Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6752
Gene name Gene Name - the full gene name approved by the HGNC.
Somatostatin receptor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SSTR2
Synonyms (NCBI Gene) Gene synonyms aliases
SST2
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q25.1
Summary Summary of gene provided in NCBI Entrez Gene.
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SST
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT666092 hsa-miR-5197-5p HITS-CLIP 23824327
MIRT666091 hsa-miR-130a-3p HITS-CLIP 23824327
MIRT666090 hsa-miR-130b-3p HITS-CLIP 23824327
MIRT666089 hsa-miR-301a-3p HITS-CLIP 23824327
MIRT666088 hsa-miR-301b-3p HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
TP53 Repression 14695784
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IBA 21873635
GO:0004994 Function Somatostatin receptor activity IBA 21873635
GO:0005515 Function Protein binding IPI 10551867, 16917505, 22651821
GO:0005829 Component Cytosol IDA
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
182452 11331 ENSG00000180616
Protein
UniProt ID P30874
Protein name Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SST2) (SRIF-1)
Protein function Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as s
PDB 7T10 , 7T11 , 7UL5 , 7WIC , 7WIG , 7WJ5 , 7XAT , 7XAU , 7XAV , 7XMR , 7Y24 , 7Y26 , 7Y27 , 7YAC , 7YAE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 60 312 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colo
Sequence
Sequence length 369
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  cAMP signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
Growth hormone synthesis, secretion and action
Gastric acid secretion
  Peptide ligand-binding receptors
G alpha (i) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Pancreatic cancer Malignant neoplasm of pancreas rs118203998, rs180177143, rs587776417, rs587776527, rs864622498, rs876659571, rs587778587, rs886039619, rs745533713, rs1555460431 19917848, 17625444, 15259086
Paraganglioma Paraganglioma rs113560320, rs104894303, rs80338843, rs587776644, rs80338844, rs80338845, rs104894302, rs587776645, rs104894304, rs104894305, rs587776646, rs104894306, rs387906358, rs121908983, rs80338842
View all (131 more)
29163802
Seizure Complex partial seizures, Generalized seizures, Visual seizure, Tonic - clonic seizures, Single Seizure rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061
View all (179 more)
16771832
Associations from Text Mining
Disease Name Relationship Type References
Acromegaly Associate 28434012
ACTH Secreting Pituitary Adenoma Associate 19318729, 26607296
Adenoma Stimulate 22200580
Adenoma Associate 26607296
Adenoma Oxyphilic Associate 10768564
Adrenocortical Carcinoma Associate 37185426
Angina Stable Associate 34980502
Arthropathy progressive pseudorheumatoid of childhood Associate 39202532
Astrocytoma Associate 11762340
Biliary Atresia Associate 34392560