Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	6887
Gene name	TAL bHLH transcription factor 2
Gene symbol	TAL2
Synonyms (NCBI Gene)	-
Chromosome	9
Chromosome location	9q31.2
Summary	This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-c

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miRTarBase ID	miRNA	Experiments	Reference
MIRT723276	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT723275	hsa-miR-1248	HITS-CLIP	19536157
MIRT723274	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT723273	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT723272	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT723271	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT723270	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT723269	hsa-miR-6844	HITS-CLIP	19536157
MIRT723268	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT723267	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT723266	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT723265	hsa-miR-6832-3p	HITS-CLIP	19536157
MIRT723276	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT723275	hsa-miR-1248	HITS-CLIP	19536157
MIRT723274	hsa-miR-130b-5p	HITS-CLIP	19536157
MIRT723273	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT723272	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT723271	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT723270	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT723269	hsa-miR-6844	HITS-CLIP	19536157
MIRT723268	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT723267	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT723266	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT723265	hsa-miR-6832-3p	HITS-CLIP	19536157
MIRT1410216	hsa-miR-1285	CLIP-seq
MIRT1410217	hsa-miR-2682	CLIP-seq
MIRT1410218	hsa-miR-302a	CLIP-seq
MIRT1410219	hsa-miR-302b	CLIP-seq
MIRT1410220	hsa-miR-302c	CLIP-seq
MIRT1410221	hsa-miR-302d	CLIP-seq
MIRT1410222	hsa-miR-302e	CLIP-seq
MIRT1410223	hsa-miR-3187-5p	CLIP-seq
MIRT1410224	hsa-miR-34a	CLIP-seq
MIRT1410225	hsa-miR-34c-5p	CLIP-seq
MIRT1410226	hsa-miR-372	CLIP-seq
MIRT1410227	hsa-miR-373	CLIP-seq
MIRT1410228	hsa-miR-378g	CLIP-seq
MIRT1410229	hsa-miR-4314	CLIP-seq
MIRT1410230	hsa-miR-4486	CLIP-seq
MIRT1410231	hsa-miR-449a	CLIP-seq
MIRT1410232	hsa-miR-449b	CLIP-seq
MIRT1410233	hsa-miR-449c	CLIP-seq
MIRT1410234	hsa-miR-4514	CLIP-seq
MIRT1410235	hsa-miR-4692	CLIP-seq
MIRT1410236	hsa-miR-512-3p	CLIP-seq
MIRT1410237	hsa-miR-520a-3p	CLIP-seq
MIRT1410238	hsa-miR-520b	CLIP-seq
MIRT1410239	hsa-miR-520c-3p	CLIP-seq
MIRT1410240	hsa-miR-520d-3p	CLIP-seq
MIRT1410241	hsa-miR-520e	CLIP-seq
MIRT1410242	hsa-miR-612	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	1763056
GO:0005515	Function	Protein binding	IPI	25416956, 33961781
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0009791	Process	Post-embryonic development	IEA
GO:0021794	Process	Thalamus development	IEA
GO:0030901	Process	Midbrain development	IEA
GO:0035264	Process	Multicellular organism growth	IEA
GO:0046983	Function	Protein dimerization activity	IEA

MIM	HGNC	e!Ensembl
186855	11557	ENSG00000186051

Q16559

Protein name

T-cell acute lymphocytic leukemia protein 2 (TAL-2) (Class A basic helix-loop-helix protein 19) (bHLHa19)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00010	HLH	3 → 55	Helix-loop-helix DNA-binding domain	Domain

Sequence

MTRKIFTNTRERWRQQNVNSAFAKLRKLIPTHPPDKKLSKNETLRLAMRYINFLVKVLGE
QSLQQTGVAAQGNILGLFPQGPHLPGLEDRTLLENYQVPSPGPSHHIP

Sequence length

108

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
LEUKEMIA, ACUTE LYMPHOBLASTIC	—	HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	19088038	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Associate	19088038	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	22058201	★★★★★ ★☆☆☆☆ Found in Text Mining only

TAL2 (TAL bHLH transcription factor 2)