STAT4 (signal transducer and activator of transcription 4)

Gene Gene information from NCBI Gene database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 6775
Gene name Signal transducer and activator of transcription 4
Gene symbol STAT4
Synonyms (NCBI Gene)
DPMCSLEB11
Chromosome 2
Chromosome location 2q32.2-q32.3
Summary The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that tran
SNPs SNP information provided by dbSNP.
1
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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SNP ID Visualize variation Clinical significance Consequence
rs7574865 T>A,G Risk-factor Intron variant
miRNA miRNA information provided by mirtarbase database.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT052905 hsa-miR-141-3p Luciferase reporter assayqRT-PCRWestern blot 24732377
MIRT052905 hsa-miR-141-3p ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 24732377
MIRT052905 hsa-miR-141-3p ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 24732377
MIRT736510 hsa-miR-200a-3p Luciferase reporter assayWestern blottingqRT-PCR 33552256
MIRT052905 hsa-miR-141-3p Luciferase reporter assayWestern blottingqRT-PCR 33552256
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
GATA3 Repression 21632975
NFKB1 Unknown 17046972
RELA Unknown 17046972
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0003677 Function DNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600558 11365 ENSG00000138378
Protein Protein information from UniProt database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14765
Protein name Signal transducer and activator of transcription 4
Protein function Transcriptional regulator mainly expressed in hematopoietic cells that plays a critical role in cellular growth, differentiation and immune response (PubMed:10961885, PubMed:37256972, PubMed:8943379). Plays a key role in the differentiation of T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02865 STAT_int 2 → 120 STAT protein, protein interaction domain Domain
PF01017 STAT_alpha 140 → 308 STAT protein, all-alpha domain Family
PF02864 STAT_bind 320 → 454 STAT protein, DNA binding domain Domain
PF00017 SH2 569 → 645 SH2 domain Domain
Sequence
Sequence length 748
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Necroptosis
JAK-STAT signaling pathway
Th1 and Th2 cell differentiation
Hepatitis B
Pathways in cancer
Inflammatory bowel disease 		  Interleukin-20 family signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Interleukin-35 Signalling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-21 signaling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Disabling pansclerotic morphea of childhood Likely pathogenic; Pathogenic rs2470644258, rs2470644108, rs2470644386 RCV003313748
RCV003313749
RCV003313750
Show/Hide Unknown Diseases (5)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cholangiocarcinoma Benign rs754067021 RCV005868662
Familial cancer of breast Benign rs754067021 RCV005868660
Malignant tumor of esophagus Benign rs754067021 RCV005868661
STAT4-related disorder Conflicting classifications of pathogenicity; Likely benign; Uncertain significance; Benign rs140675301, rs139598810, rs141331848, rs941296401, rs61756200, rs200982266, rs754067021, rs758109437, rs776987023, rs140221173 RCV003938632
RCV003893005
RCV003416612
RCV003407960
RCV003903545
RCV003978543
RCV003978712
RCV003898830
RCV003405853
RCV003982228
RCV003950402
Show/Hide Text Mining Associations (111)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Disease Associate 25076205
Addison Disease Associate 24614117
Antiphospholipid Syndrome Associate 19644876
Aortic Aneurysm Abdominal Associate 40775512
Arthritis Associate 16096332, 22937072
Arthritis Juvenile Associate 19565500, 19674979, 20722033, 25781893, 29848367
Arthritis Rheumatoid Associate 16096332, 16760256, 17223651, 17804842, 17932559, 18434327, 18576330, 18576336, 18759272, 19109131, 19445664, 19714582, 19741008, 20353580, 20454450
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Arthropathy progressive pseudorheumatoid of childhood Associate 39597056
Asthma Associate 17532201, 26399222, 35528611
Autoimmune Diseases Associate 18204446, 18576330, 19109131, 19565500, 19796918, 20131239, 22968431, 23990947, 24312163, 24614117, 25019342, 25781893, 26569609, 29276866, 29523850
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