STAT4 (signal transducer and activator of transcription 4)

Gene
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6775
Gene name Gene Name - the full gene name approved by the HGNC.
Signal transducer and activator of transcription 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
STAT4
Synonyms (NCBI Gene) Gene synonyms aliases
DPMC, SLEB11
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q32.2-q32.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that tran
SNPs SNP information provided by dbSNP.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs7574865 T>A,G Risk-factor Intron variant
miRNA miRNA information provided by mirtarbase database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(10)
miRTarBase ID miRNA Experiments Reference
MIRT052905 hsa-miR-141-3p Luciferase reporter assay, qRT-PCR, Western blot 24732377
MIRT052905 hsa-miR-141-3p Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 24732377
MIRT052905 hsa-miR-141-3p Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 24732377
MIRT736510 hsa-miR-200a-3p Luciferase reporter assay, Western blotting, qRT-PCR 33552256
MIRT052905 hsa-miR-141-3p Luciferase reporter assay, Western blotting, qRT-PCR 33552256
Transcription factors
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
GATA3 Repression 21632975
NFKB1 Unknown 17046972
RELA Unknown 17046972
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0003677 Function DNA binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600558 11365 ENSG00000138378
Protein
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q14765
Protein name Signal transducer and activator of transcription 4
Protein function Transcriptional regulator mainly expressed in hematopoietic cells that plays a critical role in cellular growth, differentiation and immune response (PubMed:10961885, PubMed:37256972, PubMed:8943379). Plays a key role in the differentiation of T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02865 STAT_int 2 → 120 STAT protein, protein interaction domain Domain
PF01017 STAT_alpha 140 → 308 STAT protein, all-alpha domain Family
PF02864 STAT_bind 320 → 454 STAT protein, DNA binding domain Domain
PF00017 SH2 569 → 645 SH2 domain Domain
Sequence
Sequence length 748
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Necroptosis
JAK-STAT signaling pathway
Th1 and Th2 cell differentiation
Hepatitis B
Pathways in cancer
Inflammatory bowel disease 		  Interleukin-20 family signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Interleukin-35 Signalling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-21 signaling
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (13)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Biliary Cholangitis Primary biliary cholangitis N/A N/A GWAS
Biliary Cirrhosis Primary biliary cirrhosis N/A N/A GWAS
Celiac disease Celiac disease N/A N/A GWAS
Crohn Disease Crohn's disease N/A N/A GWAS
Show/Hide Text Mining Associations (111)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Disease Associate 25076205
Addison Disease Associate 24614117
Antiphospholipid Syndrome Associate 19644876
Aortic Aneurysm Abdominal Associate 40775512
Arthritis Associate 16096332, 22937072
Arthritis Juvenile Associate 19565500, 19674979, 20722033, 25781893, 29848367
Arthritis Rheumatoid Associate 16096332, 16760256, 17223651, 17804842, 17932559, 18434327, 18576330, 18576336, 18759272, 19109131, 19445664, 19714582, 19741008, 20353580, 20454450
View all (15 more)
Arthropathy progressive pseudorheumatoid of childhood Associate 39597056
Asthma Associate 17532201, 26399222, 35528611
Autoimmune Diseases Associate 18204446, 18576330, 19109131, 19565500, 19796918, 20131239, 22968431, 23990947, 24312163, 24614117, 25019342, 25781893, 26569609, 29276866, 29523850
View all (1 more)