Gene Gene information from NCBI Gene database.
Entrez ID 6815
Gene name Serine/threonine/tyrosine interacting protein
Gene symbol STYX
Synonyms (NCBI Gene)
-
Chromosome 14
Chromosome location 14q22.1
Summary The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for t
miRNA miRNA information provided by mirtarbase database.
856
miRTarBase ID miRNA Experiments Reference
MIRT020255 hsa-miR-130b-3p Sequencing 20371350
MIRT028126 hsa-miR-93-5p Sequencing 20371350
MIRT028243 hsa-miR-33a-5p Sequencing 20371350
MIRT028363 hsa-miR-32-5p Sequencing 20371350
MIRT707859 hsa-miR-8485 HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0001691 Function Pseudophosphatase activity IMP 28007894
GO:0005515 Function Protein binding IPI 23847209, 27880917, 28007894
GO:0005634 Component Nucleus IDA 23847209, 28007894
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
615814 11447 ENSG00000198252
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WUJ0
Protein name Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein)
Protein function Catalytically inactive phosphatase (PubMed:23847209). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:238472
PDB 2R0B
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00782 DSPc 36 173 Dual specificity phosphatase, catalytic domain Domain
Sequence
Sequence length 223
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Gastric cancer Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Carcinogenesis Associate 32239181
★☆☆☆☆
Found in Text Mining only
Endometrial Neoplasms Associate 32239181
★☆☆☆☆
Found in Text Mining only
Lymphoma Large B Cell Diffuse Associate 40128844
★☆☆☆☆
Found in Text Mining only