SSR2 (signal sequence receptor subunit 2)

Gene

• Entrez ID: 6746
• Gene name: Signal sequence receptor subunit 2
• Gene symbol: SSR2
• Synonyms (NCBI Gene): HSD25, TLAP, TRAP-BETA, TRAPB
• Chromosome: 1
• Chromosome location: 1q22
• Summary: The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprote

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045638	hsa-miR-149-5p	CLASH	23622248
MIRT045273	hsa-miR-186-5p	CLASH	23622248
MIRT042799	hsa-miR-339-5p	CLASH	23622248
MIRT042734	hsa-miR-345-5p	CLASH	23622248
MIRT042734	hsa-miR-345-5p	CLASH	23622248
MIRT040270	hsa-miR-615-3p	CLASH	23622248
MIRT698849	hsa-miR-876-5p	HITS-CLIP	23313552
MIRT698848	hsa-miR-3167	HITS-CLIP	23313552
MIRT698847	hsa-miR-6835-3p	HITS-CLIP	23313552
MIRT698846	hsa-miR-4662a-3p	HITS-CLIP	23313552
MIRT698845	hsa-miR-619-3p	HITS-CLIP	23313552
MIRT698844	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT698843	hsa-miR-875-3p	HITS-CLIP	23313552
MIRT698842	hsa-miR-6128	HITS-CLIP	23313552
MIRT698841	hsa-miR-378j	HITS-CLIP	23313552
MIRT698840	hsa-miR-6839-5p	HITS-CLIP	23313552
MIRT698839	hsa-miR-5186	HITS-CLIP	23313552
MIRT698838	hsa-miR-6804-3p	HITS-CLIP	23313552
MIRT698837	hsa-miR-1289	HITS-CLIP	23313552
MIRT698836	hsa-miR-4294	HITS-CLIP	23313552
MIRT698835	hsa-miR-1290	HITS-CLIP	23313552
MIRT698834	hsa-miR-1299	HITS-CLIP	23313552
MIRT698833	hsa-miR-33a-5p	HITS-CLIP	23313552
MIRT698832	hsa-miR-33b-5p	HITS-CLIP	23313552
MIRT698831	hsa-miR-3978	HITS-CLIP	23313552
MIRT698830	hsa-miR-3198	HITS-CLIP	23313552
MIRT698829	hsa-miR-4309	HITS-CLIP	23313552
MIRT698828	hsa-miR-3658	HITS-CLIP	23313552
MIRT698827	hsa-miR-1185-5p	HITS-CLIP	23313552
MIRT698849	hsa-miR-876-5p	HITS-CLIP	23313552
MIRT698848	hsa-miR-3167	HITS-CLIP	23313552
MIRT698847	hsa-miR-6835-3p	HITS-CLIP	23313552
MIRT698846	hsa-miR-4662a-3p	HITS-CLIP	23313552
MIRT698845	hsa-miR-619-3p	HITS-CLIP	23313552
MIRT698844	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT698843	hsa-miR-875-3p	HITS-CLIP	23313552
MIRT698842	hsa-miR-6128	HITS-CLIP	23313552
MIRT698841	hsa-miR-378j	HITS-CLIP	23313552
MIRT698840	hsa-miR-6839-5p	HITS-CLIP	23313552
MIRT698839	hsa-miR-5186	HITS-CLIP	23313552
MIRT698838	hsa-miR-6804-3p	HITS-CLIP	23313552
MIRT698837	hsa-miR-1289	HITS-CLIP	23313552
MIRT698836	hsa-miR-4294	HITS-CLIP	23313552
MIRT698835	hsa-miR-1290	HITS-CLIP	23313552
MIRT698834	hsa-miR-1299	HITS-CLIP	23313552
MIRT698833	hsa-miR-33a-5p	HITS-CLIP	23313552
MIRT698832	hsa-miR-33b-5p	HITS-CLIP	23313552
MIRT698831	hsa-miR-3978	HITS-CLIP	23313552
MIRT698830	hsa-miR-3198	HITS-CLIP	23313552
MIRT698829	hsa-miR-4309	HITS-CLIP	23313552
MIRT698828	hsa-miR-3658	HITS-CLIP	23313552
MIRT698827	hsa-miR-1185-5p	HITS-CLIP	23313552
MIRT1392589	hsa-miR-1202	CLIP-seq
MIRT1392590	hsa-miR-1253	CLIP-seq
MIRT1392591	hsa-miR-135a	CLIP-seq
MIRT1392592	hsa-miR-135b	CLIP-seq
MIRT1392593	hsa-miR-2278	CLIP-seq
MIRT1392594	hsa-miR-3065-3p	CLIP-seq
MIRT1392595	hsa-miR-3151	CLIP-seq
MIRT1392596	hsa-miR-3194-5p	CLIP-seq
MIRT1392597	hsa-miR-33a	CLIP-seq
MIRT1392598	hsa-miR-33b	CLIP-seq
MIRT1392599	hsa-miR-3677-5p	CLIP-seq
MIRT1392600	hsa-miR-3926	CLIP-seq
MIRT1392601	hsa-miR-3942-5p	CLIP-seq
MIRT1392602	hsa-miR-3972	CLIP-seq
MIRT1392603	hsa-miR-4257	CLIP-seq
MIRT1392604	hsa-miR-4436b-3p	CLIP-seq
MIRT1392605	hsa-miR-4661-3p	CLIP-seq
MIRT1392606	hsa-miR-4691-5p	CLIP-seq
MIRT1392607	hsa-miR-4703-5p	CLIP-seq
MIRT1392608	hsa-miR-4711-5p	CLIP-seq
MIRT1392609	hsa-miR-4768-3p	CLIP-seq
MIRT1392610	hsa-miR-4796-3p	CLIP-seq
MIRT1392611	hsa-miR-486-3p	CLIP-seq
MIRT1392612	hsa-miR-548s	CLIP-seq
MIRT1392613	hsa-miR-579	CLIP-seq
MIRT1392614	hsa-miR-645	CLIP-seq
MIRT1392615	hsa-miR-665	CLIP-seq
MIRT2117777	hsa-miR-1254	CLIP-seq
MIRT1392591	hsa-miR-135a	CLIP-seq
MIRT1392592	hsa-miR-135b	CLIP-seq
MIRT2117778	hsa-miR-205	CLIP-seq
MIRT1392593	hsa-miR-2278	CLIP-seq
MIRT2117779	hsa-miR-3116	CLIP-seq
MIRT1392595	hsa-miR-3151	CLIP-seq
MIRT2117780	hsa-miR-3158-3p	CLIP-seq
MIRT2117781	hsa-miR-3689a-3p	CLIP-seq
MIRT2117782	hsa-miR-3689c	CLIP-seq
MIRT2117783	hsa-miR-3910	CLIP-seq
MIRT2117784	hsa-miR-3922-5p	CLIP-seq
MIRT1392603	hsa-miR-4257	CLIP-seq
MIRT1392604	hsa-miR-4436b-3p	CLIP-seq
MIRT2117785	hsa-miR-4446-3p	CLIP-seq
MIRT2117786	hsa-miR-4492	CLIP-seq
MIRT2117787	hsa-miR-4498	CLIP-seq
MIRT1392605	hsa-miR-4661-3p	CLIP-seq
MIRT1392608	hsa-miR-4711-5p	CLIP-seq
MIRT1392609	hsa-miR-4768-3p	CLIP-seq
MIRT1392610	hsa-miR-4796-3p	CLIP-seq
MIRT1392611	hsa-miR-486-3p	CLIP-seq
MIRT2117788	hsa-miR-548an	CLIP-seq
MIRT2117789	hsa-miR-578	CLIP-seq
MIRT1392613	hsa-miR-579	CLIP-seq
MIRT2117790	hsa-miR-619	CLIP-seq
MIRT2117791	hsa-miR-635	CLIP-seq
MIRT1392614	hsa-miR-645	CLIP-seq
MIRT1392615	hsa-miR-665	CLIP-seq
MIRT2117792	hsa-miR-762	CLIP-seq
MIRT2117777	hsa-miR-1254	CLIP-seq
MIRT2339745	hsa-miR-125a-5p	CLIP-seq
MIRT2339746	hsa-miR-125b	CLIP-seq
MIRT2339747	hsa-miR-1273d	CLIP-seq
MIRT2339748	hsa-miR-1912	CLIP-seq
MIRT2117779	hsa-miR-3116	CLIP-seq
MIRT2339749	hsa-miR-3123	CLIP-seq
MIRT2339750	hsa-miR-365	CLIP-seq
MIRT2117781	hsa-miR-3689a-3p	CLIP-seq
MIRT2117782	hsa-miR-3689c	CLIP-seq
MIRT2339751	hsa-miR-4319	CLIP-seq
MIRT2339752	hsa-miR-4324	CLIP-seq
MIRT2339753	hsa-miR-4684-5p	CLIP-seq
MIRT2117789	hsa-miR-578	CLIP-seq
MIRT2117791	hsa-miR-635	CLIP-seq
MIRT2339754	hsa-miR-942	CLIP-seq
MIRT1392589	hsa-miR-1202	CLIP-seq
MIRT2339745	hsa-miR-125a-5p	CLIP-seq
MIRT2339746	hsa-miR-125b	CLIP-seq
MIRT1392591	hsa-miR-135a	CLIP-seq
MIRT1392592	hsa-miR-135b	CLIP-seq
MIRT1392594	hsa-miR-3065-3p	CLIP-seq
MIRT2339749	hsa-miR-3123	CLIP-seq
MIRT1392595	hsa-miR-3151	CLIP-seq
MIRT1392596	hsa-miR-3194-5p	CLIP-seq
MIRT2117783	hsa-miR-3910	CLIP-seq
MIRT2117784	hsa-miR-3922-5p	CLIP-seq
MIRT1392601	hsa-miR-3942-5p	CLIP-seq
MIRT1392602	hsa-miR-3972	CLIP-seq
MIRT1392603	hsa-miR-4257	CLIP-seq
MIRT2339751	hsa-miR-4319	CLIP-seq
MIRT2339752	hsa-miR-4324	CLIP-seq
MIRT1392607	hsa-miR-4703-5p	CLIP-seq
MIRT1392608	hsa-miR-4711-5p	CLIP-seq
MIRT1392611	hsa-miR-486-3p	CLIP-seq
MIRT2117788	hsa-miR-548an	CLIP-seq
MIRT1392614	hsa-miR-645	CLIP-seq
MIRT1392590	hsa-miR-1253	CLIP-seq
MIRT1392591	hsa-miR-135a	CLIP-seq
MIRT1392592	hsa-miR-135b	CLIP-seq
MIRT2117778	hsa-miR-205	CLIP-seq
MIRT1392593	hsa-miR-2278	CLIP-seq
MIRT2692047	hsa-miR-2467-5p	CLIP-seq
MIRT1392594	hsa-miR-3065-3p	CLIP-seq
MIRT1392595	hsa-miR-3151	CLIP-seq
MIRT2117780	hsa-miR-3158-3p	CLIP-seq
MIRT2692048	hsa-miR-3173-3p	CLIP-seq
MIRT1392597	hsa-miR-33a	CLIP-seq
MIRT1392598	hsa-miR-33b	CLIP-seq
MIRT1392599	hsa-miR-3677-5p	CLIP-seq
MIRT2117783	hsa-miR-3910	CLIP-seq
MIRT2117784	hsa-miR-3922-5p	CLIP-seq
MIRT1392600	hsa-miR-3926	CLIP-seq
MIRT1392603	hsa-miR-4257	CLIP-seq
MIRT1392604	hsa-miR-4436b-3p	CLIP-seq
MIRT2117785	hsa-miR-4446-3p	CLIP-seq
MIRT2117786	hsa-miR-4492	CLIP-seq
MIRT2117787	hsa-miR-4498	CLIP-seq
MIRT1392605	hsa-miR-4661-3p	CLIP-seq
MIRT2692049	hsa-miR-4695-5p	CLIP-seq
MIRT1392608	hsa-miR-4711-5p	CLIP-seq
MIRT1392609	hsa-miR-4768-3p	CLIP-seq
MIRT2692050	hsa-miR-4771	CLIP-seq
MIRT1392610	hsa-miR-4796-3p	CLIP-seq
MIRT1392611	hsa-miR-486-3p	CLIP-seq
MIRT2117788	hsa-miR-548an	CLIP-seq
MIRT1392612	hsa-miR-548s	CLIP-seq
MIRT1392614	hsa-miR-645	CLIP-seq
MIRT1392615	hsa-miR-665	CLIP-seq
MIRT2117792	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001701	Process	In utero embryonic development	IEA
GO:0005515	Function	Protein binding	IPI	18724357
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	TAS	7789174
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006613	Process	Cotranslational protein targeting to membrane	TAS	7789174
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	7789174

Other IDs

• MIM: 600867
• HGNC: 11324
• e!Ensembl: ENSG00000163479

Protein

• UniProt ID: P43308
• Protein name: Translocon-associated protein subunit beta (TRAP-beta) (Signal sequence receptor subunit beta) (SSR-beta)
• Protein function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
• PDB: 8B6L
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05753	TRAP_beta	3 → 181		Family

• Sequence:

  MRLLSFVVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELS
  DDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGPV
  VIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKRKYDTPKT
  KKN

• Sequence length: 183

Pathways

KEGG:

Protein processing in endoplasmic reticulum