Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	6752
Gene name	Somatostatin receptor 2
Gene symbol	SSTR2
Synonyms (NCBI Gene)	SST2
Chromosome	17
Chromosome location	17q25.1
Summary	Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SST

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miRTarBase ID	miRNA	Experiments	Reference
MIRT666092	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT666091	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT666090	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT666089	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT666088	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT666087	hsa-miR-3666	HITS-CLIP	23824327
MIRT666086	hsa-miR-4295	HITS-CLIP	23824327
MIRT666085	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT666084	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT666083	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT666082	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT666081	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT666080	hsa-miR-3135b	HITS-CLIP	23824327
MIRT666079	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT666078	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT666077	hsa-miR-564	HITS-CLIP	23824327
MIRT666076	hsa-miR-3652	HITS-CLIP	23824327
MIRT666075	hsa-miR-4430	HITS-CLIP	23824327
MIRT666074	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT647875	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT647874	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT647873	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT542172	hsa-miR-1273g-3p	PAR-CLIP	21572407
MIRT542171	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT542170	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT542169	hsa-miR-191-3p	PAR-CLIP	21572407
MIRT542168	hsa-miR-4252	PAR-CLIP	21572407
MIRT542167	hsa-miR-1227-3p	PAR-CLIP	21572407
MIRT542166	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT542165	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT517888	hsa-miR-3653-5p	PAR-CLIP	23446348
MIRT517887	hsa-miR-6790-3p	PAR-CLIP	23446348
MIRT517886	hsa-miR-6821-3p	PAR-CLIP	23446348
MIRT517885	hsa-miR-6778-3p	PAR-CLIP	23446348
MIRT517884	hsa-miR-378a-5p	PAR-CLIP	23446348
MIRT542167	hsa-miR-1227-3p	PAR-CLIP	27292025
MIRT542172	hsa-miR-1273g-3p	PAR-CLIP	27292025
MIRT542169	hsa-miR-191-3p	PAR-CLIP	27292025
MIRT542168	hsa-miR-4252	PAR-CLIP	27292025
MIRT542166	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT542165	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT542171	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT542170	hsa-miR-766-3p	PAR-CLIP	27292025
MIRT666092	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT666091	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT666090	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT666089	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT666088	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT666087	hsa-miR-3666	HITS-CLIP	23824327
MIRT666086	hsa-miR-4295	HITS-CLIP	23824327
MIRT666085	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT666084	hsa-miR-183-5p	HITS-CLIP	23824327
MIRT666083	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT666082	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT666081	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT666080	hsa-miR-3135b	HITS-CLIP	23824327
MIRT666079	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT666078	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT666077	hsa-miR-564	HITS-CLIP	23824327
MIRT666076	hsa-miR-3652	HITS-CLIP	23824327
MIRT666075	hsa-miR-4430	HITS-CLIP	23824327
MIRT666074	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT647875	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT647874	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT647873	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT542172	hsa-miR-1273g-3p	PAR-CLIP	21572407
MIRT542171	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT542170	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT542169	hsa-miR-191-3p	PAR-CLIP	21572407
MIRT542168	hsa-miR-4252	PAR-CLIP	21572407
MIRT542167	hsa-miR-1227-3p	PAR-CLIP	21572407
MIRT542166	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT542165	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT517888	hsa-miR-3653-5p	PAR-CLIP	23446348
MIRT517887	hsa-miR-6790-3p	PAR-CLIP	23446348
MIRT517886	hsa-miR-6821-3p	PAR-CLIP	23446348
MIRT517885	hsa-miR-6778-3p	PAR-CLIP	23446348
MIRT517884	hsa-miR-378a-5p	PAR-CLIP	23446348
MIRT1392829	hsa-miR-1224-3p	CLIP-seq
MIRT1392830	hsa-miR-1245	CLIP-seq
MIRT1392831	hsa-miR-1294	CLIP-seq
MIRT1392832	hsa-miR-1827	CLIP-seq
MIRT1392833	hsa-miR-197	CLIP-seq
MIRT1392834	hsa-miR-2355-5p	CLIP-seq
MIRT1392835	hsa-miR-2467-3p	CLIP-seq
MIRT1392836	hsa-miR-3154	CLIP-seq
MIRT1392837	hsa-miR-3159	CLIP-seq
MIRT1392838	hsa-miR-3170	CLIP-seq
MIRT1392839	hsa-miR-3184	CLIP-seq
MIRT1392840	hsa-miR-3612	CLIP-seq
MIRT1392841	hsa-miR-3622a-5p	CLIP-seq
MIRT1392842	hsa-miR-3679-3p	CLIP-seq
MIRT1392843	hsa-miR-3689a-3p	CLIP-seq
MIRT1392844	hsa-miR-3689c	CLIP-seq
MIRT1392845	hsa-miR-3934	CLIP-seq
MIRT1392846	hsa-miR-3975	CLIP-seq
MIRT1392847	hsa-miR-423-5p	CLIP-seq
MIRT1392848	hsa-miR-4269	CLIP-seq
MIRT1392849	hsa-miR-4286	CLIP-seq
MIRT1392850	hsa-miR-4316	CLIP-seq
MIRT1392851	hsa-miR-4422	CLIP-seq
MIRT1392852	hsa-miR-4436b-3p	CLIP-seq
MIRT1392853	hsa-miR-4438	CLIP-seq
MIRT1392854	hsa-miR-4464	CLIP-seq
MIRT1392855	hsa-miR-4651	CLIP-seq
MIRT1392856	hsa-miR-4701-5p	CLIP-seq
MIRT1392857	hsa-miR-4728-5p	CLIP-seq
MIRT1392858	hsa-miR-4748	CLIP-seq
MIRT1392859	hsa-miR-5095	CLIP-seq
MIRT1392860	hsa-miR-5096	CLIP-seq
MIRT1392861	hsa-miR-548ae	CLIP-seq
MIRT1392862	hsa-miR-548aj	CLIP-seq
MIRT1392863	hsa-miR-548am	CLIP-seq
MIRT1392864	hsa-miR-548x	CLIP-seq
MIRT1392865	hsa-miR-608	CLIP-seq
MIRT1392866	hsa-miR-640	CLIP-seq
MIRT1392867	hsa-miR-650	CLIP-seq
MIRT1392868	hsa-miR-940	CLIP-seq
MIRT2117895	hsa-miR-1178	CLIP-seq
MIRT1392830	hsa-miR-1245	CLIP-seq
MIRT2117896	hsa-miR-1297	CLIP-seq
MIRT2117897	hsa-miR-150	CLIP-seq
MIRT2117898	hsa-miR-1976	CLIP-seq
MIRT2117899	hsa-miR-216a	CLIP-seq
MIRT2117900	hsa-miR-217	CLIP-seq
MIRT2117901	hsa-miR-26a	CLIP-seq
MIRT2117902	hsa-miR-26b	CLIP-seq
MIRT2117903	hsa-miR-3155	CLIP-seq
MIRT2117904	hsa-miR-3155b	CLIP-seq
MIRT2117905	hsa-miR-3977	CLIP-seq
MIRT2117906	hsa-miR-4279	CLIP-seq
MIRT1392850	hsa-miR-4316	CLIP-seq
MIRT2117907	hsa-miR-4418	CLIP-seq
MIRT2117908	hsa-miR-4465	CLIP-seq
MIRT2117909	hsa-miR-4722-3p	CLIP-seq
MIRT2117910	hsa-miR-4772-3p	CLIP-seq
MIRT2117911	hsa-miR-4775	CLIP-seq
MIRT2117912	hsa-miR-484	CLIP-seq
MIRT2117913	hsa-miR-509-3-5p	CLIP-seq
MIRT2117914	hsa-miR-509-5p	CLIP-seq
MIRT2117915	hsa-miR-548m	CLIP-seq
MIRT2117916	hsa-miR-590-3p	CLIP-seq
MIRT2339858	hsa-miR-106a	CLIP-seq
MIRT2339859	hsa-miR-106b	CLIP-seq
MIRT2117895	hsa-miR-1178	CLIP-seq
MIRT1392829	hsa-miR-1224-3p	CLIP-seq
MIRT2339860	hsa-miR-1234	CLIP-seq
MIRT2117897	hsa-miR-150	CLIP-seq
MIRT2339861	hsa-miR-17	CLIP-seq
MIRT2339862	hsa-miR-20a	CLIP-seq
MIRT2339863	hsa-miR-20b	CLIP-seq
MIRT2117899	hsa-miR-216a	CLIP-seq
MIRT2339864	hsa-miR-302a	CLIP-seq
MIRT2339865	hsa-miR-302b	CLIP-seq
MIRT2339866	hsa-miR-302c	CLIP-seq
MIRT2339867	hsa-miR-302d	CLIP-seq
MIRT2339868	hsa-miR-302e	CLIP-seq
MIRT2117903	hsa-miR-3155	CLIP-seq
MIRT2117904	hsa-miR-3155b	CLIP-seq
MIRT2339869	hsa-miR-372	CLIP-seq
MIRT2339870	hsa-miR-373	CLIP-seq
MIRT1392845	hsa-miR-3934	CLIP-seq
MIRT2117905	hsa-miR-3977	CLIP-seq
MIRT2339871	hsa-miR-4731-5p	CLIP-seq
MIRT2117911	hsa-miR-4775	CLIP-seq
MIRT2117912	hsa-miR-484	CLIP-seq
MIRT1392859	hsa-miR-5095	CLIP-seq
MIRT2339872	hsa-miR-512-3p	CLIP-seq
MIRT2339873	hsa-miR-519d	CLIP-seq
MIRT2339874	hsa-miR-520a-3p	CLIP-seq
MIRT2339875	hsa-miR-520b	CLIP-seq
MIRT2339876	hsa-miR-520c-3p	CLIP-seq
MIRT2339877	hsa-miR-520d-3p	CLIP-seq
MIRT2339878	hsa-miR-520e	CLIP-seq
MIRT2339879	hsa-miR-520g	CLIP-seq
MIRT2339880	hsa-miR-520h	CLIP-seq
MIRT2117915	hsa-miR-548m	CLIP-seq
MIRT2339881	hsa-miR-552	CLIP-seq
MIRT2117916	hsa-miR-590-3p	CLIP-seq
MIRT1392866	hsa-miR-640	CLIP-seq
MIRT2339882	hsa-miR-93	CLIP-seq
MIRT1392831	hsa-miR-1294	CLIP-seq
MIRT1392839	hsa-miR-3184	CLIP-seq
MIRT1392843	hsa-miR-3689a-3p	CLIP-seq
MIRT1392844	hsa-miR-3689c	CLIP-seq
MIRT1392845	hsa-miR-3934	CLIP-seq
MIRT1392847	hsa-miR-423-5p	CLIP-seq
MIRT1392850	hsa-miR-4316	CLIP-seq
MIRT1392855	hsa-miR-4651	CLIP-seq
MIRT1392857	hsa-miR-4728-5p	CLIP-seq
MIRT1392865	hsa-miR-608	CLIP-seq
MIRT2433585	hsa-miR-1279	CLIP-seq
MIRT2433586	hsa-miR-1305	CLIP-seq
MIRT2433587	hsa-miR-4461	CLIP-seq
MIRT2433588	hsa-miR-4731-3p	CLIP-seq
MIRT2433589	hsa-miR-4801	CLIP-seq
MIRT2117896	hsa-miR-1297	CLIP-seq
MIRT2117897	hsa-miR-150	CLIP-seq
MIRT2117898	hsa-miR-1976	CLIP-seq
MIRT2117901	hsa-miR-26a	CLIP-seq
MIRT2117902	hsa-miR-26b	CLIP-seq
MIRT2633773	hsa-miR-3688-5p	CLIP-seq
MIRT2117906	hsa-miR-4279	CLIP-seq
MIRT2633774	hsa-miR-4302	CLIP-seq
MIRT2117908	hsa-miR-4465	CLIP-seq
MIRT2633775	hsa-miR-4470	CLIP-seq
MIRT2633776	hsa-miR-4474-3p	CLIP-seq
MIRT2117896	hsa-miR-1297	CLIP-seq
MIRT2117897	hsa-miR-150	CLIP-seq
MIRT2117898	hsa-miR-1976	CLIP-seq
MIRT2117901	hsa-miR-26a	CLIP-seq
MIRT2117902	hsa-miR-26b	CLIP-seq
MIRT2633773	hsa-miR-3688-5p	CLIP-seq
MIRT2117906	hsa-miR-4279	CLIP-seq
MIRT2633774	hsa-miR-4302	CLIP-seq
MIRT2117908	hsa-miR-4465	CLIP-seq
MIRT2633775	hsa-miR-4470	CLIP-seq
MIRT2633776	hsa-miR-4474-3p	CLIP-seq
MIRT2117909	hsa-miR-4722-3p	CLIP-seq

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Transcription factor	Regulation	Reference
TP53	Repression	14695784

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004994	Function	Somatostatin receptor activity	IBA
GO:0004994	Function	Somatostatin receptor activity	IEA
GO:0004994	Function	Somatostatin receptor activity	TAS	7914078
GO:0005515	Function	Protein binding	IPI	10551867, 16917505, 18653781, 22651821
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7914078
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	7914078
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007218	Process	Neuropeptide signaling pathway	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	9892014
GO:0016020	Component	Membrane	IEA
GO:0030165	Function	PDZ domain binding	IPI	10551867
GO:0038170	Process	Somatostatin signaling pathway	IEA
GO:0042923	Function	Neuropeptide binding	IBA
GO:0043005	Component	Neuron projection	IBA
GO:0071385	Process	Cellular response to glucocorticoid stimulus	IBA
GO:0071392	Process	Cellular response to estradiol stimulus	IBA

MIM	HGNC	e!Ensembl
182452	11331	ENSG00000180616

P30874

Protein name

Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SST2) (SRIF-1)

Protein function

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as s

PDB

7T10 , 7T11 , 7UL5 , 7WIC , 7WIG , 7WJ5 , 7XAT , 7XAU , 7XAV , 7XMR , 7Y24 , 7Y26 , 7Y27 , 7YAC , 7YAE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	60 → 312	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colo

Sequence

MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCG
NTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMT
VDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIY
AGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGI
RVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVL
TYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTL
LNGDLQTSI

Sequence length

369

Interactions

View interactions

	KEGG		Reactome
	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Growth hormone synthesis, secretion and action Gastric acid secretion		Peptide ligand-binding receptors G alpha (i) signalling events

SSTR2 (somatostatin receptor 2)