Gene Gene information from NCBI Gene database.
Entrez ID 6886
Gene name TAL bHLH transcription factor 1, erythroid differentiation factor
Gene symbol TAL1
Synonyms (NCBI Gene)
SCLTCL5bHLHa17tal-1
Chromosome 1
Chromosome location 1p33
miRNA miRNA information provided by mirtarbase database.
218
miRTarBase ID miRNA Experiments Reference
MIRT053370 hsa-miR-9-5p MicroarrayqRT-PCR 23798388
MIRT054047 hsa-miR-223-3p ChIP-seqMicroarrayWestern blot 23857984
MIRT054047 hsa-miR-223-3p ChIP-seqMicroarrayWestern blot 23857984
MIRT054047 hsa-miR-223-3p ChIP-seqMicroarrayWestern blot 23857984
MIRT665956 hsa-miR-3121-3p HITS-CLIP 23313552
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
GATA1 Unknown 8058326
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
73
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000785 Component Chromatin IDA 20855495
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription cis-regulatory region binding IEA
GO:0000976 Function Transcription cis-regulatory region binding ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
187040 11556 ENSG00000162367
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P17542
Protein name T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5)
Protein function Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).
PDB 2YPA , 2YPB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00010 HLH 188 240 Helix-loop-helix DNA-binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Leukemic stem cell.
Sequence
MTERPPSEAARSDPQLEGRDAAEASMAPPHLVLLNGVAKETSRAAAAEPPVIELGARGGP
GGGPAGGGGAARDLKGRDAATAEARHRVPTTELCRPPGPAPAPAPASVTAELPGDGRMVQ
LSPPALAAPAAPGRALLYSLSQPLASLGSGFFGEPDAFPMFTTNNRVKRRPSPYEMEITD
GPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLA
KLLNDQEEEGTQRAKTGKDPVVGAGGGGGGGGGGAPPDDLLQDVLSPNSSCGSSLDGAAS
PDSYTEEPAPKHTARSLHPAMLPAADGAGPR
Sequence length 331
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    RUNX1 regulates transcription of genes involved in differentiation of HSCs
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LEUKEMIA, ACUTE LYMPHOBLASTIC HPO
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma of Lung Associate 28178989
★☆☆☆☆
Found in Text Mining only
Adenoma Islet Cell Associate 30575306
★☆☆☆☆
Found in Text Mining only
Ataxia Telangiectasia Associate 12086890, 16621969, 2040693, 22581002, 25615415, 36632736, 7678994, 9695959
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 21179004, 9819382
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 31419443
★☆☆☆☆
Found in Text Mining only
COVID 19 Associate 36709793
★☆☆☆☆
Found in Text Mining only
Dehydrated Hereditary Stomatocytosis Pseudohyperkalemia and Perinatal Edema Associate 17389645
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Associate 35046895
★☆☆☆☆
Found in Text Mining only
Diarrhea Associate 34217275
★☆☆☆☆
Found in Text Mining only
Drug Hypersensitivity Associate 22982397
★☆☆☆☆
Found in Text Mining only