SURF6 (surfeit 6)

Gene

• Entrez ID: 6838
• Gene name: Surfeit 6
• Gene symbol: SURF6
• Synonyms (NCBI Gene): RRP14
• Chromosome: 9
• Chromosome location: 9q34.2
• Summary: This gene encodes a conserved protein that is localized to the nucleolus. The encoded protein may function as a nucleolar-matrix protein with nucleic acid-binding properties. There is a pseudogene for this gene on chromosome Y. Alternative splicing result

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049761	hsa-miR-92a-3p	CLASH	23622248
MIRT047474	hsa-miR-10b-5p	CLASH	23622248
MIRT040736	hsa-miR-92b-3p	CLASH	23622248
MIRT717424	hsa-miR-622	HITS-CLIP	19536157
MIRT717423	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT717422	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT717421	hsa-miR-6859-3p	HITS-CLIP	19536157
MIRT717420	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT717419	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT717418	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT645768	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT645767	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT645766	hsa-miR-6784-3p	HITS-CLIP	23824327
MIRT645765	hsa-miR-6862-3p	HITS-CLIP	23824327
MIRT645764	hsa-miR-4469	HITS-CLIP	23824327
MIRT645762	hsa-miR-4287	HITS-CLIP	23824327
MIRT645763	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT645761	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT645760	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT645759	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT645758	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT569301	hsa-miR-3654	PAR-CLIP	20371350
MIRT569302	hsa-miR-181a-2-3p	PAR-CLIP	20371350
MIRT569300	hsa-miR-1273g-3p	PAR-CLIP	20371350
MIRT569299	hsa-miR-6719-3p	PAR-CLIP	20371350
MIRT569298	hsa-miR-4680-5p	PAR-CLIP	20371350
MIRT569297	hsa-miR-6861-3p	PAR-CLIP	20371350
MIRT569296	hsa-miR-492	PAR-CLIP	20371350
MIRT569295	hsa-miR-659-5p	PAR-CLIP	20371350
MIRT569294	hsa-miR-6509-3p	PAR-CLIP	20371350
MIRT569293	hsa-miR-7158-3p	PAR-CLIP	20371350
MIRT569292	hsa-miR-203b-3p	PAR-CLIP	20371350
MIRT569291	hsa-miR-4535	PAR-CLIP	20371350
MIRT569301	hsa-miR-3654	PAR-CLIP	20371350
MIRT569302	hsa-miR-181a-2-3p	PAR-CLIP	20371350
MIRT569300	hsa-miR-1273g-3p	PAR-CLIP	20371350
MIRT569299	hsa-miR-6719-3p	PAR-CLIP	20371350
MIRT569298	hsa-miR-4680-5p	PAR-CLIP	20371350
MIRT569297	hsa-miR-6861-3p	PAR-CLIP	20371350
MIRT569296	hsa-miR-492	PAR-CLIP	20371350
MIRT569295	hsa-miR-659-5p	PAR-CLIP	20371350
MIRT569294	hsa-miR-6509-3p	PAR-CLIP	20371350
MIRT569293	hsa-miR-7158-3p	PAR-CLIP	20371350
MIRT569292	hsa-miR-203b-3p	PAR-CLIP	20371350
MIRT569291	hsa-miR-4535	PAR-CLIP	20371350
MIRT528473	hsa-miR-552-3p	PAR-CLIP	22012620
MIRT528472	hsa-miR-6504-3p	PAR-CLIP	22012620
MIRT528471	hsa-miR-6778-3p	PAR-CLIP	22012620
MIRT528470	hsa-miR-5095	PAR-CLIP	22012620
MIRT528469	hsa-miR-7151-3p	PAR-CLIP	22012620
MIRT528468	hsa-miR-619-5p	PAR-CLIP	22012620
MIRT455941	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT455942	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT455940	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT455939	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT455938	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT455937	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT455935	hsa-miR-4784	PAR-CLIP	23592263
MIRT455936	hsa-miR-1827	PAR-CLIP	23592263
MIRT455934	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT717424	hsa-miR-622	HITS-CLIP	19536157
MIRT717423	hsa-miR-877-3p	HITS-CLIP	19536157
MIRT717422	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT717421	hsa-miR-6859-3p	HITS-CLIP	19536157
MIRT717420	hsa-miR-2682-3p	HITS-CLIP	19536157
MIRT717419	hsa-miR-6781-3p	HITS-CLIP	19536157
MIRT717418	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT645768	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT645767	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT645766	hsa-miR-6784-3p	HITS-CLIP	23824327
MIRT645765	hsa-miR-6862-3p	HITS-CLIP	23824327
MIRT645764	hsa-miR-4469	HITS-CLIP	23824327
MIRT645762	hsa-miR-4287	HITS-CLIP	23824327
MIRT645763	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT645761	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT645760	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT645759	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT645758	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT569301	hsa-miR-3654	PAR-CLIP	20371350
MIRT569302	hsa-miR-181a-2-3p	PAR-CLIP	20371350
MIRT569300	hsa-miR-1273g-3p	PAR-CLIP	20371350
MIRT569299	hsa-miR-6719-3p	PAR-CLIP	20371350
MIRT569298	hsa-miR-4680-5p	PAR-CLIP	20371350
MIRT569297	hsa-miR-6861-3p	PAR-CLIP	20371350
MIRT569296	hsa-miR-492	PAR-CLIP	20371350
MIRT569295	hsa-miR-659-5p	PAR-CLIP	20371350
MIRT569294	hsa-miR-6509-3p	PAR-CLIP	20371350
MIRT569293	hsa-miR-7158-3p	PAR-CLIP	20371350
MIRT569292	hsa-miR-203b-3p	PAR-CLIP	20371350
MIRT569291	hsa-miR-4535	PAR-CLIP	20371350
MIRT569301	hsa-miR-3654	PAR-CLIP	20371350
MIRT569302	hsa-miR-181a-2-3p	PAR-CLIP	20371350
MIRT569300	hsa-miR-1273g-3p	PAR-CLIP	20371350
MIRT569299	hsa-miR-6719-3p	PAR-CLIP	20371350
MIRT569298	hsa-miR-4680-5p	PAR-CLIP	20371350
MIRT569297	hsa-miR-6861-3p	PAR-CLIP	20371350
MIRT569296	hsa-miR-492	PAR-CLIP	20371350
MIRT569295	hsa-miR-659-5p	PAR-CLIP	20371350
MIRT569294	hsa-miR-6509-3p	PAR-CLIP	20371350
MIRT569293	hsa-miR-7158-3p	PAR-CLIP	20371350
MIRT569292	hsa-miR-203b-3p	PAR-CLIP	20371350
MIRT569291	hsa-miR-4535	PAR-CLIP	20371350
MIRT528473	hsa-miR-552-3p	PAR-CLIP	22012620
MIRT528472	hsa-miR-6504-3p	PAR-CLIP	22012620
MIRT528471	hsa-miR-6778-3p	PAR-CLIP	22012620
MIRT528470	hsa-miR-5095	PAR-CLIP	22012620
MIRT528469	hsa-miR-7151-3p	PAR-CLIP	22012620
MIRT528468	hsa-miR-619-5p	PAR-CLIP	22012620
MIRT455941	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT455942	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT455940	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT455939	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT455938	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT455937	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT455935	hsa-miR-4784	PAR-CLIP	23592263
MIRT455936	hsa-miR-1827	PAR-CLIP	23592263
MIRT455934	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT1403871	hsa-miR-1226	CLIP-seq
MIRT1403872	hsa-miR-1228	CLIP-seq
MIRT1403873	hsa-miR-1231	CLIP-seq
MIRT1403874	hsa-miR-132	CLIP-seq
MIRT1403875	hsa-miR-134	CLIP-seq
MIRT1403876	hsa-miR-194	CLIP-seq
MIRT1403877	hsa-miR-203	CLIP-seq
MIRT1403878	hsa-miR-208a	CLIP-seq
MIRT1403879	hsa-miR-208b	CLIP-seq
MIRT1403880	hsa-miR-212	CLIP-seq
MIRT1403881	hsa-miR-2682	CLIP-seq
MIRT1403882	hsa-miR-3118	CLIP-seq
MIRT1403883	hsa-miR-3119	CLIP-seq
MIRT1403884	hsa-miR-3120-5p	CLIP-seq
MIRT1403885	hsa-miR-3152-5p	CLIP-seq
MIRT1403886	hsa-miR-3160-3p	CLIP-seq
MIRT1403887	hsa-miR-34a	CLIP-seq
MIRT1403888	hsa-miR-34c-5p	CLIP-seq
MIRT1403889	hsa-miR-4252	CLIP-seq
MIRT1403890	hsa-miR-4282	CLIP-seq
MIRT1403891	hsa-miR-4423-5p	CLIP-seq
MIRT1403892	hsa-miR-4432	CLIP-seq
MIRT1403893	hsa-miR-4487	CLIP-seq
MIRT1403894	hsa-miR-4490	CLIP-seq
MIRT1403895	hsa-miR-449a	CLIP-seq
MIRT1403896	hsa-miR-449b	CLIP-seq
MIRT1403897	hsa-miR-449c	CLIP-seq
MIRT1403898	hsa-miR-4514	CLIP-seq
MIRT1403899	hsa-miR-4692	CLIP-seq
MIRT1403900	hsa-miR-4704-3p	CLIP-seq
MIRT1403901	hsa-miR-4754	CLIP-seq
MIRT1403902	hsa-miR-4774-5p	CLIP-seq
MIRT1403903	hsa-miR-4792	CLIP-seq
MIRT1403904	hsa-miR-499-5p	CLIP-seq
MIRT1403905	hsa-miR-502-5p	CLIP-seq
MIRT1403906	hsa-miR-558	CLIP-seq
MIRT1403872	hsa-miR-1228	CLIP-seq
MIRT2121174	hsa-miR-1254	CLIP-seq
MIRT2121175	hsa-miR-1290	CLIP-seq
MIRT2121176	hsa-miR-3116	CLIP-seq
MIRT2121177	hsa-miR-3167	CLIP-seq
MIRT2121178	hsa-miR-4782-5p	CLIP-seq
MIRT2121179	hsa-miR-661	CLIP-seq
MIRT2121180	hsa-miR-876-5p	CLIP-seq
MIRT2343076	hsa-miR-1178	CLIP-seq
MIRT1403872	hsa-miR-1228	CLIP-seq
MIRT2343077	hsa-miR-1270	CLIP-seq
MIRT2343078	hsa-miR-1302	CLIP-seq
MIRT2343079	hsa-miR-1305	CLIP-seq
MIRT2343080	hsa-miR-1343	CLIP-seq
MIRT2343081	hsa-miR-1825	CLIP-seq
MIRT2343082	hsa-miR-1913	CLIP-seq
MIRT2343083	hsa-miR-214	CLIP-seq
MIRT2343084	hsa-miR-29a	CLIP-seq
MIRT2343085	hsa-miR-29b	CLIP-seq
MIRT2343086	hsa-miR-29c	CLIP-seq
MIRT1403884	hsa-miR-3120-5p	CLIP-seq
MIRT2343087	hsa-miR-3189-5p	CLIP-seq
MIRT2343088	hsa-miR-324-3p	CLIP-seq
MIRT2343089	hsa-miR-3619-5p	CLIP-seq
MIRT2343090	hsa-miR-3622a-3p	CLIP-seq
MIRT2343091	hsa-miR-3622b-3p	CLIP-seq
MIRT2343092	hsa-miR-3663-3p	CLIP-seq
MIRT2343093	hsa-miR-4257	CLIP-seq
MIRT1403890	hsa-miR-4282	CLIP-seq
MIRT2343094	hsa-miR-4291	CLIP-seq
MIRT2343095	hsa-miR-4298	CLIP-seq
MIRT2343096	hsa-miR-4497	CLIP-seq
MIRT2343097	hsa-miR-452	CLIP-seq
MIRT2343098	hsa-miR-4676-3p	CLIP-seq
MIRT2343099	hsa-miR-4683	CLIP-seq
MIRT2343100	hsa-miR-4714-3p	CLIP-seq
MIRT2343101	hsa-miR-4717-3p	CLIP-seq
MIRT2343102	hsa-miR-4727-5p	CLIP-seq
MIRT2343103	hsa-miR-4755-3p	CLIP-seq
MIRT2343104	hsa-miR-4758-3p	CLIP-seq
MIRT2343105	hsa-miR-4793-3p	CLIP-seq
MIRT2343106	hsa-miR-501-3p	CLIP-seq
MIRT2343107	hsa-miR-502-3p	CLIP-seq
MIRT2343108	hsa-miR-512-5p	CLIP-seq
MIRT2343109	hsa-miR-582-5p	CLIP-seq
MIRT2343110	hsa-miR-620	CLIP-seq
MIRT2343111	hsa-miR-761	CLIP-seq
MIRT2343112	hsa-miR-764	CLIP-seq
MIRT2343113	hsa-miR-767-5p	CLIP-seq
MIRT2343114	hsa-miR-922	CLIP-seq
MIRT2343115	hsa-miR-935	CLIP-seq
MIRT1403871	hsa-miR-1226	CLIP-seq
MIRT1403872	hsa-miR-1228	CLIP-seq
MIRT1403874	hsa-miR-132	CLIP-seq
MIRT1403876	hsa-miR-194	CLIP-seq
MIRT1403880	hsa-miR-212	CLIP-seq
MIRT1403884	hsa-miR-3120-5p	CLIP-seq
MIRT1403894	hsa-miR-4490	CLIP-seq
MIRT1403900	hsa-miR-4704-3p	CLIP-seq
MIRT1403902	hsa-miR-4774-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001652	Component	Granular component	IEA
GO:0001652	Component	Granular component	ISS
GO:0003677	Function	DNA binding	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	ISS
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	ISS
GO:0003723	Function	RNA binding	TAS	10675619
GO:0005515	Function	Protein binding	IPI	22113938, 27705803, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005730	Component	Nucleolus	TAS	10675619
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042273	Process	Ribosomal large subunit biogenesis	IBA
GO:0042274	Process	Ribosomal small subunit biogenesis	IBA
GO:0140693	Function	Molecular condensate scaffold activity	IDA	30498217

Other IDs

• MIM: 185642
• HGNC: 11478
• e!Ensembl: ENSG00000148296

Protein

• UniProt ID: O75683
• Protein name: Surfeit locus protein 6
• Protein function: Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity).
• PDB: 8FKP, 8FKQ, 8FKR, 8FKS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04935	SURF6	139 → 341	Surfeit locus protein 6	Family

• Sequence:

  MASLLAKDAYLQSLAKKICSHSAPEQQARTRAGKTQGSETAGPPKKKRKKTQKKFRKREE
  KAAEHKAKSLGEKSPAASGARRPEAAKEEAAWASSSAGNPADGLATEPESVFALDVLRQR
  LHEKIQEARGQGSAKELSPAALEKRRRRKQERDRKKRKRKELRAKEKARKAEEATEAQEV
  VEATPEGACTEPREPPGLIFNKVEVSEDEPASKAQRRKEKRQRVKGNLTPLTGRNYRQLL
  ERLQARQSRLDELRGQDEGKAQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRR
  AQRQRRWEKRTAGVVEKMQQRQDRRRQNLRRKKAARAERRLLRARKKGRILPQDLERAGL
  V

• Sequence length: 361

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Breast Neoplasms	Associate	37309009	★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Associate	25134534	★☆☆☆☆ Found in Text Mining only