Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6794
Gene name	Serine/threonine kinase 11
Gene symbol	STK11
Synonyms (NCBI Gene)	LKB1PJShLKB1
Chromosome	19
Chromosome location	19p13.3
Summary	This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by

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SNP ID	Visualize variation	Clinical significance	Consequence
rs2075607	G>A,C,T	Likely-benign, conflicting-interpretations-of-pathogenicity, benign	Intron variant
rs9282859	C>G,T	Likely-benign, benign, pathogenic	Synonymous variant, stop gained, coding sequence variant
rs112675807	G>A,C,T	Pathogenic	Splice acceptor variant
rs121913315	G>A,T	Pathogenic-likely-pathogenic, pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs121913316	A>T	Likely-pathogenic	Coding sequence variant, missense variant
rs121913317	G>A,T	Uncertain-significance, likely-pathogenic	Stop gained, coding sequence variant, missense variant
rs121913319	G>-,GG	Pathogenic	Coding sequence variant, frameshift variant
rs121913320	TTTG>-	Pathogenic	Coding sequence variant, frameshift variant
rs121913321	CC>-,C,CCC	Pathogenic	Coding sequence variant, frameshift variant
rs121913322	C>A,G,T	Likely-benign, benign-likely-benign, likely-pathogenic, conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant
rs121913323	C>G,T	Likely-pathogenic, pathogenic, uncertain-significance	Stop gained, coding sequence variant, missense variant
rs121913324	C>T	Pathogenic, likely-pathogenic	Coding sequence variant, stop gained
rs121913325	G>A	Likely-pathogenic	Coding sequence variant, stop gained
rs137853075	C>A,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs137853076	A>G,T	Pathogenic	Stop gained, coding sequence variant, missense variant
rs137853077	T>C	Pathogenic-likely-pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs137853078	G>A	Pathogenic	Coding sequence variant, missense variant
rs137853079	C>A,G,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs137853080	T>G	Pathogenic	Coding sequence variant, missense variant
rs137853081	G>C,T	Pathogenic	Coding sequence variant, missense variant
rs137853082	G>A,C,T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant, stop gained
rs137853083	C>G,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs137854584	G>T	Pathogenic	Coding sequence variant, stop gained
rs148830698	G>A,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs199681533	C>A,G,T	Likely-benign, conflicting-interpretations-of-pathogenicity	Missense variant, synonymous variant, coding sequence variant
rs200078204	C>A,T	Likely-benign, conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs200824447	C>A,T	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs202011521	G>A	Conflicting-interpretations-of-pathogenicity, benign-likely-benign, benign	Synonymous variant, coding sequence variant
rs368466538	C>A,G,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, synonymous variant, coding sequence variant
rs370222210	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs370976710	G>A,C,T	Likely-benign, benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs371264852	G>A,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs372329880	C>A,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant
rs372511774	C>T	Likely-benign, benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs373167735	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Intron variant
rs376069854	C>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs376280361	G>A,C	Pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs397518440	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs397518441	->T	Pathogenic	Coding sequence variant, frameshift variant
rs397518442	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs397518443	AA>-,A	Pathogenic	Coding sequence variant, frameshift variant
rs398123405	G>A,T	Uncertain-significance, pathogenic	Stop gained, coding sequence variant, missense variant
rs398123406	G>C,T	Pathogenic	Splice acceptor variant
rs532889728	G>A	Benign, conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs552610464	G>A	Conflicting-interpretations-of-pathogenicity	5 prime UTR variant
rs553752236	G>A	Likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs556651007	G>A,T	Likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	Synonymous variant, missense variant, coding sequence variant
rs558040549	C>A,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs565993396	A>G	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs567202367	C>A,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Intron variant
rs587776656	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs587776657	TCGG>-	Pathogenic	Frameshift variant, coding sequence variant
rs587776658	G>A	Pathogenic	Splice acceptor variant
rs587776659	TG>-	Pathogenic	Frameshift variant, coding sequence variant
rs587776660	TCCGGCAGC>-	Pathogenic	Inframe indel, coding sequence variant
rs587776661	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs587778695	C>A,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance, not-provided	Coding sequence variant, missense variant
rs587780009	G>A,C	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Intron variant
rs587780013	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Intron variant
rs587781537	C>A,G,T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Stop gained, coding sequence variant, missense variant
rs587781633	A>G	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant
rs587781856	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs587782018	G>C,T	Pathogenic	Splice donor variant
rs587782259	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign, benign	3 prime UTR variant
rs587782364	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, missense variant
rs587782424	TG>-	Pathogenic	Frameshift variant, coding sequence variant
rs727504171	T>G	Likely-pathogenic	Coding sequence variant, missense variant
rs727504172	A>C,T	Pathogenic	Splice acceptor variant
rs730881958	TCATCGGCAAGT>-	Pathogenic	Inframe indel, coding sequence variant
rs730881959	GCAGGAGGGCCGT>-	Pathogenic	Frameshift variant, coding sequence variant
rs730881961	C>A,T	Benign, conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs730881963	G>A,C	Benign, conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant, missense variant
rs730881969	C>A,T	Likely-benign, pathogenic	Synonymous variant, stop gained, coding sequence variant
rs730881970	C>A,T	Uncertain-significance, pathogenic	Stop gained, coding sequence variant, missense variant
rs730881972	G>C,T	Likely-pathogenic	Coding sequence variant, missense variant
rs730881973	C>A,G	Uncertain-significance, pathogenic	Coding sequence variant, missense variant
rs730881976	C>A,G	Likely-pathogenic, pathogenic	Stop gained, coding sequence variant, missense variant
rs730881979	G>A	Pathogenic	Coding sequence variant, missense variant
rs755126393	A>G	Conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs755746417	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Intron variant
rs759090799	ATGAA>-	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Splice acceptor variant, intron variant
rs759284466	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	5 prime UTR variant
rs760399253	C>G,T	Pathogenic	Coding sequence variant, synonymous variant, stop gained
rs764244639	C>G,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs764449808	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs767565606	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, synonymous variant
rs768058962	C>G,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs774072752	G>T	Benign-likely-benign, uncertain-significance, conflicting-interpretations-of-pathogenicity	5 prime UTR variant
rs774100153	C>G,T	Conflicting-interpretations-of-pathogenicity, likely-benign	Missense variant, coding sequence variant, synonymous variant
rs775595174	G>A,C,T	Uncertain-significance, pathogenic	Missense variant, coding sequence variant, stop gained
rs778376925	C>A,G,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs786200991	->G	Pathogenic	Frameshift variant, coding sequence variant
rs786201090	C>T	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs786201213	C>A,T	Likely-pathogenic, likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs786201349	C>G,T	Likely-benign, pathogenic	Synonymous variant, coding sequence variant, stop gained
rs786202134	C>A,G,T	Likely-pathogenic	Missense variant, synonymous variant, coding sequence variant
rs786203624	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs786205864	->C	Pathogenic	Frameshift variant, coding sequence variant
rs863224448	G>A	Likely-pathogenic	Splice acceptor variant
rs863224669	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Intron variant
rs864622488	G>A,T	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant, stop gained
rs864622707	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs876658584	A>G	Pathogenic	Splice acceptor variant
rs876661012	->A	Pathogenic	Coding sequence variant, stop gained
rs878853247	G>C,T	Likely-pathogenic	Missense variant, coding sequence variant
rs878853984	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs878853985	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Synonymous variant, coding sequence variant
rs886037859	A>G	Conflicting-interpretations-of-pathogenicity, pathogenic-likely-pathogenic	Missense variant, coding sequence variant
rs886037926	A>G	Likely-pathogenic	Missense variant, coding sequence variant
rs886039554	G>T	Likely-pathogenic, pathogenic	Splice donor variant
rs886041996	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs927999961	T>-,TT	Conflicting-interpretations-of-pathogenicity	5 prime UTR variant
rs1057517830	G>A	Pathogenic	Splice acceptor variant
rs1057518830	CTG>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1057519858	G>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520017	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520018	T>C	Likely-pathogenic, likely-benign	Coding sequence variant, missense variant
rs1057520038	G>A	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520039	C>G,T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant, stop gained
rs1057520040	A>G	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520041	T>A	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520042	G>C	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520379	C>A,G	Likely-pathogenic	Coding sequence variant, missense variant
rs1057520606	G>T	Pathogenic	Coding sequence variant, stop gained
rs1057524439	T>C	Likely-pathogenic	Coding sequence variant, missense variant
rs1060499956	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Intron variant
rs1060499958	T>C	Pathogenic, likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs1060499960	ACCGGTGG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1060499961	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1060503786	C>T	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, synonymous variant
rs1064793427	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1064794805	A>C,G	Likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs1085307466	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690916	ATGGGGGACCTG>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1131690917	GGG>-,G,GGGG	Pathogenic, likely-pathogenic, uncertain-significance	Coding sequence variant, frameshift variant, inframe deletion
rs1131690920	G>A	Pathogenic, likely-pathogenic	Splice donor variant
rs1131690921	G>T	Pathogenic	Splice donor variant
rs1131690922	->ACCT	Pathogenic	Coding sequence variant, frameshift variant
rs1131690923	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690924	T>-	Pathogenic	Coding sequence variant, frameshift variant
rs1131690925	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690926	C>-	Pathogenic	Coding sequence variant, frameshift variant
rs1131690929	->A	Pathogenic	Coding sequence variant, frameshift variant
rs1131690930	->C	Pathogenic	Coding sequence variant, frameshift variant
rs1131690931	A>C	Likely-pathogenic	Splice acceptor variant
rs1131690933	->GAAGC	Pathogenic	Coding sequence variant, frameshift variant
rs1131690934	A>G	Pathogenic	Splice acceptor variant
rs1131690935	GGTTCTCCATCCGGCAGA>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs1131690936	GGTG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1131690938	A>T	Likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs1131690939	G>-,GG	Pathogenic	Coding sequence variant, frameshift variant
rs1131690940	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690941	T>C	Likely-pathogenic	Splice donor variant
rs1131690944	A>G	Likely-pathogenic	Splice acceptor variant
rs1131690945	C>T	Pathogenic	Coding sequence variant, stop gained
rs1131690946	->C	Pathogenic	Coding sequence variant, frameshift variant
rs1131690947	C>-	Pathogenic	Coding sequence variant, stop gained
rs1131690948	G>-	Pathogenic	Coding sequence variant, frameshift variant
rs1131690949	->G	Pathogenic	Coding sequence variant, frameshift variant
rs1131690950	G>A,C	Pathogenic	Splice donor variant
rs1131690951	A>G	Pathogenic	Splice donor variant
rs1131690952	->A	Pathogenic	Coding sequence variant, frameshift variant
rs1131690953	CCTGCTGGGGGA>-	Likely-pathogenic, uncertain-significance	Coding sequence variant, inframe deletion
rs1407794756	C>T	Conflicting-interpretations-of-pathogenicity	Intron variant
rs1471868090	C>A,T	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, synonymous variant
rs1555734904	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555735001	->AC	Pathogenic	Frameshift variant, coding sequence variant
rs1555735008	C>-	Pathogenic	Coding sequence variant, stop gained
rs1555735014	C>-	Pathogenic, likely-pathogenic	Frameshift variant, coding sequence variant
rs1555735080	GTAAGTA>-	Likely-pathogenic	Intron variant, coding sequence variant, splice donor variant
rs1555737444	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555737480	T>C	Likely-pathogenic	Splice donor variant
rs1555737814	GT>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555737830	G>A	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs1555738205	C>G,T	Pathogenic, likely-benign	Coding sequence variant, stop gained, synonymous variant
rs1555738219	->GGACATCA	Pathogenic	Frameshift variant, coding sequence variant
rs1555738319	G>A	Likely-pathogenic	Splice acceptor variant
rs1555738475	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555738656	->GA	Pathogenic	Frameshift variant, coding sequence variant
rs1555738667	C>-	Pathogenic	Coding sequence variant, stop gained
rs1555738683	T>AC	Pathogenic	Frameshift variant, coding sequence variant
rs1555738723	A>-	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1555738863	CCAAG>-	Pathogenic	Frameshift variant, coding sequence variant
rs1555738874	->TCCATCC	Pathogenic	Frameshift variant, coding sequence variant
rs1555738899	CA>TCC	Pathogenic	Frameshift variant, coding sequence variant
rs1568689930	->C	Pathogenic	Frameshift variant, coding sequence variant
rs1568689994	CT>-	Pathogenic	Frameshift variant, coding sequence variant
rs1568690161	->T	Pathogenic	Frameshift variant, coding sequence variant
rs1568690546	TAA>-	Likely-pathogenic	Intron variant, splice donor variant
rs1568708275	C>T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant
rs1568708382	G>A	Uncertain-significance, likely-pathogenic	Coding sequence variant, missense variant
rs1568709203	->TACAAGTT	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1568710381	G>A	Uncertain-significance, pathogenic	Coding sequence variant, missense variant
rs1599915131	TGCTGGACTCGGAGACGCTGTGCAGGAGG>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599915235	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599924500	TCCTCTCTGTCCCAGGG>-	Likely-pathogenic	Intron variant, coding sequence variant, splice acceptor variant
rs1599925303	G>T	Pathogenic	Coding sequence variant, stop gained
rs1599926521	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599927564	->TGTA	Pathogenic	Frameshift variant, coding sequence variant
rs1599927573	->C	Pathogenic	Frameshift variant, coding sequence variant
rs1599927589	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599927622	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599927645	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599927689	->ACTGTGG	Pathogenic	Frameshift variant, coding sequence variant
rs1599928360	G>-	Likely-pathogenic	Coding sequence variant, splice donor variant
rs1599929258	TGGTTCCGGA>CC	Pathogenic	Frameshift variant, coding sequence variant
rs1599929264	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599929328	C>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599929335	A>-	Pathogenic	Frameshift variant, coding sequence variant
rs1599929339	->T	Pathogenic	Frameshift variant, coding sequence variant
rs1599929369	AC>-	Likely-pathogenic	Frameshift variant, coding sequence variant

Show/Hide all (88)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020252	hsa-miR-130b-3p	Sequencing	20371350
MIRT028122	hsa-miR-93-5p	Sequencing	20371350
MIRT050817	hsa-miR-17-5p	CLASH	23622248
MIRT052942	hsa-miR-199a-3p	Luciferase reporter assayWestern blot	22265968
MIRT052942	hsa-miR-199a-3p	Luciferase reporter assayWestern blot	22265968
MIRT570514	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT570513	hsa-miR-3141	PAR-CLIP	20371350
MIRT570512	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT570511	hsa-miR-4767	PAR-CLIP	20371350
MIRT492157	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT492156	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT492154	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT492155	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT492161	hsa-miR-4446-3p	PAR-CLIP	23592263
MIRT492160	hsa-miR-6890-3p	PAR-CLIP	23592263
MIRT492159	hsa-miR-4721	PAR-CLIP	23592263
MIRT492158	hsa-miR-604	PAR-CLIP	23592263
MIRT492157	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT492156	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT492154	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT492155	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT492153	hsa-miR-6829-5p	PAR-CLIP	23592263
MIRT492152	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT492151	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT492150	hsa-miR-5698	PAR-CLIP	23592263
MIRT492149	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT492148	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT492146	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT492147	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT028122	hsa-miR-93-5p	Luciferase reporter assay	28382150
MIRT028122	hsa-miR-93-5p	Luciferase reporter assay	28382150
MIRT028122	hsa-miR-93-5p	Luciferase reporter assay	28382150
MIRT028122	hsa-miR-93-5p	Luciferase reporter assay	28382150
MIRT570514	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT570513	hsa-miR-3141	PAR-CLIP	20371350
MIRT570512	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT570511	hsa-miR-4767	PAR-CLIP	20371350
MIRT492157	hsa-miR-149-3p	PAR-CLIP	20371350
MIRT492156	hsa-miR-4728-5p	PAR-CLIP	20371350
MIRT492154	hsa-miR-6785-5p	PAR-CLIP	20371350
MIRT492155	hsa-miR-6883-5p	PAR-CLIP	20371350
MIRT492161	hsa-miR-4446-3p	PAR-CLIP	23592263
MIRT492160	hsa-miR-6890-3p	PAR-CLIP	23592263
MIRT492159	hsa-miR-4721	PAR-CLIP	23592263
MIRT492158	hsa-miR-604	PAR-CLIP	23592263
MIRT492157	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT492156	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT492154	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT492155	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT492153	hsa-miR-6829-5p	PAR-CLIP	23592263
MIRT492152	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT492151	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT492150	hsa-miR-5698	PAR-CLIP	23592263
MIRT492149	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT492148	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT492146	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT492147	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT1397196	hsa-miR-1255a	CLIP-seq
MIRT1397197	hsa-miR-1255b	CLIP-seq
MIRT1397198	hsa-miR-1299	CLIP-seq
MIRT1397199	hsa-miR-1470	CLIP-seq
MIRT1397200	hsa-miR-1471	CLIP-seq
MIRT1397201	hsa-miR-1908	CLIP-seq
MIRT1397202	hsa-miR-2115	CLIP-seq
MIRT1397203	hsa-miR-3130-3p	CLIP-seq
MIRT1397204	hsa-miR-3177-3p	CLIP-seq
MIRT1397205	hsa-miR-3663-5p	CLIP-seq
MIRT1397206	hsa-miR-3676	CLIP-seq
MIRT1397207	hsa-miR-3682-3p	CLIP-seq
MIRT1397208	hsa-miR-4433	CLIP-seq
MIRT1397209	hsa-miR-4459	CLIP-seq
MIRT1397210	hsa-miR-4479	CLIP-seq
MIRT1397211	hsa-miR-4768-3p	CLIP-seq
MIRT1397212	hsa-miR-4782-5p	CLIP-seq
MIRT1397213	hsa-miR-4793-3p	CLIP-seq
MIRT1397214	hsa-miR-516b	CLIP-seq
MIRT1397215	hsa-miR-663	CLIP-seq
MIRT1397216	hsa-miR-767-5p	CLIP-seq
MIRT2118976	hsa-miR-1205	CLIP-seq
MIRT2118977	hsa-miR-1291	CLIP-seq
MIRT1397199	hsa-miR-1470	CLIP-seq
MIRT2118978	hsa-miR-1909	CLIP-seq
MIRT2118979	hsa-miR-3173-5p	CLIP-seq
MIRT1397199	hsa-miR-1470	CLIP-seq
MIRT2341278	hsa-miR-532-3p	CLIP-seq
MIRT2341279	hsa-miR-662	CLIP-seq
MIRT2692231	hsa-miR-4484	CLIP-seq
MIRT2692232	hsa-miR-4740-3p	CLIP-seq

Show/Hide all (7)

Transcription factor	Regulation	Reference
NFYA	Unknown	22412893
NFYB	Unknown	22412893
NKX2-1	Repression	23995788
NR1H4	Activation	22265968
SP1	Unknown	22412893;23995788
STAT3	Unknown	24913037
STAT5A	Unknown	24913037

105

Show/Hide all (105)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	12805220
GO:0001558	Process	Regulation of cell growth	IEA
GO:0001558	Process	Regulation of cell growth	ISS
GO:0001894	Process	Tissue homeostasis	IEA
GO:0001944	Process	Vasculature development	IEA
GO:0001944	Process	Vasculature development	ISS
GO:0002039	Function	P53 binding	IDA	11430832
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	11430832, 12805220, 19892943
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	9428765
GO:0005515	Function	Protein binding	IPI	12595760, 12753905, 12805220, 14676191, 17216128, 19274086, 19513107, 19892943, 20562859, 22575644, 22939624, 24362629, 25036637, 25241761, 25329316, 25852190, 26479318, 28514442, 32707033, 33961781, 34591612, 35271311
GO:0005524	Function	ATP binding	IDA	12805220
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	12805220, 18854309
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	11430832, 12805220, 14517248, 17216128, 18854309
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005739	Component	Mitochondrion	IDA	11430832
GO:0005739	Component	Mitochondrion	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005929	Component	Cilium	IDA
GO:0006468	Process	Protein phosphorylation	IDA	12805220, 25329316
GO:0006468	Process	Protein phosphorylation	TAS	9428765
GO:0006470	Process	Protein dephosphorylation	IMP	15731909
GO:0006914	Process	Autophagy	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0006974	Process	DNA damage response	IBA
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IMP	25329316
GO:0007165	Process	Signal transduction	IBA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007409	Process	Axonogenesis	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IMP	17216128, 25329316
GO:0010212	Process	Response to ionizing radiation	IEA
GO:0010212	Process	Response to ionizing radiation	ISS
GO:0010508	Process	Positive regulation of autophagy	IMP	23878245
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018107	Process	Peptidyl-threonine phosphorylation	IDA	12805220
GO:0030010	Process	Establishment of cell polarity	IBA
GO:0030010	Process	Establishment of cell polarity	IEA
GO:0030010	Process	Establishment of cell polarity	IMP	24643070
GO:0030010	Process	Establishment of cell polarity	ISS
GO:0030111	Process	Regulation of Wnt signaling pathway	IBA
GO:0030111	Process	Regulation of Wnt signaling pathway	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030275	Function	LRR domain binding	IEA
GO:0030295	Function	Protein kinase activator activity	IDA	19892943
GO:0030295	Function	Protein kinase activator activity	IEA
GO:0030308	Process	Negative regulation of cell growth	IEA
GO:0030308	Process	Negative regulation of cell growth	ISS
GO:0030511	Process	Positive regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0030511	Process	Positive regulation of transforming growth factor beta receptor signaling pathway	IMP	18311138
GO:0032147	Process	Activation of protein kinase activity	IDA	18854309
GO:0032147	Process	Activation of protein kinase activity	IMP	15731909
GO:0034504	Process	Protein localization to nucleus	IEA
GO:0042593	Process	Glucose homeostasis	IEA
GO:0042593	Process	Glucose homeostasis	ISS
GO:0043276	Process	Anoikis	IMP	19622832
GO:0045059	Process	Positive thymic T cell selection	IEA
GO:0046777	Process	Protein autophosphorylation	IDA	11430832
GO:0046872	Function	Metal ion binding	IEA
GO:0048814	Process	Regulation of dendrite morphogenesis	IEA
GO:0050772	Process	Positive regulation of axonogenesis	IEA
GO:0050852	Process	T cell receptor signaling pathway	IEA
GO:0051645	Process	Golgi localization	IEA
GO:0051726	Process	Regulation of cell cycle	TAS
GO:0051896	Process	Regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0060767	Process	Epithelial cell proliferation involved in prostate gland development	IEA
GO:0060770	Process	Negative regulation of epithelial cell proliferation involved in prostate gland development	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070314	Process	G1 to G0 transition	IDA	17216128
GO:0070314	Process	G1 to G0 transition	IPI	12805220
GO:0071493	Process	Cellular response to UV-B	IDA	25329316
GO:0071493	Process	Cellular response to UV-B	IEA
GO:0072332	Process	Intrinsic apoptotic signaling pathway by p53 class mediator	IDA	11430832
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IMP	15731909
GO:0097484	Process	Dendrite extension	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	27461402
GO:0140535	Component	Intracellular protein-containing complex	IDA	12805220
GO:1900182	Process	Positive regulation of protein localization to nucleus	IEA
GO:1901610	Process	Positive regulation of vesicle transport along microtubule	IBA
GO:1901610	Process	Positive regulation of vesicle transport along microtubule	IEA
GO:1901610	Process	Positive regulation of vesicle transport along microtubule	IMP	24643070
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS
GO:1902554	Component	Serine/threonine protein kinase complex	IPI	19892943
GO:1902554	Component	Serine/threonine protein kinase complex	ISS
GO:1904262	Process	Negative regulation of TORC1 signaling	IMP	23878245

MIM	HGNC	e!Ensembl
602216	11389	ENSG00000118046

Q15831

Protein name

Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)

Protein function

Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage respo

PDB

2WTK , 4ZDR , 5WXN , 8VSU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	49 → 309	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in testis and fetal liver.

Sequence

MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSY
GKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNE
EKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPG
NLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWS
AGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSI
RQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDI
IYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSA
SSKIRRLSACKQQ

Sequence length

433

Interactions

View interactions

	KEGG		Reactome
	FoxO signaling pathway Hormone signaling Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Tight junction Adipocytokine signaling pathway		Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes

4965

Show/Hide Causal Diseases (18)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Carcinoma of pancreas	Likely pathogenic; Pathogenic	rs730881976, rs137853079, rs397518442, rs397518443, rs730881975	RCV000763422 RCV000007878 RCV000007879 RCV000007880 RCV001197734
Familial adenomatous polyposis 1	Likely pathogenic	rs2145426900	RCV002267182
Familial ovarian cancer	Pathogenic	rs121913321, rs112675807	RCV005361064 RCV005359765
Familial pancreatic carcinoma	Likely pathogenic	rs730881972, rs864622488	RCV005394564 RCV005396642
Gastric cancer	Pathogenic	rs1131690950, rs1555737480, rs2145431441	RCV005923929 RCV003164590 RCV003164592
Generalized juvenile polyposis/juvenile polyposis coli	Likely pathogenic	rs2145420502	RCV001355139
Germ cell tumor of testis	Pathogenic; Likely pathogenic	rs2145427067, rs730881972, rs864622488	RCV001542798 RCV005394564 RCV005396642
Hereditary cancer-predisposing syndrome	Pathogenic; Likely pathogenic	rs771049807, rs2145422531, rs587782018, rs2145428733, rs2145430970, rs2145428869, rs587781856, rs876661012, rs148928808, rs2512940524, rs730881971, rs2512942351, rs886039554, rs2512942525, rs2145424658 View all (112 more)	RCV005493039 RCV005493040 RCV002384545 RCV006287433 RCV004037711 RCV005493124 RCV000130164 RCV000130447 RCV002257205 RCV002373063 RCV002330392 RCV002342608 RCV002330459 RCV002356090 RCV002330711 RCV002353450 RCV002361887 RCV002337663 RCV000160967 RCV000160968 RCV000492214 RCV000161008 RCV000492356 RCV002334752 RCV000492450 RCV002345554 RCV000160995 RCV002375910 RCV002371245 RCV002430149 RCV002412566 RCV002378781 RCV002385391 RCV002369353 RCV002421462 RCV002376421 RCV002380209 RCV002375949 RCV002405390 RCV002401136 RCV002450596 RCV002452753 RCV002424339 RCV002437319 RCV000164794 RCV000167017 RCV001183047 RCV003164591 RCV000492479 RCV002444692 RCV005288830 RCV002372183 RCV005286010 RCV000132431 RCV004018586 RCV000492681 RCV000492740 RCV000492134 RCV002354151 RCV000222975 RCV003187696 RCV003203531 RCV000492112 RCV000492737 RCV005742021 RCV006287174 RCV003293654 RCV003360632 RCV003360637 RCV004518467 RCV004676348 RCV000492537 RCV000492178 RCV000492099 RCV000492327 RCV000492505 RCV000492438 RCV002367637 RCV002374885 RCV000492722 RCV000492692 RCV000492531 RCV000492762 RCV000492522 RCV000492429 RCV000492465 RCV000492614 RCV000492296 RCV000492251 RCV000492673 RCV000492655 RCV000492754 RCV000492282 RCV000492215 RCV000492647 RCV000492674 RCV000492574 RCV000492160 RCV000492400 RCV000492208 RCV000492258 RCV000492482 RCV000492457 RCV000492086 RCV000492232 RCV000492368 RCV000492404 RCV000492497 RCV000492598 RCV000492152 RCV000492320 RCV000492604 RCV000492545 RCV000563941 RCV000568657 RCV000574820 RCV000584565 RCV001178644 RCV002404753 RCV003362870 RCV005742082 RCV002343400 RCV002343505 RCV001016914 RCV000772564 RCV004949999 RCV001015503 RCV001021366 RCV001023827 RCV001026060 RCV001026963 RCV001027134 RCV001027387 RCV001019033 RCV001016940 RCV005492933 RCV005742173 RCV001185859 RCV002436817 RCV002436941 RCV000492387 RCV004678606 RCV005286024
Intestinal polyposis	Likely pathogenic	rs1057518830	RCV000415408
Lung cancer	Likely pathogenic; Pathogenic	rs863224448, rs587782018, rs730881971, rs1131690931, rs112675807	RCV005912579 RCV005886914 RCV005922893 RCV005899758 RCV005901700
Malignant tumor of testis	Likely pathogenic; Pathogenic	rs730881976, rs137853078	RCV000763422 RCV000007874
Melanoma	Pathogenic; Likely pathogenic	rs121913321, rs2512921105, rs2512940408, rs1060499964	RCV003995678 RCV004011265 RCV004011266 RCV004011267
Melanoma, cutaneous malignant, susceptibility to, 1	Likely pathogenic; Pathogenic	rs2145404496, rs2145426930, rs730881972, rs864622488, rs121913315, rs121913323, rs137853080, rs137853081, rs2512955106, rs1057520039	RCV003464277 RCV002246746 RCV005394564 RCV005396642 RCV000007876 RCV000007881 RCV000007882 RCV000007883 RCV003466420 RCV003459509
Neoplasm	Likely pathogenic; Pathogenic	rs587782018, rs730881971, rs786201090, rs1060499964, rs121913321, rs1131690921	RCV005229964 RCV006274268 RCV005230004 RCV006274420 RCV004668976 RCV004669005
Ovarian sex cord-stromal tumor	Pathogenic	rs137853076	RCV006253452
Periorbital hyperpigmentation	Likely pathogenic	rs1057518830	RCV000415408
Peutz-Jeghers syndrome	Likely pathogenic; Pathogenic	rs863224448, rs2145405146, rs112675807, rs2145420699, rs771049807, rs2145420792, rs2145422531, rs2145425021, rs2145425162, rs587782018, rs1226608647, rs2145428733, rs2145430970, rs2145426686, rs2145420751 View all (183 more)	RCV001376748 RCV001389758 RCV001389316 RCV001387076 RCV001389317 RCV001386418 RCV001389318 RCV001389447 RCV001386590 RCV001380249 RCV001384681 RCV001381098 RCV001391230 RCV001838842 RCV001936713 RCV001877147 RCV001864977 RCV001994600 RCV001904379 RCV001970180 RCV001888255 RCV002041100 RCV001878747 RCV001986006 RCV001993197 RCV001864373 RCV001994478 RCV002016309 RCV001951192 RCV001949534 RCV001890059 RCV001972514 RCV001927648 RCV001892030 RCV001992664 RCV001916542 RCV001849934 RCV002243552 RCV003101532 RCV002294600 RCV003507415 RCV000703819 RCV004019944 RCV001904587 RCV005394564 RCV000429467 RCV004796592 RCV000763422 RCV004437823 RCV001062236 RCV004796727 RCV004059120 RCV001850304 RCV000435642 RCV003235727 RCV000168375 RCV003064528 RCV003064529 RCV003050509 RCV003041338 RCV000172825 RCV000172824 RCV002846738 RCV002844047 RCV002872251 RCV002871366 RCV002876047 RCV002966525 RCV000199530 RCV000196256 RCV002999966 RCV003038678 RCV003017386 RCV000205945 RCV000205568 RCV000007865 RCV000007866 RCV000007867 RCV000007868 RCV000007869 RCV000007870 RCV000007871 RCV000007872 RCV000007873 RCV000007875 RCV000007877 RCV001042420 RCV002512881 RCV000007884 RCV000007885 RCV000007886 RCV001808581 RCV000632841 RCV003128554 RCV000240843 RCV000241351 RCV000700997 RCV002519067 RCV000796535 RCV003236430 RCV003507494 RCV003316947 RCV003485928 RCV003338153 RCV003508093 RCV003508873 RCV003508874 RCV003507230 RCV003506981 RCV003507762 RCV003507754 RCV003618367 RCV003618753 RCV003617520 RCV003619011 RCV003867381 RCV003991926 RCV004439987 RCV004440198 RCV004440205 RCV004440285 RCV004440322 RCV004440403 RCV004440412 RCV004442484 RCV004442504 RCV004442514 RCV005052084 RCV004589314 RCV004589335 RCV001808786 RCV001380725 RCV000632833 RCV000656431 RCV005052144 RCV000553835 RCV004796174 RCV005052143 RCV003138001 RCV000474608 RCV000474843 RCV000466541 RCV000464957 RCV001809438 RCV000807012 RCV001865435 RCV004023237 RCV000550769 RCV000540715 RCV000533344 RCV001856951 RCV001214909 RCV004796196 RCV003617817 RCV000819570 RCV001389743 RCV005091033 RCV001269112 RCV000557192 RCV000990129 RCV000807365 RCV003507284 RCV001386709 RCV000709574 RCV000804860 RCV000664331 RCV000515491 RCV000525862 RCV000537729 RCV000542348 RCV000554906 RCV000552113 RCV003507297 RCV001809686 RCV000586390 RCV000813229 RCV000632819 RCV000632845 RCV000632832 RCV000632808 RCV000632836 RCV000632807 RCV000632838 RCV000632803 RCV000632804 RCV002289947 RCV000698721 RCV000707328 RCV000689283 RCV000690196 RCV000696998 RCV000709570 RCV000778089 RCV000796991 RCV000818713 RCV000798408 RCV000812140 RCV000823781 RCV000815167 RCV000810792 RCV000813551 RCV001860501 RCV004030844 RCV001052181 RCV001043113 RCV001057998 RCV001067850 RCV001056706 RCV001067108 RCV001037969 RCV001041182 RCV001377432 RCV005866845 RCV001212374 RCV001209963 RCV001232825 RCV001237781 RCV001239930 RCV001239135 RCV001264565 RCV001808309 RCV005051747
STK11-related disorder	Likely pathogenic; Pathogenic	rs376280361, rs1599925303	RCV004722832 RCV004726787

Show/Hide Unknown Diseases (31)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs72618592	RCV005923389
Arthrogryposis, distal, with impaired proprioception and touch	Uncertain significance	rs540627331	RCV003330088
B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified	Conflicting classifications of pathogenicity	rs553752236	RCV000761075
Bile duct cancer	Benign; Likely benign	rs748832988	RCV001357469
Breast and/or ovarian cancer	Likely benign; Conflicting classifications of pathogenicity; Benign; Uncertain significance	rs730881973, rs373888280, rs587780008, rs200078204, rs587780009, rs370207155, rs587780717, rs587780721, rs533550278, rs376329042, rs376313955, rs375315233, rs372378119, rs202011521, rs183406870 View all (37 more)	RCV001799466 RCV003492475 RCV001798331 RCV003149797 RCV001798332 RCV001798402 RCV003492539 RCV003492540 RCV003492541 RCV001798403 RCV001798430 RCV003149874 RCV001798431 RCV003149875 RCV003149876 RCV003492578 RCV003492579 RCV003149889 RCV003149892 RCV003149893 RCV003149895 RCV003492604 RCV001798450 RCV003492623 RCV003492625 RCV001798461 RCV003149982 RCV003149983 RCV003492659 RCV003491893 RCV003492677 RCV003149986 RCV003492663 RCV001798570 RCV003491899 RCV001798571 RCV001798668 RCV003150093 RCV003491952 RCV001797996 RCV003150130 RCV003491983 RCV001798713 RCV003491999 RCV003492000 RCV003150162 RCV003492063 RCV003150213 RCV001798818 RCV003150212 RCV001798875 RCV003149766
Breast cancer, susceptibility to	Uncertain significance	rs1380135986	RCV000656476
Breast carcinoma	Conflicting classifications of pathogenicity	rs587780009, rs368466538, rs587781633, rs768058962	RCV001262518 RCV000414992 RCV000414913 RCV001262270
Carcinoma of colon	Likely benign; Conflicting classifications of pathogenicity; Benign	rs763346212, rs567202367, rs537906142, rs1176365465	RCV001356903 RCV001355110 RCV001358350 RCV001356159
Childhood neoplasm	Uncertain significance	rs863224360	RCV005626161
Colon adenocarcinoma	Conflicting classifications of pathogenicity	rs199973552, rs730881969	RCV005886916 RCV005889597
Embryonal rhabdomyosarcoma	Conflicting classifications of pathogenicity	rs768780695	RCV000761079
Endometrial carcinoma	Benign; Likely benign	rs377502057	RCV001357691
Familial adenomatous polyposis 2	Conflicting classifications of pathogenicity	rs587782302	RCV002243796
Hepatoblastoma	Conflicting classifications of pathogenicity	rs567769257	RCV000761133
Hereditary breast ovarian cancer syndrome	Conflicting classifications of pathogenicity; Benign; Likely benign	rs200078204, rs587781515, rs587782032, rs587782199, rs121913322, rs532889728, rs375622587	RCV004689610 RCV001030732 RCV006261732 RCV005089644 RCV001030733 RCV001731149 RCV005625626
Hereditary cancer	Conflicting classifications of pathogenicity	rs587782032, rs767565606, rs764739106	RCV003492602 RCV003492670 RCV001537796
Lip and oral cavity carcinoma	Conflicting classifications of pathogenicity	rs556651007	RCV001255638
Lung adenocarcinoma	Uncertain significance	rs1014036920	RCV003129630
Malignant neoplasm of brain	Benign; Likely benign	rs369097329	RCV001354357
Malignant tumor of breast	Conflicting classifications of pathogenicity; Benign; Likely benign; Uncertain significance	rs200078204, rs587780009, rs370207155, rs184271025, rs373610101, rs376329042, rs79175212, rs376313955, rs372378119, rs587781178, rs587782259, rs9282859, rs587781681, rs587782032, rs370976710 View all (20 more)	RCV001269488 RCV001354249 RCV001357027 RCV001357670 RCV001355241 RCV001357889 RCV001357485 RCV001356286 RCV001354164 RCV001357918 RCV001354382 RCV001355314 RCV001355662 RCV001358086 RCV001357059 RCV001356999 RCV001356292 RCV001356112 RCV001356654 RCV001356479 RCV001357154 RCV001358183 RCV001354948 RCV001358488 RCV001356667 RCV001356901 RCV001356672 RCV001355263 RCV001356885 RCV001355315 RCV001357284 RCV001357591 RCV001354492 RCV001354484 RCV001357260
Marfanoid habitus and intellectual disability	Conflicting classifications of pathogenicity	rs1599925362	RCV000850457
Multiple endocrine neoplasia, type 1	Uncertain significance	rs876661238	RCV003328099
Ovarian cancer	Conflicting classifications of pathogenicity	rs121913322, rs374078532, rs748202003	RCV003153424 RCV003153425 RCV003153487
Ovarian serous cystadenocarcinoma	Uncertain significance	rs876661268, rs2080673714	RCV005895080 RCV005931180
Pigmentary skin disorders	Uncertain significance	rs1568708396	RCV005863251
See cases	Conflicting classifications of pathogenicity; Uncertain significance	rs535449626, rs753834428	RCV004584354 RCV004584406
Squamous cell carcinoma	Uncertain significance; Benign	rs775348337, rs370980421	RCV003129604 RCV003129615
Squamous cell lung carcinoma	Benign; Likely benign; Uncertain significance	rs2075604, rs34928889, rs544282452, rs2080767432, rs2075606, rs2080775539, rs56354945	RCV001250928 RCV001250929 RCV001250930 RCV001250931 RCV001250932 RCV001250933 RCV001250944
Thymoma	Benign	rs72618592	RCV005923392
Uterine carcinosarcoma	Benign	rs72618592	RCV005923391
Uterine corpus endometrial carcinoma	Benign	rs72618592	RCV005923393

Show/Hide Text Mining Associations (177)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Abdominal Injuries	Associate	20497868
ACTH Secreting Pituitary Adenoma	Associate	27615706
Adenocarcinoma	Associate	10079245, 11389158, 14511408, 23287851, 26317919, 29219616, 29370903, 30885352, 30978501, 31407221, 31988001
Adenocarcinoma Mucinous	Associate	12533684, 31243107, 34103667, 38369337
Adenocarcinoma of Lung	Associate	10079245, 17711506, 19347029, 20559149, 21159649, 21532627, 22460425, 22590557, 24236184, 24419424, 25465874, 25695224, 26066407, 26069186, 26829311 View all (26 more)
Adenoma	Associate	19955943, 31248021
Adenoma Liver Cell	Associate	35961004
Adenomatous Polyposis Coli	Associate	21940722
Angioedemas Hereditary	Associate	37495171
Anodontia	Associate	28911955
Apnea	Associate	35768580
Arthritis Rheumatoid	Associate	36759597, 37174663
Astrocytoma	Associate	15367334
Atherosclerosis	Associate	36627571
Azoospermia	Associate	35849255
Birt Hogg Dube Syndrome	Associate	34031471
Breast Neoplasms	Associate	11064676, 12865922, 18794113, 19369417, 19483724, 20418665, 21294903, 22562547, 23155392, 23409019, 24498881, 24830819, 24913037, 25178656, 26534844 View all (16 more)
Bronchiolitis Obliterans Syndrome	Inhibit	34859569, 39228019
Cafe au Lait Spots	Associate	33147782
Calcinosis Cutis	Associate	32657779, 32881920
Carcinogenesis	Associate	10362809, 16407837, 22801477, 25633809, 28720067, 28813465, 29370903, 32396674, 33149122, 33219302, 34921839, 9708796
Carcinogenesis	Inhibit	25674212, 26877155
Carcinoma Ductal	Associate	34810298
Carcinoma Hepatocellular	Associate	22168747, 23679304, 33082400, 33219302, 35961004, 37787988
Carcinoma Large Cell	Associate	26317919, 26960398, 29535388, 30978501, 33031101
Carcinoma Non Small Cell Lung	Associate	17384680, 18594528, 19258070, 20193846, 21749859, 23178462, 25634010, 25769882, 26027660, 26506235, 26625312, 26847819, 26960398, 27266881, 28034771 View all (42 more)
Carcinoma Non Small Cell Lung	Inhibit	21532627
Carcinoma Ovarian Epithelial	Associate	26068970
Carcinoma Pancreatic Ductal	Associate	26015068, 26887594, 35752568, 36978154, 38086003
Carcinoma Papillary	Associate	37369462
Carcinoma Renal Cell	Associate	25179843, 25969368
Carcinoma Squamous Cell	Associate	21191146, 22768234, 24810493, 25738363, 28145643, 29980281, 32345599, 35621648, 35709927
Cell Transformation Neoplastic	Associate	34193159
Cheyne Stokes Respiration	Associate	35768580
Cholangiocarcinoma	Associate	26056085, 26517522, 34810298, 37369462
Cholangiocarcinoma	Inhibit	32653521, 35856436
Colonic Neoplasms	Associate	31243107
Colonic Polyps	Associate	23399955
Colorectal Neoplasms	Associate	10429655, 10896921, 20622004, 22168747, 26797410, 29141581, 29307989, 29967336, 30913862, 37116137, 9708796
Congenital Hyperinsulinism	Associate	20357370
Coronary Artery Disease	Associate	28349069
Death	Associate	30913862, 33264619, 37495171, 39709652
Diabetes Gestational	Associate	23706335
Diabetes Mellitus	Associate	23706335, 26345094
Diabetes Mellitus Type 2	Associate	28349069
Disease Resistance	Associate	35157996
Drug Related Side Effects and Adverse Reactions	Associate	17212587, 19258070
Early Onset Glaucoma	Associate	33264619
Endometrial Neoplasms	Inhibit	22635025
Endometrial Neoplasms	Associate	25042259, 26027660, 31308508, 36140779
Epilepsy	Associate	24260271
Esophageal Neoplasms	Associate	24022664
Esophageal Neoplasms	Inhibit	29370903
Esophageal Squamous Cell Carcinoma	Associate	35463992, 37080995
Fibrosis	Associate	36276641
Gallbladder Neoplasms	Associate	24508317, 32045060, 32839463
Ganglioneuroma	Associate	23399955
Gastrointestinal Diseases	Associate	26430231, 35189935
Gastrointestinal Hemorrhage	Associate	20497868
Gastrointestinal Neoplasms	Associate	10353780, 10429655, 12865922, 16407375, 32396674, 32799895
Genetic Diseases Inborn	Associate	10079245, 31712642
Genomic Instability	Associate	36044718
Glassy cell carcinoma of the cervix	Associate	12533684
Glioma	Associate	25399650, 26488897
Glucagonoma	Associate	28921546
Glycogen Storage Disease IB	Associate	35961004
Glycogen Storage Disease Type II	Associate	35961004
Glycogen Storage Disease Type IV	Associate	25695224
Gout	Associate	33493135
Granulosa Cell Tumor	Associate	10389980
Granulosa cell tumor of the ovary	Associate	10389980
Guillain Barre Syndrome	Associate	36139470
Gynecomastia	Associate	24037887
Hamartoma	Associate	10201537, 10389980, 10429655, 11733352, 14726968, 20939895, 32390703, 9708796
Hamartoma Syndrome Multiple	Associate	25208626, 29496690, 36011318, 9708796
Head and Neck Neoplasms	Associate	32911741
Hematologic Neoplasms	Associate	25846811
Hematuria Benign Familial	Associate	23679304
Hepatoblastoma	Associate	34828353
Hereditary Breast and Ovarian Cancer Syndrome	Associate	25178656, 29496690, 30623411, 33646313, 37563628, 39684258
Hypercapnia	Associate	35768580
Hyperpigmentation	Associate	17921699
Hyperplasia	Associate	23027127
Hypoventilation	Associate	35768580
Hypoxia	Associate	35768580
Hypoxia	Inhibit	39228019
Hypoxia Brain	Associate	35768580
Infections	Associate	28813465
Infertility Male	Associate	31418107
Inflammation	Associate	20622004, 21150337, 33493135, 36627571, 37172591, 37174663
Intestinal Obstruction	Associate	37377590
Intestinal Polyposis	Associate	23399955
Intestinal Polyps	Associate	10362809, 27721366
Intussusception	Associate	20497868, 26607058, 29685139, 37377590
Keratoacanthoma	Associate	26319365
Laryngeal Neoplasms	Associate	17641416
Lead Poisoning Nervous System	Associate	27705915
Leiomyoma	Associate	27748285
Leukemia	Associate	24705122
Leukemia Lymphoma Adult T Cell	Associate	23577667
Leukemia Myeloid Acute	Associate	25846811, 28882949
Leukemia Myeloid Acute	Inhibit	39369651
Lip Hamartomatous	Associate	33147782
Liver Failure	Inhibit	22265968
Lung Diseases	Associate	24285539, 31292535
Lung Neoplasms	Associate	17384680, 17711506, 20010869, 21150337, 21532627, 24236184, 24285539, 24419424, 25042259, 25465874, 25477232, 26420428, 26625312, 26701889, 26864623 View all (21 more)
Lung Neoplasms	Inhibit	29138862
Lymphatic Metastasis	Inhibit	17641416
Lymphoma Non Hodgkin	Associate	24998186
Melanoma	Associate	10201537, 20193846, 25349262, 25846811, 28870692
Meningeal Carcinomatosis	Associate	27721366
Mesothelioma Malignant	Associate	25514803
Microsatellite Instability	Associate	37838086
Mouth Diseases	Associate	21940722
Multiple Sclerosis	Associate	25694554, 34371271
Multiple Sclerosis Relapsing Remitting	Associate	34371271
Neoplasm Metastasis	Associate	17641416, 20418665, 25178656, 25179843, 25224251, 25349262, 25695224, 27756406, 28700115, 32374727, 32657779
Neoplasm Metastasis	Inhibit	26015068, 35856436
Neoplasm Recurrence Local	Associate	33527763
Neoplasms	Associate	10079245, 10201537, 10362809, 10429655, 11389158, 12865922, 14511408, 14726968, 16344569, 16407375, 16407837, 16707622, 17921699, 19340305, 19369417 View all (103 more)
Neoplasms	Inhibit	10389980, 10896921, 11733352, 16189157, 17928927, 18794113, 19258070, 19347029, 19483724, 20418665, 21118512, 21532627, 22168747, 22460425, 22635025 View all (55 more)
Neoplastic Syndromes Hereditary	Associate	23584481
Neuroendocrine Tumors	Stimulate	33031101
Neuroendocrine Tumors	Associate	39346064
Nose Diseases	Associate	16775120
Obesity	Associate	22635025
Optic Atrophy Autosomal Dominant	Associate	37495171
Osteoblastoma	Associate	28632727
Osteosarcoma	Inhibit	28632727
Osteosarcoma	Associate	29496690
Ovarian Neoplasms	Associate	10201537, 10389980, 10429654, 26068970, 31464709, 33560870, 35017636
Ovarian Neoplasms	Inhibit	24022664, 29257268
Pancreatic Intraductal Neoplasms	Associate	11733352, 36578081
Pancreatic Neoplasms	Associate	10079245, 10362809, 11733352, 14511408, 20193846, 25479140, 26098869, 27615706, 30538291, 30997723, 32354656
Papilloma Inverted	Associate	29779136
Parkinson Disease	Stimulate	31234232
Parkinson Disease	Associate	31234232, 33552685
Parovarian Cyst	Associate	33534223
Pelvic Inflammatory Disease	Associate	33534223
Peutz Jeghers Syndrome	Associate	10079245, 10201537, 10353780, 10362809, 10389980, 10429654, 10429655, 10623683, 10780518, 10896921, 11039077, 11389158, 11430832, 11445556, 11733352 View all (91 more)
Pigmentation Disorders	Associate	10389980, 29685139
Pituitary Neoplasms	Associate	27615706
Pneumothorax	Associate	34031471
Polycystic Ovary Syndrome	Associate	18000088
Polyneuropathies	Associate	36139470
Polypoidal Choroidal Vasculopathy	Associate	32677196
Polyposis Syndrome Hereditary Mixed 1	Associate	11215281
Polyps	Associate	17921699, 23399955, 26607058, 28231849, 32799895
Primary Graft Dysfunction	Inhibit	39228019
Prodromal Symptoms	Associate	30913862
Prostatic Neoplasms	Inhibit	25674212, 26616116
Rectal Neoplasms	Associate	20622004
Retinal Dysplasia	Associate	19340305
Sarcoma Ewing	Associate	27077911
Sertoli Cell Tumor	Associate	22160729
Sex Cord Gonadal Stromal Tumors	Associate	10623683, 19955943
Sezary Syndrome	Associate	30518812
Signs and Symptoms	Associate	15121768
Small Cell Lung Carcinoma	Associate	36044718, 37062002
Spinocerebellar Degenerations	Associate	34754157
Squamous Cell Carcinoma of Head and Neck	Associate	16407837, 25234657, 25871473, 33527763
Stomach Neoplasms	Associate	10429655, 19615099, 22723903, 25372287, 26182300, 31308508, 31855952, 31949278, 36484990
Sveinsson Chorioretinal Atrophy	Associate	32931935
Tertiary Lymphoid Structures	Associate	17641416
Thyroid cancer medullary	Associate	26295973
Thyroid Neoplasms	Associate	38165228
Triple Negative Breast Neoplasms	Associate	33314633
Tuberous Sclerosis 1	Associate	18794113
Turcot syndrome	Associate	37838086
Uterine Cervical Dysplasia	Associate	25738363
Uterine Cervical Neoplasms	Associate	17212587, 19340305, 20193846, 22735790, 24390348, 27581326, 32345599
Uterine Cervical Neoplasms	Inhibit	24792998, 25155037
Uterine Cervicitis	Associate	24285539
Uveal melanoma	Associate	37647867, 37966164
Virilism	Associate	20357370, 21575951
Wilms Tumor	Associate	40340749
Wounds and Injuries	Associate	22265968

STK11 (serine/threonine kinase 11)