Gene Gene information from NCBI Gene database.
Entrez ID 6728
Gene name Signal recognition particle 19
Gene symbol SRP19
Synonyms (NCBI Gene)
-
Chromosome 5
Chromosome location 5q22.2
miRNA miRNA information provided by mirtarbase database.
293
miRTarBase ID miRNA Experiments Reference
MIRT031967 hsa-miR-16-5p Proteomics 18668040
MIRT627530 hsa-miR-6760-5p HITS-CLIP 19536157
MIRT627529 hsa-miR-1321 HITS-CLIP 19536157
MIRT627528 hsa-miR-4739 HITS-CLIP 19536157
MIRT627527 hsa-miR-4756-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0003723 Function RNA binding IEA
GO:0003723 Function RNA binding IPI 17434535
GO:0005515 Function Protein binding IPI 24700861, 33961781, 35271311
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
182175 11300 ENSG00000153037
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P09132
Protein name Signal recognition particle 19 kDa protein (SRP19)
Protein function Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). Binds directly to 7SL RNA (
PDB 1JID , 1MFQ , 1RY1 , 2J37 , 3KTV , 4P3E , 5M73 , 7NFX , 7QWQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01922 SRP19 17 115 SRP19 protein Family
Sequence
Sequence length 144
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Protein export   SRP-dependent cotranslational protein targeting to membrane
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Severe congenital neutropenia Pathogenic rs1322282571 RCV001199429
Shwachman-Diamond syndrome 1 Pathogenic rs1322282571 RCV001199429
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Continuous Muscle Fiber Activity Hereditary Associate 27525944
Fluorosis Dental Associate 29317700
Kashin Beck Disease Associate 29317700
Lupus Erythematosus Systemic Associate 31494269
Muscular Diseases Associate 27525944
Stomach Diseases Associate 25210923