SSR1 (signal sequence receptor subunit 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6745
Gene name Gene Name - the full gene name approved by the HGNC.
Signal sequence receptor subunit 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SSR1
Synonyms (NCBI Gene) Gene synonyms aliases
TRAPA
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p24.3
Summary Summary of gene provided in NCBI Entrez Gene.
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprot
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2365)
miRTarBase ID miRNA Experiments Reference
MIRT005046 hsa-let-7b-5p Microarray 17699775
MIRT024095 hsa-miR-1-3p Proteomics 18668040
MIRT046983 hsa-miR-218-5p CLASH 23622248
MIRT046983 hsa-miR-218-5p CLASH 23622248
MIRT101407 hsa-miR-216b-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(8)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 17380188, 22314232, 29568061
GO:0005783 Component Endoplasmic reticulum IBA 21873635
GO:0005783 Component Endoplasmic reticulum IDA
GO:0005789 Component Endoplasmic reticulum membrane TAS
GO:0006613 Process Cotranslational protein targeting to membrane TAS 8050590
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600868 11323 ENSG00000124783
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P43307
Protein name Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha)
Protein function TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the transloc
PDB 8B6L
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03896 TRAP_alpha 6 → 285 Translocon-associated protein (TRAP), alpha subunit Family
Sequence
Sequence length 286
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Protein processing in endoplasmic reticulum   XBP1(S) activates chaperone genes
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)		 30054458, 28869590, 24509480
Show/Hide Unknown Diseases (3)
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Insomnia Insomnia GWAS
Show/Hide Text Mining Associations (5)
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 39940786
Diabetes Gestational Associate 40004118
Inflammation Inhibit 23352462
Inflammatory Breast Neoplasms Associate 31532791
Multiple Myeloma Associate 35192775