Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6810
Gene name	Syntaxin 4
Gene symbol	STX4
Synonyms (NCBI Gene)	DFNB123STX4Ap35-2
Chromosome	16
Chromosome location	16p11.2

178

Show/Hide all (178)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031473	hsa-miR-16-5p	Proteomics	18668040
MIRT050473	hsa-miR-22-3p	CLASH	23622248
MIRT694836	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT694835	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT694834	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT694833	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT694832	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT694831	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT694830	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT694829	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT694828	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT694827	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT694826	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT694825	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT694824	hsa-miR-302e	HITS-CLIP	23313552
MIRT694823	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT694822	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT694821	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT694820	hsa-miR-520b	HITS-CLIP	23313552
MIRT694819	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT694818	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT694817	hsa-miR-520e	HITS-CLIP	23313552
MIRT694816	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT694815	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT694814	hsa-miR-520h	HITS-CLIP	23313552
MIRT694813	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT694812	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT694811	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT694810	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT694808	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT694809	hsa-miR-548q	HITS-CLIP	23313552
MIRT694806	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT694807	hsa-miR-1254	HITS-CLIP	23313552
MIRT694805	hsa-miR-3116	HITS-CLIP	23313552
MIRT694804	hsa-miR-661	HITS-CLIP	23313552
MIRT694802	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT694803	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT694801	hsa-miR-2861	HITS-CLIP	23313552
MIRT694800	hsa-miR-4466	HITS-CLIP	23313552
MIRT694799	hsa-miR-675-5p	HITS-CLIP	23313552
MIRT694798	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT694797	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT694796	hsa-miR-3130-3p	HITS-CLIP	23313552
MIRT694795	hsa-miR-5186	HITS-CLIP	23313552
MIRT694794	hsa-miR-4252	HITS-CLIP	23313552
MIRT694793	hsa-miR-4505	HITS-CLIP	23313552
MIRT694792	hsa-miR-5787	HITS-CLIP	23313552
MIRT670661	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT670660	hsa-miR-4787-5p	HITS-CLIP	23824327
MIRT670659	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT670658	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT670657	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT670655	hsa-miR-4284	HITS-CLIP	23824327
MIRT670656	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT670654	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT670653	hsa-miR-3178	HITS-CLIP	23824327
MIRT670652	hsa-miR-128-1-5p	HITS-CLIP	23824327
MIRT670651	hsa-miR-128-2-5p	HITS-CLIP	23824327
MIRT670649	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT670661	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT670660	hsa-miR-4787-5p	HITS-CLIP	23824327
MIRT670659	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT670658	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT670657	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT670655	hsa-miR-4284	HITS-CLIP	23824327
MIRT670656	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT670654	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT670653	hsa-miR-3178	HITS-CLIP	23824327
MIRT670652	hsa-miR-128-1-5p	HITS-CLIP	23824327
MIRT670651	hsa-miR-128-2-5p	HITS-CLIP	23824327
MIRT670650	hsa-miR-7977	HITS-CLIP	23824327
MIRT670649	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT641184	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT641183	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT641182	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT641181	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT641180	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT641179	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT641178	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT641177	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT641175	hsa-miR-5688	HITS-CLIP	23824327
MIRT641176	hsa-miR-618	HITS-CLIP	23824327
MIRT641174	hsa-miR-5684	HITS-CLIP	23824327
MIRT670650	hsa-miR-7977	HITS-CLIP	27418678
MIRT694836	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT694835	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT694834	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT694833	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT694832	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT694831	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT694830	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT694829	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT694828	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT694827	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT694826	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT694825	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT694824	hsa-miR-302e	HITS-CLIP	23313552
MIRT694823	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT694822	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT694821	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT694820	hsa-miR-520b	HITS-CLIP	23313552
MIRT694819	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT694818	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT694817	hsa-miR-520e	HITS-CLIP	23313552
MIRT694816	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT694815	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT694814	hsa-miR-520h	HITS-CLIP	23313552
MIRT694813	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT694812	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT694811	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT694810	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT694808	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT694809	hsa-miR-548q	HITS-CLIP	23313552
MIRT694806	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT694807	hsa-miR-1254	HITS-CLIP	23313552
MIRT694805	hsa-miR-3116	HITS-CLIP	23313552
MIRT694804	hsa-miR-661	HITS-CLIP	23313552
MIRT694802	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT694803	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT694801	hsa-miR-2861	HITS-CLIP	23313552
MIRT694800	hsa-miR-4466	HITS-CLIP	23313552
MIRT694799	hsa-miR-675-5p	HITS-CLIP	23313552
MIRT694798	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT694797	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT694796	hsa-miR-3130-3p	HITS-CLIP	23313552
MIRT694795	hsa-miR-5186	HITS-CLIP	23313552
MIRT694794	hsa-miR-4252	HITS-CLIP	23313552
MIRT694793	hsa-miR-4505	HITS-CLIP	23313552
MIRT694792	hsa-miR-5787	HITS-CLIP	23313552
MIRT670661	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT670660	hsa-miR-4787-5p	HITS-CLIP	23824327
MIRT670659	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT670658	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT670657	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT670655	hsa-miR-4284	HITS-CLIP	23824327
MIRT670656	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT670654	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT670653	hsa-miR-3178	HITS-CLIP	23824327
MIRT670652	hsa-miR-128-1-5p	HITS-CLIP	23824327
MIRT670651	hsa-miR-128-2-5p	HITS-CLIP	23824327
MIRT670649	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT670661	hsa-miR-6499-5p	HITS-CLIP	23824327
MIRT670660	hsa-miR-4787-5p	HITS-CLIP	23824327
MIRT670659	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT670658	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT670657	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT670655	hsa-miR-4284	HITS-CLIP	23824327
MIRT670656	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT670654	hsa-miR-6781-5p	HITS-CLIP	23824327
MIRT670653	hsa-miR-3178	HITS-CLIP	23824327
MIRT670652	hsa-miR-128-1-5p	HITS-CLIP	23824327
MIRT670651	hsa-miR-128-2-5p	HITS-CLIP	23824327
MIRT670650	hsa-miR-7977	HITS-CLIP	23824327
MIRT670649	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT641184	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT641183	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT641182	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT641181	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT641180	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT641179	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT641178	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT641177	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT641175	hsa-miR-5688	HITS-CLIP	23824327
MIRT641176	hsa-miR-618	HITS-CLIP	23824327
MIRT641174	hsa-miR-5684	HITS-CLIP	23824327
MIRT1401045	hsa-miR-1537	CLIP-seq
MIRT1401046	hsa-miR-3657	CLIP-seq
MIRT1401047	hsa-miR-4449	CLIP-seq
MIRT1401048	hsa-miR-4669	CLIP-seq
MIRT1401049	hsa-miR-520d-5p	CLIP-seq
MIRT1401050	hsa-miR-524-5p	CLIP-seq
MIRT2120250	hsa-miR-361-3p	CLIP-seq
MIRT1401045	hsa-miR-1537	CLIP-seq
MIRT1401046	hsa-miR-3657	CLIP-seq
MIRT1401047	hsa-miR-4449	CLIP-seq
MIRT1401048	hsa-miR-4669	CLIP-seq
MIRT1401049	hsa-miR-520d-5p	CLIP-seq
MIRT1401050	hsa-miR-524-5p	CLIP-seq

Show/Hide all (83)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA
GO:0000149	Function	SNARE binding	IEA
GO:0000322	Component	Storage vacuole	IEA
GO:0002639	Process	Positive regulation of immunoglobulin production	IMP	24055037
GO:0005484	Function	SNAP receptor activity	IBA
GO:0005484	Function	SNAP receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	12130530, 12855681, 15576373, 16189514, 16677249, 21516116, 22153078, 25416956, 25910212, 28514442, 29892012, 30833792, 31515488, 32296183, 33845483, 33961781, 34706264, 35271311
GO:0005615	Component	Extracellular space	IDA	22226963
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IDA	20956541
GO:0005773	Component	Vacuole	TAS	16339081
GO:0005802	Component	Trans-Golgi network	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	20956541, 21720706
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006836	Process	Neurotransmitter transport	IEA
GO:0006886	Process	Intracellular protein transport	IBA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006887	Process	Exocytosis	IBA
GO:0006906	Process	Vesicle fusion	IBA
GO:0007605	Process	Sensory perception of sound	IEA
GO:0007605	Process	Sensory perception of sound	IMP	36355422
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	21720706
GO:0009986	Component	Cell surface	IDA	15576373, 20434989
GO:0009986	Component	Cell surface	IEA
GO:0012505	Component	Endomembrane system	IBA
GO:0016020	Component	Membrane	IDA	7690687
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0016230	Function	Sphingomyelin phosphodiesterase activator activity	IMP	20956541
GO:0016323	Component	Basolateral plasma membrane	IDA	16339081
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0017157	Process	Regulation of exocytosis	IMP	20434989
GO:0030027	Component	Lamellipodium	IDA	21720706
GO:0030335	Process	Positive regulation of cell migration	IMP	15351710
GO:0030670	Component	Phagocytic vesicle membrane	TAS
GO:0031201	Component	SNARE complex	IBA
GO:0031201	Component	SNARE complex	IDA	12130530, 19546860
GO:0031201	Component	SNARE complex	IEA
GO:0032420	Component	Stereocilium	IEA
GO:0032420	Component	Stereocilium	ISS
GO:0032589	Component	Neuron projection membrane	ISS
GO:0034394	Process	Protein localization to cell surface	ISS
GO:0034599	Process	Cellular response to oxidative stress	IDA	22226963
GO:0035493	Process	SNARE complex assembly	IEA
GO:0035749	Component	Myelin sheath adaxonal region	IEA
GO:0035774	Process	Positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA	24552216
GO:0035774	Process	Positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	12855681
GO:0036477	Component	Somatodendritic compartment	IDA	20434989
GO:0042581	Component	Specific granule	IDA	18588921
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0043085	Process	Positive regulation of catalytic activity	IMP	20956541
GO:0043197	Component	Dendritic spine	IDA	20434989
GO:0043219	Component	Lateral loop	IEA
GO:0043311	Process	Positive regulation of eosinophil degranulation	IMP	16677249
GO:0045202	Component	Synapse	IDA	20434989
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0045785	Process	Positive regulation of cell adhesion	IMP	21720706
GO:0048278	Process	Vesicle docking	IBA
GO:0048284	Process	Organelle fusion	IDA	20434989
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	ISS
GO:0050921	Process	Positive regulation of chemotaxis	IMP	21720706
GO:0060291	Process	Long-term synaptic potentiation	IDA	20434989
GO:0061024	Process	Membrane organization	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071346	Process	Cellular response to type II interferon	IEA
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098794	Component	Postsynapse	IDA	27662481
GO:0098794	Component	Postsynapse	IEA
GO:0098794	Component	Postsynapse	IMP	27662481
GO:0098978	Component	Glutamatergic synapse	IDA	27662481
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IMP	27662481
GO:0099072	Process	Regulation of postsynaptic membrane neurotransmitter receptor levels	IEA
GO:1902041	Process	Regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP	20956541
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IMP	15351710, 20956541, 21720706
GO:1903575	Process	Cornified envelope assembly	IDA	22226963
GO:2000010	Process	Positive regulation of protein localization to cell surface	IMP	21720706

MIM	HGNC	e!Ensembl
186591	11439	ENSG00000103496

Q12846

Protein name

Syntaxin-4 (Renal carcinoma antigen NY-REN-31)

Protein function

Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00804	Syntaxin	39 → 235	Syntaxin	Domain
PF05739	SNARE	236 → 293	SNARE domain	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation. {ECO:0000269|PubMed:10080545}.

Sequence

MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQ
ELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNT
RMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSG
QSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINR
IEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG

Sequence length

297

Interactions

View interactions

	KEGG		Reactome
	SNARE interactions in vesicular transport Vasopressin-regulated water reabsorption		Disinhibition of SNARE formation ER-Phagosome pathway trans-Golgi Network Vesicle Budding Other interleukin signaling

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Hearing loss, autosomal recessive 123	Likely pathogenic; Pathogenic	rs763815427	RCV003883471
Sensorineural hearing loss disorder	Likely pathogenic; Pathogenic	rs763815427	RCV002291511

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	34937778
Asthma	Associate	40514687
Atherosclerosis	Associate	23451202
Breast Neoplasms	Associate	34876482
Carcinoma Renal Cell	Stimulate	34482824
Epilepsy Generalized	Associate	40495522
Mast Cell Activation Disorders	Associate	21128998
Neoplasm Metastasis	Associate	34876482
Neoplasms	Associate	28798239, 34482824
Polycystic Ovary Syndrome	Associate	22390153
Triple Negative Breast Neoplasms	Associate	34876482

STX4 (syntaxin 4)