Gene Gene information from NCBI Gene database.
Entrez ID 6801
Gene name Striatin
Gene symbol STRN
Synonyms (NCBI Gene)
PPP2R6ASG2NASTRN1
Chromosome 2
Chromosome location 2p22.2
miRNA miRNA information provided by mirtarbase database.
1738
miRTarBase ID miRNA Experiments Reference
MIRT005191 hsa-miR-30a-5p pSILAC 18668040
MIRT020667 hsa-miR-155-5p Proteomics 18668040
MIRT005191 hsa-miR-30a-5p Proteomics;Other 18668040
MIRT048077 hsa-miR-197-3p CLASH 23622248
MIRT043722 hsa-miR-342-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
38
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 17540176, 18782753, 22153077, 23455922, 24255178, 24366813, 25416956, 26496610, 28330616, 28514442, 32296183, 32707033, 33961781, 35271311
GO:0005516 Function Calmodulin binding IEA
GO:0005516 Function Calmodulin binding ISS
GO:0005516 Function Calmodulin binding NAS 9693043, 10748158
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614765 11424 ENSG00000115808
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O43815
Protein name Striatin
Protein function Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multi
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08232 Striatin 48 177 Striatin family Family
PF00400 WD40 453 491 WD domain, G-beta repeat Repeat
PF00400 WD40 506 544 WD domain, G-beta repeat Repeat
PF00400 WD40 559 597 WD domain, G-beta repeat Repeat
PF00400 WD40 696 734 WD domain, G-beta repeat Repeat
PF00400 WD40 738 779 WD domain, G-beta repeat Repeat
Tissue specificity TISSUE SPECIFICITY: Preferentially expressed in brain. {ECO:0000269|PubMed:9693043}.
Sequence
MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEW
ARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLK
YGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILD
VKS
KRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESA
AADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNE
SRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLAN
LRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESE
LGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLIT
ASEDHTLKMWN
LQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLI
QGWN
TTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE
VAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTT
ANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLY
LMSGSHDCSIRLWN
LESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVFV
Sequence length 780
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Extra-nuclear estrogen signaling
Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
17
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BASAL CELL CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Chronic lymphocytic leukemia/small lymphocytic lymphoma Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acanthosis Nigricans Associate 35277199
★☆☆☆☆
Found in Text Mining only
Acrocephalosyndactylia Associate 31821324
★☆☆☆☆
Found in Text Mining only
Adenoma Pleomorphic Associate 34985683
★☆☆☆☆
Found in Text Mining only
Brain Ischemia Associate 31821324
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 32280692
★☆☆☆☆
Found in Text Mining only
Carcinoma Intraductal Noninfiltrating Associate 32661669
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 33960639
★☆☆☆☆
Found in Text Mining only
Cerebral Cavernous Malformations 3 Associate 18782753
★☆☆☆☆
Found in Text Mining only
Coronary Artery Disease Associate 31821324
★☆☆☆☆
Found in Text Mining only
Depressive Disorder Associate 32801349
★☆☆☆☆
Found in Text Mining only