Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
688
Gene name Gene Name - the full gene name approved by the HGNC.
KLF transcription factor 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KLF5
Synonyms (NCBI Gene) Gene synonyms aliases
BTEB2, CKLF, IKLF
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001812 hsa-miR-141-3p Luciferase reporter assay 15131085
MIRT021472 hsa-miR-9-5p Microarray 17612493
MIRT001812 hsa-miR-141-3p Reporter assay;Other 15131085
MIRT022040 hsa-miR-128-3p Microarray 17612493
MIRT030940 hsa-miR-21-5p Microarray 18591254
Transcription factors
Transcription factor Regulation Reference
AR Unknown 19460858
SMURF2 Repression 21953463
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 16595680
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602903 6349 ENSG00000102554
Protein
UniProt ID Q13887
Protein name Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2)
Protein function Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.
PDB 2EBT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00096 zf-C2H2 373 397 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 403 427 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 433 455 Zinc finger, C2H2 type Domain
Tissue specificity TISSUE SPECIFICITY: Expressed only in testis and placenta.
Sequence
MATRVLSMSARLGPVPQPPAPQDEPVFAQLKPVLGAANPARDAALFPGEELKHAHHRPQA
QPAPAQAPQPAQPPATGPRLPPEDLVQTRCEMEKYLTPQLPPVPIIPEHKKYRRDSASVV
DQFFTDTEGLPYSINMNVFLPDITHLRTGLYKSQRPCVTHIKTEPVAIFSHQSETTAPPP
APTQALPEFTSIFSSHQTAAPEVNNIFIKQELPTPDLHLSVPTQQGHLYQLLNTPDLDMP
SSTNQTAAMDTLNVSMSAAMAGLNTHTSAVPQTAVKQFQGMPPCTYTMPSQFLPQQATYF
PPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNLPTTLPVNSQNIQPVRYN
RRSNPDLEKRRIHYCDYPGCTKVYTKSSHLKAHLRTHTGEKPYKCTWEGCDWRFARSDEL
TRHYRKH
TGAKPFQCGVCNRSFSRSDHLALHMKRHQN
Sequence length 457
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Chemical carcinogenesis - receptor activation  
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Dilated Cardiomyopathy Dilated cardiomyopathy 1FF rs2044646731 N/A
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Colorectal Cancer Colorectal cancer N/A N/A GWAS
Eczema Eczema N/A N/A GWAS
Keratoconus Keratoconus N/A N/A GWAS
Prostate cancer Prostate cancer N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 32880368, 33115806
Adenocarcinoma of Lung Associate 27158780, 35154481, 37181807
Anophthalmia with pulmonary hypoplasia Associate 38433576
Aortic Aneurysm Abdominal Associate 28912007
Atherosclerosis Stimulate 26992033
Barrett Esophagus Associate 32880368
Biliary Atresia Associate 40366121
Breast Neoplasms Associate 19411256, 19569049, 21674249, 23913682, 26079537, 26419610, 27117709, 31360115, 31467112, 35022570, 35342356, 37063424, 37997376
Breast Neoplasms Inhibit 21542805, 31640084
Carcinogenesis Associate 16223724, 16357509, 16595680, 18774944, 19671674, 20388706, 21542805, 23913682, 23975368, 24401325, 30770877, 31467112, 33827480