Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6774
Gene name Gene Name - the full gene name approved by the HGNC.
Signal transducer and activator of transcription 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
STAT3
Synonyms (NCBI Gene) Gene synonyms aliases
ADMIO, ADMIO1, APRF, HIES
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the ce
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs113994135 G>A Pathogenic Coding sequence variant, missense variant
rs113994136 C>A,T Pathogenic Coding sequence variant, missense variant
rs113994137 C>T Pathogenic Coding sequence variant, missense variant
rs113994138 CAC>- Pathogenic Coding sequence variant, inframe deletion
rs113994139 C>T Pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000497 hsa-miR-20b-5p qRT-PCR, ELISA, ChIP, Western blot 20232316
MIRT005006 hsa-miR-125b-5p Microarray 17891175
MIRT006959 hsa-miR-337-3p Luciferase reporter assay, qRT-PCR, Western blot 22723956
MIRT021003 hsa-miR-155-5p Proteomics 18668040
MIRT028178 hsa-miR-93-5p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
BCL6 Unknown 17951530
BRCA1 Unknown 11163768
CEBPA Unknown 24429361
HDAC1 Unknown 18611949
HIC1 Activation 24067369
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II TAS 8675499
GO:0000785 Component Chromatin IDA 16835372
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription cis-regulatory region binding IDA 17324931
GO:0000976 Function Transcription cis-regulatory region binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
102582 11364 ENSG00000168610
Protein
UniProt ID P40763
Protein name Signal transducer and activator of transcription 3 (Acute-phase response factor)
Protein function Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed
PDB 5AX3 , 5U5S , 6NJS , 6NUQ , 6QHD , 6TLC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02865 STAT_int 2 120 STAT protein, protein interaction domain Domain
PF01017 STAT_alpha 141 313 STAT protein, all-alpha domain Family
PF02864 STAT_bind 325 464 STAT protein, DNA binding domain Domain
PF00017 SH2 584 674 SH2 domain Domain
Tissue specificity TISSUE SPECIFICITY: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in naive CD4(+) T cells as well as T-helper Th17, Th1 and Th2 cells (PubMed:31899195). {ECO:0000269|PubMed:31899195}.
Sequence
Sequence length 770
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  EGFR tyrosine kinase inhibitor resistance
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Hormone signaling
Necroptosis
Signaling pathways regulating pluripotency of stem cells
JAK-STAT signaling pathway
Th17 cell differentiation
Prolactin signaling pathway
Adipocytokine signaling pathway
Insulin resistance
AGE-RAGE signaling pathway in diabetic complications
Growth hormone synthesis, secretion and action
Toxoplasmosis
Hepatitis C
Hepatitis B
Measles
Human cytomegalovirus infection
Kaposi sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Coronavirus disease - COVID-19
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Chemical carcinogenesis - receptor activation
Pancreatic cancer
Acute myeloid leukemia
Non-small cell lung cancer
PD-L1 expression and PD-1 checkpoint pathway in cancer
Inflammatory bowel disease
Lipid and atherosclerosis
  Interleukin-6 signaling
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Senescence-Associated Secretory Phenotype (SASP)
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Transcriptional regulation of pluripotent stem cells
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
PTK6 Activates STAT3
Interleukin-20 family signaling
MET activates STAT3
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-37 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Hyper-IgE Syndrome Hyper-IgE recurrent infection syndrome 1, autosomal dominant rs193922716, rs1057521091, rs193922717, rs113994138, rs1131691937, rs113994135, rs1555563871, rs193922720, rs869312888, rs1555563717, rs193922721, rs113994136, rs1598381121, rs193922722, rs397514766
View all (2 more)
N/A
hyper-ige syndrome Hyper-IgE syndrome rs113994139, rs886039434 N/A
Immunodeficiency Inherited Immunodeficiency Diseases rs113994136, rs1064794957 N/A
Multisystem Autoimmune Disease stat3-related early-onset multisystem autoimmune disease rs869312892, rs1064794957, rs869312894, rs869312889, rs193922717, rs869312888, rs113994135, rs869312893, rs869312891, rs869312887, rs587777648, rs869312890, rs113994137, rs587777649, rs587777650 N/A
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Adenocarcinoma adenoid cystic carcinoma N/A N/A ClinVar
Asthma Atopic asthma N/A N/A GWAS
Crohn Disease Crohn's disease N/A N/A GWAS
Dermatitis Atopic dermatitis N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Spontaneous Associate 26969967
Abscess Associate 33717144
Acidosis Stimulate 35927628
Acquired Immunodeficiency Syndrome Associate 18024124
Acrocephalosyndactylia Associate 23726368
Acute Disease Associate 25663681, 36688918
Acute Kidney Injury Associate 33505213
Acute Lung Injury Associate 37864659
Adenocarcinoma Associate 18320073, 29890775, 29991802, 31085800, 31291201, 32869704
Adenocarcinoma Stimulate 36225196