SUPV3L1 (Suv3 like RNA helicase)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6832
Gene name Gene Name - the full gene name approved by the HGNC.
Suv3 like RNA helicase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SUPV3L1
Synonyms (NCBI Gene) Gene synonyms aliases
SUV3
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q22.1
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(4)
miRTarBase ID miRNA Experiments Reference
MIRT027436 hsa-miR-98-5p Microarray 19088304
MIRT046569 hsa-miR-200b-3p CLASH 23622248
MIRT046174 hsa-miR-27b-3p CLASH 23622248
MIRT044646 hsa-miR-320a CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(33)
GO ID Ontology Definition Evidence Reference
GO:0000958 Process Mitochondrial mRNA catabolic process IMP 19864255
GO:0000962 Process Positive regulation of mitochondrial RNA catabolic process IDA 19509288, 29967381
GO:0000962 Process Positive regulation of mitochondrial RNA catabolic process IMP 19864255
GO:0000965 Process Mitochondrial RNA 3'-end processing IBA 21873635
GO:0000965 Process Mitochondrial RNA 3'-end processing IMP 19864255
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
605122 11471 ENSG00000156502
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q8IYB8
Protein name ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) (Suppressor of var1 3-like protein 1) (SUV3-like protein 1)
Protein function Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradati
PDB 3RC3 , 3RC8 , 7W1R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18114 Suv3_N 62 → 179 Suv3 helical N-terminal domain Domain
PF00271 Helicase_C 352 → 475 Helicase conserved C-terminal domain Family
PF18147 Suv3_C_1 556 → 598 Suv3 C-terminal domain 1 Domain
PF12513 SUV3_C 625 → 672 Mitochondrial degradasome RNA helicase subunit C terminal Family
Tissue specificity TISSUE SPECIFICITY: Broadly expressed. {ECO:0000269|PubMed:10453991}.
Sequence 
MSFSRALLWARLPAGRQAGHRAAICSALRPHFGPFPGVLGQVSVLATASSSASGGSKIPN
TSLFVPLTVKPQGPSADGDVGAELTRPLDKNEVKKVLDKFYKRKEIQKLGADYGLDARLF
HQAFISFRNYIMQSHSLDVDIHIVLNDICFGAAHADDLFPFFLRHAKQIFPVLDCKDDLR
KISDLRIPPNWYPDARAMQRKIIFHSGPTNSGKTYHAIQKYFSAKSGVYCGPLKLLAHEI
FEKSNAAGVPCDLVTGEERVTVQPNGKQASHVSCTVEMCSVTTPYEVAVIDEIQMIRDPA
RGWAWTRALLGLCAEEVHLCGEPAAIDLVMELMYTTGEEVEVRDYKRLTPISVLDHALES
LDNLRPGDCIVCFSKNDIYSVSRQIEIRGLESAVIYGSLPPGTKLAQAKKFNDPNDPCKI
LVATDAIGMGLNLSIRRIIFYSLIKPSINEKGERELEPITTSQALQIAGRAGRFSSRFKE
GEVTTMNHEDLSLLKEILKRPVDPIRAAGLHPTAEQIEMFAYHLPDATLSNLIDIFVDFS
QVDGQYFVCNMDDFKFSAELIQHIPLSLRVRYVFCTAPINKKQPFVCSSLLQFARQYSRN
EPLTFAWLRRYIKWPLLPPKNIKDLMDLEAVHDVLDLYLWLSYRFMDMFPDASLIRDLQK
ELDGIIQDGVHNITKLIKMSETHKLLNLEGFPSGSQSRLSGTLKSQARRTRGTKALGSKA
TEPPSPDAGELSLASRLVQQGLLTPDMLKQLEKEWMTQQTEHNKEKTESGTHPKGTRRKK
KEPDSD
Sequence length 786
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Ichthyosis Ichthyoses rs199766569, rs587776996, rs587777262, rs863223405, rs370031870, rs1569044747, rs200806519 19145458
Show/Hide Text Mining Associations (24)
Associations from Text Mining
Disease Name Relationship Type References
Ataxia Associate 39596606
Autoimmune Diseases Associate 35023579
Calcinosis Associate 35023579
Cognition Disorders Associate 39596606
Congenital Abnormalities Associate 35023579
Epithelial Recurrent Erosion Dystrophy Associate 35023579
Fetal Growth Retardation Associate 35023579
Gait Ataxia Associate 39596606
Heredodegenerative Disorders Nervous System Associate 35023579
Hypopigmentation Associate 35023579, 39596606