TAL2 (TAL bHLH transcription factor 2)

Gene

• Entrez ID: 6887
• Gene name: TAL bHLH transcription factor 2
• Gene symbol: TAL2
• Synonyms (NCBI Gene): -
• Chromosome: 9
• Chromosome location: 9q31.2
• Summary: This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-c

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT723276	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT723275	hsa-miR-1248	HITS-CLIP	19536157
MIRT723274	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT723273	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT723272	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT723271	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT723270	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT723269	hsa-miR-6844	HITS-CLIP	19536157
MIRT723268	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT723267	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT723266	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT723265	hsa-miR-6832-3p	HITS-CLIP	19536157
MIRT723276	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT723275	hsa-miR-1248	HITS-CLIP	19536157
MIRT723274	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT723273	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT723272	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT723271	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT723270	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT723269	hsa-miR-6844	HITS-CLIP	19536157
MIRT723268	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT723267	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT723266	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT723265	hsa-miR-6832-3p	HITS-CLIP	19536157
MIRT1410216	hsa-miR-1285	CLIP-seq
MIRT1410217	hsa-miR-2682	CLIP-seq
MIRT1410218	hsa-miR-302a	CLIP-seq
MIRT1410219	hsa-miR-302b	CLIP-seq
MIRT1410220	hsa-miR-302c	CLIP-seq
MIRT1410221	hsa-miR-302d	CLIP-seq
MIRT1410222	hsa-miR-302e	CLIP-seq
MIRT1410223	hsa-miR-3187-5p	CLIP-seq
MIRT1410224	hsa-miR-34a	CLIP-seq
MIRT1410225	hsa-miR-34c-5p	CLIP-seq
MIRT1410226	hsa-miR-372	CLIP-seq
MIRT1410227	hsa-miR-373	CLIP-seq
MIRT1410228	hsa-miR-378g	CLIP-seq
MIRT1410229	hsa-miR-4314	CLIP-seq
MIRT1410230	hsa-miR-4486	CLIP-seq
MIRT1410231	hsa-miR-449a	CLIP-seq
MIRT1410232	hsa-miR-449b	CLIP-seq
MIRT1410233	hsa-miR-449c	CLIP-seq
MIRT1410234	hsa-miR-4514	CLIP-seq
MIRT1410235	hsa-miR-4692	CLIP-seq
MIRT1410236	hsa-miR-512-3p	CLIP-seq
MIRT1410237	hsa-miR-520a-3p	CLIP-seq
MIRT1410238	hsa-miR-520b	CLIP-seq
MIRT1410239	hsa-miR-520c-3p	CLIP-seq
MIRT1410240	hsa-miR-520d-3p	CLIP-seq
MIRT1410241	hsa-miR-520e	CLIP-seq
MIRT1410242	hsa-miR-612	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	TAS	1763056
GO:0005515	Function	Protein binding	IPI	25416956
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0009791	Process	Post-embryonic development	IEA
GO:0021794	Process	Thalamus development	IEA
GO:0030901	Process	Midbrain development	IEA
GO:0035264	Process	Multicellular organism growth	IEA
GO:0046983	Function	Protein dimerization activity	IEA

Other IDs

• MIM: 186855
• HGNC: 11557
• e!Ensembl: ENSG00000186051

Protein

• UniProt ID: Q16559
• Protein name: T-cell acute lymphocytic leukemia protein 2 (TAL-2) (Class A basic helix-loop-helix protein 19) (bHLHa19)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00010	HLH	3 → 55	Helix-loop-helix DNA-binding domain	Domain

• Sequence:

  MTRKIFTNTRERWRQQNVNSAFAKLRKLIPTHPPDKKLSKNETLRLAMRYINFLVKVLGE
  QSLQQTGVAAQGNILGLFPQGPHLPGLEDRTLLENYQVPSPGPSHHIP

• Sequence length: 108

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Lymphoblastic leukemia	Childhood Acute Lymphoblastic Leukemia, L2 Acute Lymphoblastic Leukemia, Precursor Cell Lymphoblastic Leukemia Lymphoma	rs387906351, rs104894562, rs398122513, rs398122840, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591

Unknown
Disease term	Disease name	Evidence	References	Source
Schizophrenia	Schizophrenia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	19088038
Lung Neoplasms	Associate	19088038
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	22058201