Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6877
Gene name	TATA-box binding protein associated factor 5
Gene symbol	TAF5
Synonyms (NCBI Gene)	TAF(II)100TAF2DTAFII-100TAFII100
Chromosome	10
Chromosome location	10q24.33
Summary	Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly,

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miRTarBase ID	miRNA	Experiments	Reference
MIRT027509	hsa-miR-98-5p	Microarray	19088304
MIRT030707	hsa-miR-21-5p	Microarray	18591254
MIRT052580	hsa-let-7a-5p	CLASH	23622248
MIRT051848	hsa-let-7c-5p	CLASH	23622248
MIRT1409512	hsa-let-7a	CLIP-seq
MIRT1409513	hsa-let-7b	CLIP-seq
MIRT1409514	hsa-let-7c	CLIP-seq
MIRT1409515	hsa-let-7d	CLIP-seq
MIRT1409516	hsa-let-7e	CLIP-seq
MIRT1409517	hsa-let-7f	CLIP-seq
MIRT1409518	hsa-let-7g	CLIP-seq
MIRT1409519	hsa-let-7i	CLIP-seq
MIRT1409520	hsa-miR-103a	CLIP-seq
MIRT1409521	hsa-miR-107	CLIP-seq
MIRT1409522	hsa-miR-1243	CLIP-seq
MIRT1409523	hsa-miR-1245b-3p	CLIP-seq
MIRT1409524	hsa-miR-127-5p	CLIP-seq
MIRT1409525	hsa-miR-1278	CLIP-seq
MIRT1409526	hsa-miR-1293	CLIP-seq
MIRT1409527	hsa-miR-1297	CLIP-seq
MIRT1409528	hsa-miR-1323	CLIP-seq
MIRT1409529	hsa-miR-15a	CLIP-seq
MIRT1409530	hsa-miR-15b	CLIP-seq
MIRT1409531	hsa-miR-16	CLIP-seq
MIRT1409532	hsa-miR-195	CLIP-seq
MIRT1409533	hsa-miR-202	CLIP-seq
MIRT1409534	hsa-miR-203	CLIP-seq
MIRT1409535	hsa-miR-204	CLIP-seq
MIRT1409536	hsa-miR-211	CLIP-seq
MIRT1409537	hsa-miR-2115	CLIP-seq
MIRT1409538	hsa-miR-223	CLIP-seq
MIRT1409539	hsa-miR-24	CLIP-seq
MIRT1409540	hsa-miR-26a	CLIP-seq
MIRT1409541	hsa-miR-26b	CLIP-seq
MIRT1409542	hsa-miR-297	CLIP-seq
MIRT1409543	hsa-miR-29a	CLIP-seq
MIRT1409544	hsa-miR-29b	CLIP-seq
MIRT1409545	hsa-miR-29c	CLIP-seq
MIRT1409546	hsa-miR-3120-5p	CLIP-seq
MIRT1409547	hsa-miR-3140-3p	CLIP-seq
MIRT1409548	hsa-miR-3149	CLIP-seq
MIRT1409549	hsa-miR-3164	CLIP-seq
MIRT1409550	hsa-miR-330-3p	CLIP-seq
MIRT1409551	hsa-miR-345	CLIP-seq
MIRT1409552	hsa-miR-34a	CLIP-seq
MIRT1409553	hsa-miR-34b	CLIP-seq
MIRT1409554	hsa-miR-34c-5p	CLIP-seq
MIRT1409555	hsa-miR-3654	CLIP-seq
MIRT1409556	hsa-miR-3668	CLIP-seq
MIRT1409557	hsa-miR-3682-3p	CLIP-seq
MIRT1409558	hsa-miR-3689d	CLIP-seq
MIRT1409559	hsa-miR-374c	CLIP-seq
MIRT1409560	hsa-miR-3942-3p	CLIP-seq
MIRT1409561	hsa-miR-410	CLIP-seq
MIRT1409562	hsa-miR-421	CLIP-seq
MIRT1409563	hsa-miR-424	CLIP-seq
MIRT1409564	hsa-miR-4287	CLIP-seq
MIRT1409565	hsa-miR-4420	CLIP-seq
MIRT1409566	hsa-miR-4427	CLIP-seq
MIRT1409567	hsa-miR-4458	CLIP-seq
MIRT1409568	hsa-miR-4465	CLIP-seq
MIRT1409569	hsa-miR-4469	CLIP-seq
MIRT1409570	hsa-miR-4474-5p	CLIP-seq
MIRT1409571	hsa-miR-4483	CLIP-seq
MIRT1409572	hsa-miR-449a	CLIP-seq
MIRT1409573	hsa-miR-449b	CLIP-seq
MIRT1409574	hsa-miR-4500	CLIP-seq
MIRT1409575	hsa-miR-4635	CLIP-seq
MIRT1409576	hsa-miR-4678	CLIP-seq
MIRT1409577	hsa-miR-4680-3p	CLIP-seq
MIRT1409578	hsa-miR-4685-3p	CLIP-seq
MIRT1409579	hsa-miR-4687-3p	CLIP-seq
MIRT1409580	hsa-miR-4697-3p	CLIP-seq
MIRT1409581	hsa-miR-4708-3p	CLIP-seq
MIRT1409582	hsa-miR-4709-5p	CLIP-seq
MIRT1409583	hsa-miR-4718	CLIP-seq
MIRT1409584	hsa-miR-4762-3p	CLIP-seq
MIRT1409585	hsa-miR-4797-3p	CLIP-seq
MIRT1409586	hsa-miR-4799-5p	CLIP-seq
MIRT1409587	hsa-miR-497	CLIP-seq
MIRT1409588	hsa-miR-548ac	CLIP-seq
MIRT1409589	hsa-miR-548ae	CLIP-seq
MIRT1409590	hsa-miR-548aj	CLIP-seq
MIRT1409591	hsa-miR-548am	CLIP-seq
MIRT1409592	hsa-miR-548d-3p	CLIP-seq
MIRT1409593	hsa-miR-548o	CLIP-seq
MIRT1409594	hsa-miR-548x	CLIP-seq
MIRT1409595	hsa-miR-548z	CLIP-seq
MIRT1409596	hsa-miR-567	CLIP-seq
MIRT1409597	hsa-miR-601	CLIP-seq
MIRT1409598	hsa-miR-617	CLIP-seq
MIRT1409599	hsa-miR-654-3p	CLIP-seq
MIRT1409600	hsa-miR-655	CLIP-seq
MIRT1409601	hsa-miR-767-5p	CLIP-seq
MIRT1409602	hsa-miR-944	CLIP-seq
MIRT1409603	hsa-miR-98	CLIP-seq
MIRT1409512	hsa-let-7a	CLIP-seq
MIRT1409513	hsa-let-7b	CLIP-seq
MIRT1409514	hsa-let-7c	CLIP-seq
MIRT1409515	hsa-let-7d	CLIP-seq
MIRT1409516	hsa-let-7e	CLIP-seq
MIRT1409517	hsa-let-7f	CLIP-seq
MIRT1409518	hsa-let-7g	CLIP-seq
MIRT1409519	hsa-let-7i	CLIP-seq
MIRT1409520	hsa-miR-103a	CLIP-seq
MIRT1409521	hsa-miR-107	CLIP-seq
MIRT2345181	hsa-miR-153	CLIP-seq
MIRT1409529	hsa-miR-15a	CLIP-seq
MIRT1409530	hsa-miR-15b	CLIP-seq
MIRT1409531	hsa-miR-16	CLIP-seq
MIRT1409532	hsa-miR-195	CLIP-seq
MIRT1409533	hsa-miR-202	CLIP-seq
MIRT2345182	hsa-miR-21	CLIP-seq
MIRT1409543	hsa-miR-29a	CLIP-seq
MIRT1409544	hsa-miR-29b	CLIP-seq
MIRT1409545	hsa-miR-29c	CLIP-seq
MIRT2345183	hsa-miR-3137	CLIP-seq
MIRT2345184	hsa-miR-3180-5p	CLIP-seq
MIRT1409550	hsa-miR-330-3p	CLIP-seq
MIRT1409553	hsa-miR-34b	CLIP-seq
MIRT2345185	hsa-miR-3692	CLIP-seq
MIRT1409563	hsa-miR-424	CLIP-seq
MIRT1409565	hsa-miR-4420	CLIP-seq
MIRT1409567	hsa-miR-4458	CLIP-seq
MIRT1409574	hsa-miR-4500	CLIP-seq
MIRT1409576	hsa-miR-4678	CLIP-seq
MIRT2345186	hsa-miR-494	CLIP-seq
MIRT1409587	hsa-miR-497	CLIP-seq
MIRT2345187	hsa-miR-520a-5p	CLIP-seq
MIRT2345188	hsa-miR-525-5p	CLIP-seq
MIRT2345189	hsa-miR-543	CLIP-seq
MIRT2345190	hsa-miR-590-5p	CLIP-seq
MIRT1409601	hsa-miR-767-5p	CLIP-seq
MIRT1409603	hsa-miR-98	CLIP-seq
MIRT2440886	hsa-miR-3143	CLIP-seq
MIRT2440887	hsa-miR-4658	CLIP-seq
MIRT2440888	hsa-miR-4729	CLIP-seq
MIRT2440889	hsa-miR-4758-5p	CLIP-seq
MIRT2440890	hsa-miR-4803	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	24289924
GO:0005515	Function	Protein binding	IPI	9045704, 15899866, 20953165, 33961781
GO:0005634	Component	Nucleus	EXP	23332750
GO:0005634	Component	Nucleus	IDA	15637059
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005669	Component	Transcription factor TFIID complex	IBA
GO:0005669	Component	Transcription factor TFIID complex	IDA	9045704, 14580349, 29111974
GO:0005669	Component	Transcription factor TFIID complex	IPI	23332750
GO:0005669	Component	Transcription factor TFIID complex	ISS
GO:0005730	Component	Nucleolus	IDA	15637059
GO:0006282	Process	Regulation of DNA repair	NAS	11406595
GO:0006352	Process	DNA-templated transcription initiation	IDA	9603525
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	9603525
GO:0006367	Process	Transcription initiation at RNA polymerase II promoter	IBA
GO:0006367	Process	Transcription initiation at RNA polymerase II promoter	IDA	9045704, 9603525
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016251	Function	RNA polymerase II general transcription initiation factor activity	IBA
GO:0016251	Function	RNA polymerase II general transcription initiation factor activity	IDA	9603525
GO:0016251	Function	RNA polymerase II general transcription initiation factor activity	IMP	9045704
GO:0033276	Component	Transcription factor TFTC complex	IDA	9603525, 10373431
GO:0033276	Component	Transcription factor TFTC complex	NAS	10373431
GO:0042789	Process	MRNA transcription by RNA polymerase II	IDA	17884155
GO:0042802	Function	Identical protein binding	IPI	17227857
GO:0045893	Process	Positive regulation of DNA-templated transcription	NAS	18206972
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	IPI	27007846
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	ISS
GO:0060261	Process	Positive regulation of transcription initiation by RNA polymerase II	IDA	17884155

MIM	HGNC	e!Ensembl
601787	11539	ENSG00000148835

Q15542

Protein name

Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100)

Protein function

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TAT

PDB

2NXP , 6F3T , 6MZC , 6MZD , 6MZL , 6MZM , 7EDX , 7EG7 , 7EG8 , 7EG9 , 7EGA , 7EGB , 7EGC , 7EGD , 7EGE , 7EGF , 7EGG , 7EGI , 7EGJ , 7ENA , 7ENC , 8GXQ , 8GXS , 8WAK , 8WAL , 8WAN , 8WAO , 8WAP , 8WAQ , 8WAR , 8WAS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04494	TFIID_NTD2	208 → 337	WD40 associated region in TFIID subunit, NTD2 domain	Family
PF00400	WD40	461 → 498	WD domain, G-beta repeat	Repeat
PF00400	WD40	533 → 571	WD domain, G-beta repeat	Repeat
PF00400	WD40	575 → 612	WD domain, G-beta repeat	Repeat
PF00400	WD40	617 → 655	WD domain, G-beta repeat	Repeat
PF00400	WD40	659 → 697	WD domain, G-beta repeat	Repeat
PF00400	WD40	701 → 739	WD domain, G-beta repeat	Repeat

Sequence

MAALAEEQTEVAVKLEPEGPPTLLPPQAGDGAGEGSGGTTNNGPNGGGGNVAASSSTGGD
GGTPKPTVAVSAAAPAGAAPVPAAAPDAGAPHDRQTLLAVLQFLRQSKLREAEEALRREA
GLLEEAVAGSGAPGEVDSAGAEVTSALLSRVTASAPGPAAPDPPGTGASGATVVSGSASG
PAAPGKVGSVAVEDQPDVSAVLSAYNQQGDPTMYEEYYSGLKHFIECSLDCHRAELSQLF
YPLFVHMYLELVYNQHENEAKSFFEKFHGDQECYYQDDLRVLSSLTKKEHMKGNETMLDF
RTSKFVLRISRDSYQLLKRHLQEKQNNQIWNIVQEHLYIDIFDGMPRSKQQIDAMVGSLA
GEAKREANKSKVFFGLLKEPEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPN
APPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTD
DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILY
GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYF
VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN
CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS
RDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPV
VHLHFTRRNLVLAAGAYSPQ

Sequence length

800

Interactions

View interactions

	KEGG		Reactome
	Basal transcription factors		RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

TAF5 (TATA-box binding protein associated factor 5)