SYCP1 (synaptonemal complex protein 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6847
Gene name Gene Name - the full gene name approved by the HGNC.
Synaptonemal complex protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SYCP1
Synonyms (NCBI Gene) Gene synonyms aliases
CT8, HOM-TES-14, SCP-1, SCP1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.2
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(9)
miRTarBase ID miRNA Experiments Reference
MIRT054241 hsa-miR-124-3p Flow cytometry, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot 23548312
MIRT054241 hsa-miR-124-3p Luciferase reporter assay 23313552
MIRT438804 hsa-miR-96-5p Luciferase reporter assay 23313552
MIRT054241 hsa-miR-124-3p Luciferase reporter assay 23313552
MIRT438804 hsa-miR-96-5p Luciferase reporter assay 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(38)
GO ID Ontology Definition Evidence Reference
GO:0000711 Process Meiotic DNA repair synthesis IBA
GO:0000711 Process Meiotic DNA repair synthesis IEA
GO:0000775 Component Chromosome, centromeric region IEA
GO:0000794 Component Condensed nuclear chromosome IEA
GO:0000795 Component Synaptonemal complex IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
602162 11487 ENSG00000198765
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q15431
Protein name Synaptonemal complex protein 1 (SCP-1) (Cancer/testis antigen 8) (CT8)
Protein function Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centrome
PDB 4YTO , 6F5X , 6F62 , 6F63 , 6F64
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05483 SCP-1 28 → 792 Synaptonemal complex protein 1 (SCP-1) Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Testis. {ECO:0000269|PubMed:9371398}.
Sequence 
MEKQKPFALFVPPRSSSSQVSAVKPQTLGGDSTFFKSFNKCTEDDFEFPFAKTNLSKNGE
NIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWK
VSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATR
HLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMH
FKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE
EKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKE
TQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELE
EMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHD
LEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLE
LKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEEN
CNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEI
TDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQ
YDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKRE
AKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLW
TSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDL
LSMVSEEETLKTLYRNNNPPASHLCVKTPKKAPSSLTTPGSTLKFGAIRKMREDRWAVIA
KMDRKKKLKEAEKLFV
Sequence length 976
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Mycotic Aneurysm, Intracranial mycotic aneurysm, intracranial N/A N/A ClinVar
Show/Hide Text Mining Associations (22)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 11531257
Carcinoma Renal Cell Associate 9560255
Colorectal Neoplasms Associate 15756003, 39208330
general anxiety disorder Associate 36344488
Glioma Associate 9560255
Hereditary Breast and Ovarian Cancer Syndrome Associate 9560255
Infertility Associate 18706547
Intracranial Aneurysm Associate 35228681
Leukemia Lymphocytic Chronic B Cell Associate 10584877
Leukemia Myeloid Acute Associate 21898529