Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6886
Gene name Gene Name - the full gene name approved by the HGNC.
TAL bHLH transcription factor 1, erythroid differentiation factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TAL1
Synonyms (NCBI Gene) Gene synonyms aliases
SCL, TCL5, bHLHa17, tal-1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p33
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT053370 hsa-miR-9-5p Microarray, qRT-PCR 23798388
MIRT054047 hsa-miR-223-3p ChIP-seq, Microarray, Western blot 23857984
MIRT054047 hsa-miR-223-3p ChIP-seq, Microarray, Western blot 23857984
MIRT054047 hsa-miR-223-3p ChIP-seq, Microarray, Western blot 23857984
MIRT665956 hsa-miR-3121-3p HITS-CLIP 23313552
Transcription factors
Transcription factor Regulation Reference
GATA1 Unknown 8058326
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000118 Component Histone deacetylase complex IDA 19497860
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000785 Component Chromatin IDA 20855495
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription regulatory region sequence-specific DNA binding ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
187040 11556 ENSG00000162367
Protein
UniProt ID P17542
Protein name T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5)
Protein function Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).
PDB 2YPA , 2YPB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00010 HLH 188 240 Helix-loop-helix DNA-binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Leukemic stem cell.
Sequence
MTERPPSEAARSDPQLEGRDAAEASMAPPHLVLLNGVAKETSRAAAAEPPVIELGARGGP
GGGPAGGGGAARDLKGRDAATAEARHRVPTTELCRPPGPAPAPAPASVTAELPGDGRMVQ
LSPPALAAPAAPGRALLYSLSQPLASLGSGFFGEPDAFPMFTTNNRVKRRPSPYEMEITD
GPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLA
KLLNDQEEEGTQRAKTGKDPVVGAGGGGGGGGGGAPPDDLLQDVLSPNSSCGSSLDGAAS
PDSYTEEPAPKHTARSLHPAMLPAADGAGPR
Sequence length 331
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    RUNX1 regulates transcription of genes involved in differentiation of HSCs
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lymphoblastic leukemia Childhood Acute Lymphoblastic Leukemia, L2 Acute Lymphoblastic Leukemia, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Precursor Cell Lymphoblastic Leukemia Lymphoma, Precursor T-cell acute lymphoblastic leukemia rs387906351, rs104894562, rs398122513, rs398122840, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699
View all (13 more)
24394663, 19246562
Unknown
Disease term Disease name Evidence References Source
Neuroticism Neuroticism GWAS
Mental Depression Mental Depression GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 28178989
Adenoma Islet Cell Associate 30575306
Ataxia Telangiectasia Associate 12086890, 16621969, 2040693, 22581002, 25615415, 36632736, 7678994, 9695959
Carcinogenesis Associate 21179004, 9819382
Carcinoma Hepatocellular Associate 31419443
COVID 19 Associate 36709793
Dehydrated Hereditary Stomatocytosis Pseudohyperkalemia and Perinatal Edema Associate 17389645
Diabetes Mellitus Type 2 Associate 35046895
Diarrhea Associate 34217275
Drug Hypersensitivity Associate 22982397