsa-miR-548ae	CLIP-seq
MIRT1413949	hsa-miR-548aj	CLIP-seq
MIRT1413950	hsa-miR-548am	CLIP-seq
MIRT1413951	hsa-miR-548d-3p	CLIP-seq
MIRT1413952	hsa-miR-548x	CLIP-seq
MIRT1413953	hsa-miR-548z	CLIP-seq
MIRT1413954	hsa-miR-577	CLIP-seq
MIRT2124216	hsa-miR-155	CLIP-seq
MIRT2346532	hsa-miR-1246	CLIP-seq
MIRT2124216	hsa-miR-155	CLIP-seq
MIRT1413941	hsa-miR-23a	CLIP-seq
MIRT1413942	hsa-miR-23b	CLIP-seq
MIRT1413943	hsa-miR-23c	CLIP-seq
MIRT2346533	hsa-miR-3662	CLIP-seq
MIRT1413944	hsa-miR-380	CLIP-seq
MIRT2346534	hsa-miR-4274	CLIP-seq
MIRT1413945	hsa-miR-4495	CLIP-seq
MIRT2346535	hsa-miR-4519	CLIP-seq
MIRT2346536	hsa-miR-4694-3p	CLIP-seq
MIRT1413946	hsa-miR-4705	CLIP-seq
MIRT2346537	hsa-miR-4789-3p	CLIP-seq
MIRT2346538	hsa-miR-508-3p	CLIP-seq
MIRT2346539	hsa-miR-548aa	CLIP-seq
MIRT1413947	hsa-miR-548ac	CLIP-seq
MIRT1413948	hsa-miR-548ae	CLIP-seq
MIRT1413949	hsa-miR-548aj	CLIP-seq
MIRT1413950	hsa-miR-548am	CLIP-seq
MIRT1413951	hsa-miR-548d-3p	CLIP-seq
MIRT1413952	hsa-miR-548x	CLIP-seq
MIRT1413953	hsa-miR-548z	CLIP-seq
MIRT1413954	hsa-miR-577	CLIP-seq
MIRT2346540	hsa-miR-711	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	21044950, 32353859, 33060197
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005874	Component	Microtubule	IEA
GO:0006457	Process	Protein folding	IBA	21873635
GO:0006457	Process	Protein folding	TAS	8706133
GO:0007021	Process	Tubulin complex assembly	IBA	21873635
GO:0007023	Process	Post-chaperonin tubulin folding pathway	IEA
GO:0015630	Component	Microtubule cytoskeleton	IBA	21873635
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0015631	Function	Tubulin binding	IBA	21873635
GO:0048487	Function	Beta-tubulin binding	IEA
GO:0051087	Function	Chaperone binding	TAS	8706133

Other IDs

• MIM: 610058
• HGNC: 11579
• e!Ensembl: ENSG00000171530

Protein

• UniProt ID: O75347
• Protein name: Tubulin-specific chaperone A (TCP1-chaperonin cofactor A) (Tubulin-folding cofactor A) (CFA)
• Protein function: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
• PDB: 1H7C
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02970	TBCA	9 → 95	Tubulin binding cofactor A	Domain

• Sequence:

  MADPRVRQIKIKTGVVKRLVKEKVMYEKEAKQQEEKIEKMRAEDGENYDIKKQAEILQES
  RMMIPDCQRRLEAAYLDLQRILENEKDLEEAEEYKEARLVLDSVKLEA

• Sequence length: 108

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Hypertrophic cardiomyopathy	Hypertrophic Cardiomyopathy, Hypertrophic obstructive cardiomyopathy	rs63750743, rs104894655, rs121908987, rs587776643, rs28938173, rs121908989, rs121908991, rs267606977, rs267606978, rs193922384, rs121909374, rs886041030, rs886041031, rs121909375, rs121909377, rs2856655, rs587776700, rs387906397, rs104894204, rs121434470, rs104894828, rs121964855, rs121964856, rs121964858, rs74315380, rs104894724, rs104894725, rs104894727, rs104894728, rs104894729, rs104894730, rs267607127, rs2147283135, rs267607128, rs267607125, rs104894502, rs104894503, rs104894504, rs28933405, rs111033560, rs121434594, rs80338797, rs104893748, rs104894368, rs104894369, rs104894370, rs121913624, rs3218713, rs121913625, rs121913626, rs121913627, rs121913628, rs121913629, rs121913630, rs121913631, rs121913632, rs121913633, rs121913634, rs3218714, rs121913636, rs121913637, rs121913638, rs121913639, rs121913641, rs121913642, rs121913643, rs121913647, rs121913650, rs121913651, rs36211715, rs121913654, rs267606911, rs267606908, rs730880850, rs121912675, rs267606629, rs193922680, rs1600482909, rs387906898, rs199476398, rs387907079, rs199474815, rs199474703, rs199476305, rs199476306, rs199476315, rs199476316, rs199476317, rs199476321, rs199476311, rs193922649, rs36211723, rs187830361, rs193922383, rs193922386, rs193922390, rs193922697, rs387907267, rs397507520, rs727505017, rs397515888, rs397515889, rs397515891, rs397515893, rs397515894, rs397515895, rs397515896, rs397515897, rs397515903, rs397515905, rs375882485, rs397515907, rs397515910, rs397515912, rs397515916, rs397515920, rs397515925, rs397515926, rs397515931, rs397515933, rs397515934, rs397515935, rs397515937, rs397515942, rs397515943, rs397515944, rs397515947, rs397515948, rs397515952, rs397515954, rs112738974, rs111729952, rs397515960, rs397515963, rs397515965, rs397515966, rs397515970, rs397515972, rs397515973, rs397515974, rs397515975, rs397515977, rs376395543, rs397515979, rs397515982, rs397515987, rs397515990, rs397515991, rs397515992, rs397515995, rs397515997, rs397516001, rs397516005, rs113358486, rs397516006, rs397516007, rs397516008, rs397516010, rs397516013, rs397516014, rs373746463, rs397516019, rs397516020, rs397516022, rs397516023, rs397516029, rs397516031, rs397516032, rs397516035, rs397516037, rs397516038, rs397516040, rs397516042, rs397516044, rs397516047, rs397516049, rs397516052, rs397516056, rs397516057, rs397516058, rs397516059, rs397516061, rs397516067, rs397516068, rs397516070, rs397516072, rs397516073, rs397516074, rs397516076, rs397516077, rs397516080, rs201078659, rs397516082, rs397516083, rs1555122751, rs397516088, rs397516089, rs397516095, rs397516098, rs397516101, rs397516103, rs397516110, rs397516127, rs371898076, rs397516132, rs397516134, rs397516142, rs3218716, rs397516153, rs397516154, rs397516155, rs397516156, rs397516157, rs397516160, rs397516161, rs397516165, rs397516166, rs397516170, rs397516171, rs397516172, rs397516178, rs397516179, rs397516187, rs397516201, rs397516202, rs145213771, rs397516207, rs397516209, rs397516212, rs397516238, rs397516248, rs397516254, rs397516258, rs397516260, rs45516091, rs397516264, rs397516266, rs397516269, rs397516340, rs397516347, rs121917760, rs397516349, rs397516353, rs397516354, rs397516355, rs397516357, rs397516373, rs397516406, rs397516455, rs397516456, rs397516457, rs397516463, rs397516464, rs45525839, rs397516470, rs397516471, rs45578238, rs111377893, rs397516736, rs397516738, rs397516739, rs397516751, rs397516752, rs397516784, rs397517283, rs397514752, rs143697995, rs267607490, rs199472948, rs138193236, rs398123279, rs869320740, rs606231340, rs606231324, rs587779392, rs587779393, rs587782951, rs587782957, rs587782958, rs587782962, rs587782965, rs138049878, rs376897125, rs368765949, rs727504247, rs376923877, rs727504277, rs727504255, rs727504246, rs727504331, rs727503513, rs727504392, rs397516039, rs727504271, rs727504321, rs727504289, rs727504305, rs727503172, rs573821685, rs727503176, rs727503178, rs727504423, rs727503180, rs727504333, rs727503182, rs727504265, rs727503184, rs727503186, rs727503187, rs727504252, rs727504864, rs727504334, rs727503192, rs397515932, rs727504366, rs727504248, rs727504287, rs200411226, rs727503204, rs727504329, rs727504269, rs573916965, rs367947846, rs727503210, rs730880335, rs727503166, rs727504390, rs730880361, rs727504276, rs111683277, rs727503174, rs727503175, rs727504349, rs727504314, rs727504371, rs730880341, rs727504293, rs727503195, rs111437311, rs727503202, rs727503203, rs727504279, rs727505152, rs727503209, rs727503211, rs727503212, rs727503217, rs727503219, rs730880366, rs727503220, rs727504356, rs727504311, rs727503261, rs727503264, rs727504238, rs148808089, rs727503271, rs727504409, rs727503276, rs727504283, rs727503296, rs45544633, rs727503246, rs727503252, rs727503253, rs202141173, rs2754158, rs727504310, rs727503260, rs727504272, rs727504240, rs727503263, rs727504239, rs727504925, rs727504237, rs727504236, rs727505202, rs727504267, rs727503278, rs727504243, rs727504285, rs727503499, rs727503504, rs727504242, rs727504264, rs727504275, rs727503500, rs727503503, rs727503120, rs730880336, rs730880337, rs730880362, rs730880210, rs730880143, rs730880159, rs730881116, rs730881122, rs730880162, rs730880605, rs730880604, rs730880600, rs730880702, rs730880598, rs730880597, rs730880699, rs730880592, rs730880675, rs730880720, rs730880719, rs730880672, rs730880668, rs730880718, rs730880666, rs730880586, rs730880584, rs11570112, rs730880578, rs730880576, rs730880660, rs730880657, rs730880655, rs730880654, rs730880653, rs730880652, rs730880714, rs730880651, rs730880558, rs730880649, rs730880647, rs730880713, rs730880646, rs730880546, rs727503197, rs730880695, rs730880644, rs730880640, rs730880712, rs730880544, rs730880542, rs730880541, rs730880538, rs730880533, rs730880531, rs730880641, rs730880639, rs397515890, rs730880724, rs730880635, rs730880723, rs730880686, rs730880631, rs730880678, rs730880629, rs730880684, rs368121566, rs730880621, rs730880681, rs375607980, rs730880618, rs730880680, rs730880679, rs730880677, rs730880704, rs730880703, rs730880721, rs730880698, rs730880664, rs730880663, rs730880662, rs730880659, rs730880916, rs727504558, rs730880759, rs730880756, rs730880750, rs730880749, rs730880748, rs730880736, rs727504241, rs727504299, rs730880732, rs730880883, rs730880930, rs730880929, rs730880875, rs370310929, rs730880926, rs730880864, rs730880856, rs397516268, rs730880922, rs730880845, rs730880388, rs730881091, rs786204352, rs786204339, rs786204338, rs786204336, rs786204329, rs2069544, rs281865416, rs773317399, rs121913648, rs730880809, rs863224483, rs863224899, rs863224900, rs863225120, rs863225121, rs863225107, rs863225114, rs863225113, rs863225104, rs863225105, rs863225112, rs863225106, rs863225109, rs863225111, rs863225100, rs863225103, rs863225102, rs863225097, rs863225101, rs730880876, rs863225272, rs863225271, rs190228518, rs863225269, rs761507504, rs864622224, rs1057515421, rs869025470, rs869025469, rs869025461, rs869025468, rs869025460, rs869025467, rs869025466, rs869025465, rs869025464, rs869025463, rs869025459, rs869025462, rs727503512, rs876657706, rs876657705, rs876657703, rs876657702, rs727503213, rs876657884, rs878854428, rs878853831, rs878853842, rs1562999443, rs1563003848, rs1562991002, rs879255639, rs886037900, rs886037902, rs886037901, rs886038822, rs886039030, rs886039185, rs754664923, rs141019458, rs1057517766, rs1057517767, rs779650200, rs1057518030, rs1057517711, rs1057519503, rs1057520814, rs1060499673, rs1060501480, rs1060501484, rs1060501481, rs1060501478, rs1064792936, rs1060501475, rs1060501479, rs1064792935, rs1060501436, rs1060501448, rs1060501443, rs1060501452, rs1060505018, rs1060499604, rs781135153, rs1064796231, rs1064793202, rs977277400, rs1064793429, rs771929829, rs745811346, rs1114167419, rs1114167361, rs1555409659, rs1555123389, rs1131691514, rs1131692185, rs1131692058, rs1553279294, rs1555120920, rs1555121924, rs1555338319, rs1555120300, rs1555121488, rs373792537, rs1444727212, rs1555338462, rs1555120937, rs1555123629, rs794727046, rs1555123633, rs1555121172, rs1555123438, rs1555336467, rs1555338658, rs1213930919, rs1432810664, rs1555122188, rs764743402, rs974671846, rs1420159591, rs745688425, rs1555338080, rs200889953, rs1555120258, rs1298025872, rs767039057, rs1555120529, rs1555121247, rs774521272, rs1555122156, rs1555123473, rs1555123496, rs1555123597, rs1555337701, rs2856897, rs869312381, rs1555122928, rs1555123743, rs1554401581, rs1555120651, rs868819340, rs1555122053, rs730880742, rs758891557, rs1555337794, rs1555338378, rs1555338758, rs1245885836, rs1566530698, rs1566513862, rs1565629792, rs730880751, rs727504294, rs1563001548, rs1565622952, rs1565625473, rs1565626409, rs1565627536, rs1565628062, rs1565628486, rs1565631430, rs1391622163, rs1131691685, rs749007293, rs1566535491, rs1565624090, rs1565625777, rs1565631428, rs1568858210, rs1566537070, rs1565627566, rs1567864804, rs1563161306, rs1565622703, rs190765116, rs1595843598, rs1565625795, rs1565628078, rs774316050, rs1565631381, rs1565631424, rs1566531421, rs730880872, rs730880870, rs1566536418, rs1566536436, rs1565623216, rs1265248322, rs113276889, rs1562998062, rs1419032418, rs1565627615, rs1565624196, rs1595843640, rs1595846398, rs764950910, rs1600448065, rs1600462474, rs1417887060, rs1600477808, rs1600480573, rs1050997719, rs1420394583, rs1595840648, rs1595841063, rs1595843549, rs1595843758, rs1595845565, rs1595845888, rs1595846344, rs1595846475, rs1595849931, rs1595070747, rs1246272841, rs730880741, rs1173617248, rs1595085409, rs730880879, rs1299079662, rs1595848628, rs1595849603, rs1450218521, rs1571627587, rs1603037717, rs1603038411, rs1595850762, rs777702465, rs1595841736, rs1595842238, rs1595845204, rs1025692267, rs1595070689, rs1198682781, rs2095879705, rs201911056, rs727504425, rs141414377, rs1596303148, rs1595841206, rs1595844714, rs1595842632, rs1595843828, rs113709679, rs1595841552, rs1595849742, rs754529157, rs1709195189, rs1342121466, rs2095880935, rs2095883508, rs2095884984, rs2095889902, rs2095891411, rs2095898532, rs780625785, rs1892592854, rs1892948780, rs2095879167, rs1956121988, rs2095893477, rs2095894178, rs1801002279, rs1892956157	9527842

Unknown
Disease term	Disease name	Evidence	References	Source
Multiple myeloma	Multiple myeloma	MM cells lacking PSMC6 also developed resistance against Carfilzomib (CAR)		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
Alzheimer Disease	Associate	39392298
Carcinoma Hepatocellular	Associate	34557456