Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6873
Gene name	TATA-box binding protein associated factor 2
Gene symbol	TAF2
Synonyms (NCBI Gene)	CIF150MRT40TAF2BTAFII150
Chromosome	8
Chromosome location	8q24.12
Summary	Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly,

Show/Hide all (2)

SNP ID	Visualize variation	Clinical significance	Consequence
rs398124645	A>G	Pathogenic	Coding sequence variant, missense variant
rs750451843	G>A,C	Likely-pathogenic	Missense variant, coding sequence variant

180

Show/Hide all (180)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025140	hsa-miR-181a-5p	Microarray	17612493
MIRT224088	hsa-miR-4803	HITS-CLIP	19536157
MIRT722012	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT722011	hsa-miR-3148	HITS-CLIP	19536157
MIRT722010	hsa-miR-1206	HITS-CLIP	19536157
MIRT722009	hsa-miR-6853-3p	HITS-CLIP	19536157
MIRT722008	hsa-miR-6844	HITS-CLIP	19536157
MIRT722007	hsa-miR-375	HITS-CLIP	19536157
MIRT722006	hsa-miR-6739-3p	HITS-CLIP	19536157
MIRT224088	hsa-miR-4803	HITS-CLIP	19536157
MIRT722012	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT722011	hsa-miR-3148	HITS-CLIP	19536157
MIRT722010	hsa-miR-1206	HITS-CLIP	19536157
MIRT722009	hsa-miR-6853-3p	HITS-CLIP	19536157
MIRT722008	hsa-miR-6844	HITS-CLIP	19536157
MIRT722007	hsa-miR-375	HITS-CLIP	19536157
MIRT722006	hsa-miR-6739-3p	HITS-CLIP	19536157
MIRT1409285	hsa-miR-105	CLIP-seq
MIRT1409286	hsa-miR-1183	CLIP-seq
MIRT1409287	hsa-miR-1244	CLIP-seq
MIRT1409288	hsa-miR-1270	CLIP-seq
MIRT1409289	hsa-miR-1271	CLIP-seq
MIRT1409290	hsa-miR-1273g	CLIP-seq
MIRT1409291	hsa-miR-1278	CLIP-seq
MIRT1409292	hsa-miR-1322	CLIP-seq
MIRT1409293	hsa-miR-140-3p	CLIP-seq
MIRT1409294	hsa-miR-140-5p	CLIP-seq
MIRT1409295	hsa-miR-144	CLIP-seq
MIRT1409296	hsa-miR-182	CLIP-seq
MIRT1409297	hsa-miR-199a-3p	CLIP-seq
MIRT1409298	hsa-miR-199b-3p	CLIP-seq
MIRT1409299	hsa-miR-2052	CLIP-seq
MIRT1409300	hsa-miR-2110	CLIP-seq
MIRT1409301	hsa-miR-27a	CLIP-seq
MIRT1409302	hsa-miR-27b	CLIP-seq
MIRT1409303	hsa-miR-300	CLIP-seq
MIRT1409304	hsa-miR-3129-5p	CLIP-seq
MIRT1409305	hsa-miR-3137	CLIP-seq
MIRT1409306	hsa-miR-3150a-3p	CLIP-seq
MIRT1409307	hsa-miR-3175	CLIP-seq
MIRT1409308	hsa-miR-3194-3p	CLIP-seq
MIRT1409309	hsa-miR-3199	CLIP-seq
MIRT1409310	hsa-miR-338-5p	CLIP-seq
MIRT1409311	hsa-miR-34a	CLIP-seq
MIRT1409312	hsa-miR-34c-5p	CLIP-seq
MIRT1409313	hsa-miR-3545-5p	CLIP-seq
MIRT1409314	hsa-miR-3646	CLIP-seq
MIRT1409315	hsa-miR-3686	CLIP-seq
MIRT1409316	hsa-miR-381	CLIP-seq
MIRT1409317	hsa-miR-3978	CLIP-seq
MIRT1409318	hsa-miR-4252	CLIP-seq
MIRT1409319	hsa-miR-4260	CLIP-seq
MIRT1409320	hsa-miR-4261	CLIP-seq
MIRT1409321	hsa-miR-4420	CLIP-seq
MIRT1409322	hsa-miR-4452	CLIP-seq
MIRT1409323	hsa-miR-4460	CLIP-seq
MIRT1409324	hsa-miR-449a	CLIP-seq
MIRT1409325	hsa-miR-449b	CLIP-seq
MIRT1409326	hsa-miR-4643	CLIP-seq
MIRT1409327	hsa-miR-4652-3p	CLIP-seq
MIRT1409328	hsa-miR-4652-5p	CLIP-seq
MIRT1409329	hsa-miR-466	CLIP-seq
MIRT1409330	hsa-miR-4666-3p	CLIP-seq
MIRT1409331	hsa-miR-4683	CLIP-seq
MIRT1409332	hsa-miR-4694-5p	CLIP-seq
MIRT1409333	hsa-miR-4717-3p	CLIP-seq
MIRT1409334	hsa-miR-4730	CLIP-seq
MIRT1409335	hsa-miR-4775	CLIP-seq
MIRT1409336	hsa-miR-4786-5p	CLIP-seq
MIRT1409337	hsa-miR-4789-3p	CLIP-seq
MIRT1409338	hsa-miR-4789-5p	CLIP-seq
MIRT1409339	hsa-miR-4802-3p	CLIP-seq
MIRT1409340	hsa-miR-511	CLIP-seq
MIRT1409341	hsa-miR-513a-5p	CLIP-seq
MIRT1409342	hsa-miR-522	CLIP-seq
MIRT1409343	hsa-miR-590-3p	CLIP-seq
MIRT1409344	hsa-miR-591	CLIP-seq
MIRT1409345	hsa-miR-620	CLIP-seq
MIRT1409346	hsa-miR-767-5p	CLIP-seq
MIRT1409347	hsa-miR-936	CLIP-seq
MIRT1409348	hsa-miR-939	CLIP-seq
MIRT1409349	hsa-miR-96	CLIP-seq
MIRT1409297	hsa-miR-199a-3p	CLIP-seq
MIRT1409298	hsa-miR-199b-3p	CLIP-seq
MIRT1409301	hsa-miR-27a	CLIP-seq
MIRT1409302	hsa-miR-27b	CLIP-seq
MIRT1409304	hsa-miR-3129-5p	CLIP-seq
MIRT2122746	hsa-miR-412	CLIP-seq
MIRT2122747	hsa-miR-4503	CLIP-seq
MIRT1409341	hsa-miR-513a-5p	CLIP-seq
MIRT2122748	hsa-miR-548p	CLIP-seq
MIRT1409347	hsa-miR-936	CLIP-seq
MIRT1409288	hsa-miR-1270	CLIP-seq
MIRT1409289	hsa-miR-1271	CLIP-seq
MIRT1409290	hsa-miR-1273g	CLIP-seq
MIRT2345126	hsa-miR-1283	CLIP-seq
MIRT2345127	hsa-miR-1288	CLIP-seq
MIRT2345128	hsa-miR-1297	CLIP-seq
MIRT2345129	hsa-miR-1303	CLIP-seq
MIRT1409293	hsa-miR-140-3p	CLIP-seq
MIRT1409294	hsa-miR-140-5p	CLIP-seq
MIRT2345130	hsa-miR-181a	CLIP-seq
MIRT2345131	hsa-miR-181b	CLIP-seq
MIRT2345132	hsa-miR-181c	CLIP-seq
MIRT2345133	hsa-miR-181d	CLIP-seq
MIRT1409296	hsa-miR-182	CLIP-seq
MIRT2345134	hsa-miR-26a	CLIP-seq
MIRT2345135	hsa-miR-26b	CLIP-seq
MIRT1409301	hsa-miR-27a	CLIP-seq
MIRT1409302	hsa-miR-27b	CLIP-seq
MIRT2345136	hsa-miR-3161	CLIP-seq
MIRT2345137	hsa-miR-3182	CLIP-seq
MIRT1409309	hsa-miR-3199	CLIP-seq
MIRT2345138	hsa-miR-3201	CLIP-seq
MIRT1409311	hsa-miR-34a	CLIP-seq
MIRT1409312	hsa-miR-34c-5p	CLIP-seq
MIRT1409313	hsa-miR-3545-5p	CLIP-seq
MIRT2345139	hsa-miR-3681	CLIP-seq
MIRT2345140	hsa-miR-374a	CLIP-seq
MIRT2345141	hsa-miR-374b	CLIP-seq
MIRT2345142	hsa-miR-3936	CLIP-seq
MIRT2345143	hsa-miR-3977	CLIP-seq
MIRT2122746	hsa-miR-412	CLIP-seq
MIRT2345144	hsa-miR-4262	CLIP-seq
MIRT2345145	hsa-miR-4263	CLIP-seq
MIRT1409323	hsa-miR-4460	CLIP-seq
MIRT2345146	hsa-miR-4465	CLIP-seq
MIRT1409324	hsa-miR-449a	CLIP-seq
MIRT1409325	hsa-miR-449b	CLIP-seq
MIRT2122747	hsa-miR-4503	CLIP-seq
MIRT1409328	hsa-miR-4652-5p	CLIP-seq
MIRT1409331	hsa-miR-4683	CLIP-seq
MIRT1409333	hsa-miR-4717-3p	CLIP-seq
MIRT2345147	hsa-miR-4791	CLIP-seq
MIRT1409339	hsa-miR-4802-3p	CLIP-seq
MIRT1409341	hsa-miR-513a-5p	CLIP-seq
MIRT2122748	hsa-miR-548p	CLIP-seq
MIRT2345148	hsa-miR-576-5p	CLIP-seq
MIRT1409345	hsa-miR-620	CLIP-seq
MIRT1409346	hsa-miR-767-5p	CLIP-seq
MIRT2345149	hsa-miR-877	CLIP-seq
MIRT1409349	hsa-miR-96	CLIP-seq
MIRT2345126	hsa-miR-1283	CLIP-seq
MIRT1409299	hsa-miR-2052	CLIP-seq
MIRT1409300	hsa-miR-2110	CLIP-seq
MIRT2638180	hsa-miR-3119	CLIP-seq
MIRT1409306	hsa-miR-3150a-3p	CLIP-seq
MIRT2638181	hsa-miR-3158-3p	CLIP-seq
MIRT1409307	hsa-miR-3175	CLIP-seq
MIRT1409308	hsa-miR-3194-3p	CLIP-seq
MIRT2345138	hsa-miR-3201	CLIP-seq
MIRT2638182	hsa-miR-3616-3p	CLIP-seq
MIRT2345139	hsa-miR-3681	CLIP-seq
MIRT2638183	hsa-miR-3685	CLIP-seq
MIRT2638184	hsa-miR-384	CLIP-seq
MIRT1409319	hsa-miR-4260	CLIP-seq
MIRT1409320	hsa-miR-4261	CLIP-seq
MIRT2638185	hsa-miR-4496	CLIP-seq
MIRT2638186	hsa-miR-4721	CLIP-seq
MIRT2345147	hsa-miR-4791	CLIP-seq
MIRT2638187	hsa-miR-488	CLIP-seq
MIRT1409348	hsa-miR-939	CLIP-seq
MIRT2345126	hsa-miR-1283	CLIP-seq
MIRT1409299	hsa-miR-2052	CLIP-seq
MIRT1409300	hsa-miR-2110	CLIP-seq
MIRT2638180	hsa-miR-3119	CLIP-seq
MIRT1409306	hsa-miR-3150a-3p	CLIP-seq
MIRT2638181	hsa-miR-3158-3p	CLIP-seq
MIRT1409307	hsa-miR-3175	CLIP-seq
MIRT1409308	hsa-miR-3194-3p	CLIP-seq
MIRT2345138	hsa-miR-3201	CLIP-seq
MIRT2638182	hsa-miR-3616-3p	CLIP-seq
MIRT2345139	hsa-miR-3681	CLIP-seq
MIRT1409319	hsa-miR-4260	CLIP-seq
MIRT1409320	hsa-miR-4261	CLIP-seq
MIRT2638185	hsa-miR-4496	CLIP-seq
MIRT2638186	hsa-miR-4721	CLIP-seq
MIRT2345147	hsa-miR-4791	CLIP-seq
MIRT2638187	hsa-miR-488	CLIP-seq
MIRT1409348	hsa-miR-939	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	IMP	10409744
GO:0000976	Function	Transcription cis-regulatory region binding	IBA
GO:0000976	Function	Transcription cis-regulatory region binding	IEA
GO:0000976	Function	Transcription cis-regulatory region binding	IMP	10409744
GO:0003682	Function	Chromatin binding	IBA
GO:0005515	Function	Protein binding	IPI	9418870, 32296183
GO:0005634	Component	Nucleus	EXP	23332750
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	TAS
GO:0005669	Component	Transcription factor TFIID complex	IBA
GO:0005669	Component	Transcription factor TFIID complex	IDA	9774672, 10409744, 14580349, 27007846, 29111974
GO:0005669	Component	Transcription factor TFIID complex	IEA
GO:0005669	Component	Transcription factor TFIID complex	IPI	23332750
GO:0005669	Component	Transcription factor TFIID complex	ISS
GO:0006282	Process	Regulation of DNA repair	NAS	11406595
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	9603525
GO:0006367	Process	Transcription initiation at RNA polymerase II promoter	IBA
GO:0006367	Process	Transcription initiation at RNA polymerase II promoter	IDA	9418870
GO:0006367	Process	Transcription initiation at RNA polymerase II promoter	IMP	10409744
GO:0016251	Function	RNA polymerase II general transcription initiation factor activity	IBA
GO:0016251	Function	RNA polymerase II general transcription initiation factor activity	IC	29111974
GO:0033276	Component	Transcription factor TFTC complex	IDA	10373431
GO:0033276	Component	Transcription factor TFTC complex	NAS	10373431
GO:0042789	Process	MRNA transcription by RNA polymerase II	IDA	17884155
GO:0045893	Process	Positive regulation of DNA-templated transcription	NAS	18206972
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	IEA
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	IPI	27007846
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	ISS
GO:0060261	Process	Positive regulation of transcription initiation by RNA polymerase II	IDA	17884155
GO:1901562	Process	Response to paraquat	IEA

MIM	HGNC	e!Ensembl
604912	11536	ENSG00000064313

Q6P1X5

Protein name

Transcription initiation factor TFIID subunit 2 (150 kDa cofactor of initiator function) (RNA polymerase II TBP-associated factor subunit B) (TBP-associated factor 150 kDa) (Transcription initiation factor TFIID 150 kDa subunit) (TAF(II)150) (TAFII-150) (

Protein function

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TAT

PDB

5FUR , 6MZC , 6MZL , 6MZM , 7EDX , 7EG7 , 7EG8 , 7EG9 , 7EGA , 7EGB , 7EGC , 7EGD , 7EGE , 7EGH , 7EGI , 7EGJ , 7ENA , 7ENC , 8GXQ , 8GXS , 8WAK , 8WAL , 8WAN , 8WAO , 8WAP , 8WAQ , 8WAR , 8WAS

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed in all tissues tested. {ECO:0000269|PubMed:9774672}.

Sequence

MPLTGVEPARMNRKKGDKGFESPRPYKLTHQVVCINNINFQRKSVVGFVELTIFPTVANL
NRIKLNSKQCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRNLNYFSNAYAAAVSAVDPD
AGNGELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVVPSVEGSMAERGAHVFSC
GYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNGDLVETVYTHDMRKKTFHYMLTI
PTAASNISLAIGPFEILVDPYMHEVTHFCLPQLLPLLKHTTSYLHEVFEFYEEILTCRYP
YSCFKTVFIDEAYVEVAAYASMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFIS
RMSWSDEWVLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTGGVLLHPIFGG
GKEKDNPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENRISMEFMLQVFNKLLSLA
STASSQKFQSHMWSQMLVSTSGFLKSISNVSGKDIQPLIKQWVDQSGVVKFYGSFAFNRK
RNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSFNHTLQIEENSLKHDIPCHSKSRRNK
KKKIPLMNGEEVDMDLSAMDADSPLLWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVV
AQQESILALEKFPTPASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMK
SLFTRMFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFILDLIK
YNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPDVRLILEEITRFLNME
KLLPSYRHTITVSCLRAIRVLQKNGHVPSDPALFKSYAEYGHFVDIRIAALEAVVDYTKV
DRSYEELQWLLNMIQNDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSG
TSHDWRLRCGAVDLYFTLFGLSRPSCLPLPELGLVLNLKEKKAVLNPTIIPESVAGNQEA
ANNPSSHPQLVGFQNPFSSSQDEEEIDMDTVHDSQAFISHHLNMLERPSTPGLSKYRPAS
SRSALIPQHSAGCDSTPTTKPQWSLELARKGTGKEQAPLEMSMHPAASAPLSVFTKESTA
SKHSDHHHHHHHEHKKKKKKHKHKHKHKHKHDSKEKDKEPFTFSSPASGRSIRSPSLSD

Sequence length

1199

Interactions

View interactions

	KEGG		Reactome
	Basal transcription factors		RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Microcephaly-thin corpus callosum-intellectual disability syndrome	Likely pathogenic; Pathogenic	rs2131063622, rs398124645	RCV001374390 RCV000077872

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign; Uncertain significance	rs61753749, rs542084457	RCV005921060 RCV005939240
Cervical cancer	Benign	rs61753749	RCV005921062
Colon adenocarcinoma	Benign	rs61753749	RCV005921059
Colorectal cancer	Benign	rs61753749	RCV005921064
Lung cancer	Benign	rs61753749	RCV005921070
Malignant lymphoma, large B-cell, diffuse	Benign	rs61753749	RCV005921063
Malignant tumor of esophagus	Benign	rs147577004, rs61753749	RCV005869671 RCV005921061
Melanoma	Benign	rs61753749	RCV005921069
Microcephaly	Uncertain significance	rs142223051	RCV001252786
Ovarian serous cystadenocarcinoma	Benign	rs61753749	RCV005921066
Sarcoma	Benign; Uncertain significance	rs61753749, rs746100564	RCV005921065 RCV005930477
TAF2-related disorder	Benign; Likely benign; Uncertain significance	rs956748, rs956749, rs1509348, rs191349554, rs61753749, rs370737151, rs767768594, rs866380056, rs770932636, rs1820015231, rs28619538, rs142223051	RCV003980622 RCV003980623 RCV003980624 RCV003913403 RCV003913569 RCV003943799 RCV003943715 RCV004757583 RCV003896506 RCV003904014 RCV003913225 RCV003898028
Thyroid cancer, nonmedullary, 1	Benign; Uncertain significance	rs61753749, rs137940227	RCV005921068 RCV005930497
Uterine carcinosarcoma	Benign	rs61753749	RCV005921067
Uterine corpus endometrial carcinoma	Benign	rs61753749	RCV005921071

TAF2 (TATA-box binding protein associated factor 2)