XCL2 (X-C motif chemokine ligand 2)

Gene

• Entrez ID: 6846
• Gene name: X-C motif chemokine ligand 2
• Gene symbol: XCL2
• Synonyms (NCBI Gene): SCM-1b, SCM1B, SCYC2
• Chromosome: 1
• Chromosome location: 1q24.2

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 28381538, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0006954	Process	Inflammatory response	IBA
GO:0006955	Process	Immune response	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	7875320
GO:0008009	Function	Chemokine activity	IBA
GO:0008009	Function	Chemokine activity	IEA
GO:0008009	Function	Chemokine activity	TAS	7875320
GO:0008015	Process	Blood circulation	TAS	7875320
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0048020	Function	CCR chemokine receptor binding	IBA
GO:0060326	Process	Cell chemotaxis	IBA
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IBA
GO:0070098	Process	Chemokine-mediated signaling pathway	IBA

Other IDs

• MIM: 604828
• HGNC: 10646
• e!Ensembl: ENSG00000143185

Protein

• UniProt ID: Q9UBD3
• Protein name: Cytokine SCM-1 beta (C motif chemokine 2) (XC chemokine ligand 2)
• Protein function: Chemotactic activity for lymphocytes but not for monocytes or neutrophils.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00048	IL8	30 → 84	Small cytokines (intecrine/chemokine), interleukin-8 like	Domain

• Sequence:

  MRLLILALLGICSLTAYIVEGVGSEVSHRRTCVSLTTQRLPVSRIKTYTITEGSLRAVIF
  ITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG

• Sequence length: 114

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Chemokine signaling pathway

Reactome:

Chemokine receptors bind chemokines
G alpha (q) signalling events

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BASAL CELL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BELL'S PALSY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DRY EYE SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR POSITIVE BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LYMPHOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Breast Neoplasms	Associate	24172169, 36046784	★☆☆☆☆ Found in Text Mining only
Bronchiectasis	Inhibit	40536885	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Associate	27156946	★☆☆☆☆ Found in Text Mining only
Melanoma	Associate	37305390	★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Associate	31983065	★☆☆☆☆ Found in Text Mining only
Microsatellite Instability	Associate	37905956	★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	27156946	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	31801909, 37305390	★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	37905956	★☆☆☆☆ Found in Text Mining only
Neuralgia	Associate	34741226	★☆☆☆☆ Found in Text Mining only
Obesity	Associate	27919438	★☆☆☆☆ Found in Text Mining only
Pemphigoid Benign Mucous Membrane	Associate	37690517	★☆☆☆☆ Found in Text Mining only
Renal Insufficiency	Associate	37690517	★☆☆☆☆ Found in Text Mining only
Tooth Loss	Associate	37690517	★☆☆☆☆ Found in Text Mining only