Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6790
Gene name	Aurora kinase A
Gene symbol	AURKA
Synonyms (NCBI Gene)	AIKARK1AURABTAKPPP1R47STK15STK6STK7
Chromosome	20
Chromosome location	20q13.2
Summary	The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cel

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SNP ID	Visualize variation	Clinical significance	Consequence
rs2273535	A>C,G,T	Risk-factor	Missense variant, coding sequence variant
rs1455074519	G>A,T	Likely-pathogenic	Missense variant, synonymous variant, coding sequence variant

332

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005051	hsa-let-7b-5p	Microarray	17699775
MIRT020589	hsa-miR-155-5p	Proteomics	18668040
MIRT022391	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT005051	hsa-let-7b-5p	Proteomics	18668040
MIRT044891	hsa-miR-193a-3p	CLASH	23622248
MIRT568366	hsa-miR-581	PAR-CLIP	20371350
MIRT568365	hsa-miR-3616-3p	PAR-CLIP	20371350
MIRT568364	hsa-miR-4721	PAR-CLIP	20371350
MIRT568363	hsa-miR-518d-5p	PAR-CLIP	20371350
MIRT568362	hsa-miR-518e-5p	PAR-CLIP	20371350
MIRT568361	hsa-miR-518f-5p	PAR-CLIP	20371350
MIRT568360	hsa-miR-519a-5p	PAR-CLIP	20371350
MIRT568359	hsa-miR-519b-5p	PAR-CLIP	20371350
MIRT568358	hsa-miR-519c-5p	PAR-CLIP	20371350
MIRT568357	hsa-miR-520c-5p	PAR-CLIP	20371350
MIRT568356	hsa-miR-522-5p	PAR-CLIP	20371350
MIRT568355	hsa-miR-523-5p	PAR-CLIP	20371350
MIRT568354	hsa-miR-526a	PAR-CLIP	20371350
MIRT568353	hsa-miR-4777-5p	PAR-CLIP	20371350
MIRT568352	hsa-miR-6834-5p	PAR-CLIP	20371350
MIRT568351	hsa-miR-1226-5p	PAR-CLIP	20371350
MIRT568350	hsa-miR-6734-5p	PAR-CLIP	20371350
MIRT568349	hsa-miR-578	PAR-CLIP	20371350
MIRT559289	hsa-miR-6779-3p	PAR-CLIP	21572407
MIRT541460	hsa-miR-154-5p	PAR-CLIP	21572407
MIRT559288	hsa-miR-8076	PAR-CLIP	21572407
MIRT559287	hsa-miR-183-5p	PAR-CLIP	21572407
MIRT559286	hsa-miR-6748-3p	PAR-CLIP	21572407
MIRT559285	hsa-miR-4421	PAR-CLIP	21572407
MIRT559284	hsa-miR-5699-3p	PAR-CLIP	21572407
MIRT559283	hsa-miR-149-5p	PAR-CLIP	21572407
MIRT559282	hsa-miR-885-3p	PAR-CLIP	21572407
MIRT559281	hsa-miR-4284	PAR-CLIP	21572407
MIRT559280	hsa-miR-24-3p	PAR-CLIP	21572407
MIRT559279	hsa-miR-4326	PAR-CLIP	21572407
MIRT559278	hsa-miR-7152-5p	PAR-CLIP	21572407
MIRT541473	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT541472	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT541471	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT541470	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT541469	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT541468	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT541467	hsa-miR-4476	PAR-CLIP	21572407
MIRT541466	hsa-miR-6876-5p	PAR-CLIP	21572407
MIRT541465	hsa-miR-4436b-3p	PAR-CLIP	21572407
MIRT541464	hsa-miR-4632-5p	PAR-CLIP	21572407
MIRT541462	hsa-miR-6735-5p	PAR-CLIP	21572407
MIRT541463	hsa-miR-6879-5p	PAR-CLIP	21572407
MIRT541461	hsa-miR-7843-5p	PAR-CLIP	21572407
MIRT541460	hsa-miR-154-5p	PAR-CLIP	21572407
MIRT541459	hsa-miR-6736-3p	PAR-CLIP	21572407
MIRT296432	hsa-miR-3918	PAR-CLIP	21572407
MIRT541458	hsa-miR-4448	PAR-CLIP	21572407
MIRT541457	hsa-miR-137	PAR-CLIP	21572407
MIRT541456	hsa-miR-3127-5p	PAR-CLIP	21572407
MIRT541473	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT541470	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT541472	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT541472	hsa-miR-32-5p	Luciferase reporter assayqRT-PCRWestern blot	26036635
MIRT732545	hsa-miR-106a-3p	RNA-seq	33037409
MIRT734205	hsa-miR-4715-3p	Luciferase reporter assayqRT-PCRWestern blotting	31740746
MIRT734205	hsa-miR-4715-3p	Luciferase reporter assayqRT-PCRWestern blotting	31740746
MIRT734205	hsa-miR-4715-3p	Luciferase reporter assayqRT-PCRWestern blotting	31740746
MIRT734205	hsa-miR-4715-3p	Luciferase reporter assayqRT-PCRWestern blotting	31740746
MIRT736544	hsa-let-7a-5p	Luciferase reporter assayWestern blottingqRT-PCR	32849824
MIRT736786	hsa-miR-621	Luciferase reporter assayqRT-PCR	33629578
MIRT737291	hsa-miR-490-3p	qRT-PCR	32733789
MIRT737358	hsa-miR-497-3p	RNA-seq	32156775
MIRT568366	hsa-miR-581	PAR-CLIP	20371350
MIRT568365	hsa-miR-3616-3p	PAR-CLIP	20371350
MIRT568364	hsa-miR-4721	PAR-CLIP	20371350
MIRT568363	hsa-miR-518d-5p	PAR-CLIP	20371350
MIRT568362	hsa-miR-518e-5p	PAR-CLIP	20371350
MIRT568361	hsa-miR-518f-5p	PAR-CLIP	20371350
MIRT568360	hsa-miR-519a-5p	PAR-CLIP	20371350
MIRT568359	hsa-miR-519b-5p	PAR-CLIP	20371350
MIRT568358	hsa-miR-519c-5p	PAR-CLIP	20371350
MIRT568357	hsa-miR-520c-5p	PAR-CLIP	20371350
MIRT568356	hsa-miR-522-5p	PAR-CLIP	20371350
MIRT568355	hsa-miR-523-5p	PAR-CLIP	20371350
MIRT568354	hsa-miR-526a	PAR-CLIP	20371350
MIRT568353	hsa-miR-4777-5p	PAR-CLIP	20371350
MIRT568352	hsa-miR-6834-5p	PAR-CLIP	20371350
MIRT568351	hsa-miR-1226-5p	PAR-CLIP	20371350
MIRT568350	hsa-miR-6734-5p	PAR-CLIP	20371350
MIRT568349	hsa-miR-578	PAR-CLIP	20371350
MIRT559289	hsa-miR-6779-3p	PAR-CLIP	21572407
MIRT541460	hsa-miR-154-5p	PAR-CLIP	21572407
MIRT559288	hsa-miR-8076	PAR-CLIP	21572407
MIRT559287	hsa-miR-183-5p	PAR-CLIP	21572407
MIRT559286	hsa-miR-6748-3p	PAR-CLIP	21572407
MIRT559285	hsa-miR-4421	PAR-CLIP	21572407
MIRT559284	hsa-miR-5699-3p	PAR-CLIP	21572407
MIRT559283	hsa-miR-149-5p	PAR-CLIP	21572407
MIRT559282	hsa-miR-885-3p	PAR-CLIP	21572407
MIRT559281	hsa-miR-4284	PAR-CLIP	21572407
MIRT559280	hsa-miR-24-3p	PAR-CLIP	21572407
MIRT559279	hsa-miR-4326	PAR-CLIP	21572407
MIRT559278	hsa-miR-7152-5p	PAR-CLIP	21572407
MIRT541473	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT541472	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT541471	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT541470	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT541469	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT541468	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT541467	hsa-miR-4476	PAR-CLIP	21572407
MIRT541466	hsa-miR-6876-5p	PAR-CLIP	21572407
MIRT541465	hsa-miR-4436b-3p	PAR-CLIP	21572407
MIRT541464	hsa-miR-4632-5p	PAR-CLIP	21572407
MIRT541462	hsa-miR-6735-5p	PAR-CLIP	21572407
MIRT541463	hsa-miR-6879-5p	PAR-CLIP	21572407
MIRT541461	hsa-miR-7843-5p	PAR-CLIP	21572407
MIRT541460	hsa-miR-154-5p	PAR-CLIP	21572407
MIRT541459	hsa-miR-6736-3p	PAR-CLIP	21572407
MIRT296432	hsa-miR-3918	PAR-CLIP	21572407
MIRT541458	hsa-miR-4448	PAR-CLIP	21572407
MIRT541457	hsa-miR-137	PAR-CLIP	21572407
MIRT541456	hsa-miR-3127-5p	PAR-CLIP	21572407
MIRT812105	hsa-let-7a	CLIP-seq
MIRT812106	hsa-let-7b	CLIP-seq
MIRT812107	hsa-let-7c	CLIP-seq
MIRT812108	hsa-let-7d	CLIP-seq
MIRT812109	hsa-let-7e	CLIP-seq
MIRT812110	hsa-let-7f	CLIP-seq
MIRT812111	hsa-let-7g	CLIP-seq
MIRT812112	hsa-let-7i	CLIP-seq
MIRT812113	hsa-miR-1179	CLIP-seq
MIRT812114	hsa-miR-129-3p	CLIP-seq
MIRT812115	hsa-miR-154	CLIP-seq
MIRT812116	hsa-miR-199a-3p	CLIP-seq
MIRT812117	hsa-miR-199b-3p	CLIP-seq
MIRT812118	hsa-miR-2278	CLIP-seq
MIRT812119	hsa-miR-25	CLIP-seq
MIRT812120	hsa-miR-300	CLIP-seq
MIRT812121	hsa-miR-3129-5p	CLIP-seq
MIRT812122	hsa-miR-3180	CLIP-seq
MIRT812123	hsa-miR-3180-3p	CLIP-seq
MIRT812124	hsa-miR-3182	CLIP-seq
MIRT812125	hsa-miR-3196	CLIP-seq
MIRT812126	hsa-miR-32	CLIP-seq
MIRT812127	hsa-miR-3200-3p	CLIP-seq
MIRT812128	hsa-miR-329	CLIP-seq
MIRT812129	hsa-miR-362-3p	CLIP-seq
MIRT812130	hsa-miR-363	CLIP-seq
MIRT812131	hsa-miR-367	CLIP-seq
MIRT812132	hsa-miR-3680	CLIP-seq
MIRT812133	hsa-miR-3686	CLIP-seq
MIRT812134	hsa-miR-3689d	CLIP-seq
MIRT812135	hsa-miR-3713	CLIP-seq
MIRT812136	hsa-miR-381	CLIP-seq
MIRT812137	hsa-miR-3919	CLIP-seq
MIRT812138	hsa-miR-3921	CLIP-seq
MIRT812139	hsa-miR-3927	CLIP-seq
MIRT812140	hsa-miR-3941	CLIP-seq
MIRT812141	hsa-miR-4251	CLIP-seq
MIRT812142	hsa-miR-4274	CLIP-seq
MIRT812143	hsa-miR-4307	CLIP-seq
MIRT812144	hsa-miR-4310	CLIP-seq
MIRT812145	hsa-miR-4329	CLIP-seq
MIRT812146	hsa-miR-4451	CLIP-seq
MIRT812147	hsa-miR-4458	CLIP-seq
MIRT812148	hsa-miR-4500	CLIP-seq
MIRT812149	hsa-miR-4509	CLIP-seq
MIRT812150	hsa-miR-4643	CLIP-seq
MIRT812151	hsa-miR-4653-5p	CLIP-seq
MIRT812152	hsa-miR-466	CLIP-seq
MIRT812153	hsa-miR-4672	CLIP-seq
MIRT812154	hsa-miR-4694-3p	CLIP-seq
MIRT812155	hsa-miR-4717-3p	CLIP-seq
MIRT812156	hsa-miR-4732-5p	CLIP-seq
MIRT812157	hsa-miR-4733-5p	CLIP-seq
MIRT812158	hsa-miR-4742-3p	CLIP-seq
MIRT812159	hsa-miR-4757-5p	CLIP-seq
MIRT812160	hsa-miR-4802-5p	CLIP-seq
MIRT812161	hsa-miR-510	CLIP-seq
MIRT812162	hsa-miR-522	CLIP-seq
MIRT812163	hsa-miR-603	CLIP-seq
MIRT812164	hsa-miR-605	CLIP-seq
MIRT812165	hsa-miR-642b	CLIP-seq
MIRT812166	hsa-miR-759	CLIP-seq
MIRT812167	hsa-miR-92a	CLIP-seq
MIRT812168	hsa-miR-92b	CLIP-seq
MIRT812169	hsa-miR-936	CLIP-seq
MIRT812170	hsa-miR-938	CLIP-seq
MIRT812171	hsa-miR-98	CLIP-seq
MIRT812105	hsa-let-7a	CLIP-seq
MIRT812106	hsa-let-7b	CLIP-seq
MIRT812107	hsa-let-7c	CLIP-seq
MIRT812108	hsa-let-7d	CLIP-seq
MIRT812109	hsa-let-7e	CLIP-seq
MIRT812110	hsa-let-7f	CLIP-seq
MIRT812111	hsa-let-7g	CLIP-seq
MIRT812112	hsa-let-7i	CLIP-seq
MIRT812113	hsa-miR-1179	CLIP-seq
MIRT812118	hsa-miR-2278	CLIP-seq
MIRT812172	hsa-miR-337-3p	CLIP-seq
MIRT812173	hsa-miR-342-5p	CLIP-seq
MIRT812174	hsa-miR-3687	CLIP-seq
MIRT812134	hsa-miR-3689d	CLIP-seq
MIRT812135	hsa-miR-3713	CLIP-seq
MIRT812139	hsa-miR-3927	CLIP-seq
MIRT812144	hsa-miR-4310	CLIP-seq
MIRT812175	hsa-miR-4442	CLIP-seq
MIRT812146	hsa-miR-4451	CLIP-seq
MIRT812147	hsa-miR-4458	CLIP-seq
MIRT812148	hsa-miR-4500	CLIP-seq
MIRT812149	hsa-miR-4509	CLIP-seq
MIRT812176	hsa-miR-4655-5p	CLIP-seq
MIRT812177	hsa-miR-4664-5p	CLIP-seq
MIRT812154	hsa-miR-4694-3p	CLIP-seq
MIRT812156	hsa-miR-4732-5p	CLIP-seq
MIRT812157	hsa-miR-4733-5p	CLIP-seq
MIRT812160	hsa-miR-4802-5p	CLIP-seq
MIRT812162	hsa-miR-522	CLIP-seq
MIRT812164	hsa-miR-605	CLIP-seq
MIRT812171	hsa-miR-98	CLIP-seq
MIRT812178	hsa-miR-149	CLIP-seq
MIRT812115	hsa-miR-154	CLIP-seq
MIRT812179	hsa-miR-183	CLIP-seq
MIRT812180	hsa-miR-24	CLIP-seq
MIRT812120	hsa-miR-300	CLIP-seq
MIRT812136	hsa-miR-381	CLIP-seq
MIRT812181	hsa-miR-4713-5p	CLIP-seq
MIRT812166	hsa-miR-759	CLIP-seq
MIRT1940204	hsa-miR-1228	CLIP-seq
MIRT812115	hsa-miR-154	CLIP-seq
MIRT1940205	hsa-miR-186	CLIP-seq
MIRT812119	hsa-miR-25	CLIP-seq
MIRT1940206	hsa-miR-3135	CLIP-seq
MIRT1940207	hsa-miR-3160-5p	CLIP-seq
MIRT812122	hsa-miR-3180	CLIP-seq
MIRT812123	hsa-miR-3180-3p	CLIP-seq
MIRT812125	hsa-miR-3196	CLIP-seq
MIRT812126	hsa-miR-32	CLIP-seq
MIRT812127	hsa-miR-3200-3p	CLIP-seq
MIRT812128	hsa-miR-329	CLIP-seq
MIRT1940208	hsa-miR-3545-5p	CLIP-seq
MIRT812129	hsa-miR-362-3p	CLIP-seq
MIRT812130	hsa-miR-363	CLIP-seq
MIRT812131	hsa-miR-367	CLIP-seq
MIRT812132	hsa-miR-3680	CLIP-seq
MIRT1940209	hsa-miR-370	CLIP-seq
MIRT1940210	hsa-miR-3929	CLIP-seq
MIRT812140	hsa-miR-3941	CLIP-seq
MIRT812142	hsa-miR-4274	CLIP-seq
MIRT1940211	hsa-miR-4419b	CLIP-seq
MIRT1940212	hsa-miR-4427	CLIP-seq
MIRT1940213	hsa-miR-4438	CLIP-seq
MIRT1940214	hsa-miR-4478	CLIP-seq
MIRT1940215	hsa-miR-4491	CLIP-seq
MIRT1940216	hsa-miR-4633-3p	CLIP-seq
MIRT1940217	hsa-miR-4657	CLIP-seq
MIRT812152	hsa-miR-466	CLIP-seq
MIRT1940218	hsa-miR-4663	CLIP-seq
MIRT812153	hsa-miR-4672	CLIP-seq
MIRT1940219	hsa-miR-4680-3p	CLIP-seq
MIRT812155	hsa-miR-4717-3p	CLIP-seq
MIRT1940220	hsa-miR-4762-3p	CLIP-seq
MIRT812161	hsa-miR-510	CLIP-seq
MIRT812163	hsa-miR-603	CLIP-seq
MIRT812165	hsa-miR-642b	CLIP-seq
MIRT812166	hsa-miR-759	CLIP-seq
MIRT812167	hsa-miR-92a	CLIP-seq
MIRT812168	hsa-miR-92b	CLIP-seq
MIRT1940204	hsa-miR-1228	CLIP-seq
MIRT2179093	hsa-miR-124	CLIP-seq
MIRT2179094	hsa-miR-1321	CLIP-seq
MIRT812115	hsa-miR-154	CLIP-seq
MIRT2179095	hsa-miR-1972	CLIP-seq
MIRT812116	hsa-miR-199a-3p	CLIP-seq
MIRT812117	hsa-miR-199b-3p	CLIP-seq
MIRT812118	hsa-miR-2278	CLIP-seq
MIRT2179096	hsa-miR-2355-5p	CLIP-seq
MIRT812119	hsa-miR-25	CLIP-seq
MIRT812120	hsa-miR-300	CLIP-seq
MIRT812121	hsa-miR-3129-5p	CLIP-seq
MIRT2179097	hsa-miR-3155	CLIP-seq
MIRT2179098	hsa-miR-3155b	CLIP-seq
MIRT2179099	hsa-miR-3162-5p	CLIP-seq
MIRT812122	hsa-miR-3180	CLIP-seq
MIRT812123	hsa-miR-3180-3p	CLIP-seq
MIRT812125	hsa-miR-3196	CLIP-seq
MIRT812126	hsa-miR-32	CLIP-seq
MIRT812127	hsa-miR-3200-3p	CLIP-seq
MIRT812172	hsa-miR-337-3p	CLIP-seq
MIRT812173	hsa-miR-342-5p	CLIP-seq
MIRT1940208	hsa-miR-3545-5p	CLIP-seq
MIRT812130	hsa-miR-363	CLIP-seq
MIRT812131	hsa-miR-367	CLIP-seq
MIRT2179100	hsa-miR-3679-3p	CLIP-seq
MIRT812132	hsa-miR-3680	CLIP-seq
MIRT812174	hsa-miR-3687	CLIP-seq
MIRT1940209	hsa-miR-370	CLIP-seq
MIRT2179101	hsa-miR-3714	CLIP-seq
MIRT812136	hsa-miR-381	CLIP-seq
MIRT2179102	hsa-miR-3910	CLIP-seq
MIRT812137	hsa-miR-3919	CLIP-seq
MIRT812139	hsa-miR-3927	CLIP-seq
MIRT1940210	hsa-miR-3929	CLIP-seq
MIRT812140	hsa-miR-3941	CLIP-seq
MIRT812142	hsa-miR-4274	CLIP-seq
MIRT2179103	hsa-miR-4286	CLIP-seq
MIRT1940211	hsa-miR-4419b	CLIP-seq
MIRT1940212	hsa-miR-4427	CLIP-seq
MIRT1940213	hsa-miR-4438	CLIP-seq
MIRT812175	hsa-miR-4442	CLIP-seq
MIRT812146	hsa-miR-4451	CLIP-seq
MIRT1940214	hsa-miR-4478	CLIP-seq
MIRT1940215	hsa-miR-4491	CLIP-seq
MIRT2179104	hsa-miR-4650-5p	CLIP-seq
MIRT812176	hsa-miR-4655-5p	CLIP-seq
MIRT1940217	hsa-miR-4657	CLIP-seq
MIRT1940218	hsa-miR-4663	CLIP-seq
MIRT812177	hsa-miR-4664-5p	CLIP-seq
MIRT812156	hsa-miR-4732-5p	CLIP-seq
MIRT812157	hsa-miR-4733-5p	CLIP-seq
MIRT2179105	hsa-miR-4739	CLIP-seq
MIRT2179106	hsa-miR-4756-5p	CLIP-seq
MIRT2179107	hsa-miR-484	CLIP-seq
MIRT2179108	hsa-miR-506	CLIP-seq
MIRT812161	hsa-miR-510	CLIP-seq
MIRT2179109	hsa-miR-562	CLIP-seq
MIRT812164	hsa-miR-605	CLIP-seq
MIRT812166	hsa-miR-759	CLIP-seq
MIRT812167	hsa-miR-92a	CLIP-seq
MIRT812168	hsa-miR-92b	CLIP-seq
MIRT812169	hsa-miR-936	CLIP-seq
MIRT812116	hsa-miR-199a-3p	CLIP-seq
MIRT812117	hsa-miR-199b-3p	CLIP-seq
MIRT812121	hsa-miR-3129-5p	CLIP-seq
MIRT812169	hsa-miR-936	CLIP-seq
MIRT812140	hsa-miR-3941	CLIP-seq

Show/Hide all (4)

Transcription factor	Regulation	Reference
E2F1	Activation	20300951
E2F3	Activation	18776222
MED1	Activation	16574658
OTX2	Activation	21047732

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Show/Hide all (117)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	TAS
GO:0000166	Function	Nucleotide binding	IEA
GO:0000212	Process	Meiotic spindle organization	IEA
GO:0000212	Process	Meiotic spindle organization	IEA
GO:0000226	Process	Microtubule cytoskeleton organization	IEA
GO:0000226	Process	Microtubule cytoskeleton organization	IEA
GO:0000278	Process	Mitotic cell cycle	IEA
GO:0000278	Process	Mitotic cell cycle	IEA
GO:0000278	Process	Mitotic cell cycle	TAS	9153231
GO:0000776	Component	Kinetochore	IBA
GO:0000922	Component	Spindle pole	IBA
GO:0000922	Component	Spindle pole	IEA
GO:0004672	Function	Protein kinase activity	IDA	14580337, 19801554, 21600873
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	EXP	13678582, 18566290, 21807936
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IMP	28218735
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	IEA
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	TAS	19774610
GO:0005515	Function	Protein binding	IPI	12244051, 14580337, 15987997, 16890155, 17604723, 17726514, 17939994, 18361916, 18521620, 18615013, 18662907, 18663142, 19111882, 19357306, 19801554, 20360068, 20460379, 20596670, 20643351, 21242313, 21821029, 22014574, 22110403, 22305495, 22306998, 22340593, 23213400, 23520446, 237
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	20531406
GO:0005634	Component	Nucleus	TAS	9153231
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IBA
GO:0005813	Component	Centrosome	IDA	17726514, 21399614, 21600873, 23213400, 25657325, 30538148
GO:0005813	Component	Centrosome	IEA
GO:0005813	Component	Centrosome	TAS	19774610
GO:0005814	Component	Centriole	IEA
GO:0005815	Component	Microtubule organizing center	IEA
GO:0005819	Component	Spindle	TAS	9153231, 19774610
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005876	Component	Spindle microtubule	IDA	19801554
GO:0005886	Component	Plasma membrane	IEA
GO:0005929	Component	Cilium	IEA
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006468	Process	Protein phosphorylation	IDA	21600873
GO:0006468	Process	Protein phosphorylation	IDA	21820309
GO:0006468	Process	Protein phosphorylation	TAS	9153231
GO:0006915	Process	Apoptotic process	IEA
GO:0007051	Process	Spindle organization	IMP	21820309
GO:0007052	Process	Mitotic spindle organization	IBA
GO:0007052	Process	Mitotic spindle organization	IEA
GO:0007052	Process	Mitotic spindle organization	IEA
GO:0007057	Process	Spindle assembly involved in female meiosis I	IEA
GO:0007098	Process	Centrosome cycle	IEA
GO:0007098	Process	Centrosome cycle	IEA
GO:0007100	Process	Mitotic centrosome separation	IEA
GO:0007100	Process	Mitotic centrosome separation	IEA
GO:0009611	Process	Response to wounding	IDA	19435814
GO:0009948	Process	Anterior/posterior axis specification	IEA
GO:0010389	Process	Regulation of G2/M transition of mitotic cell cycle	TAS
GO:0010629	Process	Negative regulation of gene expression	IMP	28218735
GO:0014069	Component	Postsynaptic density	IEA
GO:0015630	Component	Microtubule cytoskeleton	IDA	19801554
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	ISS
GO:0016740	Function	Transferase activity	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IMP	28218735
GO:0019901	Function	Protein kinase binding	IPI	18615013
GO:0030030	Process	Cell projection organization	IEA
GO:0030496	Component	Midbody	IEA
GO:0030496	Component	Midbody	TAS	19774610
GO:0031616	Component	Spindle pole centrosome	IDA	19801554
GO:0031625	Function	Ubiquitin protein ligase binding	IEA
GO:0031647	Process	Regulation of protein stability	IMP	15987997
GO:0032091	Process	Negative regulation of protein binding	IDA	21820309
GO:0032133	Component	Chromosome passenger complex	IBA
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA
GO:0032465	Process	Regulation of cytokinesis	IBA
GO:0032886	Process	Regulation of microtubule-based process	IEA
GO:0035175	Function	Histone H3S10 kinase activity	IEA
GO:0036064	Component	Ciliary basal body	IDA	17604723
GO:0042585	Component	Germinal vesicle	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
GO:0043203	Component	Axon hillock	IEA
GO:0044839	Process	Cell cycle G2/M phase transition	IEA
GO:0045120	Component	Pronucleus	IEA
GO:0045840	Process	Positive regulation of mitotic nuclear division	TAS	19774610
GO:0045931	Process	Positive regulation of mitotic cell cycle	ISS
GO:0046605	Process	Regulation of centrosome cycle	TAS	19774610
GO:0046777	Process	Protein autophosphorylation	TAS	19774610
GO:0046982	Function	Protein heterodimerization activity	IPI	20460379
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	20531406
GO:0051233	Component	Spindle midzone	IBA
GO:0051301	Process	Cell division	IEA
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0051642	Process	Centrosome localization	IEA
GO:0061523	Process	Cilium disassembly	IMP	17604723
GO:0071539	Process	Protein localization to centrosome	IEA
GO:0072686	Component	Mitotic spindle	IDA
GO:0072686	Component	Mitotic spindle	IEA
GO:0072687	Component	Meiotic spindle	IEA
GO:0090068	Process	Positive regulation of cell cycle process	IEA
GO:0090141	Process	Positive regulation of mitochondrial fission	IMP	21822277
GO:0097421	Process	Liver regeneration	IDA	19435814
GO:0097431	Component	Mitotic spindle pole	IDA	25657325
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0140677	Function	Molecular function activator activity	EXP	12237287
GO:1900195	Process	Positive regulation of oocyte maturation	IEA
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	IEA
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS
GO:1990138	Process	Neuron projection extension	IEA

MIM	HGNC	e!Ensembl
603072	11393	ENSG00000087586

O14965

Protein name

Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/

Protein function

Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:11039908, PubMed:12390251, PubMed:17125279, PubMed:17360485, PubMed:18615013, PubMed:26246606). Associates with the centrosome and the spindle m

PDB

1MQ4 , 1MUO , 1OL5 , 1OL6 , 1OL7 , 2BMC , 2C6D , 2C6E , 2DWB , 2J4Z , 2J50 , 2NP8 , 2W1C , 2W1D , 2W1E , 2W1F , 2W1G , 2WQE , 2WTV , 2WTW , 2X6D , 2X6E , 2X81 , 2XNE , 2XNG , 2XRU , 3COH , 3E5A , 3EFW , 3FDN , 3H0Y , 3H0Z , 3H10 , 3HA6 , 3K5U , 3LAU , 3M11 , 3MYG , 3NRM , 3O50 , 3O51 , 3P9J , 3QBN , 3R21 , 3R22 , 3UNZ , 3UO4 , 3UO5 , 3UO6 , 3UOD , 3UOH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	133 → 383	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.

Sequence

MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS

Sequence length

403

Interactions

View interactions

	KEGG		Reactome
	Oocyte meiosis Progesterone-mediated oocyte maturation		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of PLK1 Activity at G2/M Transition TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation FBXL7 down-regulates AURKA during mitotic entry and in early mitosis AURKA Activation by TPX2 Interaction between PHLDA1 and AURKA

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Multiple myeloma	Likely pathogenic	rs1455074519	RCV000984118

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
AURKA-related disorder	Benign; Likely benign	rs2273535, rs1047972, rs34361943, rs2230743, rs142801740	RCV003982828 RCV003979654 RCV003916831 RCV003911552 RCV003959741
Colon cancer, susceptibility to	Benign	rs2273535	RCV000007021
Colorectal cancer	Uncertain significance	rs2146120963	RCV003990638

Show/Hide Text Mining Associations (172)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
ACTH Secreting Pituitary Adenoma	Associate	35563252
Adenocarcinoma	Associate	18043979, 18311783, 22389870, 24943686, 24953013, 29760449, 31740746, 33967624
Adenocarcinoma	Stimulate	19648887
Adenocarcinoma of Lung	Associate	30195659, 30353687, 30588191, 31698633, 32323809, 33050100, 34880385, 36311724, 37737707, 37768502, 38017020, 40191558
Adenocarcinoma of Lung	Stimulate	33398330
Adenoma	Stimulate	20358421
Adenomatous Polyps	Associate	26423403
Adrenal Cortex Neoplasms	Associate	33716050
Adrenocortical Carcinoma	Associate	12547710, 30413320, 32287321, 35500219, 38053725
Agenesis of Cerebellar Vermis	Associate	25395580
Aneuploidy	Associate	11259099, 16790082, 17322345, 17438137, 17591802, 17627006, 18812553, 19648887, 19801554, 23092930, 25153724, 28102366
Aneuploidy	Stimulate	11551964
Aneuploidy	Inhibit	25333414
Anophthalmia with pulmonary hypoplasia	Associate	39358545
Arthritis Rheumatoid	Associate	17082220, 36911710
Ataxia Telangiectasia	Associate	35782055
Atherosclerosis	Associate	37005319
Barrett Esophagus	Associate	17591802, 21470402, 24705000
Brain Neoplasms	Associate	27926948, 37260393
Breast Neoplasms	Associate	11259099, 14692019, 17627006, 18431743, 18628459, 20423983, 20473280, 21352579, 21412660, 21731694, 21761334, 21785467, 22262870, 22485147, 22538974 View all (37 more)
Breast Neoplasms	Stimulate	34895070, 36113844
Burkitt Lymphoma	Associate	37436268, 38099309
Calcinosis Cutis	Associate	23026799
Capillary Malformation Arteriovenous Malformation	Associate	20423983
Carcinogenesis	Associate	14523000, 17322345, 18043979, 18820130, 19306133, 19412426, 19502819, 20423983, 21584819, 21829699, 23411487, 24778030, 25261653, 25436453, 25632068 View all (12 more)
Carcinoma Adenoid Cystic	Associate	37861550
Carcinoma Basal Cell	Associate	17465238
Carcinoma Ductal	Associate	28906374
Carcinoma Ductal Breast	Associate	28906374, 35533650
Carcinoma Hepatocellular	Associate	23255113, 23966163, 24722014, 28427193, 29333101, 29556353, 29843214, 30702595, 31322223, 31746405, 32390596, 32722976, 33051418, 33750838, 33946043 View all (6 more)
Carcinoma Intraductal Noninfiltrating	Associate	35533650
Carcinoma Non Small Cell Lung	Associate	18043979, 18708766, 21718475, 25082261, 25634113, 26036635, 28101582, 30195659, 31805030, 32059076, 32795325, 35058503, 39914199
Carcinoma Ovarian Epithelial	Associate	30200102, 31336942, 33726773, 34794761
Carcinoma Renal Cell	Associate	19551141, 23785518, 25183163, 25313256, 26061684, 27574806, 30518623, 32986937
Carcinoma Small Cell	Associate	22586648, 25128228
Carcinoma Small Cell	Stimulate	25512615
Carcinoma Squamous Cell	Associate	21718475, 28404933, 28949095, 31642613, 32340320, 36247089, 36352434, 37442189
Chondrosarcoma	Inhibit	22809428
Chromosomal Instability	Associate	17457043, 17591802, 17999753, 19412426, 24976383, 26831064
Chromosomal Instability	Stimulate	27329586
Chromosome Aberrations	Associate	19801554, 20423983, 20732714, 23092930, 33277547
Chromosome Disorders	Associate	18812553
Colitis Associated Neoplasms	Associate	17322345
Colitis Ulcerative	Associate	17322345, 25333414
Colonic Neoplasms	Associate	17999753, 26423403
Colorectal Neoplasms	Associate	17003782, 17457043, 17999753, 19412426, 19648887, 19690970, 19799648, 19801554, 20929925, 22240781, 24104968, 24125984, 24876664, 24976383, 25261653 View all (17 more)
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	19690970
Corneal Neovascularization	Associate	33349071
COVID 19	Associate	33839760, 36913345
Death	Associate	22213102, 22587416
Depressive Disorder Major	Associate	36911710
Disease	Associate	25924824
Disease Progression	Associate	25924824
Dissection Thoracic Aorta	Associate	31380418
Donohue Syndrome	Associate	2808704, 3631076
Drug Related Side Effects and Adverse Reactions	Associate	19770595
Ectodermal Dysplasia	Associate	12547710
Endocrine System Diseases	Associate	36892847
Endometrial Neoplasms	Associate	33824269, 34725206, 35588308, 37803076
Enteropathy Familial with Villous Edema and Immunoglobulin G2 Deficiency	Associate	31740746
Ependymoma	Associate	22274399
Epstein Barr Virus Infections	Stimulate	37839162
Esophageal Neoplasms	Associate	15867347, 16572587, 22213102, 23991974, 25124567, 25436453, 32443386, 34232175
Esophageal Squamous Cell Carcinoma	Associate	19770595, 21470402, 22522455, 24980814, 25124567, 25217103, 25436453, 25924824, 27125974, 32546690, 34232175, 34758762, 37083097, 38043467
Esophagitis	Associate	23991974
Fibrolamellar hepatocellular carcinoma	Associate	26489647, 28270654, 32154962
Gastrointestinal Neoplasms	Associate	18311783, 26778597, 30191522, 31740746
Gastrointestinal Stromal Tumors	Associate	24901229
Glioblastoma	Associate	22160182, 22274399, 23761169, 31754113, 34471141, 35039475, 39528802
Glioma	Associate	20529377, 20838435, 22274399, 23761169, 26468983, 30995921, 33892537, 36703644
Glucosephosphate Dehydrogenase Deficiency	Associate	29963728
Glycosuria Renal	Associate	30518623
Graft vs Host Disease	Associate	26606970
Head and Neck Neoplasms	Associate	25889801, 33091845
Headache	Associate	37436268
Hepatitis B	Associate	36077449
Hereditary Breast and Ovarian Cancer Syndrome	Associate	25830658, 38043467
Hereditary Renal Cancer Associated 1	Associate	30190438
Hyperammonemia	Associate	28270654
Hypoxia	Stimulate	18562694, 22274399, 23966163, 24778030
Hypoxia	Associate	28114281
Hypoxia Brain	Stimulate	22274399
Inflammation	Associate	37005319, 37861550
Inflammatory Breast Neoplasms	Associate	36717329
Insulin Receptor Defect in	Associate	3631076
Kidney Neoplasms	Associate	23151618, 26911844
Laryngeal Neoplasms	Associate	21584819, 36919585
Leukemia	Associate	18160664, 18820130, 29477140, 31122263
Leukemia Lymphocytic Chronic B Cell	Associate	18931650
Leukemia Lymphoma Adult T Cell	Associate	20180813
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	18820130, 22116466, 31122263, 36175852
Leukemia Myeloid Acute	Associate	18160664, 20732714, 25887548, 28034990, 31207577
Leukemia T Cell	Associate	27271876
Light Fixation Seizure Syndrome	Associate	31740746
Liver Cirrhosis	Associate	37861550
Lung Diseases	Inhibit	21566536
Lung Neoplasms	Associate	18708766, 21566536, 21718475, 23520446, 25082261, 27713168, 31160567, 31314582, 32469983, 32655004, 32831194, 35178291, 36984548
Lupus Erythematosus Systemic	Associate	31494269
Lymphatic Metastasis	Stimulate	19891769, 21584819, 27125974, 32323809
Lymphatic Metastasis	Associate	25082261, 25217103, 28404933
Lymphoma B Cell	Associate	12716366, 23411487
Lymphoma Large B Cell Diffuse	Stimulate	34565287
Lymphoma Large Cell Anaplastic	Associate	23411487
Lymphoma Non Hodgkin	Associate	12716366
Lymphoma T Cell	Associate	23153524, 23411487
Lymphoma T Cell Cutaneous	Stimulate	25848977
Lymphoma T Cell Peripheral	Associate	23153524
Lymphoma T Cell Peripheral	Inhibit	23411487
Melanoma	Associate	16116595, 23362874, 24374110, 25074438, 25444926, 30518564, 31173299, 34673281
Mesothelioma Malignant	Associate	30700254, 33032291
Mohr Tranebjaerg syndrome	Associate	22213102
MORM syndrome	Associate	25395580
Mosaic variegated aneuploidy syndrome	Associate	25153724
Mouth Neoplasms	Associate	28152093, 28465536, 31174434, 37641028
Multiple Myeloma	Associate	17213289, 19171872, 19270264, 23411487, 23522059, 32978717
Muscular Diseases	Associate	37005319
Myelodysplastic Syndromes	Associate	23092930, 23339595
Nasopharyngeal Carcinoma	Associate	19502819, 22587416
Necrosis	Associate	37861550
Neoplasm Invasiveness	Associate	35533650
Neoplasm Metastasis	Associate	19306133, 19770595, 22320980, 22587416, 23186136, 23219753, 25889801, 27574806, 30232224, 31173190, 31173299, 32469983, 33173433, 33674749, 34154613 View all (5 more)
Neoplasm Metastasis	Stimulate	28427193, 36113844
Neoplasms	Associate	11259099, 12237287, 12467573, 12716366, 14523000, 15867347, 16222316, 16572587, 16863506, 17003782, 17438137, 17465238, 17627006, 17999753, 18562694 View all (140 more)
Neoplasms	Stimulate	16790082, 20864688, 23785518, 35533650
Neoplasms	Inhibit	21410931
Neuroblastoma	Associate	19111882, 19671766, 21731748, 22305495, 23317189, 24439602, 24778030, 25268132, 26481147, 27837025, 30518564, 32757706, 34884931
Neuroendocrine Tumors	Associate	22389870, 23676460, 25128228
Neutropenia	Stimulate	36892847
Nut Hypersensitivity	Associate	28152093
Obesity	Associate	31412932
Oligodendroglioma	Associate	26468983
Osteochondritis	Associate	31758856
Osteosarcoma	Associate	24129234, 32200684
Ovarian Diseases	Associate	20423983
Ovarian Neoplasms	Associate	17673924, 18431743, 20423983, 21623171, 22174824, 22895067, 27209210, 28187748, 29122619, 29367628, 29575713, 29693178, 34706741
Ovarian Neoplasms	Stimulate	34794761
Pancreatic Neoplasms	Associate	17505013, 20423983, 28193222
Personality Disorders	Associate	26911844
Polyposis Syndrome Hereditary Mixed 1	Associate	20358421, 27329586
Polyps	Associate	26423403
Primary cortisol resistance	Associate	32287321
Prostatic Intraepithelial Neoplasia	Associate	17898866
Prostatic Neoplasms	Associate	17898866, 22389870, 23075505, 23333597, 23358695, 24294372, 25128228, 26425080, 29269934, 29453313, 30232224, 30518564, 33037409, 33630978, 34337875 View all (7 more)
Prostatic Neoplasms	Stimulate	35965682
Prostatic Neoplasms Castration Resistant	Associate	28205582, 29269934, 29453313, 34625072, 36601001
Prostatitis	Associate	22389870, 27196755
Pulmonary Disease Chronic Obstructive	Associate	32655004
Respiratory Distress Syndrome	Associate	26507871
Retinal Dysplasia	Associate	24705000, 25333414
Sarcoma Ewing	Associate	19074838, 36050939
Sarcoma Kaposi	Stimulate	22396649
Sarcopenia	Associate	38644354
Skin Neoplasms	Associate	38410032
Small Cell Lung Carcinoma	Associate	35263037
Squamous Cell Carcinoma of Head and Neck	Associate	19107951, 21584819, 21865609, 23219753, 24810160, 24980817, 25547434, 28152093, 28465536, 33315534, 33892811, 34198450, 36165728, 39323031
Squamous Intraepithelial Lesions	Stimulate	36352434
Status Asthmaticus	Stimulate	28137284
Stomach Neoplasms	Associate	11259099, 19060929, 22320980, 24439602, 24953013, 25558650, 25609923, 26778597, 27270838, 28260026, 30013101, 30536456, 31521144, 33629578, 34337875, 37839162 View all (1 more)
Thyroid cancer medullary	Associate	24488334
Thyroid Carcinoma Anaplastic	Associate	30213925
Thyroid Neoplasms	Associate	17914111, 36990998
Tissue Adhesions	Associate	34968168
Tongue Neoplasms	Associate	19891769
Tooth Supernumerary	Associate	17999753
Triple Negative Breast Neoplasms	Associate	23437271, 31359594, 32558176, 33674749, 36077449, 36372230, 36998242, 37384380
Typical Teratoid Rhabdoid Tumor	Associate	22246202, 25688119
Urea Cycle Disorders Inborn	Associate	28270654
Urinary Bladder Neoplasms	Associate	18361427, 18812553, 19389507, 28102366, 34702201, 36245371, 39456780
Urinary Bladder Neoplasms	Stimulate	30547784, 33217824
Uterine Cervical Dysplasia	Associate	31642613
Uterine Cervical Neoplasms	Associate	19306133, 23052694, 31706100, 32258155, 33967624, 35428744
von Hippel Lindau Disease	Associate	25313256, 30518623, 34002003

AURKA (aurora kinase A)