SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit)

Gene

• Entrez ID: 6827
• Gene name: SPT4 homolog, DSIF elongation factor subunit
• Gene symbol: SUPT4H1
• Synonyms (NCBI Gene): SPT4, SPT4H, SUPT4H, Supt4a
• Chromosome: 17
• Chromosome location: 17q22
• Summary: This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized t

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025924	hsa-miR-7-5p	Microarray	19073608
MIRT027878	hsa-miR-96-5p	Sequencing	20371350
MIRT051537	hsa-let-7e-5p	CLASH	23622248
MIRT1403533	hsa-miR-1206	CLIP-seq
MIRT1403534	hsa-miR-1207-3p	CLIP-seq
MIRT1403535	hsa-miR-124	CLIP-seq
MIRT1403536	hsa-miR-1253	CLIP-seq
MIRT1403537	hsa-miR-1303	CLIP-seq
MIRT1403538	hsa-miR-132	CLIP-seq
MIRT1403539	hsa-miR-1909	CLIP-seq
MIRT1403540	hsa-miR-200b	CLIP-seq
MIRT1403541	hsa-miR-200c	CLIP-seq
MIRT1403542	hsa-miR-2110	CLIP-seq
MIRT1403543	hsa-miR-212	CLIP-seq
MIRT1403544	hsa-miR-219-2-3p	CLIP-seq
MIRT1403545	hsa-miR-23a	CLIP-seq
MIRT1403546	hsa-miR-23b	CLIP-seq
MIRT1403547	hsa-miR-23c	CLIP-seq
MIRT1403548	hsa-miR-2964a-3p	CLIP-seq
MIRT1403549	hsa-miR-3121-3p	CLIP-seq
MIRT1403550	hsa-miR-3162-5p	CLIP-seq
MIRT1403551	hsa-miR-3167	CLIP-seq
MIRT1403552	hsa-miR-3180-5p	CLIP-seq
MIRT1403553	hsa-miR-3189-3p	CLIP-seq
MIRT1403554	hsa-miR-3616-5p	CLIP-seq
MIRT1403555	hsa-miR-3622b-5p	CLIP-seq
MIRT1403556	hsa-miR-3647-5p	CLIP-seq
MIRT1403557	hsa-miR-3661	CLIP-seq
MIRT1403558	hsa-miR-369-3p	CLIP-seq
MIRT1403559	hsa-miR-374a	CLIP-seq
MIRT1403560	hsa-miR-374b	CLIP-seq
MIRT1403561	hsa-miR-410	CLIP-seq
MIRT1403562	hsa-miR-421	CLIP-seq
MIRT1403563	hsa-miR-4271	CLIP-seq
MIRT1403564	hsa-miR-429	CLIP-seq
MIRT1403565	hsa-miR-4310	CLIP-seq
MIRT1403566	hsa-miR-4419a	CLIP-seq
MIRT1403567	hsa-miR-4427	CLIP-seq
MIRT1403568	hsa-miR-4443	CLIP-seq
MIRT1403569	hsa-miR-4450	CLIP-seq
MIRT1403570	hsa-miR-4476	CLIP-seq
MIRT1403571	hsa-miR-4477a	CLIP-seq
MIRT1403572	hsa-miR-4496	CLIP-seq
MIRT1403573	hsa-miR-4510	CLIP-seq
MIRT1403574	hsa-miR-4640-5p	CLIP-seq
MIRT1403575	hsa-miR-4642	CLIP-seq
MIRT1403576	hsa-miR-4652-3p	CLIP-seq
MIRT1403577	hsa-miR-4670-3p	CLIP-seq
MIRT1403578	hsa-miR-4680-3p	CLIP-seq
MIRT1403579	hsa-miR-4698	CLIP-seq
MIRT1403580	hsa-miR-4709-3p	CLIP-seq
MIRT1403581	hsa-miR-4709-5p	CLIP-seq
MIRT1403582	hsa-miR-4725-3p	CLIP-seq
MIRT1403583	hsa-miR-4726-5p	CLIP-seq
MIRT1403584	hsa-miR-4728-5p	CLIP-seq
MIRT1403585	hsa-miR-4729	CLIP-seq
MIRT1403586	hsa-miR-4747-5p	CLIP-seq
MIRT1403587	hsa-miR-4775	CLIP-seq
MIRT1403588	hsa-miR-506	CLIP-seq
MIRT1403589	hsa-miR-5096	CLIP-seq
MIRT1403590	hsa-miR-520a-5p	CLIP-seq
MIRT1403591	hsa-miR-525-5p	CLIP-seq
MIRT1403592	hsa-miR-548ag	CLIP-seq
MIRT1403593	hsa-miR-548ai	CLIP-seq
MIRT1403594	hsa-miR-573	CLIP-seq
MIRT1403595	hsa-miR-579	CLIP-seq
MIRT1403596	hsa-miR-590-3p	CLIP-seq
MIRT1403597	hsa-miR-627	CLIP-seq
MIRT1403598	hsa-miR-631	CLIP-seq
MIRT1403599	hsa-miR-876-5p	CLIP-seq
MIRT1403600	hsa-miR-877	CLIP-seq
MIRT1403601	hsa-miR-924	CLIP-seq
MIRT1403602	hsa-miR-944	CLIP-seq
MIRT1554321	hsa-miR-1283	CLIP-seq
MIRT1403570	hsa-miR-4476	CLIP-seq
MIRT1554322	hsa-miR-4705	CLIP-seq
MIRT1403534	hsa-miR-1207-3p	CLIP-seq
MIRT2120974	hsa-miR-1207-5p	CLIP-seq
MIRT2120975	hsa-miR-1224-3p	CLIP-seq
MIRT2120976	hsa-miR-1227	CLIP-seq
MIRT2120977	hsa-miR-1260	CLIP-seq
MIRT2120978	hsa-miR-1260b	CLIP-seq
MIRT2120979	hsa-miR-1280	CLIP-seq
MIRT1403544	hsa-miR-219-2-3p	CLIP-seq
MIRT1403548	hsa-miR-2964a-3p	CLIP-seq
MIRT2120980	hsa-miR-298	CLIP-seq
MIRT2120981	hsa-miR-300	CLIP-seq
MIRT2120982	hsa-miR-30a	CLIP-seq
MIRT2120983	hsa-miR-30b	CLIP-seq
MIRT2120984	hsa-miR-30c	CLIP-seq
MIRT2120985	hsa-miR-30d	CLIP-seq
MIRT2120986	hsa-miR-30e	CLIP-seq
MIRT2120987	hsa-miR-3163	CLIP-seq
MIRT2120988	hsa-miR-3616-3p	CLIP-seq
MIRT2120989	hsa-miR-3662	CLIP-seq
MIRT2120990	hsa-miR-381	CLIP-seq
MIRT1403567	hsa-miR-4427	CLIP-seq
MIRT2120991	hsa-miR-4436b-3p	CLIP-seq
MIRT1403568	hsa-miR-4443	CLIP-seq
MIRT2120992	hsa-miR-4514	CLIP-seq
MIRT1403578	hsa-miR-4680-3p	CLIP-seq
MIRT2120993	hsa-miR-4692	CLIP-seq
MIRT1403586	hsa-miR-4747-5p	CLIP-seq
MIRT2120994	hsa-miR-4755-3p	CLIP-seq
MIRT2120995	hsa-miR-4763-3p	CLIP-seq
MIRT2120996	hsa-miR-516a-5p	CLIP-seq
MIRT2120997	hsa-miR-532-3p	CLIP-seq
MIRT2120998	hsa-miR-577	CLIP-seq
MIRT2120999	hsa-miR-595	CLIP-seq
MIRT1403597	hsa-miR-627	CLIP-seq
MIRT1403601	hsa-miR-924	CLIP-seq
MIRT2121000	hsa-miR-940	CLIP-seq
MIRT2342968	hsa-let-7a	CLIP-seq
MIRT2342969	hsa-let-7b	CLIP-seq
MIRT2342970	hsa-let-7c	CLIP-seq
MIRT2342971	hsa-let-7d	CLIP-seq
MIRT2342972	hsa-let-7e	CLIP-seq
MIRT2342973	hsa-let-7f	CLIP-seq
MIRT2342974	hsa-let-7g	CLIP-seq
MIRT2342975	hsa-let-7i	CLIP-seq
MIRT2342976	hsa-miR-1200	CLIP-seq
MIRT1403534	hsa-miR-1207-3p	CLIP-seq
MIRT2120974	hsa-miR-1207-5p	CLIP-seq
MIRT2120976	hsa-miR-1227	CLIP-seq
MIRT1403535	hsa-miR-124	CLIP-seq
MIRT1554321	hsa-miR-1283	CLIP-seq
MIRT1403538	hsa-miR-132	CLIP-seq
MIRT2342977	hsa-miR-192	CLIP-seq
MIRT1403540	hsa-miR-200b	CLIP-seq
MIRT1403541	hsa-miR-200c	CLIP-seq
MIRT2342978	hsa-miR-202	CLIP-seq
MIRT1403542	hsa-miR-2110	CLIP-seq
MIRT1403543	hsa-miR-212	CLIP-seq
MIRT2342979	hsa-miR-215	CLIP-seq
MIRT1403544	hsa-miR-219-2-3p	CLIP-seq
MIRT1403545	hsa-miR-23a	CLIP-seq
MIRT1403546	hsa-miR-23b	CLIP-seq
MIRT1403547	hsa-miR-23c	CLIP-seq
MIRT1403548	hsa-miR-2964a-3p	CLIP-seq
MIRT2120982	hsa-miR-30a	CLIP-seq
MIRT2120983	hsa-miR-30b	CLIP-seq
MIRT2120984	hsa-miR-30c	CLIP-seq
MIRT2120985	hsa-miR-30d	CLIP-seq
MIRT2120986	hsa-miR-30e	CLIP-seq
MIRT2342980	hsa-miR-3154	CLIP-seq
MIRT1403551	hsa-miR-3167	CLIP-seq
MIRT1403553	hsa-miR-3189-3p	CLIP-seq
MIRT2342981	hsa-miR-335	CLIP-seq
MIRT1403555	hsa-miR-3622b-5p	CLIP-seq
MIRT1403558	hsa-miR-369-3p	CLIP-seq
MIRT1403559	hsa-miR-374a	CLIP-seq
MIRT1403560	hsa-miR-374b	CLIP-seq
MIRT1403561	hsa-miR-410	CLIP-seq
MIRT1403562	hsa-miR-421	CLIP-seq
MIRT1403563	hsa-miR-4271	CLIP-seq
MIRT1403564	hsa-miR-429	CLIP-seq
MIRT2342982	hsa-miR-4324	CLIP-seq
MIRT1403566	hsa-miR-4419a	CLIP-seq
MIRT1403567	hsa-miR-4427	CLIP-seq
MIRT1403568	hsa-miR-4443	CLIP-seq
MIRT2342983	hsa-miR-4458	CLIP-seq
MIRT1403570	hsa-miR-4476	CLIP-seq
MIRT1403571	hsa-miR-4477a	CLIP-seq
MIRT2342984	hsa-miR-4500	CLIP-seq
MIRT1403573	hsa-miR-4510	CLIP-seq
MIRT2120992	hsa-miR-4514	CLIP-seq
MIRT1403575	hsa-miR-4642	CLIP-seq
MIRT2342985	hsa-miR-4659a-3p	CLIP-seq
MIRT2342986	hsa-miR-4659b-3p	CLIP-seq
MIRT1403578	hsa-miR-4680-3p	CLIP-seq
MIRT2120993	hsa-miR-4692	CLIP-seq
MIRT1554322	hsa-miR-4705	CLIP-seq
MIRT1403581	hsa-miR-4709-5p	CLIP-seq
MIRT1403582	hsa-miR-4725-3p	CLIP-seq
MIRT1403586	hsa-miR-4747-5p	CLIP-seq
MIRT2342987	hsa-miR-4753-3p	CLIP-seq
MIRT2120994	hsa-miR-4755-3p	CLIP-seq
MIRT2120995	hsa-miR-4763-3p	CLIP-seq
MIRT1403587	hsa-miR-4775	CLIP-seq
MIRT2342988	hsa-miR-489	CLIP-seq
MIRT1403588	hsa-miR-506	CLIP-seq
MIRT1403589	hsa-miR-5096	CLIP-seq
MIRT2342989	hsa-miR-544b	CLIP-seq
MIRT2342990	hsa-miR-548l	CLIP-seq
MIRT2342991	hsa-miR-548n	CLIP-seq
MIRT1403596	hsa-miR-590-3p	CLIP-seq
MIRT1403597	hsa-miR-627	CLIP-seq
MIRT1403599	hsa-miR-876-5p	CLIP-seq
MIRT1403601	hsa-miR-924	CLIP-seq
MIRT2121000	hsa-miR-940	CLIP-seq
MIRT2342992	hsa-miR-98	CLIP-seq
MIRT1554321	hsa-miR-1283	CLIP-seq
MIRT1403545	hsa-miR-23a	CLIP-seq
MIRT1403546	hsa-miR-23b	CLIP-seq
MIRT1403547	hsa-miR-23c	CLIP-seq
MIRT1554322	hsa-miR-4705	CLIP-seq
MIRT1403589	hsa-miR-5096	CLIP-seq
MIRT1403536	hsa-miR-1253	CLIP-seq
MIRT1554321	hsa-miR-1283	CLIP-seq
MIRT2636901	hsa-miR-1321	CLIP-seq
MIRT2636902	hsa-miR-1470	CLIP-seq
MIRT1403539	hsa-miR-1909	CLIP-seq
MIRT2636903	hsa-miR-193a-3p	CLIP-seq
MIRT2636904	hsa-miR-193b	CLIP-seq
MIRT2636905	hsa-miR-2116	CLIP-seq
MIRT2636906	hsa-miR-3065-3p	CLIP-seq
MIRT1403549	hsa-miR-3121-3p	CLIP-seq
MIRT2636907	hsa-miR-3123	CLIP-seq
MIRT2342980	hsa-miR-3154	CLIP-seq
MIRT1403551	hsa-miR-3167	CLIP-seq
MIRT2636908	hsa-miR-3170	CLIP-seq
MIRT2636909	hsa-miR-3176	CLIP-seq
MIRT2636910	hsa-miR-3192	CLIP-seq
MIRT2636911	hsa-miR-3194-3p	CLIP-seq
MIRT2636912	hsa-miR-326	CLIP-seq
MIRT2636913	hsa-miR-330-5p	CLIP-seq
MIRT2342981	hsa-miR-335	CLIP-seq
MIRT2636914	hsa-miR-3612	CLIP-seq
MIRT2636915	hsa-miR-3664-3p	CLIP-seq
MIRT2636916	hsa-miR-3665	CLIP-seq
MIRT2636917	hsa-miR-3672	CLIP-seq
MIRT2636918	hsa-miR-3714	CLIP-seq
MIRT2636919	hsa-miR-3918	CLIP-seq
MIRT2636920	hsa-miR-3922-3p	CLIP-seq
MIRT2636921	hsa-miR-3929	CLIP-seq
MIRT2636922	hsa-miR-3934	CLIP-seq
MIRT2636923	hsa-miR-4314	CLIP-seq
MIRT2636924	hsa-miR-4318	CLIP-seq
MIRT2636925	hsa-miR-4329	CLIP-seq
MIRT1403566	hsa-miR-4419a	CLIP-seq
MIRT2636926	hsa-miR-4419b	CLIP-seq
MIRT2120991	hsa-miR-4436b-3p	CLIP-seq
MIRT2636927	hsa-miR-4463	CLIP-seq
MIRT1403570	hsa-miR-4476	CLIP-seq
MIRT1403571	hsa-miR-4477a	CLIP-seq
MIRT2636928	hsa-miR-4478	CLIP-seq
MIRT1403573	hsa-miR-4510	CLIP-seq
MIRT2636929	hsa-miR-4512	CLIP-seq
MIRT2636930	hsa-miR-4646-5p	CLIP-seq
MIRT2342985	hsa-miR-4659a-3p	CLIP-seq
MIRT2342986	hsa-miR-4659b-3p	CLIP-seq
MIRT2636931	hsa-miR-4685-5p	CLIP-seq
MIRT2636932	hsa-miR-4693-5p	CLIP-seq
MIRT2636933	hsa-miR-4708-3p	CLIP-seq
MIRT1403580	hsa-miR-4709-3p	CLIP-seq
MIRT1403584	hsa-miR-4728-5p	CLIP-seq
MIRT2636934	hsa-miR-4733-3p	CLIP-seq
MIRT2636935	hsa-miR-4736	CLIP-seq
MIRT2636936	hsa-miR-4739	CLIP-seq
MIRT1403586	hsa-miR-4747-5p	CLIP-seq
MIRT2636937	hsa-miR-4756-5p	CLIP-seq
MIRT2636938	hsa-miR-4757-5p	CLIP-seq
MIRT2636939	hsa-miR-4761-3p	CLIP-seq
MIRT2636940	hsa-miR-4782-5p	CLIP-seq
MIRT2636941	hsa-miR-485-5p	CLIP-seq
MIRT2120996	hsa-miR-516a-5p	CLIP-seq
MIRT2636942	hsa-miR-520d-5p	CLIP-seq
MIRT2636943	hsa-miR-524-5p	CLIP-seq
MIRT1403592	hsa-miR-548ag	CLIP-seq
MIRT1403593	hsa-miR-548ai	CLIP-seq
MIRT2636944	hsa-miR-550a	CLIP-seq
MIRT2636945	hsa-miR-650	CLIP-seq
MIRT2636946	hsa-miR-7	CLIP-seq
MIRT1403599	hsa-miR-876-5p	CLIP-seq
MIRT2636947	hsa-miR-892a	CLIP-seq
MIRT2121000	hsa-miR-940	CLIP-seq
MIRT1403602	hsa-miR-944	CLIP-seq
MIRT1403536	hsa-miR-1253	CLIP-seq
MIRT1554321	hsa-miR-1283	CLIP-seq
MIRT2636901	hsa-miR-1321	CLIP-seq
MIRT2636902	hsa-miR-1470	CLIP-seq
MIRT1403539	hsa-miR-1909	CLIP-seq
MIRT2636903	hsa-miR-193a-3p	CLIP-seq
MIRT2636904	hsa-miR-193b	CLIP-seq
MIRT2636905	hsa-miR-2116	CLIP-seq
MIRT2636906	hsa-miR-3065-3p	CLIP-seq
MIRT1403549	hsa-miR-3121-3p	CLIP-seq
MIRT2636907	hsa-miR-3123	CLIP-seq
MIRT2342980	hsa-miR-3154	CLIP-seq
MIRT1403551	hsa-miR-3167	CLIP-seq
MIRT2636908	hsa-miR-3170	CLIP-seq
MIRT2636909	hsa-miR-3176	CLIP-seq
MIRT2636910	hsa-miR-3192	CLIP-seq
MIRT2636911	hsa-miR-3194-3p	CLIP-seq
MIRT2636912	hsa-miR-326	CLIP-seq
MIRT2636913	hsa-miR-330-5p	CLIP-seq
MIRT2342981	hsa-miR-335	CLIP-seq
MIRT2636914	hsa-miR-3612	CLIP-seq
MIRT2636915	hsa-miR-3664-3p	CLIP-seq
MIRT2636916	hsa-miR-3665	CLIP-seq
MIRT2636917	hsa-miR-3672	CLIP-seq
MIRT2636918	hsa-miR-3714	CLIP-seq
MIRT2636919	hsa-miR-3918	CLIP-seq
MIRT2636920	hsa-miR-3922-3p	CLIP-seq
MIRT2636921	hsa-miR-3929	CLIP-seq
MIRT2636922	hsa-miR-3934	CLIP-seq
MIRT2636923	hsa-miR-4314	CLIP-seq
MIRT2636924	hsa-miR-4318	CLIP-seq
MIRT2636925	hsa-miR-4329	CLIP-seq
MIRT1403566	hsa-miR-4419a	CLIP-seq
MIRT2636926	hsa-miR-4419b	CLIP-seq
MIRT2120991	hsa-miR-4436b-3p	CLIP-seq
MIRT2636927	hsa-miR-4463	CLIP-seq
MIRT1403570	hsa-miR-4476	CLIP-seq
MIRT1403571	hsa-miR-4477a	CLIP-seq
MIRT2636928	hsa-miR-4478	CLIP-seq
MIRT1403573	hsa-miR-4510	CLIP-seq
MIRT2636929	hsa-miR-4512	CLIP-seq
MIRT2636930	hsa-miR-4646-5p	CLIP-seq
MIRT2342985	hsa-miR-4659a-3p	CLIP-seq
MIRT2342986	hsa-miR-4659b-3p	CLIP-seq
MIRT2636931	hsa-miR-4685-5p	CLIP-seq
MIRT2636932	hsa-miR-4693-5p	CLIP-seq
MIRT2636933	hsa-miR-4708-3p	CLIP-seq
MIRT1403580	hsa-miR-4709-3p	CLIP-seq
MIRT1403584	hsa-miR-4728-5p	CLIP-seq
MIRT2636934	hsa-miR-4733-3p	CLIP-seq
MIRT2636935	hsa-miR-4736	CLIP-seq
MIRT2636936	hsa-miR-4739	CLIP-seq
MIRT1403586	hsa-miR-4747-5p	CLIP-seq
MIRT2636937	hsa-miR-4756-5p	CLIP-seq
MIRT2636938	hsa-miR-4757-5p	CLIP-seq
MIRT2636939	hsa-miR-4761-3p	CLIP-seq
MIRT2636940	hsa-miR-4782-5p	CLIP-seq
MIRT2636941	hsa-miR-485-5p	CLIP-seq
MIRT2120996	hsa-miR-516a-5p	CLIP-seq
MIRT2636942	hsa-miR-520d-5p	CLIP-seq
MIRT2636943	hsa-miR-524-5p	CLIP-seq
MIRT1403592	hsa-miR-548ag	CLIP-seq
MIRT1403593	hsa-miR-548ai	CLIP-seq
MIRT2636944	hsa-miR-550a	CLIP-seq
MIRT2636945	hsa-miR-650	CLIP-seq
MIRT2636946	hsa-miR-7	CLIP-seq
MIRT1403599	hsa-miR-876-5p	CLIP-seq
MIRT2636947	hsa-miR-892a	CLIP-seq
MIRT2121000	hsa-miR-940	CLIP-seq
MIRT1403602	hsa-miR-944	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	9450929, 9857195
GO:0000993	Function	RNA polymerase II complex binding	IBA
GO:0005515	Function	Protein binding	IPI	10075709, 17404243, 24981860, 25416956, 25502805, 26496610, 26789250, 27107012, 31515488, 35271311
GO:0005634	Component	Nucleus	IDA	9450929
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	TAS	8786137
GO:0006368	Process	Transcription elongation by RNA polymerase II	IBA
GO:0006368	Process	Transcription elongation by RNA polymerase II	IDA	9450929, 9857195
GO:0008270	Function	Zinc ion binding	IEA
GO:0032044	Component	DSIF complex	IBA
GO:0032044	Component	DSIF complex	IDA	9450929
GO:0032044	Component	DSIF complex	IPI	19860741
GO:0032785	Process	Negative regulation of DNA-templated transcription, elongation	IDA	9450929, 9857195
GO:0032785	Process	Negative regulation of DNA-templated transcription, elongation	IEA
GO:0032786	Process	Positive regulation of DNA-templated transcription, elongation	IDA	9450929
GO:0034243	Process	Regulation of transcription elongation by RNA polymerase II	IDA	9450929
GO:0034243	Process	Regulation of transcription elongation by RNA polymerase II	IEA
GO:0034244	Process	Negative regulation of transcription elongation by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	9450929
GO:0046872	Function	Metal ion binding	IEA
GO:0046982	Function	Protein heterodimerization activity	IPI	9450929
GO:0140673	Process	Transcription elongation-coupled chromatin remodeling	IEA

Other IDs

• MIM: 603555
• HGNC: 11467
• e!Ensembl: ENSG00000213246

Protein

• UniProt ID: P63272
• Protein name: Transcription elongation factor SPT4 (hSPT4) (DRB sensitivity-inducing factor 14 kDa subunit) (DSIF p14) (DRB sensitivity-inducing factor small subunit) (DSIF small subunit)
• Protein function: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10454543, PubMed:10912001, PubMed:11112772, PubM
• PDB: 3H7H, 5OIK, 6GMH, 6GML, 6TED, 7OKY, 7UND, 7YCX, 8A3Y, 8P4C, 8P4D, 8P4F, 8UHA, 8UHD, 8W8E, 8W8F, 9EGX, 9EGY, 9EGZ, 9EH0, 9EH1, 9EH2, 9J0N, 9J0O, 9J0P
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06093	Spt4	13 → 90	Spt4/RpoE2 zinc finger	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:8649394, ECO:0000269|PubMed:8786137}.
• Sequence:

  MALETVPKDLRHLRACLLCSLVKTIDQFEYDGCDNCDAYLQMKGNREMVYDCTSSSFDGI
  IAMMSPEDSWVSKWQRVSNFKPGVYAVSVTGRLPQGIVRELKSRGVAYKSRDTAIKT

• Sequence length: 117

Pathways

KEGG:

Viral life cycle - HIV-1

Reactome:

Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Amyotrophic Lateral Sclerosis	Associate	30605685	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	32444848	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	27461012	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	32444848	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Associate	28009271, 30605685	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	31917448	★☆☆☆☆ Found in Text Mining only
Peritonitis	Associate	27461012	★☆☆☆☆ Found in Text Mining only