Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	6822
Gene name	Sulfotransferase family 2A member 1
Gene symbol	SULT2A1
Synonyms (NCBI Gene)	DHEA-STDHEA-ST8DHEASHSTST2ST2A1ST2A3STDSULT2A3hSTa
Chromosome	19
Chromosome location	19q13.33
Summary	This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This pr

127

Show/Hide all (127)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017405	hsa-miR-335-5p	Microarray	18185580
MIRT030437	hsa-miR-24-3p	Microarray	19748357
MIRT736032	hsa-miR-486-5p	Luciferase reporter assayWestern blottingqRT-PCR	31445882
MIRT1402899	hsa-miR-1183	CLIP-seq
MIRT1402900	hsa-miR-1193	CLIP-seq
MIRT1402901	hsa-miR-1200	CLIP-seq
MIRT1402902	hsa-miR-1208	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT1402904	hsa-miR-139-3p	CLIP-seq
MIRT1402905	hsa-miR-1976	CLIP-seq
MIRT1402906	hsa-miR-2392	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT1402908	hsa-miR-3137	CLIP-seq
MIRT1402909	hsa-miR-3152-3p	CLIP-seq
MIRT1402910	hsa-miR-3170	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT1402912	hsa-miR-3672	CLIP-seq
MIRT1402913	hsa-miR-4264	CLIP-seq
MIRT1402914	hsa-miR-4324	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402916	hsa-miR-4438	CLIP-seq
MIRT1402917	hsa-miR-4454	CLIP-seq
MIRT1402918	hsa-miR-4473	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402920	hsa-miR-4662a-5p	CLIP-seq
MIRT1402921	hsa-miR-4676-5p	CLIP-seq
MIRT1402922	hsa-miR-4682	CLIP-seq
MIRT1402923	hsa-miR-4731-5p	CLIP-seq
MIRT1402924	hsa-miR-4797-3p	CLIP-seq
MIRT1402925	hsa-miR-5095	CLIP-seq
MIRT1402926	hsa-miR-5096	CLIP-seq
MIRT1402927	hsa-miR-512-3p	CLIP-seq
MIRT1402928	hsa-miR-520f	CLIP-seq
MIRT1402929	hsa-miR-544b	CLIP-seq
MIRT1402930	hsa-miR-575	CLIP-seq
MIRT1402931	hsa-miR-622	CLIP-seq
MIRT1402932	hsa-miR-668	CLIP-seq
MIRT1402933	hsa-miR-720	CLIP-seq
MIRT1402901	hsa-miR-1200	CLIP-seq
MIRT2120784	hsa-miR-129-5p	CLIP-seq
MIRT2120785	hsa-miR-4279	CLIP-seq
MIRT1402914	hsa-miR-4324	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402922	hsa-miR-4682	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120787	hsa-miR-4740-3p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2120789	hsa-miR-4777-3p	CLIP-seq
MIRT1402929	hsa-miR-544b	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT1402900	hsa-miR-1193	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT1402905	hsa-miR-1976	CLIP-seq
MIRT1402906	hsa-miR-2392	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT1402913	hsa-miR-4264	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402924	hsa-miR-4797-3p	CLIP-seq
MIRT1402931	hsa-miR-622	CLIP-seq
MIRT1402933	hsa-miR-720	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT2395426	hsa-miR-24	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT2395427	hsa-miR-3186-5p	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT2395428	hsa-miR-4284	CLIP-seq
MIRT2395429	hsa-miR-4317	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT2395430	hsa-miR-767-5p	CLIP-seq
MIRT2460815	hsa-miR-296-3p	CLIP-seq
MIRT2460816	hsa-miR-3149	CLIP-seq
MIRT2460817	hsa-miR-411	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT2460816	hsa-miR-3149	CLIP-seq
MIRT2460817	hsa-miR-411	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT1402901	hsa-miR-1200	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT2120784	hsa-miR-129-5p	CLIP-seq
MIRT2395426	hsa-miR-24	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT2460816	hsa-miR-3149	CLIP-seq
MIRT2395427	hsa-miR-3186-5p	CLIP-seq
MIRT2636672	hsa-miR-3199	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT2460817	hsa-miR-411	CLIP-seq
MIRT2395428	hsa-miR-4284	CLIP-seq
MIRT2395429	hsa-miR-4317	CLIP-seq
MIRT1402914	hsa-miR-4324	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402922	hsa-miR-4682	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2636673	hsa-miR-4787-3p	CLIP-seq
MIRT2636674	hsa-miR-4794	CLIP-seq
MIRT1402929	hsa-miR-544b	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT2395430	hsa-miR-767-5p	CLIP-seq
MIRT1402901	hsa-miR-1200	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT2120784	hsa-miR-129-5p	CLIP-seq
MIRT2395426	hsa-miR-24	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT2460816	hsa-miR-3149	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT2460817	hsa-miR-411	CLIP-seq
MIRT2395428	hsa-miR-4284	CLIP-seq
MIRT2395429	hsa-miR-4317	CLIP-seq
MIRT1402914	hsa-miR-4324	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402922	hsa-miR-4682	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2636673	hsa-miR-4787-3p	CLIP-seq
MIRT2636674	hsa-miR-4794	CLIP-seq
MIRT1402929	hsa-miR-544b	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT2395430	hsa-miR-767-5p	CLIP-seq

Show/Hide all (5)

Transcription factor	Regulation	Reference
GATA6	Activation	15388788;19497978
MED1	Activation	19497978
PPARA	Unknown	20110263
SF1	Activation	15388788
SF1	Unknown	15878968

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004027	Function	Alcohol sulfotransferase activity	IDA	7854148, 19589875
GO:0004027	Function	Alcohol sulfotransferase activity	IEA
GO:0005515	Function	Protein binding	IPI	21988832, 25416956, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	2268288
GO:0005829	Component	Cytosol	TAS
GO:0006068	Process	Ethanol catabolic process	IDA	23207770
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006805	Process	Xenobiotic metabolic process	IDA	7854148
GO:0008146	Function	Sulfotransferase activity	IBA
GO:0008146	Function	Sulfotransferase activity	IDA	19548878, 20056724
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0008202	Process	Steroid metabolic process	IDA	1588921, 23207770
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008202	Process	Steroid metabolic process	IMP	29671343
GO:0008203	Process	Cholesterol metabolic process	IDA	19589875
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030573	Process	Bile acid catabolic process	IEA
GO:0042403	Process	Thyroid hormone metabolic process	IDA	10199779
GO:0047704	Function	Bile-salt sulfotransferase activity	IDA	1588921, 2268288
GO:0047704	Function	Bile-salt sulfotransferase activity	IEA
GO:0050294	Function	Steroid sulfotransferase activity	IDA	23207770
GO:0050294	Function	Steroid sulfotransferase activity	IMP	29671343
GO:0050427	Process	3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA	23207770
GO:0050656	Function	3'-phosphoadenosine 5'-phosphosulfate binding	IDA	10854859, 12471039
GO:0051923	Process	Sulfation	IBA
GO:0051923	Process	Sulfation	IDA	19548878
GO:0051923	Process	Sulfation	IDA	20056724, 23207770

MIM	HGNC	e!Ensembl
125263	11458	ENSG00000105398

Q06520

Protein name

Sulfotransferase 2A1 (ST2A1) (EC 2.8.2.2) (Bile salt sulfotransferase) (EC 2.8.2.14) (Dehydroepiandrosterone sulfotransferase) (DHEA-ST) (DHEA-ST8) (Hydroxysteroid Sulfotransferase) (HST) (ST2) (SULT2A3)

Protein function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, inclu

PDB

1EFH , 1J99 , 1OV4 , 2QP3 , 2QP4 , 3F3Y , 4IFB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00685	Sulfotransfer_1	34 → 278	Sulfotransferase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.

Sequence

MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSK
GDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLM
RNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFL
LLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVV
DKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE

Sequence length

285

Interactions

View interactions

	KEGG		Reactome
	Metabolism of xenobiotics by cytochrome P450 Bile secretion Chemical carcinogenesis - DNA adducts		Cytosolic sulfonation of small molecules PPARA activates gene expression

SULT2A1 (sulfotransferase family 2A member 1)