STK10 (serine/threonine kinase 10)

Gene

• Entrez ID: 6793
• Gene name: Serine/threonine kinase 10
• Gene symbol: STK10
• Synonyms (NCBI Gene): LOK, PRO2729
• Chromosome: 5
• Chromosome location: 5q35.1
• Summary: This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT042193	hsa-miR-484	CLASH	23622248
MIRT1397130	hsa-miR-1184	CLIP-seq
MIRT1397131	hsa-miR-1205	CLIP-seq
MIRT1397132	hsa-miR-1252	CLIP-seq
MIRT1397133	hsa-miR-1275	CLIP-seq
MIRT1397134	hsa-miR-1291	CLIP-seq
MIRT1397135	hsa-miR-1301	CLIP-seq
MIRT1397136	hsa-miR-1324	CLIP-seq
MIRT1397137	hsa-miR-137	CLIP-seq
MIRT1397138	hsa-miR-181a	CLIP-seq
MIRT1397139	hsa-miR-181b	CLIP-seq
MIRT1397140	hsa-miR-181c	CLIP-seq
MIRT1397141	hsa-miR-181d	CLIP-seq
MIRT1397142	hsa-miR-1914	CLIP-seq
MIRT1397143	hsa-miR-1976	CLIP-seq
MIRT1397144	hsa-miR-2114	CLIP-seq
MIRT1397145	hsa-miR-2467-3p	CLIP-seq
MIRT1397146	hsa-miR-27a	CLIP-seq
MIRT1397147	hsa-miR-27b	CLIP-seq
MIRT1397148	hsa-miR-3123	CLIP-seq
MIRT1397149	hsa-miR-3158-5p	CLIP-seq
MIRT1397150	hsa-miR-3166	CLIP-seq
MIRT1397151	hsa-miR-3622a-3p	CLIP-seq
MIRT1397152	hsa-miR-3622b-3p	CLIP-seq
MIRT1397153	hsa-miR-3675-5p	CLIP-seq
MIRT1397154	hsa-miR-3919	CLIP-seq
MIRT1397155	hsa-miR-4262	CLIP-seq
MIRT1397156	hsa-miR-4271	CLIP-seq
MIRT1397157	hsa-miR-4279	CLIP-seq
MIRT1397158	hsa-miR-4290	CLIP-seq
MIRT1397159	hsa-miR-4292	CLIP-seq
MIRT1397160	hsa-miR-4424	CLIP-seq
MIRT1397161	hsa-miR-4428	CLIP-seq
MIRT1397162	hsa-miR-4434	CLIP-seq
MIRT1397163	hsa-miR-4470	CLIP-seq
MIRT1397164	hsa-miR-4493	CLIP-seq
MIRT1397165	hsa-miR-4516	CLIP-seq
MIRT1397166	hsa-miR-4525	CLIP-seq
MIRT1397167	hsa-miR-4640-5p	CLIP-seq
MIRT1397168	hsa-miR-4660	CLIP-seq
MIRT1397169	hsa-miR-4665-5p	CLIP-seq
MIRT1397170	hsa-miR-4666-5p	CLIP-seq
MIRT1397171	hsa-miR-4667-3p	CLIP-seq
MIRT1397172	hsa-miR-4667-5p	CLIP-seq
MIRT1397173	hsa-miR-4687-5p	CLIP-seq
MIRT1397174	hsa-miR-4700-5p	CLIP-seq
MIRT1397175	hsa-miR-4717-5p	CLIP-seq
MIRT1397176	hsa-miR-4722-3p	CLIP-seq
MIRT1397177	hsa-miR-4723-5p	CLIP-seq
MIRT1397178	hsa-miR-4725-3p	CLIP-seq
MIRT1397179	hsa-miR-4726-5p	CLIP-seq
MIRT1397180	hsa-miR-4740-3p	CLIP-seq
MIRT1397181	hsa-miR-4768-3p	CLIP-seq
MIRT1397182	hsa-miR-4771	CLIP-seq
MIRT1397183	hsa-miR-4786-3p	CLIP-seq
MIRT1397184	hsa-miR-4787-5p	CLIP-seq
MIRT1397185	hsa-miR-486-3p	CLIP-seq
MIRT1397186	hsa-miR-5047	CLIP-seq
MIRT1397187	hsa-miR-5096	CLIP-seq
MIRT1397188	hsa-miR-513a-5p	CLIP-seq
MIRT1397189	hsa-miR-541	CLIP-seq
MIRT1397190	hsa-miR-544	CLIP-seq
MIRT1397191	hsa-miR-625	CLIP-seq
MIRT1397192	hsa-miR-637	CLIP-seq
MIRT1397193	hsa-miR-654-5p	CLIP-seq
MIRT1397194	hsa-miR-660	CLIP-seq
MIRT1397195	hsa-miR-671-5p	CLIP-seq
MIRT1397130	hsa-miR-1184	CLIP-seq
MIRT1397131	hsa-miR-1205	CLIP-seq
MIRT1397149	hsa-miR-3158-5p	CLIP-seq
MIRT1397190	hsa-miR-544	CLIP-seq
MIRT1397130	hsa-miR-1184	CLIP-seq
MIRT2118895	hsa-miR-1200	CLIP-seq
MIRT2118896	hsa-miR-122	CLIP-seq
MIRT2118897	hsa-miR-1229	CLIP-seq
MIRT1397132	hsa-miR-1252	CLIP-seq
MIRT2118898	hsa-miR-127-5p	CLIP-seq
MIRT2118899	hsa-miR-1287	CLIP-seq
MIRT2118900	hsa-miR-1290	CLIP-seq
MIRT2118901	hsa-miR-1343	CLIP-seq
MIRT1397143	hsa-miR-1976	CLIP-seq
MIRT2118902	hsa-miR-217	CLIP-seq
MIRT2118903	hsa-miR-24	CLIP-seq
MIRT1397146	hsa-miR-27a	CLIP-seq
MIRT1397147	hsa-miR-27b	CLIP-seq
MIRT1397148	hsa-miR-3123	CLIP-seq
MIRT2118904	hsa-miR-3124-3p	CLIP-seq
MIRT2118905	hsa-miR-3135b	CLIP-seq
MIRT2118906	hsa-miR-3140-5p	CLIP-seq
MIRT2118907	hsa-miR-3157-5p	CLIP-seq
MIRT1397149	hsa-miR-3158-5p	CLIP-seq
MIRT2118908	hsa-miR-3167	CLIP-seq
MIRT2118909	hsa-miR-3170	CLIP-seq
MIRT2118910	hsa-miR-3184	CLIP-seq
MIRT2118911	hsa-miR-3187-3p	CLIP-seq
MIRT2118912	hsa-miR-3199	CLIP-seq
MIRT2118913	hsa-miR-342-3p	CLIP-seq
MIRT2118914	hsa-miR-342-5p	CLIP-seq
MIRT2118915	hsa-miR-3650	CLIP-seq
MIRT2118916	hsa-miR-3652	CLIP-seq
MIRT2118917	hsa-miR-3679-3p	CLIP-seq
MIRT1397154	hsa-miR-3919	CLIP-seq
MIRT2118918	hsa-miR-3929	CLIP-seq
MIRT2118919	hsa-miR-3936	CLIP-seq
MIRT2118920	hsa-miR-423-5p	CLIP-seq
MIRT2118921	hsa-miR-4259	CLIP-seq
MIRT2118922	hsa-miR-4269	CLIP-seq
MIRT1397157	hsa-miR-4279	CLIP-seq
MIRT2118923	hsa-miR-4324	CLIP-seq
MIRT2118924	hsa-miR-4418	CLIP-seq
MIRT2118925	hsa-miR-4419b	CLIP-seq
MIRT1397160	hsa-miR-4424	CLIP-seq
MIRT1397161	hsa-miR-4428	CLIP-seq
MIRT2118926	hsa-miR-4430	CLIP-seq
MIRT1397162	hsa-miR-4434	CLIP-seq
MIRT2118927	hsa-miR-4435	CLIP-seq
MIRT2118928	hsa-miR-4453	CLIP-seq
MIRT2118929	hsa-miR-4469	CLIP-seq
MIRT2118930	hsa-miR-4474-5p	CLIP-seq
MIRT2118931	hsa-miR-4478	CLIP-seq
MIRT2118932	hsa-miR-4487	CLIP-seq
MIRT2118933	hsa-miR-4492	CLIP-seq
MIRT1397164	hsa-miR-4493	CLIP-seq
MIRT2118934	hsa-miR-4498	CLIP-seq
MIRT2118935	hsa-miR-4514	CLIP-seq
MIRT1397165	hsa-miR-4516	CLIP-seq
MIRT2118936	hsa-miR-4538	CLIP-seq
MIRT1397167	hsa-miR-4640-5p	CLIP-seq
MIRT2118937	hsa-miR-4643	CLIP-seq
MIRT2118938	hsa-miR-4648	CLIP-seq
MIRT2118939	hsa-miR-4649-3p	CLIP-seq
MIRT2118940	hsa-miR-4649-5p	CLIP-seq
MIRT2118941	hsa-miR-4651	CLIP-seq
MIRT2118942	hsa-miR-4659a-5p	CLIP-seq
MIRT2118943	hsa-miR-4659b-5p	CLIP-seq
MIRT2118944	hsa-miR-466	CLIP-seq
MIRT2118945	hsa-miR-4664-5p	CLIP-seq
MIRT1397170	hsa-miR-4666-5p	CLIP-seq
MIRT2118946	hsa-miR-4668-5p	CLIP-seq
MIRT2118947	hsa-miR-4682	CLIP-seq
MIRT2118948	hsa-miR-4692	CLIP-seq
MIRT2118949	hsa-miR-4701-5p	CLIP-seq
MIRT2118950	hsa-miR-4707-5p	CLIP-seq
MIRT2118951	hsa-miR-4716-5p	CLIP-seq
MIRT1397176	hsa-miR-4722-3p	CLIP-seq
MIRT2118952	hsa-miR-4722-5p	CLIP-seq
MIRT1397179	hsa-miR-4726-5p	CLIP-seq
MIRT2118953	hsa-miR-4731-5p	CLIP-seq
MIRT2118954	hsa-miR-4736	CLIP-seq
MIRT1397180	hsa-miR-4740-3p	CLIP-seq
MIRT2118955	hsa-miR-4742-5p	CLIP-seq
MIRT2118956	hsa-miR-4746-5p	CLIP-seq
MIRT2118957	hsa-miR-4755-3p	CLIP-seq
MIRT2118958	hsa-miR-4761-5p	CLIP-seq
MIRT2118959	hsa-miR-4772-3p	CLIP-seq
MIRT2118960	hsa-miR-4781-3p	CLIP-seq
MIRT2118961	hsa-miR-4789-3p	CLIP-seq
MIRT1397185	hsa-miR-486-3p	CLIP-seq
MIRT2118962	hsa-miR-498	CLIP-seq
MIRT2118963	hsa-miR-509-3-5p	CLIP-seq
MIRT2118964	hsa-miR-509-5p	CLIP-seq
MIRT1397188	hsa-miR-513a-5p	CLIP-seq
MIRT2118965	hsa-miR-544b	CLIP-seq
MIRT2118966	hsa-miR-548s	CLIP-seq
MIRT2118967	hsa-miR-588	CLIP-seq
MIRT2118968	hsa-miR-608	CLIP-seq
MIRT2118969	hsa-miR-615-5p	CLIP-seq
MIRT2118970	hsa-miR-635	CLIP-seq
MIRT2118971	hsa-miR-642a	CLIP-seq
MIRT2118972	hsa-miR-645	CLIP-seq
MIRT2118973	hsa-miR-762	CLIP-seq
MIRT2118974	hsa-miR-876-5p	CLIP-seq
MIRT2118975	hsa-miR-888	CLIP-seq
MIRT1397130	hsa-miR-1184	CLIP-seq
MIRT2118895	hsa-miR-1200	CLIP-seq
MIRT2341270	hsa-miR-1202	CLIP-seq
MIRT1397131	hsa-miR-1205	CLIP-seq
MIRT2118896	hsa-miR-122	CLIP-seq
MIRT2118897	hsa-miR-1229	CLIP-seq
MIRT2118901	hsa-miR-1343	CLIP-seq
MIRT1397137	hsa-miR-137	CLIP-seq
MIRT2341271	hsa-miR-146b-3p	CLIP-seq
MIRT1397138	hsa-miR-181a	CLIP-seq
MIRT1397139	hsa-miR-181b	CLIP-seq
MIRT1397140	hsa-miR-181c	CLIP-seq
MIRT1397141	hsa-miR-181d	CLIP-seq
MIRT1397143	hsa-miR-1976	CLIP-seq
MIRT2118902	hsa-miR-217	CLIP-seq
MIRT2118905	hsa-miR-3135b	CLIP-seq
MIRT1397149	hsa-miR-3158-5p	CLIP-seq
MIRT2341272	hsa-miR-3194-5p	CLIP-seq
MIRT2341273	hsa-miR-339-5p	CLIP-seq
MIRT2118913	hsa-miR-342-3p	CLIP-seq
MIRT2118915	hsa-miR-3650	CLIP-seq
MIRT2118916	hsa-miR-3652	CLIP-seq
MIRT2118917	hsa-miR-3679-3p	CLIP-seq
MIRT2118918	hsa-miR-3929	CLIP-seq
MIRT2118919	hsa-miR-3936	CLIP-seq
MIRT2341274	hsa-miR-3972	CLIP-seq
MIRT1397155	hsa-miR-4262	CLIP-seq
MIRT2118922	hsa-miR-4269	CLIP-seq
MIRT1397157	hsa-miR-4279	CLIP-seq
MIRT2118923	hsa-miR-4324	CLIP-seq
MIRT2118924	hsa-miR-4418	CLIP-seq
MIRT2118925	hsa-miR-4419b	CLIP-seq
MIRT1397160	hsa-miR-4424	CLIP-seq
MIRT2118926	hsa-miR-4430	CLIP-seq
MIRT2118931	hsa-miR-4478	CLIP-seq
MIRT2341275	hsa-miR-4494	CLIP-seq
MIRT2118935	hsa-miR-4514	CLIP-seq
MIRT2118937	hsa-miR-4643	CLIP-seq
MIRT2118942	hsa-miR-4659a-5p	CLIP-seq
MIRT2118943	hsa-miR-4659b-5p	CLIP-seq
MIRT2118944	hsa-miR-466	CLIP-seq
MIRT1397170	hsa-miR-4666-5p	CLIP-seq
MIRT2118946	hsa-miR-4668-5p	CLIP-seq
MIRT2118947	hsa-miR-4682	CLIP-seq
MIRT2341276	hsa-miR-4690-3p	CLIP-seq
MIRT2118948	hsa-miR-4692	CLIP-seq
MIRT2118951	hsa-miR-4716-5p	CLIP-seq
MIRT1397176	hsa-miR-4722-3p	CLIP-seq
MIRT2341277	hsa-miR-4726-3p	CLIP-seq
MIRT1397180	hsa-miR-4740-3p	CLIP-seq
MIRT2118955	hsa-miR-4742-5p	CLIP-seq
MIRT2118957	hsa-miR-4755-3p	CLIP-seq
MIRT2118959	hsa-miR-4772-3p	CLIP-seq
MIRT2118961	hsa-miR-4789-3p	CLIP-seq
MIRT1397185	hsa-miR-486-3p	CLIP-seq
MIRT2118962	hsa-miR-498	CLIP-seq
MIRT2118963	hsa-miR-509-3-5p	CLIP-seq
MIRT2118964	hsa-miR-509-5p	CLIP-seq
MIRT1397190	hsa-miR-544	CLIP-seq
MIRT2118965	hsa-miR-544b	CLIP-seq
MIRT2118969	hsa-miR-615-5p	CLIP-seq
MIRT2118972	hsa-miR-645	CLIP-seq
MIRT1397130	hsa-miR-1184	CLIP-seq
MIRT2118895	hsa-miR-1200	CLIP-seq
MIRT1397131	hsa-miR-1205	CLIP-seq
MIRT2118896	hsa-miR-122	CLIP-seq
MIRT1397135	hsa-miR-1301	CLIP-seq
MIRT1397138	hsa-miR-181a	CLIP-seq
MIRT1397139	hsa-miR-181b	CLIP-seq
MIRT1397140	hsa-miR-181c	CLIP-seq
MIRT1397141	hsa-miR-181d	CLIP-seq
MIRT2395350	hsa-miR-1909	CLIP-seq
MIRT2118903	hsa-miR-24	CLIP-seq
MIRT2118905	hsa-miR-3135b	CLIP-seq
MIRT1397149	hsa-miR-3158-5p	CLIP-seq
MIRT2118915	hsa-miR-3650	CLIP-seq
MIRT2118916	hsa-miR-3652	CLIP-seq
MIRT2118918	hsa-miR-3929	CLIP-seq
MIRT2118919	hsa-miR-3936	CLIP-seq
MIRT1397155	hsa-miR-4262	CLIP-seq
MIRT2118923	hsa-miR-4324	CLIP-seq
MIRT2118925	hsa-miR-4419b	CLIP-seq
MIRT1397160	hsa-miR-4424	CLIP-seq
MIRT2118926	hsa-miR-4430	CLIP-seq
MIRT2118931	hsa-miR-4478	CLIP-seq
MIRT2395351	hsa-miR-4522	CLIP-seq
MIRT1397168	hsa-miR-4660	CLIP-seq
MIRT1397170	hsa-miR-4666-5p	CLIP-seq
MIRT2118946	hsa-miR-4668-5p	CLIP-seq
MIRT2118947	hsa-miR-4682	CLIP-seq
MIRT1397186	hsa-miR-5047	CLIP-seq
MIRT1397190	hsa-miR-544	CLIP-seq
MIRT2118965	hsa-miR-544b	CLIP-seq
MIRT2118969	hsa-miR-615-5p	CLIP-seq
MIRT2118972	hsa-miR-645	CLIP-seq
MIRT2118901	hsa-miR-1343	CLIP-seq
MIRT1397143	hsa-miR-1976	CLIP-seq
MIRT2460661	hsa-miR-2355-5p	CLIP-seq
MIRT2460662	hsa-miR-29a	CLIP-seq
MIRT2460663	hsa-miR-29b	CLIP-seq
MIRT2460664	hsa-miR-29c	CLIP-seq
MIRT2460665	hsa-miR-3065-3p	CLIP-seq
MIRT2118917	hsa-miR-3679-3p	CLIP-seq
MIRT2460666	hsa-miR-411	CLIP-seq
MIRT1397157	hsa-miR-4279	CLIP-seq
MIRT1397176	hsa-miR-4722-3p	CLIP-seq
MIRT2460667	hsa-miR-4735-5p	CLIP-seq
MIRT1397180	hsa-miR-4740-3p	CLIP-seq
MIRT2460668	hsa-miR-4775	CLIP-seq
MIRT2460669	hsa-miR-4794	CLIP-seq
MIRT2118962	hsa-miR-498	CLIP-seq
MIRT2460670	hsa-miR-501-3p	CLIP-seq
MIRT2460671	hsa-miR-502-3p	CLIP-seq
MIRT2460672	hsa-miR-590-3p	CLIP-seq
MIRT2460673	hsa-miR-767-5p	CLIP-seq
MIRT2341270	hsa-miR-1202	CLIP-seq
MIRT2118896	hsa-miR-122	CLIP-seq
MIRT2635143	hsa-miR-1224-3p	CLIP-seq
MIRT2635144	hsa-miR-1285	CLIP-seq
MIRT2118901	hsa-miR-1343	CLIP-seq
MIRT1397143	hsa-miR-1976	CLIP-seq
MIRT2635145	hsa-miR-203	CLIP-seq
MIRT2118903	hsa-miR-24	CLIP-seq
MIRT1397145	hsa-miR-2467-3p	CLIP-seq
MIRT2635146	hsa-miR-298	CLIP-seq
MIRT2118905	hsa-miR-3135b	CLIP-seq
MIRT2118906	hsa-miR-3140-5p	CLIP-seq
MIRT2635147	hsa-miR-3155	CLIP-seq
MIRT2635148	hsa-miR-3155b	CLIP-seq
MIRT2635149	hsa-miR-3187-5p	CLIP-seq
MIRT2341272	hsa-miR-3194-5p	CLIP-seq
MIRT2118912	hsa-miR-3199	CLIP-seq
MIRT2118915	hsa-miR-3650	CLIP-seq
MIRT2118916	hsa-miR-3652	CLIP-seq
MIRT1397153	hsa-miR-3675-5p	CLIP-seq
MIRT2118918	hsa-miR-3929	CLIP-seq
MIRT2341274	hsa-miR-3972	CLIP-seq
MIRT2460666	hsa-miR-411	CLIP-seq
MIRT2118922	hsa-miR-4269	CLIP-seq
MIRT1397157	hsa-miR-4279	CLIP-seq
MIRT1397158	hsa-miR-4290	CLIP-seq
MIRT2118925	hsa-miR-4419b	CLIP-seq
MIRT2118926	hsa-miR-4430	CLIP-seq
MIRT2635150	hsa-miR-4438	CLIP-seq
MIRT1397163	hsa-miR-4470	CLIP-seq
MIRT2118931	hsa-miR-4478	CLIP-seq
MIRT2118935	hsa-miR-4514	CLIP-seq
MIRT1397166	hsa-miR-4525	CLIP-seq
MIRT2635151	hsa-miR-4530	CLIP-seq
MIRT2118938	hsa-miR-4648	CLIP-seq
MIRT2118942	hsa-miR-4659a-5p	CLIP-seq
MIRT2118943	hsa-miR-4659b-5p	CLIP-seq
MIRT1397171	hsa-miR-4667-3p	CLIP-seq
MIRT1397173	hsa-miR-4687-5p	CLIP-seq
MIRT2341276	hsa-miR-4690-3p	CLIP-seq
MIRT2118948	hsa-miR-4692	CLIP-seq
MIRT2635152	hsa-miR-4708-3p	CLIP-seq
MIRT1397176	hsa-miR-4722-3p	CLIP-seq
MIRT2341277	hsa-miR-4726-3p	CLIP-seq
MIRT2460667	hsa-miR-4735-5p	CLIP-seq
MIRT1397180	hsa-miR-4740-3p	CLIP-seq
MIRT2118955	hsa-miR-4742-5p	CLIP-seq
MIRT2118957	hsa-miR-4755-3p	CLIP-seq
MIRT2118958	hsa-miR-4761-5p	CLIP-seq
MIRT2635153	hsa-miR-4766-5p	CLIP-seq
MIRT2460668	hsa-miR-4775	CLIP-seq
MIRT2635154	hsa-miR-4776-3p	CLIP-seq
MIRT1397184	hsa-miR-4787-5p	CLIP-seq
MIRT2460669	hsa-miR-4794	CLIP-seq
MIRT1397185	hsa-miR-486-3p	CLIP-seq
MIRT2118962	hsa-miR-498	CLIP-seq
MIRT2460670	hsa-miR-501-3p	CLIP-seq
MIRT2460671	hsa-miR-502-3p	CLIP-seq
MIRT2635155	hsa-miR-545	CLIP-seq
MIRT2460672	hsa-miR-590-3p	CLIP-seq
MIRT2635156	hsa-miR-612	CLIP-seq
MIRT2118972	hsa-miR-645	CLIP-seq
MIRT2460673	hsa-miR-767-5p	CLIP-seq
MIRT2692227	hsa-miR-1289	CLIP-seq
MIRT2118901	hsa-miR-1343	CLIP-seq
MIRT1397143	hsa-miR-1976	CLIP-seq
MIRT2692228	hsa-miR-214	CLIP-seq
MIRT2460666	hsa-miR-411	CLIP-seq
MIRT1397157	hsa-miR-4279	CLIP-seq
MIRT1397161	hsa-miR-4428	CLIP-seq
MIRT2692229	hsa-miR-4433	CLIP-seq
MIRT1397164	hsa-miR-4493	CLIP-seq
MIRT2635151	hsa-miR-4530	CLIP-seq
MIRT1397176	hsa-miR-4722-3p	CLIP-seq
MIRT2118952	hsa-miR-4722-5p	CLIP-seq
MIRT2460667	hsa-miR-4735-5p	CLIP-seq
MIRT1397180	hsa-miR-4740-3p	CLIP-seq
MIRT2460668	hsa-miR-4775	CLIP-seq
MIRT2692230	hsa-miR-4790-5p	CLIP-seq
MIRT2460669	hsa-miR-4794	CLIP-seq
MIRT2118962	hsa-miR-498	CLIP-seq
MIRT2460670	hsa-miR-501-3p	CLIP-seq
MIRT2460671	hsa-miR-502-3p	CLIP-seq
MIRT2460672	hsa-miR-590-3p	CLIP-seq
MIRT2460673	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	18239682, 19255442
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	12639966
GO:0005515	Function	Protein binding	IPI	12639966, 19255442
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	19255442
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006468	Process	Protein phosphorylation	TAS
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0016740	Function	Transferase activity	IEA
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035579	Component	Specific granule membrane	TAS
GO:0042802	Function	Identical protein binding	IPI	18239682
GO:0042803	Function	Protein homodimerization activity	IDA	18239682
GO:0046777	Process	Protein autophosphorylation	IDA	12639966, 18239682
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071593	Process	Lymphocyte aggregation	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:2000401	Process	Regulation of lymphocyte migration	IBA
GO:2000401	Process	Regulation of lymphocyte migration	IEA
GO:2000401	Process	Regulation of lymphocyte migration	IMP	19255442

Other IDs

• MIM: 603919
• HGNC: 11388
• e!Ensembl: ENSG00000072786

Protein

• UniProt ID: O94804
• Protein name: Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase)
• Protein function: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative re
• PDB: 2J7T, 4AOT, 4BC6, 4EQU, 4USD, 4USE, 5AJQ, 5OWQ, 5OWR, 6EIM, 6GTT, 6HXF, 6I2Y, 7QGP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	36 → 294	Protein kinase domain	Domain
  PF12474	PKK	587 → 725	Polo kinase kinase	Family
  PF12474	PKK	755 → 895	Polo kinase kinase	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung. {ECO:0000269|PubMed:1263996
• Sequence:

  MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGA
  LAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDA
  IMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSA
  KNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHEL
  NPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSN
  KALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEE
  SPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDA
  RIQVAQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGP
  SKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEV
  SITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQ
  EINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLM
  KKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRRE
  ICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKE
  REQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKI
  KQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLK
  ALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFF
  PYSSADAS

• Sequence length: 968

Pathways

KEGG:

Progesterone-mediated oocyte maturation

Reactome:

Neutrophil degranulation

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Uncertain significance	rs367724546	RCV005929166
Colon adenocarcinoma	Uncertain significance	rs367724546	RCV005929165

Associations from Text Mining
Disease Name	Relationship Type	References
Arthritis Rheumatoid	Associate	24690414
Burkitt Lymphoma	Associate	26325594
Drug Hypersensitivity	Associate	21905501
Leishmaniasis Cutaneous	Associate	21905501
Leukemia Myeloid Acute	Associate	35501867
Lung Neoplasms	Stimulate	37980468
Neoplasm Metastasis	Associate	36716920
Neoplasms	Stimulate	35501867
Neuroendocrine Tumors	Associate	34571875
Sarcoma Ewing	Associate	20718987
Status Asthmaticus	Associate	21905501
Uveal melanoma	Associate	37923138