Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6787
Gene name Gene Name - the full gene name approved by the HGNC.	NIMA related kinase 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NEK4
Synonyms (NCBI Gene) Gene synonyms aliases	NRK2, STK2, pp12301
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p21.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs770418305	->T	Likely-pathogenic	Coding sequence variant, genic downstream transcript variant, frameshift variant

Show/Hide all(109)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004215	hsa-miR-197-3p	Microarray	16822819
MIRT686017	hsa-miR-3714	HITS-CLIP	23313552
MIRT686016	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT686015	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT686014	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT686013	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT686012	hsa-miR-940	HITS-CLIP	23313552
MIRT686011	hsa-miR-6760-5p	HITS-CLIP	23313552
MIRT686010	hsa-miR-1321	HITS-CLIP	23313552
MIRT686009	hsa-miR-4739	HITS-CLIP	23313552
MIRT686008	hsa-miR-4756-5p	HITS-CLIP	23313552
MIRT686007	hsa-miR-3622a-3p	HITS-CLIP	23313552
MIRT686006	hsa-miR-3622b-3p	HITS-CLIP	23313552
MIRT686005	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT686004	hsa-miR-1288-5p	HITS-CLIP	23313552
MIRT686003	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT686002	hsa-miR-4459	HITS-CLIP	23313552
MIRT686001	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT686000	hsa-miR-4514	HITS-CLIP	23313552
MIRT685999	hsa-miR-4692	HITS-CLIP	23313552
MIRT685998	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT685997	hsa-miR-544b	HITS-CLIP	23313552
MIRT685996	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT685995	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT685994	hsa-miR-4738-3p	HITS-CLIP	23313552
MIRT685993	hsa-miR-3926	HITS-CLIP	23313552
MIRT685992	hsa-miR-3162-5p	HITS-CLIP	23313552
MIRT685991	hsa-miR-548s	HITS-CLIP	23313552
MIRT685990	hsa-miR-2909	HITS-CLIP	23313552
MIRT650613	hsa-miR-6847-5p	HITS-CLIP	23824327
MIRT650612	hsa-miR-4257	HITS-CLIP	23824327
MIRT650611	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT650610	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT686017	hsa-miR-3714	HITS-CLIP	23313552
MIRT686016	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT686015	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT686014	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT686013	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT686012	hsa-miR-940	HITS-CLIP	23313552
MIRT686011	hsa-miR-6760-5p	HITS-CLIP	23313552
MIRT686010	hsa-miR-1321	HITS-CLIP	23313552
MIRT686009	hsa-miR-4739	HITS-CLIP	23313552
MIRT686008	hsa-miR-4756-5p	HITS-CLIP	23313552
MIRT686007	hsa-miR-3622a-3p	HITS-CLIP	23313552
MIRT686006	hsa-miR-3622b-3p	HITS-CLIP	23313552
MIRT686005	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT686004	hsa-miR-1288-5p	HITS-CLIP	23313552
MIRT686003	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT686002	hsa-miR-4459	HITS-CLIP	23313552
MIRT686001	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT686000	hsa-miR-4514	HITS-CLIP	23313552
MIRT685999	hsa-miR-4692	HITS-CLIP	23313552
MIRT685998	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT685997	hsa-miR-544b	HITS-CLIP	23313552
MIRT685996	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT685995	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT685994	hsa-miR-4738-3p	HITS-CLIP	23313552
MIRT685993	hsa-miR-3926	HITS-CLIP	23313552
MIRT685992	hsa-miR-3162-5p	HITS-CLIP	23313552
MIRT685991	hsa-miR-548s	HITS-CLIP	23313552
MIRT685990	hsa-miR-2909	HITS-CLIP	23313552
MIRT650613	hsa-miR-6847-5p	HITS-CLIP	23824327
MIRT650612	hsa-miR-4257	HITS-CLIP	23824327
MIRT650611	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT650610	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT1180148	hsa-miR-1297	CLIP-seq
MIRT1180149	hsa-miR-154	CLIP-seq
MIRT1180150	hsa-miR-2355-3p	CLIP-seq
MIRT1180151	hsa-miR-24	CLIP-seq
MIRT1180152	hsa-miR-26a	CLIP-seq
MIRT1180153	hsa-miR-26b	CLIP-seq
MIRT1180154	hsa-miR-28-3p	CLIP-seq
MIRT1180155	hsa-miR-30a	CLIP-seq
MIRT1180156	hsa-miR-30b	CLIP-seq
MIRT1180157	hsa-miR-30c	CLIP-seq
MIRT1180158	hsa-miR-30d	CLIP-seq
MIRT1180159	hsa-miR-30e	CLIP-seq
MIRT1180160	hsa-miR-3123	CLIP-seq
MIRT1180161	hsa-miR-3137	CLIP-seq
MIRT1180162	hsa-miR-3149	CLIP-seq
MIRT1180163	hsa-miR-3163	CLIP-seq
MIRT1180164	hsa-miR-3686	CLIP-seq
MIRT1180165	hsa-miR-374a	CLIP-seq
MIRT1180166	hsa-miR-374b	CLIP-seq
MIRT1180167	hsa-miR-3909	CLIP-seq
MIRT740167	hsa-miR-4279	CLIP-seq
MIRT1180168	hsa-miR-4311	CLIP-seq
MIRT1180169	hsa-miR-4465	CLIP-seq
MIRT1180170	hsa-miR-4477a	CLIP-seq
MIRT1180171	hsa-miR-4517	CLIP-seq
MIRT1180172	hsa-miR-4646-3p	CLIP-seq
MIRT1180173	hsa-miR-4652-3p	CLIP-seq
MIRT1180174	hsa-miR-4690-5p	CLIP-seq
MIRT1180175	hsa-miR-4719	CLIP-seq
MIRT1180176	hsa-miR-4757-3p	CLIP-seq
MIRT1180177	hsa-miR-4775	CLIP-seq
MIRT1180178	hsa-miR-4778-5p	CLIP-seq
MIRT1180179	hsa-miR-4797-3p	CLIP-seq
MIRT1180180	hsa-miR-495	CLIP-seq
MIRT1180181	hsa-miR-568	CLIP-seq
MIRT740168	hsa-miR-579	CLIP-seq
MIRT1180182	hsa-miR-606	CLIP-seq
MIRT740169	hsa-miR-616	CLIP-seq
MIRT1180183	hsa-miR-676	CLIP-seq
MIRT1180184	hsa-miR-767-3p	CLIP-seq
MIRT2052132	hsa-miR-3140-3p	CLIP-seq
MIRT1180163	hsa-miR-3163	CLIP-seq
MIRT1180176	hsa-miR-4757-3p	CLIP-seq
MIRT2052133	hsa-miR-656	CLIP-seq

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000278	Process	Mitotic cell cycle	IMP	22851694
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	ISS
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	8208544
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005929	Component	Cilium	IEA
GO:0006468	Process	Protein phosphorylation	ISS
GO:0006468	Process	Protein phosphorylation	TAS	8208544
GO:0006974	Process	DNA damage response	IBA
GO:0006974	Process	DNA damage response	IMP	22851694
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030145	Function	Manganese ion binding	ISS
GO:0035253	Component	Ciliary rootlet	IEA
GO:0035869	Component	Ciliary transition zone	IEA
GO:0036064	Component	Ciliary basal body	IEA
GO:0042995	Component	Cell projection	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IMP	22851694
GO:0046872	Function	Metal ion binding	IEA
GO:0051301	Process	Cell division	IEA
GO:0097014	Component	Ciliary plasm	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:2000772	Process	Regulation of cellular senescence	IMP	22851694

MIM	HGNC	e!Ensembl
601959	11399	ENSG00000114904

Protein

UniProt ID

P51957

Protein name

Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)

Protein function

Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycl

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	6 → 261	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas. {ECO:0000269|PubMed:21685204, ECO:0000269|PubMed:8208544}.

Sequence

MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL
KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ
YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN
KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT
MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE
SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA
TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ
PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLG
SSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR
REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS
RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL
SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS
KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE
VLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMN
F

Sequence length

841

Interactions

View interactions

NEK4 (NIMA related kinase 4)