Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6725
Gene name Gene Name - the full gene name approved by the HGNC.	Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SRMS
Synonyms (NCBI Gene) Gene synonyms aliases	C20orf148, PTK70, SRM, dJ697K14.1
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20q13.33

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004713	Function	Protein tyrosine kinase activity	EXP	25897081
GO:0004713	Function	Protein tyrosine kinase activity	IBA	21873635
GO:0004713	Function	Protein tyrosine kinase activity	IDA	23822091, 29496907
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IBA	21873635
GO:0005102	Function	Signaling receptor binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	23822091, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	23822091, 29496907
GO:0005829	Component	Cytosol	TAS
GO:0007169	Process	Transmembrane receptor protein tyrosine kinase signaling pathway	IBA	21873635
GO:0009968	Process	Negative regulation of signal transduction	TAS
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IDA	29496907
GO:0030154	Process	Cell differentiation	IBA	21873635
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	IBA	21873635
GO:0038083	Process	Peptidyl-tyrosine autophosphorylation	IDA	23822091
GO:0045087	Process	Innate immune response	IBA	21873635

MIM	HGNC	e!Ensembl
617797	11298	ENSG00000125508

Protein

UniProt ID

Q9H3Y6

Protein name

Tyrosine-protein kinase Srms (EC 2.7.10.2)

Protein function

Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00017	SH2	120 → 197	SH2 domain	Domain
PF07714	PK_Tyr_Ser-Thr	230 → 480	Protein tyrosine and serine/threonine kinase	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in most breast cancers (at protein level).

Sequence

MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALY
DFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPW
YFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLY
LQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGY
FGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYI
VTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDD
GLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVF
TYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL
HAIHRCHP

Sequence length

488

Interactions

View interactions

	Reactome
			PTK6 Down-Regulation

SRMS (src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites)