Gene Gene information from NCBI Gene database.
Entrez ID 6781
Gene name Stanniocalcin 1
Gene symbol STC1
Synonyms (NCBI Gene)
STC
Chromosome 8
Chromosome location 8p21.2
Summary This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5` UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cy
miRNA miRNA information provided by mirtarbase database.
638
miRTarBase ID miRNA Experiments Reference
MIRT639887 hsa-miR-5195-5p HITS-CLIP 23824327
MIRT639886 hsa-miR-6887-3p HITS-CLIP 23824327
MIRT639885 hsa-miR-4667-3p HITS-CLIP 23824327
MIRT639883 hsa-miR-2276-5p HITS-CLIP 23824327
MIRT639884 hsa-miR-5193 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0001503 Process Ossification IEA
GO:0001886 Process Endothelial cell morphogenesis IDA 14500721
GO:0003421 Process Growth plate cartilage axis specification IDA 16377640
GO:0005179 Function Hormone activity IEA
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601185 11373 ENSG00000159167
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P52823
Protein name Stanniocalcin-1 (STC-1)
Protein function Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03298 Stanniocalcin 6 206 Stanniocalcin family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not dete
Sequence
Sequence length 247
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
14
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BLADDER CALCULUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma of Lung Associate 26577859, 35403268, 37576511
★☆☆☆☆
Found in Text Mining only
Altitude Sickness Associate 39201771
★☆☆☆☆
Found in Text Mining only
Asthma Associate 30669148
★☆☆☆☆
Found in Text Mining only
Brain Edema Associate 39201771
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 21720730, 28665755, 29593009, 36336967, 37400459
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 21672207, 25740019, 26577859, 32037949, 35798563
★☆☆☆☆
Found in Text Mining only
Carcinoma Endometrioid Inhibit 34650342
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 37004088
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Associate 25740019
★☆☆☆☆
Found in Text Mining only
Cardiomyopathy Dilated Associate 18309109
★☆☆☆☆
Found in Text Mining only