Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6854
Gene name Gene Name - the full gene name approved by the HGNC.	Synapsin II
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SYN2
Synonyms (NCBI Gene) Gene synonyms aliases	SYNII
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p25.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptog

Show/Hide all(66)

miRTarBase ID	miRNA	Experiments
MIRT1405397	hsa-miR-1	CLIP-seq
MIRT1405398	hsa-miR-206	CLIP-seq
MIRT1405399	hsa-miR-3121-3p	CLIP-seq
MIRT1405400	hsa-miR-3190	CLIP-seq
MIRT1405401	hsa-miR-3202	CLIP-seq
MIRT1405402	hsa-miR-4495	CLIP-seq
MIRT1405403	hsa-miR-4533	CLIP-seq
MIRT1405404	hsa-miR-548c-3p	CLIP-seq
MIRT1405405	hsa-miR-613	CLIP-seq
MIRT1405406	hsa-miR-105	CLIP-seq
MIRT1405407	hsa-miR-1285	CLIP-seq
MIRT1405408	hsa-miR-133a	CLIP-seq
MIRT1405409	hsa-miR-133b	CLIP-seq
MIRT1405410	hsa-miR-2278	CLIP-seq
MIRT1405411	hsa-miR-3150a-3p	CLIP-seq
MIRT1405412	hsa-miR-3150b-3p	CLIP-seq
MIRT1405413	hsa-miR-3175	CLIP-seq
MIRT1405414	hsa-miR-3187-5p	CLIP-seq
MIRT1405415	hsa-miR-323b-5p	CLIP-seq
MIRT1405416	hsa-miR-329	CLIP-seq
MIRT1405417	hsa-miR-362-3p	CLIP-seq
MIRT1405418	hsa-miR-3689d	CLIP-seq
MIRT1405419	hsa-miR-378g	CLIP-seq
MIRT1405420	hsa-miR-3936	CLIP-seq
MIRT1405421	hsa-miR-431	CLIP-seq
MIRT1405422	hsa-miR-4314	CLIP-seq
MIRT1405423	hsa-miR-432	CLIP-seq
MIRT1405424	hsa-miR-4420	CLIP-seq
MIRT1405425	hsa-miR-4443	CLIP-seq
MIRT1405426	hsa-miR-4486	CLIP-seq
MIRT1405427	hsa-miR-4667-5p	CLIP-seq
MIRT1405428	hsa-miR-4700-5p	CLIP-seq
MIRT1405429	hsa-miR-4784	CLIP-seq
MIRT1405430	hsa-miR-522	CLIP-seq
MIRT1405431	hsa-miR-612	CLIP-seq
MIRT1405432	hsa-miR-657	CLIP-seq
MIRT1405433	hsa-miR-765	CLIP-seq
MIRT1405434	hsa-miR-939	CLIP-seq
MIRT1405410	hsa-miR-2278	CLIP-seq
MIRT2121600	hsa-miR-25	CLIP-seq
MIRT2121601	hsa-miR-3163	CLIP-seq
MIRT2121602	hsa-miR-32	CLIP-seq
MIRT2121603	hsa-miR-335	CLIP-seq
MIRT2121604	hsa-miR-34a	CLIP-seq
MIRT2121605	hsa-miR-34c-5p	CLIP-seq
MIRT2121606	hsa-miR-363	CLIP-seq
MIRT2121607	hsa-miR-367	CLIP-seq
MIRT2121608	hsa-miR-4468	CLIP-seq
MIRT2121609	hsa-miR-449a	CLIP-seq
MIRT2121610	hsa-miR-449b	CLIP-seq
MIRT2121611	hsa-miR-4731-3p	CLIP-seq
MIRT2121612	hsa-miR-4801	CLIP-seq
MIRT2121613	hsa-miR-92a	CLIP-seq
MIRT2121614	hsa-miR-92b	CLIP-seq
MIRT2343636	hsa-miR-1292	CLIP-seq
MIRT2343637	hsa-miR-3122	CLIP-seq
MIRT2343638	hsa-miR-3913-5p	CLIP-seq
MIRT2343639	hsa-miR-4471	CLIP-seq
MIRT1405412	hsa-miR-3150b-3p	CLIP-seq
MIRT1405423	hsa-miR-432	CLIP-seq
MIRT1405424	hsa-miR-4420	CLIP-seq
MIRT1405425	hsa-miR-4443	CLIP-seq
MIRT1405427	hsa-miR-4667-5p	CLIP-seq
MIRT1405428	hsa-miR-4700-5p	CLIP-seq
MIRT1405429	hsa-miR-4784	CLIP-seq
MIRT1405433	hsa-miR-765	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
EGR1	Unknown	7592648
ETV4	Unknown	7592648

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23406870, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005524	Function	ATP binding	TAS	15217342
GO:0005886	Component	Plasma membrane	IEA
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0007268	Process	Chemical synaptic transmission	TAS	8964517
GO:0007269	Process	Neurotransmitter secretion	IEA
GO:0007269	Process	Neurotransmitter secretion	IEA
GO:0007269	Process	Neurotransmitter secretion	ISS
GO:0008021	Component	Synaptic vesicle	IEA
GO:0014069	Component	Postsynaptic density	IEA
GO:0017156	Process	Calcium-ion regulated exocytosis	IEA
GO:0030672	Component	Synaptic vesicle membrane	IBA
GO:0030672	Component	Synaptic vesicle membrane	IEA
GO:0030672	Component	Synaptic vesicle membrane	ISS
GO:0031201	Component	SNARE complex	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0045202	Component	Synapse	IEA
GO:0045202	Component	Synapse	ISS
GO:0050808	Process	Synapse organization	IBA
GO:0097091	Process	Synaptic vesicle clustering	IBA
GO:0097091	Process	Synaptic vesicle clustering	IEA
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099504	Process	Synaptic vesicle cycle	IEA

MIM	HGNC	e!Ensembl
600755	11495	ENSG00000157152

Protein

UniProt ID

Q92777

Protein name

Synapsin-2 (Synapsin II)

Protein function

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity). {ECO:0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10581	Synapsin_N	2 → 39	Synapsin N-terminal	Domain
PF02078	Synapsin	111 → 212	Synapsin, N-terminal domain	Domain
PF02750	Synapsin_C	214 → 416	Synapsin, ATP binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Central and peripheral nervous systems.

Sequence

MMNFLRRRLSDSSFIANLPNGYMTDLQRPEPQQPPPPPPPGPGAASASAAPPTASPGPER
RPPPASAPAPQPAPTPSVGSSFFSSLSQAVKQTAASAGLVDAPAPAPAAARKAKVLLVVD
EPHADWAKCFRGKKVLGDYDIKVEQAEFSELNLVAHADGTYAVDMQVLRNGTKVVRSFRP
DFVLIRQHAFGMAENEDFRHLIIGMQYAGLPSINSLESIYNFCDKPWVFAQLVAIYKTLG
GEKFPLIEQTYYPNHKEMLTLPTFPVVVKIGHAHSGMGKVKVENHYDFQDIASVVALTQT
YATAEPFIDSKYDIRVQKIGNNYKAYMRTSISGNWKTNTGSAMLEQIAMSDRYKLWVDTC
SEMFGGLDICAVKAVHGKDGKDYIFEVMDCSMPLIGEHQVEDRQLITELVISKMNQLLSR
TPALSPQRPLTTQQPQSGTLKDPDSSKTPPQRPPPQGGPGQPQGMQPPGKVLPPRRLPPG
PSLPPSSSSSSSSSSSAPQRPGGPTTHGDAPSSSSSLAEAQPPLAAPPQKPQPHPQLNKS
QSLTNAFSFSESSFFRSSANEDEAKAETIRSLRKSFASLFSD

Sequence length

582

Interactions

View interactions

	Reactome
			Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle

Show/Hide Unknown Diseases (6)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Acne	acne vulgaris	N/A	N/A	GWAS
Diabetes	Type 2 diabetes, Circulating leptin levels or type 2 diabetes, Diabetic kidney disease in type 2 diabetes (ESRD vs. no ESRD), Type 2 diabetes or prostate cancer (pleiotropy)	N/A	N/A	GWAS
Hypothyroidism	Hypothyroidism	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Neuroticism	Neuroticism	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (14)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	39650656
Bipolar Disorder	Associate	22384280, 27515700
Bone Diseases Metabolic	Associate	29763751
COVID 19	Associate	34299101
Depressive Disorder Major	Associate	27515700
Diabetes Mellitus Type 2	Associate	21084393, 32948839
Epilepsy	Associate	22571925
Mental Disorders	Associate	22571925
Mood Disorders	Associate	27515700
Mucocutaneous Lymph Node Syndrome	Associate	37894766
Multiple Sclerosis	Inhibit	36992419
Obesity	Associate	32948839
Osteoporosis	Associate	29763751
Schizophrenia	Associate	22571925, 23529008

SYN2 (synapsin II)