Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6789
Gene name Gene Name - the full gene name approved by the HGNC.
Serine/threonine kinase 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
STK4
Synonyms (NCBI Gene) Gene synonyms aliases
KRS2, MST1, YSK3
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q13.12
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protei
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs387907316 C>T Pathogenic Genic downstream transcript variant, coding sequence variant, stop gained
rs1601230245 G>A Pathogenic Coding sequence variant, stop gained, genic downstream transcript variant
rs1601240010 T>- Pathogenic Frameshift variant, coding sequence variant, genic downstream transcript variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002541 hsa-miR-373-3p Microarray 15685193
MIRT002541 hsa-miR-373-3p Microarray;Other 15685193
MIRT048938 hsa-miR-92a-3p CLASH 23622248
MIRT438460 hsa-miR-18a-5p Immunohistochemistry, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot 24752237
MIRT438460 hsa-miR-18a-5p Immunohistochemistry, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot 24752237
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000287 Function Magnesium ion binding IDA 8566796
GO:0000287 Function Magnesium ion binding IEA
GO:0000902 Process Cell morphogenesis IDA 11805089
GO:0001569 Process Branching involved in blood vessel morphogenesis IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604965 11408 ENSG00000101109
Protein
UniProt ID Q13043
Protein name Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-prot
Protein function Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal ro
PDB 2JO8 , 3COM , 4NR2 , 4OH8 , 5TWG , 5TWH , 6YAT , 8A5J , 8PAV , 8PAW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 30 281 Protein kinase domain Domain
PF11629 Mst1_SARAH 433 480 C terminal SARAH domain of Mst1 Family
Tissue specificity TISSUE SPECIFICITY: Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Ubiquitously expressed. {ECO:0000269|PubMed:17932490}.
Sequence
Sequence length 487
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
Ras signaling pathway
FoxO signaling pathway
Pathways in cancer
Non-small cell lung cancer
  Signaling by Hippo
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Immunodeficiency Inherited Immunodeficiency Diseases rs387907316 N/A
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Bipolar Disorder Bipolar I disorder, Bipolar disorder N/A N/A GWAS
Schizophrenia Schizophrenia N/A N/A GWAS
Severe combined immunodeficiency disease combined immunodeficiency due to STK4 deficiency N/A N/A GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abscess Associate 32118703
Autoimmune Lymphoproliferative Syndrome Associate 30386345
Breast Neoplasms Associate 34868337
Candidiasis Associate 32118703
Carcinoma Endometrioid Associate 36550267
Carcinoma Non Small Cell Lung Associate 37081781
Cognitive Dysfunction Associate 34427831
Colorectal Neoplasms Associate 19638618, 21228115
Congenital Abnormalities Associate 33382390
Endometrial Neoplasms Associate 36550267