Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6822
Gene name Gene Name - the full gene name approved by the HGNC.	Sulfotransferase family 2A member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SULT2A1
Synonyms (NCBI Gene) Gene synonyms aliases	DHEA-ST, DHEA-ST8, DHEAS, HST, ST2, ST2A1, ST2A3, STD, SULT2A3, hSTa
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.33
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This pr

Show/Hide all(127)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017405	hsa-miR-335-5p	Microarray	18185580
MIRT030437	hsa-miR-24-3p	Microarray	19748357
MIRT736032	hsa-miR-486-5p	Luciferase reporter assay, Western blotting, qRT-PCR	31445882
MIRT1402899	hsa-miR-1183	CLIP-seq
MIRT1402900	hsa-miR-1193	CLIP-seq
MIRT1402901	hsa-miR-1200	CLIP-seq
MIRT1402902	hsa-miR-1208	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT1402904	hsa-miR-139-3p	CLIP-seq
MIRT1402905	hsa-miR-1976	CLIP-seq
MIRT1402906	hsa-miR-2392	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT1402908	hsa-miR-3137	CLIP-seq
MIRT1402909	hsa-miR-3152-3p	CLIP-seq
MIRT1402910	hsa-miR-3170	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT1402912	hsa-miR-3672	CLIP-seq
MIRT1402913	hsa-miR-4264	CLIP-seq
MIRT1402914	hsa-miR-4324	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402916	hsa-miR-4438	CLIP-seq
MIRT1402917	hsa-miR-4454	CLIP-seq
MIRT1402918	hsa-miR-4473	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402920	hsa-miR-4662a-5p	CLIP-seq
MIRT1402921	hsa-miR-4676-5p	CLIP-seq
MIRT1402922	hsa-miR-4682	CLIP-seq
MIRT1402923	hsa-miR-4731-5p	CLIP-seq
MIRT1402924	hsa-miR-4797-3p	CLIP-seq
MIRT1402925	hsa-miR-5095	CLIP-seq
MIRT1402926	hsa-miR-5096	CLIP-seq
MIRT1402927	hsa-miR-512-3p	CLIP-seq
MIRT1402928	hsa-miR-520f	CLIP-seq
MIRT1402929	hsa-miR-544b	CLIP-seq
MIRT1402930	hsa-miR-575	CLIP-seq
MIRT1402931	hsa-miR-622	CLIP-seq
MIRT1402932	hsa-miR-668	CLIP-seq
MIRT1402933	hsa-miR-720	CLIP-seq
MIRT1402901	hsa-miR-1200	CLIP-seq
MIRT2120784	hsa-miR-129-5p	CLIP-seq
MIRT2120785	hsa-miR-4279	CLIP-seq
MIRT1402914	hsa-miR-4324	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402922	hsa-miR-4682	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120787	hsa-miR-4740-3p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2120789	hsa-miR-4777-3p	CLIP-seq
MIRT1402929	hsa-miR-544b	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT1402900	hsa-miR-1193	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT1402905	hsa-miR-1976	CLIP-seq
MIRT1402906	hsa-miR-2392	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT1402913	hsa-miR-4264	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402924	hsa-miR-4797-3p	CLIP-seq
MIRT1402931	hsa-miR-622	CLIP-seq
MIRT1402933	hsa-miR-720	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT2395426	hsa-miR-24	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT2395427	hsa-miR-3186-5p	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT2395428	hsa-miR-4284	CLIP-seq
MIRT2395429	hsa-miR-4317	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT2395430	hsa-miR-767-5p	CLIP-seq
MIRT2460815	hsa-miR-296-3p	CLIP-seq
MIRT2460816	hsa-miR-3149	CLIP-seq
MIRT2460817	hsa-miR-411	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT2460816	hsa-miR-3149	CLIP-seq
MIRT2460817	hsa-miR-411	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT1402901	hsa-miR-1200	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT2120784	hsa-miR-129-5p	CLIP-seq
MIRT2395426	hsa-miR-24	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT2460816	hsa-miR-3149	CLIP-seq
MIRT2395427	hsa-miR-3186-5p	CLIP-seq
MIRT2636672	hsa-miR-3199	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT2460817	hsa-miR-411	CLIP-seq
MIRT2395428	hsa-miR-4284	CLIP-seq
MIRT2395429	hsa-miR-4317	CLIP-seq
MIRT1402914	hsa-miR-4324	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402922	hsa-miR-4682	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2636673	hsa-miR-4787-3p	CLIP-seq
MIRT2636674	hsa-miR-4794	CLIP-seq
MIRT1402929	hsa-miR-544b	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT2395430	hsa-miR-767-5p	CLIP-seq
MIRT1402901	hsa-miR-1200	CLIP-seq
MIRT1402903	hsa-miR-122	CLIP-seq
MIRT2120784	hsa-miR-129-5p	CLIP-seq
MIRT2395426	hsa-miR-24	CLIP-seq
MIRT1402907	hsa-miR-3135b	CLIP-seq
MIRT2460816	hsa-miR-3149	CLIP-seq
MIRT1402911	hsa-miR-3652	CLIP-seq
MIRT2460817	hsa-miR-411	CLIP-seq
MIRT2395428	hsa-miR-4284	CLIP-seq
MIRT2395429	hsa-miR-4317	CLIP-seq
MIRT1402914	hsa-miR-4324	CLIP-seq
MIRT1402915	hsa-miR-4430	CLIP-seq
MIRT1402919	hsa-miR-4634	CLIP-seq
MIRT1402922	hsa-miR-4682	CLIP-seq
MIRT2120786	hsa-miR-4735-5p	CLIP-seq
MIRT2120788	hsa-miR-4775	CLIP-seq
MIRT2636673	hsa-miR-4787-3p	CLIP-seq
MIRT2636674	hsa-miR-4794	CLIP-seq
MIRT1402929	hsa-miR-544b	CLIP-seq
MIRT2120790	hsa-miR-590-3p	CLIP-seq
MIRT2395430	hsa-miR-767-5p	CLIP-seq

Transcription factors

Show/Hide all(5)

Transcription factor	Regulation	Reference
GATA6	Activation	15388788;19497978
MED1	Activation	19497978
PPARA	Unknown	20110263
SF1	Activation	15388788
SF1	Unknown	15878968

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004027	Function	Alcohol sulfotransferase activity	IDA	7854148, 19589875
GO:0004027	Function	Alcohol sulfotransferase activity	IEA
GO:0005515	Function	Protein binding	IPI	21988832, 25416956, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	2268288
GO:0005829	Component	Cytosol	TAS
GO:0006068	Process	Ethanol catabolic process	IDA	23207770
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006805	Process	Xenobiotic metabolic process	IDA	7854148
GO:0008146	Function	Sulfotransferase activity	IBA
GO:0008146	Function	Sulfotransferase activity	IDA	19548878, 20056724
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0008202	Process	Steroid metabolic process	IDA	1588921, 23207770
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008202	Process	Steroid metabolic process	IMP	29671343
GO:0008203	Process	Cholesterol metabolic process	IDA	19589875
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030573	Process	Bile acid catabolic process	IEA
GO:0042403	Process	Thyroid hormone metabolic process	IDA	10199779
GO:0047704	Function	Bile-salt sulfotransferase activity	IDA	1588921, 2268288
GO:0047704	Function	Bile-salt sulfotransferase activity	IEA
GO:0050294	Function	Steroid sulfotransferase activity	IDA	23207770
GO:0050294	Function	Steroid sulfotransferase activity	IMP	29671343
GO:0050427	Process	3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA	23207770
GO:0050656	Function	3'-phosphoadenosine 5'-phosphosulfate binding	IDA	10854859, 12471039
GO:0051923	Process	Sulfation	IBA
GO:0051923	Process	Sulfation	IDA	19548878
GO:0051923	Process	Sulfation	IDA	20056724, 23207770

MIM	HGNC	e!Ensembl
125263	11458	ENSG00000105398

Protein

UniProt ID

Q06520

Protein name

Sulfotransferase 2A1 (ST2A1) (EC 2.8.2.2) (Bile salt sulfotransferase) (EC 2.8.2.14) (Dehydroepiandrosterone sulfotransferase) (DHEA-ST) (DHEA-ST8) (Hydroxysteroid Sulfotransferase) (HST) (ST2) (SULT2A3)

Protein function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, inclu

PDB

1EFH , 1J99 , 1OV4 , 2QP3 , 2QP4 , 3F3Y , 4IFB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00685	Sulfotransfer_1	34 → 278	Sulfotransferase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.

Sequence

MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSK
GDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLM
RNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFL
LLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVV
DKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE

Sequence length

285

Interactions

View interactions

	KEGG		Reactome
	Metabolism of xenobiotics by cytochrome P450 Bile secretion Chemical carcinogenesis - DNA adducts		Cytosolic sulfonation of small molecules PPARA activates gene expression

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Cholecystitis	Cholecystitis	N/A	N/A	GWAS
Cholelithiasis	Cholelithiasis	N/A	N/A	GWAS
Intrahepatic Cholestasis Of Pregnancy	Intrahepatic cholestasis of pregnancy	N/A	N/A	GWAS

Show/Hide Text Mining Associations (24)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adrenocortical Adenoma	Inhibit	8930526
Alcoholism	Inhibit	23775849
Arthritis Rheumatoid	Associate	28712091
Autism Spectrum Disorder	Associate	33024080
Carcinoma Hepatocellular	Associate	28634336
Carcinoma Hepatocellular	Inhibit	35599597
Carcinoma Non Small Cell Lung	Associate	32072637
Cholangitis Sclerosing	Associate	26504856
Cholestasis	Inhibit	25798860
Cholestasis	Associate	25948711
Colitis Ulcerative	Associate	17491508
Cushing Syndrome	Inhibit	8930526
Death	Associate	32072637
Depressive Disorder Major	Stimulate	28752602
Hepatitis Chronic	Stimulate	11228044
Liver Cirrhosis Biliary	Associate	26504856
Muscular Dystrophy Duchenne	Associate	29232479
Neoplasm Metastasis	Inhibit	35599597
Neoplasms	Associate	28634336
Non alcoholic Fatty Liver Disease	Inhibit	23223517
Ovarian Neoplasms	Associate	32590918
Personality Disorders	Associate	22542949
Prostatic Neoplasms	Associate	22542949
Virilism	Associate	32590918

SULT2A1 (sulfotransferase family 2A member 1)