TARBP1 (tRNA guanosine 2 -O-methyltransferase TARBP1)

Gene

• Entrez ID: 6894
• Gene name: TRNA guanosine 2 -O-methyltransferase TARBP1
• Gene symbol: TARBP1
• Synonyms (NCBI Gene): TRM3, TRMT3, TRP-185, TRP185
• Chromosome: 1
• Chromosome location: 1q42.2
• Summary: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002569	hsa-miR-124-3p	Microarray	15685193
MIRT002569	hsa-miR-124-3p	Microarray	18668037
MIRT002569	hsa-miR-124-3p	Microarray	15685193
MIRT2123510	hsa-miR-124	CLIP-seq
MIRT2123511	hsa-miR-4476	CLIP-seq
MIRT2123512	hsa-miR-4521	CLIP-seq
MIRT2123513	hsa-miR-506	CLIP-seq
MIRT2345579	hsa-miR-15a	CLIP-seq
MIRT2345580	hsa-miR-15b	CLIP-seq
MIRT2345581	hsa-miR-16	CLIP-seq
MIRT2345582	hsa-miR-195	CLIP-seq
MIRT2345583	hsa-miR-424	CLIP-seq
MIRT2345584	hsa-miR-4539	CLIP-seq
MIRT2345585	hsa-miR-497	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	8846792
GO:0005634	Component	Nucleus	TAS	8846792
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	8846792
GO:0006396	Process	RNA processing	IEA
GO:0008033	Process	TRNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008173	Function	RNA methyltransferase activity	IEA
GO:0016423	Function	TRNA (guanine) methyltransferase activity	IBA
GO:0016423	Function	TRNA (guanine) methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030488	Process	TRNA methylation	IBA
GO:0030488	Process	TRNA methylation	IEA
GO:0030488	Process	TRNA methylation	IMP	38867004
GO:0032259	Process	Methylation	IEA
GO:0141100	Function	TRNA (guanine(18)-2'-O)-methyltransferase activity	IEA
GO:0141100	Function	TRNA (guanine(18)-2'-O)-methyltransferase activity	IMP	38867004

Other IDs

• MIM: 605052
• HGNC: 11568
• e!Ensembl: ENSG00000059588

Protein

• UniProt ID: Q13395
• Protein name: tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1 (EC 2.1.1.34) (TAR RNA-binding protein 1) (TAR RNA-binding protein of 185 kDa) (TRP-185)
• Protein function: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA (PubMed:18412263, PubMed:31019095, PubMed:38867004). Selectively mediates Gm18 methyla
• PDB: 2HA8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00588	SpoU_methylase	1463 → 1606	SpoU rRNA Methylase family	Family

• Sequence:

  MEWVLAEALLSQSRDPRALLGALCQGEASAERVETLRFLLQRLEDEEARGSGGAGALPEA
  AREVAAGYLVPLLRSLRGRPAGGPDPSLQPRHRRRVLRAAGAALRSCVRLAGRPQLAAAL
  AEEALRDLLAGWRAPGAEAAVEVLAAVGPCLRPREDGPLLERVAGTAVALALGGGGDGDE
  AGPAEDAAALVAGRLLPVLVQCGGAALRAVWGGLAAPGASLGSGRVEEKLLVLSALAEKL
  LPEPGGDRARGAREAGPDARRCWRFWRTVQAGLGQADALTRKRARYLLQRAVEVSAELGA
  DCTCGPQEGNGPSLFWWSERKKDELLKFWENYILIMETLEGNQIHVIKPVLPKLNNLFEY
  AVSEENGCWLFHPSWHMCIYKRMFESENKILSKEGVIHFLELYETKILPFSPEFSEFIIG
  PLMDALSESSLYSRSPGQPIGSCSPLGLKLQKFLVTYISLLPEEIKSSFLLKFIRKMTSR
  HWCAVPILFLSKALANVPRHKALGIDGLLALRDVIHCTMITHQILLRGAAQCYLLQTAMN
  LLDVEKVSLSDVSTFLMSLRQEESLGRGTSLWTELCDWLRVNESYFKPSPTCSSIGLHKT
  SLNAYVKSIVQEYVKSSAWETGENCFMPDWFEAKLVSLMVLLAVDVEGMKTQYSGKQRTE
  NVLRIFLDPLLDVLMKFSTNAYMPLLKTDRCLQLLLKLLNTCRLKGSSAQDDEVSTVLQN
  FFMSTTESISEFILRRLTMNELNSVSDLDRCHLYLMVLTELINLHLKVGWKRGNPIWRVI
  SLLKNASIQHLQEMDSGQEPTVGSQIQRVVSMAALAMVCEAIDQKPELQLDSLHAGPLES
  FLSSLQLNQTLQKPHAEEQSSYAHPLECSSVLEESSSSQGWGKIVAQYIHDQWVCLSFLL
  KKYHTLIPTTGSEILEPFLPAVQMPIRTLQSALEALTVLSSDQVLPVFHCLKVLVPKLLT
  SSESLCIESFDMAWKIISSLSNTQLIFWANLKAFVQFVFDNKVLTIAAKIKGQAYFKIKE
  IMYKIIEMSAIKTGVFNTLISYCCQSWIVSASNVSQGSLSSAKNYSELILEACIFGTVFR
  RDQRLVQDVQTFIENLGHDCAANIVMENTKREDHYVRICAVKFLCLLDGSNMSHKLFIED
  LAIKLLDKDELVSKSKKRYYVNSLQHRVKNRVWQTLLVLFPRLDQNFLNGIIDRIFQAGF
  TNNQASIKYFIEWIIILILHKFPQFLPKFWDCFSYGEENLKTSICTFLAVLSHLDIITQN
  IPEKKLILKQALIVVLQWCFNHNFSVRLYALVALKKLWTVCKVLSVEEFDALTPVIESSL
  HQVESMHGAGNAKKNWQRIQEHFFFATFHPLKDYCLETIFYILPRLSGLIEDEWITIDKF
  TRFTDVPLAAGFQWYLSQTQLSKLKPGDWSQQDIGTNLVEADNQAEWTDVQKKIIPWNSR
  VSDLDLELLFQDRAARLGKSISRLIVVASLIDKPTNLGGLCRTCEVFGASVLVVGSLQCI
  SDKQFQHLSVSAEQWLPLVEVKPPQLIDYLQQKKTEGYTIIGVEQTAKSLDLTQYCFPEK
  SLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEYTRQQLLSHGDTK
  P

• Sequence length: 1621

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Ataxia Telangiectasia	Associate	38183111	★☆☆☆☆ Found in Text Mining only
Attention Deficit Disorder with Hyperactivity	Associate	33137342	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	26464651, 32200387, 32213663	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	31957540, 38183111	★☆☆☆☆ Found in Text Mining only