Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6814
Gene name	Syntaxin binding protein 3
Gene symbol	STXBP3
Synonyms (NCBI Gene)	MUNC18-3MUNC18CPSPUNC-18C
Chromosome	1
Chromosome location	1p13.3

174

Show/Hide all (174)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023896	hsa-miR-1-3p	Proteomics	18668040
MIRT029784	hsa-miR-26b-5p	Microarray	19088304
MIRT031842	hsa-miR-16-5p	Proteomics	18668040
MIRT043953	hsa-miR-378a-3p	CLASH	23622248
MIRT057906	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT057908	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT031842	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT057909	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT1401402	hsa-miR-101	CLIP-seq
MIRT1401403	hsa-miR-1283	CLIP-seq
MIRT1401404	hsa-miR-15a	CLIP-seq
MIRT1401405	hsa-miR-15b	CLIP-seq
MIRT1401406	hsa-miR-16	CLIP-seq
MIRT1401407	hsa-miR-195	CLIP-seq
MIRT1401408	hsa-miR-216b	CLIP-seq
MIRT1401409	hsa-miR-3124-3p	CLIP-seq
MIRT1401410	hsa-miR-3125	CLIP-seq
MIRT1401411	hsa-miR-3143	CLIP-seq
MIRT1401412	hsa-miR-329	CLIP-seq
MIRT1401413	hsa-miR-330-3p	CLIP-seq
MIRT1401414	hsa-miR-34b	CLIP-seq
MIRT1401415	hsa-miR-3613-3p	CLIP-seq
MIRT1401416	hsa-miR-362-3p	CLIP-seq
MIRT1401417	hsa-miR-3653	CLIP-seq
MIRT1401418	hsa-miR-3658	CLIP-seq
MIRT1401419	hsa-miR-3662	CLIP-seq
MIRT1401420	hsa-miR-3672	CLIP-seq
MIRT1401421	hsa-miR-3675-3p	CLIP-seq
MIRT1401422	hsa-miR-376c	CLIP-seq
MIRT1401423	hsa-miR-3916	CLIP-seq
MIRT1401424	hsa-miR-3941	CLIP-seq
MIRT1401425	hsa-miR-3942-5p	CLIP-seq
MIRT1401426	hsa-miR-424	CLIP-seq
MIRT1401427	hsa-miR-4261	CLIP-seq
MIRT1401428	hsa-miR-4291	CLIP-seq
MIRT1401429	hsa-miR-4310	CLIP-seq
MIRT1401430	hsa-miR-4328	CLIP-seq
MIRT1401431	hsa-miR-4496	CLIP-seq
MIRT1401432	hsa-miR-4506	CLIP-seq
MIRT1401433	hsa-miR-4643	CLIP-seq
MIRT1401434	hsa-miR-4659a-3p	CLIP-seq
MIRT1401435	hsa-miR-4659b-3p	CLIP-seq
MIRT1401436	hsa-miR-466	CLIP-seq
MIRT1401437	hsa-miR-4668-3p	CLIP-seq
MIRT1401438	hsa-miR-4672	CLIP-seq
MIRT1401439	hsa-miR-4680-3p	CLIP-seq
MIRT1401440	hsa-miR-4703-5p	CLIP-seq
MIRT1401441	hsa-miR-4712-5p	CLIP-seq
MIRT1401442	hsa-miR-4753-3p	CLIP-seq
MIRT1401443	hsa-miR-4760-5p	CLIP-seq
MIRT1401444	hsa-miR-4789-3p	CLIP-seq
MIRT1401445	hsa-miR-485-3p	CLIP-seq
MIRT1401446	hsa-miR-487a	CLIP-seq
MIRT1401447	hsa-miR-488	CLIP-seq
MIRT1401448	hsa-miR-497	CLIP-seq
MIRT1401449	hsa-miR-520d-5p	CLIP-seq
MIRT1401450	hsa-miR-524-5p	CLIP-seq
MIRT1401451	hsa-miR-543	CLIP-seq
MIRT1401452	hsa-miR-548ae	CLIP-seq
MIRT1401453	hsa-miR-548aj	CLIP-seq
MIRT1401454	hsa-miR-548am	CLIP-seq
MIRT1401455	hsa-miR-548g	CLIP-seq
MIRT1401456	hsa-miR-548x	CLIP-seq
MIRT1401457	hsa-miR-555	CLIP-seq
MIRT1401458	hsa-miR-582-5p	CLIP-seq
MIRT1401459	hsa-miR-590-3p	CLIP-seq
MIRT1401460	hsa-miR-603	CLIP-seq
MIRT1401461	hsa-miR-770-5p	CLIP-seq
MIRT1401462	hsa-miR-877	CLIP-seq
MIRT1401463	hsa-miR-942	CLIP-seq
MIRT1401464	hsa-miR-944	CLIP-seq
MIRT1401402	hsa-miR-101	CLIP-seq
MIRT2120368	hsa-miR-299-3p	CLIP-seq
MIRT1401412	hsa-miR-329	CLIP-seq
MIRT1401415	hsa-miR-3613-3p	CLIP-seq
MIRT1401416	hsa-miR-362-3p	CLIP-seq
MIRT1401419	hsa-miR-3662	CLIP-seq
MIRT2120369	hsa-miR-3688-5p	CLIP-seq
MIRT1401422	hsa-miR-376c	CLIP-seq
MIRT1401424	hsa-miR-3941	CLIP-seq
MIRT2120370	hsa-miR-4282	CLIP-seq
MIRT2120371	hsa-miR-4470	CLIP-seq
MIRT2120372	hsa-miR-4491	CLIP-seq
MIRT2120373	hsa-miR-4657	CLIP-seq
MIRT1401441	hsa-miR-4712-5p	CLIP-seq
MIRT1401457	hsa-miR-555	CLIP-seq
MIRT1401460	hsa-miR-603	CLIP-seq
MIRT1401461	hsa-miR-770-5p	CLIP-seq
MIRT1401403	hsa-miR-1283	CLIP-seq
MIRT1401404	hsa-miR-15a	CLIP-seq
MIRT1401405	hsa-miR-15b	CLIP-seq
MIRT1401406	hsa-miR-16	CLIP-seq
MIRT1401407	hsa-miR-195	CLIP-seq
MIRT1401410	hsa-miR-3125	CLIP-seq
MIRT1401411	hsa-miR-3143	CLIP-seq
MIRT1401413	hsa-miR-330-3p	CLIP-seq
MIRT1401419	hsa-miR-3662	CLIP-seq
MIRT1401422	hsa-miR-376c	CLIP-seq
MIRT1401423	hsa-miR-3916	CLIP-seq
MIRT1401425	hsa-miR-3942-5p	CLIP-seq
MIRT1401426	hsa-miR-424	CLIP-seq
MIRT1401427	hsa-miR-4261	CLIP-seq
MIRT1401431	hsa-miR-4496	CLIP-seq
MIRT1401432	hsa-miR-4506	CLIP-seq
MIRT1401434	hsa-miR-4659a-3p	CLIP-seq
MIRT1401435	hsa-miR-4659b-3p	CLIP-seq
MIRT1401440	hsa-miR-4703-5p	CLIP-seq
MIRT1401441	hsa-miR-4712-5p	CLIP-seq
MIRT1401445	hsa-miR-485-3p	CLIP-seq
MIRT1401446	hsa-miR-487a	CLIP-seq
MIRT1401448	hsa-miR-497	CLIP-seq
MIRT1401449	hsa-miR-520d-5p	CLIP-seq
MIRT1401450	hsa-miR-524-5p	CLIP-seq
MIRT1401451	hsa-miR-543	CLIP-seq
MIRT1401452	hsa-miR-548ae	CLIP-seq
MIRT1401453	hsa-miR-548aj	CLIP-seq
MIRT1401454	hsa-miR-548am	CLIP-seq
MIRT1401456	hsa-miR-548x	CLIP-seq
MIRT1401457	hsa-miR-555	CLIP-seq
MIRT1401461	hsa-miR-770-5p	CLIP-seq
MIRT1401462	hsa-miR-877	CLIP-seq
MIRT1401463	hsa-miR-942	CLIP-seq
MIRT1401422	hsa-miR-376c	CLIP-seq
MIRT1401432	hsa-miR-4506	CLIP-seq
MIRT1401457	hsa-miR-555	CLIP-seq
MIRT2433652	hsa-miR-2277-3p	CLIP-seq
MIRT2433653	hsa-miR-3120-3p	CLIP-seq
MIRT2433654	hsa-miR-421	CLIP-seq
MIRT2433652	hsa-miR-2277-3p	CLIP-seq
MIRT2433653	hsa-miR-3120-3p	CLIP-seq
MIRT1401411	hsa-miR-3143	CLIP-seq
MIRT2636278	hsa-miR-3163	CLIP-seq
MIRT1401417	hsa-miR-3653	CLIP-seq
MIRT1401418	hsa-miR-3658	CLIP-seq
MIRT1401420	hsa-miR-3672	CLIP-seq
MIRT1401422	hsa-miR-376c	CLIP-seq
MIRT2433654	hsa-miR-421	CLIP-seq
MIRT2636279	hsa-miR-4279	CLIP-seq
MIRT2120370	hsa-miR-4282	CLIP-seq
MIRT1401432	hsa-miR-4506	CLIP-seq
MIRT1401434	hsa-miR-4659a-3p	CLIP-seq
MIRT1401435	hsa-miR-4659b-3p	CLIP-seq
MIRT2636280	hsa-miR-4687-3p	CLIP-seq
MIRT2636281	hsa-miR-4691-5p	CLIP-seq
MIRT2636282	hsa-miR-4699-3p	CLIP-seq
MIRT1401441	hsa-miR-4712-5p	CLIP-seq
MIRT1401443	hsa-miR-4760-5p	CLIP-seq
MIRT2636283	hsa-miR-513a-3p	CLIP-seq
MIRT1401451	hsa-miR-543	CLIP-seq
MIRT1401457	hsa-miR-555	CLIP-seq
MIRT2636284	hsa-miR-587	CLIP-seq
MIRT2636285	hsa-miR-618	CLIP-seq
MIRT1401461	hsa-miR-770-5p	CLIP-seq
MIRT1401463	hsa-miR-942	CLIP-seq
MIRT2433652	hsa-miR-2277-3p	CLIP-seq
MIRT2433653	hsa-miR-3120-3p	CLIP-seq
MIRT2636278	hsa-miR-3163	CLIP-seq
MIRT1401417	hsa-miR-3653	CLIP-seq
MIRT1401418	hsa-miR-3658	CLIP-seq
MIRT1401420	hsa-miR-3672	CLIP-seq
MIRT1401422	hsa-miR-376c	CLIP-seq
MIRT2433654	hsa-miR-421	CLIP-seq
MIRT2636279	hsa-miR-4279	CLIP-seq
MIRT2120370	hsa-miR-4282	CLIP-seq
MIRT1401432	hsa-miR-4506	CLIP-seq
MIRT2636280	hsa-miR-4687-3p	CLIP-seq
MIRT2636281	hsa-miR-4691-5p	CLIP-seq
MIRT1401441	hsa-miR-4712-5p	CLIP-seq
MIRT1401443	hsa-miR-4760-5p	CLIP-seq
MIRT2636283	hsa-miR-513a-3p	CLIP-seq
MIRT1401457	hsa-miR-555	CLIP-seq
MIRT2636284	hsa-miR-587	CLIP-seq
MIRT2636285	hsa-miR-618	CLIP-seq
MIRT1401461	hsa-miR-770-5p	CLIP-seq

Show/Hide all (45)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001678	Process	Intracellular glucose homeostasis	IEA
GO:0005515	Function	Protein binding	IPI	12773094
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	18588921
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	18588921
GO:0005886	Component	Plasma membrane	IEA
GO:0006886	Process	Intracellular protein transport	IBA
GO:0006887	Process	Exocytosis	IEA
GO:0006904	Process	Vesicle docking involved in exocytosis	IBA
GO:0006950	Process	Response to stress	IEA
GO:0006955	Process	Immune response	IEA
GO:0007420	Process	Brain development	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0017075	Function	Syntaxin-1 binding	IBA
GO:0017075	Function	Syntaxin-1 binding	IEA
GO:0019905	Function	Syntaxin binding	IEA
GO:0019905	Function	Syntaxin binding	IPI	12773094, 15576373
GO:0022615	Process	Protein to membrane docking	IEA
GO:0030073	Process	Insulin secretion	IEA
GO:0030141	Component	Secretory granule	IBA
GO:0030141	Component	Secretory granule	IEA
GO:0031091	Component	Platelet alpha granule	IDA	12773094
GO:0032868	Process	Response to insulin	IEA
GO:0042581	Component	Specific granule	IDA	18588921
GO:0043312	Process	Neutrophil degranulation	IEP	18588921
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045055	Process	Regulated exocytosis	IEA
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0045955	Process	Negative regulation of calcium ion-dependent exocytosis	IMP	12649283
GO:0046325	Process	Negative regulation of D-glucose import	IEA
GO:0051051	Process	Negative regulation of transport	IEA
GO:0065008	Process	Regulation of biological quality	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070527	Process	Platelet aggregation	IMP	12773094
GO:0070820	Component	Tertiary granule	IDA	18588921
GO:0071346	Process	Cellular response to type II interferon	IEA
GO:0098793	Component	Presynapse	IEA
GO:0099525	Process	Presynaptic dense core vesicle exocytosis	IBA

MIM	HGNC	e!Ensembl
608339	11446	ENSG00000116266

O00186

Protein name

Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C)

Protein function

Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00995	Sec1	33 → 575	Sec1 family	Family

Tissue specificity

TISSUE SPECIFICITY: Megakaryocytes and platelets.

Sequence

MAPPVAERGLKSVVWQKIKATVFDDCKKEGEWKIMLLDEFTTKLLASCCKMTDLLEEGIT
VVENIYKNREPVRQMKALYFITPTSKSVDCFLHDFASKSENKYKAAYIYFTDFCPDNLFN
KIKASCSKSIRRCKEINISFIPHESQVYTLDVPDAFYYCYSPDPGNAKGKDAIMETMADQ
IVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDEKSLIKGKTHSQLLIIDR
GFDPVSTVLHELTFQAMAYDLLPIENDTYKYKTDGKEKEAILEEEDDLWVRIRHRHIAVV
LEEIPKLMKEISSTKKATEGKTSLSALTQLMKKMPHFRKQITKQVVHLNLAEDCMNKFKL
NIEKLCKTEQDLALGTDAEGQKVKDSMRVLLPVLLNKNHDNCDKIRAILLYIFSINGTTE
ENLDRLIQNVKIENESDMIRNWSYLGVPIVPQSQQGKPLRKDRSAEETFQLSRWTPFIKD
IMEDAIDNRLDSKEWPYCSQCPAVWNGSGAVSARQKPRANYLEDRKNGSKLIVFVIGGIT
YSEVRCAYEVSQAHKSCEVIIGSTHVLTPKKLLDDIKMLNKPKDKVSLIKDE

Sequence length

592

Interactions

View interactions

	Reactome
			Disinhibition of SNARE formation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Immune dysregulation, autoimmunity, and autoinflammation	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	34876482	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Associate	20460426	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hearing Loss Sensorineural	Associate	33891011	★★★★★ ★☆☆☆☆ Found in Text Mining only
HIV Infections	Associate	21897333	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	21897333	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Associate	33891011	★★★★★ ★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Associate	20460426	★★★★★ ★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Inhibit	22390153	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	34876482	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	18556422, 28798239	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Inhibit	23700440	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity Morbid	Inhibit	23700440	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Associate	22390153	★★★★★ ★☆☆☆☆ Found in Text Mining only

STXBP3 (syntaxin binding protein 3)