Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6821
Gene name Gene Name - the full gene name approved by the HGNC.	Sulfite oxidase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SUOX
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxid

Show/Hide all(18)

SNP ID	Visualize variation	Clinical significance	Consequence
rs76537761	G>A	Uncertain-significance, benign, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs121908007	G>A	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs121908008	C>A	Pathogenic	Coding sequence variant, missense variant
rs121908009	G>A	Pathogenic	Coding sequence variant, missense variant
rs141735896	C>T	Conflicting-interpretations-of-pathogenicity, benign	Missense variant, coding sequence variant
rs144064367	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs202085145	G>T	Benign, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs747461754	C>G	Pathogenic	Coding sequence variant, stop gained
rs748900391	TG>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs770792767	G>T	Likely-pathogenic	Coding sequence variant, missense variant
rs773937413	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs776356158	G>A	Likely-pathogenic	Missense variant, coding sequence variant
rs781081194	C>A,T	Likely-pathogenic	Missense variant, coding sequence variant
rs794729211	T>A	Likely-pathogenic	Missense variant, coding sequence variant
rs1555198521	G>-,GG	Pathogenic	Frameshift variant, coding sequence variant
rs1565798380	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1565799723	CG>AC	Pathogenic	Missense variant, coding sequence variant
rs1565799921	C>T	Pathogenic-likely-pathogenic	Missense variant, coding sequence variant

Show/Hide all(149)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051024	hsa-miR-17-5p	CLASH	23622248
MIRT551001	hsa-miR-490-3p	PAR-CLIP	21572407
MIRT187727	hsa-miR-4662a-3p	PAR-CLIP	21572407
MIRT551000	hsa-miR-619-3p	PAR-CLIP	21572407
MIRT187720	hsa-miR-196a-5p	PAR-CLIP	21572407
MIRT187723	hsa-miR-196b-5p	PAR-CLIP	21572407
MIRT550999	hsa-miR-4254	PAR-CLIP	21572407
MIRT187713	hsa-let-7a-5p	PAR-CLIP	21572407
MIRT187714	hsa-let-7b-5p	PAR-CLIP	21572407
MIRT187715	hsa-let-7c-5p	PAR-CLIP	21572407
MIRT187716	hsa-let-7d-5p	PAR-CLIP	21572407
MIRT187717	hsa-let-7e-5p	PAR-CLIP	21572407
MIRT187718	hsa-let-7f-5p	PAR-CLIP	21572407
MIRT187721	hsa-let-7g-5p	PAR-CLIP	21572407
MIRT187722	hsa-let-7i-5p	PAR-CLIP	21572407
MIRT187725	hsa-miR-4458	PAR-CLIP	21572407
MIRT187726	hsa-miR-4500	PAR-CLIP	21572407
MIRT187719	hsa-miR-98-5p	PAR-CLIP	21572407
MIRT550998	hsa-miR-185-5p	PAR-CLIP	21572407
MIRT550997	hsa-miR-4306	PAR-CLIP	21572407
MIRT550996	hsa-miR-4644	PAR-CLIP	21572407
MIRT550995	hsa-miR-5192	PAR-CLIP	21572407
MIRT550994	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT551001	hsa-miR-490-3p	PAR-CLIP	21572407
MIRT187727	hsa-miR-4662a-3p	PAR-CLIP	21572407
MIRT551000	hsa-miR-619-3p	PAR-CLIP	21572407
MIRT187720	hsa-miR-196a-5p	PAR-CLIP	21572407
MIRT187723	hsa-miR-196b-5p	PAR-CLIP	21572407
MIRT550999	hsa-miR-4254	PAR-CLIP	21572407
MIRT187713	hsa-let-7a-5p	PAR-CLIP	21572407
MIRT187714	hsa-let-7b-5p	PAR-CLIP	21572407
MIRT187715	hsa-let-7c-5p	PAR-CLIP	21572407
MIRT187716	hsa-let-7d-5p	PAR-CLIP	21572407
MIRT187717	hsa-let-7e-5p	PAR-CLIP	21572407
MIRT187718	hsa-let-7f-5p	PAR-CLIP	21572407
MIRT187721	hsa-let-7g-5p	PAR-CLIP	21572407
MIRT187722	hsa-let-7i-5p	PAR-CLIP	21572407
MIRT187725	hsa-miR-4458	PAR-CLIP	21572407
MIRT187726	hsa-miR-4500	PAR-CLIP	21572407
MIRT187719	hsa-miR-98-5p	PAR-CLIP	21572407
MIRT550998	hsa-miR-185-5p	PAR-CLIP	21572407
MIRT550997	hsa-miR-4306	PAR-CLIP	21572407
MIRT550996	hsa-miR-4644	PAR-CLIP	21572407
MIRT550995	hsa-miR-5192	PAR-CLIP	21572407
MIRT550994	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT1403481	hsa-miR-5096	CLIP-seq
MIRT1403482	hsa-miR-640	CLIP-seq
MIRT2120886	hsa-miR-4473	CLIP-seq
MIRT2120887	hsa-miR-4476	CLIP-seq
MIRT2120888	hsa-miR-512-3p	CLIP-seq
MIRT2120889	hsa-miR-520f	CLIP-seq
MIRT2120890	hsa-miR-548p	CLIP-seq
MIRT2636836	hsa-miR-1225-5p	CLIP-seq
MIRT2636837	hsa-miR-1245b-5p	CLIP-seq
MIRT2636838	hsa-miR-1262	CLIP-seq
MIRT2636839	hsa-miR-135a	CLIP-seq
MIRT2636840	hsa-miR-135b	CLIP-seq
MIRT2636841	hsa-miR-194	CLIP-seq
MIRT2636842	hsa-miR-203	CLIP-seq
MIRT2636843	hsa-miR-3064-3p	CLIP-seq
MIRT2636844	hsa-miR-3142	CLIP-seq
MIRT2636845	hsa-miR-3177-5p	CLIP-seq
MIRT2636846	hsa-miR-3189-3p	CLIP-seq
MIRT2636847	hsa-miR-34a	CLIP-seq
MIRT2636848	hsa-miR-34c-5p	CLIP-seq
MIRT2636849	hsa-miR-3689d	CLIP-seq
MIRT2636850	hsa-miR-380	CLIP-seq
MIRT2636851	hsa-miR-3921	CLIP-seq
MIRT2636852	hsa-miR-3922-5p	CLIP-seq
MIRT2636853	hsa-miR-3925-3p	CLIP-seq
MIRT2636854	hsa-miR-3941	CLIP-seq
MIRT2120886	hsa-miR-4473	CLIP-seq
MIRT2120887	hsa-miR-4476	CLIP-seq
MIRT2636855	hsa-miR-4493	CLIP-seq
MIRT2636856	hsa-miR-4495	CLIP-seq
MIRT2636857	hsa-miR-449a	CLIP-seq
MIRT2636858	hsa-miR-449b	CLIP-seq
MIRT2636859	hsa-miR-4539	CLIP-seq
MIRT2636860	hsa-miR-4643	CLIP-seq
MIRT2636861	hsa-miR-4653-5p	CLIP-seq
MIRT2636862	hsa-miR-466	CLIP-seq
MIRT2636863	hsa-miR-4672	CLIP-seq
MIRT2636864	hsa-miR-4694-3p	CLIP-seq
MIRT2636865	hsa-miR-4701-3p	CLIP-seq
MIRT2636866	hsa-miR-4747-5p	CLIP-seq
MIRT2636867	hsa-miR-4753-5p	CLIP-seq
MIRT2636868	hsa-miR-4768-5p	CLIP-seq
MIRT2636869	hsa-miR-4789-3p	CLIP-seq
MIRT2636870	hsa-miR-4802-5p	CLIP-seq
MIRT2636871	hsa-miR-4803	CLIP-seq
MIRT2636872	hsa-miR-488	CLIP-seq
MIRT2636873	hsa-miR-493	CLIP-seq
MIRT1403481	hsa-miR-5096	CLIP-seq
MIRT2120888	hsa-miR-512-3p	CLIP-seq
MIRT2120889	hsa-miR-520f	CLIP-seq
MIRT2120890	hsa-miR-548p	CLIP-seq
MIRT2636874	hsa-miR-583	CLIP-seq
MIRT2636875	hsa-miR-636	CLIP-seq
MIRT1403482	hsa-miR-640	CLIP-seq
MIRT2636876	hsa-miR-766	CLIP-seq
MIRT2636877	hsa-miR-890	CLIP-seq
MIRT2636836	hsa-miR-1225-5p	CLIP-seq
MIRT2636837	hsa-miR-1245b-5p	CLIP-seq
MIRT2636838	hsa-miR-1262	CLIP-seq
MIRT2636839	hsa-miR-135a	CLIP-seq
MIRT2636840	hsa-miR-135b	CLIP-seq
MIRT2636841	hsa-miR-194	CLIP-seq
MIRT2636842	hsa-miR-203	CLIP-seq
MIRT2636843	hsa-miR-3064-3p	CLIP-seq
MIRT2636844	hsa-miR-3142	CLIP-seq
MIRT2636845	hsa-miR-3177-5p	CLIP-seq
MIRT2636846	hsa-miR-3189-3p	CLIP-seq
MIRT2636847	hsa-miR-34a	CLIP-seq
MIRT2636848	hsa-miR-34c-5p	CLIP-seq
MIRT2636849	hsa-miR-3689d	CLIP-seq
MIRT2636850	hsa-miR-380	CLIP-seq
MIRT2636851	hsa-miR-3921	CLIP-seq
MIRT2636852	hsa-miR-3922-5p	CLIP-seq
MIRT2636853	hsa-miR-3925-3p	CLIP-seq
MIRT2636854	hsa-miR-3941	CLIP-seq
MIRT2120886	hsa-miR-4473	CLIP-seq
MIRT2120887	hsa-miR-4476	CLIP-seq
MIRT2636855	hsa-miR-4493	CLIP-seq
MIRT2636856	hsa-miR-4495	CLIP-seq
MIRT2636857	hsa-miR-449a	CLIP-seq
MIRT2636858	hsa-miR-449b	CLIP-seq
MIRT2636859	hsa-miR-4539	CLIP-seq
MIRT2636860	hsa-miR-4643	CLIP-seq
MIRT2636861	hsa-miR-4653-5p	CLIP-seq
MIRT2636862	hsa-miR-466	CLIP-seq
MIRT2636863	hsa-miR-4672	CLIP-seq
MIRT2636864	hsa-miR-4694-3p	CLIP-seq
MIRT2636865	hsa-miR-4701-3p	CLIP-seq
MIRT2636866	hsa-miR-4747-5p	CLIP-seq
MIRT2636867	hsa-miR-4753-5p	CLIP-seq
MIRT2636868	hsa-miR-4768-5p	CLIP-seq
MIRT2636869	hsa-miR-4789-3p	CLIP-seq
MIRT2636870	hsa-miR-4802-5p	CLIP-seq
MIRT2636871	hsa-miR-4803	CLIP-seq
MIRT2636872	hsa-miR-488	CLIP-seq
MIRT2636873	hsa-miR-493	CLIP-seq
MIRT2120888	hsa-miR-512-3p	CLIP-seq
MIRT2120889	hsa-miR-520f	CLIP-seq
MIRT2120890	hsa-miR-548p	CLIP-seq
MIRT2636874	hsa-miR-583	CLIP-seq
MIRT2636875	hsa-miR-636	CLIP-seq
MIRT1403482	hsa-miR-640	CLIP-seq
MIRT2636876	hsa-miR-766	CLIP-seq
MIRT2636877	hsa-miR-890	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25910212, 32296183
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005758	Component	Mitochondrial intermembrane space	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006790	Process	Sulfur compound metabolic process	IBA	21873635
GO:0008482	Function	Sulfite oxidase activity	IBA	21873635
GO:0020037	Function	Heme binding	IBA	21873635
GO:0030151	Function	Molybdenum ion binding	IEA
GO:0043546	Function	Molybdopterin cofactor binding	IBA	21873635
GO:0070221	Process	Sulfide oxidation, using sulfide:quinone oxidoreductase	TAS

MIM	HGNC	e!Ensembl
606887	11460	ENSG00000139531

Protein

UniProt ID

P51687

Protein name

Sulfite oxidase, mitochondrial (EC 1.8.3.1)

Protein function

Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.

PDB

1MJ4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00173	Cyt-b5	86 → 161	Cytochrome b5-like Heme/Steroid binding domain	Domain
PF00174	Oxidored_molyb	219 → 395	Oxidoreductase molybdopterin binding domain	Domain
PF03404	Mo-co_dimer	417 → 544	Mo-co oxidoreductase dimerisation domain	Domain

Sequence

MLLLHRAVVLRLQQACRLKSIPSRICIQACSTNDSFQPQRPSLTFSGDNSSTQGWRVMGT
LLGLGAVLAYQDHRCRAAQESTHIYTKEEVSSHTSPETGIWVTLGSEVFDVTEFVDLHPG
GPSKLMLAAGGPLEPFWALYAVHNQSHVRELLAQYKIGELNPEDKVAPTVETSDPYADDP
VRHPALKVNSQRPFNAEPPPELLTENYITPNPIFFTRNHLPVPNLDPDTYRLHVVGAPGG
QSLSLSLDDLHNFPRYEITVTLQCAGNRRSEMTQVKEVKGLEWRTGAISTARWAGARLCD
VLAQAGHQLCETEAHVCFEGLDSDPTGTAYGASIPLARAMDPEAEVLLAYEMNGQPLPRD
HGFPVRVVVPGVVGARHVKWLGRVSVQPEESYSHWQRRDYKGFSPSVDWETVDFDSAPSI
QELPVQSAITEPRDGETVESGEVTIKGYAWSGGGRAVIRVDVSLDGGLTWQVAKLDGEEQ
RPRKAWAWRLWQLKAPVPAGQKELNIVCKAVDDGYNVQPDTVAPIWNLRGVLSNAWHRVH
VYVSP

Sequence length

545

Interactions

View interactions

	KEGG		Reactome
	Sulfur metabolism Metabolic pathways		Sulfide oxidation to sulfate

Show/Hide Causal Diseases (10)

Disease term	Disease name	dbSNP ID	References
Causal
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	26301688
Autoimmune diseases	Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2	rs869025224	26301688
Common variable immunodeficiency	Common Variable Immunodeficiency	rs72553883, rs121908379, rs104894650, rs587776775, rs398122863, rs398122864, rs397514332, rs397514331, rs727502786, rs727502787, rs72553882, rs869320688, rs869320689, rs869320754, rs773694113 View all (35 more)	26301688
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291 View all (32 more)
Diabetes mellitus	Diabetes Mellitus, Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	26301688
Ectopia lentis	Ectopia Lentis	rs118203985, rs137854464, rs137854480, rs587776927, rs199473693, rs794726688, rs368482584, rs794726689, rs747160538, rs397514558, rs397515793, rs757318536, rs781691587, rs363806
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26301688
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	24390342, 30423114
Sulfite oxidase deficiency	Sulfite oxidase deficiency	rs121908007, rs121908009, rs398122797, rs121908605, rs398122799, rs121908606, rs121908607, rs121908608, rs121908609, rs397518417, rs397518418, rs397518419, rs104893969, rs141982812, rs397518420 View all (18 more)	9050047, 9600976, 16140720, 27289259, 12112661, 28725568, 28980090, 15952210
Sulfocysteinuria	Sulfocysteinuria	rs121908009, rs748900391, rs776356158, rs770792767	10519592, 9428520, 9600976, 12368985, 12112661, 23994568, 15952210, 24938149, 28629418

Show/Hide Unknown Diseases (5)

Disease term	Disease name	References	Source
Unknown
Celiac disease	Celiac Disease	26301688	ClinVar
Crohn disease	Crohn Disease	26301688	ClinVar
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome		GWAS
Vitiligo	Vitiligo		GWAS
Asthma	Asthma		GWAS

Show/Hide Text Mining Associations (23)

Disease Name	Relationship Type	References
Associations from Text Mining
Amyotrophic Lateral Sclerosis	Associate	33417599
Anorexia	Associate	33417599
Arthritis Rheumatoid	Associate	27898717
Attention Deficit and Disruptive Behavior Disorders	Associate	28629418
Brain Diseases Metabolic Inborn	Associate	24968320
Depressive Disorder Major	Associate	33417599
Diabetes Mellitus Type 1	Associate	22144904, 22403184
Disease	Associate	33417599
Glycogen Storage Disease Type IV	Associate	33402469
Heredodegenerative Disorders Nervous System	Associate	33417599
Molybdenum cofactor deficiency	Inhibit	12385777, 9634514
Molybdenum cofactor deficiency	Associate	27289259
Multiple Sclerosis	Associate	33417599
Neoplasms	Associate	33402469
Neoplasms Cystic Mucinous and Serous	Associate	34449156
Pancreatitis	Associate	22403184
Parkinson Disease	Associate	33417599
Polycystic Ovary Syndrome	Associate	25904635, 27217259, 33664499
Schizophrenia	Associate	33417599
Stiff Person Syndrome	Associate	27289259
Stomach Neoplasms	Associate	33402469
Sulfite oxidase deficiency	Associate	24968320, 27289259, 28629418, 33335014, 33405344, 34117075, 34449156, 34741542, 40440599, 9600976
Sulfite oxidase deficiency	Inhibit	9600976

SUOX (sulfite oxidase)