Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6865
Gene name Gene Name - the full gene name approved by the HGNC.	Tachykinin receptor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TACR2
Synonyms (NCBI Gene) Gene synonyms aliases	NK2R, NKNAR, SKR, TAC2R
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5`-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins an

Show/Hide all(94)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017841	hsa-miR-335-5p	Microarray	18185580
MIRT645579	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT645578	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT645576	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT645577	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT645575	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT645574	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT645573	hsa-miR-1976	HITS-CLIP	23824327
MIRT645572	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT645571	hsa-miR-4252	HITS-CLIP	23824327
MIRT645570	hsa-miR-1254	HITS-CLIP	23824327
MIRT645569	hsa-miR-3116	HITS-CLIP	23824327
MIRT645568	hsa-miR-661	HITS-CLIP	23824327
MIRT645567	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT645566	hsa-miR-7703	HITS-CLIP	23824327
MIRT569262	hsa-miR-4293	PAR-CLIP	20371350
MIRT569261	hsa-miR-1178-5p	PAR-CLIP	20371350
MIRT569260	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT569262	hsa-miR-4293	PAR-CLIP	20371350
MIRT569261	hsa-miR-1178-5p	PAR-CLIP	20371350
MIRT569260	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT645579	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT645578	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT645576	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT645577	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT645575	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT645574	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT645573	hsa-miR-1976	HITS-CLIP	23824327
MIRT645572	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT645571	hsa-miR-4252	HITS-CLIP	23824327
MIRT645570	hsa-miR-1254	HITS-CLIP	23824327
MIRT645569	hsa-miR-3116	HITS-CLIP	23824327
MIRT645568	hsa-miR-661	HITS-CLIP	23824327
MIRT645567	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT645566	hsa-miR-7703	HITS-CLIP	23824327
MIRT569262	hsa-miR-4293	PAR-CLIP	20371350
MIRT569261	hsa-miR-1178-5p	PAR-CLIP	20371350
MIRT569260	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT569262	hsa-miR-4293	PAR-CLIP	20371350
MIRT569261	hsa-miR-1178-5p	PAR-CLIP	20371350
MIRT569260	hsa-miR-6823-5p	PAR-CLIP	20371350
MIRT1408517	hsa-miR-1260	CLIP-seq
MIRT1408518	hsa-miR-1260b	CLIP-seq
MIRT1408519	hsa-miR-1273f	CLIP-seq
MIRT1408520	hsa-miR-1292	CLIP-seq
MIRT1408521	hsa-miR-1293	CLIP-seq
MIRT1408522	hsa-miR-141	CLIP-seq
MIRT1408523	hsa-miR-142-5p	CLIP-seq
MIRT1408524	hsa-miR-143	CLIP-seq
MIRT1408525	hsa-miR-150	CLIP-seq
MIRT1408526	hsa-miR-186	CLIP-seq
MIRT1408527	hsa-miR-188-3p	CLIP-seq
MIRT1408528	hsa-miR-200a	CLIP-seq
MIRT1408529	hsa-miR-24	CLIP-seq
MIRT1408530	hsa-miR-3122	CLIP-seq
MIRT1408531	hsa-miR-3133	CLIP-seq
MIRT1408532	hsa-miR-3155	CLIP-seq
MIRT1408533	hsa-miR-3155b	CLIP-seq
MIRT1408534	hsa-miR-3156-3p	CLIP-seq
MIRT1408535	hsa-miR-3162-3p	CLIP-seq
MIRT1408536	hsa-miR-3202	CLIP-seq
MIRT1408537	hsa-miR-340	CLIP-seq
MIRT1408538	hsa-miR-3909	CLIP-seq
MIRT1408539	hsa-miR-3910	CLIP-seq
MIRT1408540	hsa-miR-3913-5p	CLIP-seq
MIRT1408541	hsa-miR-3921	CLIP-seq
MIRT1408542	hsa-miR-4251	CLIP-seq
MIRT1408543	hsa-miR-4284	CLIP-seq
MIRT1408544	hsa-miR-4299	CLIP-seq
MIRT1408545	hsa-miR-4329	CLIP-seq
MIRT1408546	hsa-miR-4456	CLIP-seq
MIRT1408547	hsa-miR-4471	CLIP-seq
MIRT1408548	hsa-miR-4483	CLIP-seq
MIRT1408549	hsa-miR-4493	CLIP-seq
MIRT1408550	hsa-miR-4533	CLIP-seq
MIRT1408551	hsa-miR-4653-5p	CLIP-seq
MIRT1408552	hsa-miR-4708-5p	CLIP-seq
MIRT1408553	hsa-miR-4770	CLIP-seq
MIRT1408554	hsa-miR-484	CLIP-seq
MIRT1408555	hsa-miR-548q	CLIP-seq
MIRT1408556	hsa-miR-554	CLIP-seq
MIRT1408557	hsa-miR-583	CLIP-seq
MIRT2344965	hsa-miR-3125	CLIP-seq
MIRT2344966	hsa-miR-3916	CLIP-seq
MIRT2344967	hsa-miR-4311	CLIP-seq
MIRT2344968	hsa-miR-4710	CLIP-seq
MIRT2344969	hsa-miR-4717-3p	CLIP-seq
MIRT2344970	hsa-miR-4792	CLIP-seq
MIRT1408523	hsa-miR-142-5p	CLIP-seq
MIRT1408526	hsa-miR-186	CLIP-seq
MIRT1408531	hsa-miR-3133	CLIP-seq
MIRT1408537	hsa-miR-340	CLIP-seq
MIRT2461057	hsa-miR-3672	CLIP-seq
MIRT1408557	hsa-miR-583	CLIP-seq

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004995	Function	Tachykinin receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	12716968, 23597562
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	2173708
GO:0006936	Process	Muscle contraction	TAS	2173708
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007217	Process	Tachykinin receptor signaling pathway	TAS	8307161
GO:0007588	Process	Excretion	TAS	10862829
GO:0014057	Process	Positive regulation of acetylcholine secretion, neurotransmission	IEA
GO:0014827	Process	Intestine smooth muscle contraction	IEA
GO:0016497	Function	Substance K receptor activity	IBA	21873635
GO:0033685	Process	Negative regulation of luteinizing hormone secretion	IEA
GO:0035106	Process	Operant conditioning	IEA
GO:0036126	Component	Sperm flagellum	IDA	17437961
GO:0043117	Process	Positive regulation of vascular permeability	IEA
GO:0051602	Process	Response to electrical stimulus	IEA
GO:0061827	Component	Sperm head	IDA	17437961
GO:0070459	Process	Prolactin secretion	IEA
GO:0070474	Process	Positive regulation of uterine smooth muscle contraction	IEA
GO:0097225	Component	Sperm midpiece	IBA	21873635
GO:0097225	Component	Sperm midpiece	IDA	17437961
GO:1902093	Process	Positive regulation of flagellated sperm motility	IBA	21873635
GO:1902093	Process	Positive regulation of flagellated sperm motility	IMP	17437961

MIM	HGNC	e!Ensembl
162321	11527	ENSG00000075073

Protein

UniProt ID

P21452

Protein name

Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2)

Protein function

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is:

PDB

7XWO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	50 → 307	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI

Sequence length

398

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway Neuroactive ligand-receptor interaction		Tachykinin receptors bind tachykinins G alpha (q) signalling events

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining
Colitis Ulcerative	Associate	11073811
Cough	Associate	16893949, 35509099
Crohn Disease	Stimulate	11073811
Cystitis Interstitial	Inhibit	20008142
Inflammation	Associate	11073811
Inflammatory Bowel Diseases	Associate	11073811
Leiomyoma	Associate	27456549
Leukemia Lymphoma Adult T Cell	Associate	34446027
Paraparesis Tropical Spastic	Associate	34446027

TACR2 (tachykinin receptor 2)