Gene Gene information from NCBI Gene database.
Entrez ID 6747
Gene name Signal sequence receptor subunit 3
Gene symbol SSR3
Synonyms (NCBI Gene)
TRAPG
Chromosome 3
Chromosome location 3q25.31
Summary The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The fir
miRNA miRNA information provided by mirtarbase database.
1163
miRTarBase ID miRNA Experiments Reference
MIRT019355 hsa-miR-148b-3p Microarray 17612493
MIRT021752 hsa-miR-132-3p Microarray 17612493
MIRT023217 hsa-miR-122-5p Microarray 17612493
MIRT045912 hsa-miR-125b-5p CLASH 23622248
MIRT039643 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
6
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005783 Component Endoplasmic reticulum IBA
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005789 Component Endoplasmic reticulum membrane IEA
GO:0006614 Process SRP-dependent cotranslational protein targeting to membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606213 11325 ENSG00000114850
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UNL2
Protein name Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma)
Protein function TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
PDB 8B6L
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07074 TRAP-gamma 12 183 Translocon-associated protein, gamma subunit (TRAP-gamma) Family
Sequence
Sequence length 185
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Protein processing in endoplasmic reticulum  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
13
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Congenital disorder of glycosylation Likely pathogenic rs1719856599 RCV001261805
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARCINOMA, BASAL CELL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONGENITAL DISORDERS OF GLYCOSYLATION Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Colorectal Neoplasms Associate 29328363
★☆☆☆☆
Found in Text Mining only
Congenital Disorder Of Glycosylation Type In Associate 30945312
★☆☆☆☆
Found in Text Mining only
Congenital Disorders of Glycosylation Associate 30945312
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Esophageal Squamous Cell Carcinoma Associate 15761962
★☆☆☆☆
Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck Associate 33091845
★☆☆☆☆
Found in Text Mining only